Details for: VIT

Gene ID: 5212

Symbol: VIT

Ensembl ID: ENSG00000205221

Description: vitrin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 14.4683
    Cell Significance Index: 98.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.5201
    Cell Significance Index: 50.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.7986
    Cell Significance Index: 61.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.1998
    Cell Significance Index: 34.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8359
    Cell Significance Index: 112.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.6244
    Cell Significance Index: 82.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4843
    Cell Significance Index: 28.9700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.4408
    Cell Significance Index: 13.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.3613
    Cell Significance Index: 1850.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1065
    Cell Significance Index: 35.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8312
    Cell Significance Index: 23.2300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.7730
    Cell Significance Index: 1.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7180
    Cell Significance Index: 32.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6093
    Cell Significance Index: 19.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5973
    Cell Significance Index: 113.6700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4425
    Cell Significance Index: 4.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4045
    Cell Significance Index: 51.8600
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.3954
    Cell Significance Index: 3.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3425
    Cell Significance Index: 33.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2888
    Cell Significance Index: 260.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2747
    Cell Significance Index: 5.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2535
    Cell Significance Index: 390.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1910
    Cell Significance Index: 20.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1844
    Cell Significance Index: 3.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1829
    Cell Significance Index: 29.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1685
    Cell Significance Index: 5.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1671
    Cell Significance Index: 10.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0978
    Cell Significance Index: 6.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0850
    Cell Significance Index: 156.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0554
    Cell Significance Index: 11.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0394
    Cell Significance Index: 2.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0359
    Cell Significance Index: 6.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0267
    Cell Significance Index: 0.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0199
    Cell Significance Index: 8.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0156
    Cell Significance Index: 2.6700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0058
    Cell Significance Index: 1.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0024
    Cell Significance Index: 4.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0010
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0015
    Cell Significance Index: -1.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0132
    Cell Significance Index: -4.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0176
    Cell Significance Index: -0.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0197
    Cell Significance Index: -0.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0319
    Cell Significance Index: -3.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0352
    Cell Significance Index: -5.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0352
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0369
    Cell Significance Index: -7.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0552
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0651
    Cell Significance Index: -8.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0665
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0676
    Cell Significance Index: -7.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0764
    Cell Significance Index: -9.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0788
    Cell Significance Index: -2.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0808
    Cell Significance Index: -8.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0817
    Cell Significance Index: -8.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0827
    Cell Significance Index: -5.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0844
    Cell Significance Index: -1.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0867
    Cell Significance Index: -6.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0940
    Cell Significance Index: -4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0940
    Cell Significance Index: -2.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1010
    Cell Significance Index: -4.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1069
    Cell Significance Index: -2.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1131
    Cell Significance Index: -8.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1223
    Cell Significance Index: -7.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1253
    Cell Significance Index: -1.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1279
    Cell Significance Index: -7.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1302
    Cell Significance Index: -6.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1387
    Cell Significance Index: -8.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1408
    Cell Significance Index: -6.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1479
    Cell Significance Index: -3.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1541
    Cell Significance Index: -6.8200
  • Cell Name: reticular cell (CL0000432)
    Fold Change: -0.1554
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1651
    Cell Significance Index: -4.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1725
    Cell Significance Index: -2.6000
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1729
    Cell Significance Index: -1.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1746
    Cell Significance Index: -9.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1798
    Cell Significance Index: -6.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1849
    Cell Significance Index: -7.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1969
    Cell Significance Index: -10.2300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1997
    Cell Significance Index: -2.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2089
    Cell Significance Index: -10.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2122
    Cell Significance Index: -3.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2187
    Cell Significance Index: -6.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2279
    Cell Significance Index: -7.4600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2290
    Cell Significance Index: -1.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2406
    Cell Significance Index: -3.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2436
    Cell Significance Index: -4.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2456
    Cell Significance Index: -6.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2514
    Cell Significance Index: -6.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2558
    Cell Significance Index: -7.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Vitrin is a transmembrane protein with a unique structure, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is rich in glycosaminoglycans (GAGs), which are essential for the binding of vitrin to the ECM. This interaction is crucial for the organization of the ECM and the regulation of cell-substrate adhesion. Vitrin has been shown to interact with various ECM components, including collagens, laminins, and proteoglycans, and has been implicated in the regulation of cellular processes such as migration, proliferation, and differentiation. **Pathways and Functions:** Vitrin plays a crucial role in the organization of the ECM and the regulation of cell-substrate adhesion through several pathways: 1. **Extracellular matrix organization:** Vitrin interacts with ECM components to regulate the organization of the ECM and maintain tissue architecture. 2. **Glycosaminoglycan binding:** The extracellular domain of vitrin is rich in GAGs, which bind to ECM components and regulate cell-substrate adhesion. 3. **Positive regulation of cell-substrate adhesion:** Vitrin promotes cell-substrate adhesion by interacting with ECM components and regulating the expression of adhesion molecules. 4. **Spinal cord development:** Vitrin has been shown to play a role in the development of the spinal cord, where it regulates the organization of the ECM and the migration of neural cells. **Significantly expressed cells:** Vitrin is expressed in various cell types, including: 1. **Skeletal muscle fibroblasts:** Vitrin is expressed in skeletal muscle fibroblasts, where it regulates the organization of the ECM and the contraction of muscle fibers. 2. **Secondary lens fiber:** Vitrin is expressed in secondary lens fibers, where it regulates the organization of the ECM and the transparency of the lens. 3. **Retinal ganglion cells:** Vitrin is expressed in retinal ganglion cells, where it regulates the organization of the ECM and the transmission of visual information. 4. **Keratocytes:** Vitrin is expressed in keratocytes, where it regulates the organization of the ECM and the integrity of the cornea. **Clinical Significance:** Dysregulation of vitrin has been implicated in various disease states, including: 1. **Muscular dystrophy:** Mutations in the VITRN gene have been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cataracts:** Abnormal expression of vitrin in the lens has been linked to cataracts, a clouding of the lens that can lead to vision loss. 3. **Spinal cord injury:** Dysregulation of vitrin has been implicated in spinal cord injury, where it can lead to the disruption of the ECM and the loss of neural function. 4. **Cardiovascular disease:** Abnormal expression of vitrin in cardiac endothelial cells has been linked to cardiovascular disease, a group of conditions characterized by the narrowing or blockage of blood vessels. In conclusion, vitrin is a critical regulator of cellular adhesion and ECM organization, and its dysregulation has been implicated in various disease states. Further research is needed to fully elucidate the role of vitrin in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 1795766917

Symbol: VITRN_HUMAN

Name: Vitrin

UniProtKB Accession Codes:

Q6UXI7 A1A526 A6NKI9 A8K7Y4 E9PF47 Q6P7T3 Q96DM8 Q96DT1 Q9UDN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10830112

Title: VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily.

PubMed ID: 10830112

DOI: 10.1042/bst0270832

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 678
  • Mass: 73930
  • Checksum: 9870E75A218C686C
  • Sequence:
    • MRTVVLTMKA SVIEMFLVLL VTGVHSNKET AKKIKRPKFT VPQINCDVKA GKIIDPEFIV 
KCPAGCQDPK YHVYGTDVYA SYSSVCGAAV HSGVLDNSGG KILVRKVAGQ SGYKGSYSNG 
VQSLSLPRWR ESFIVLESKP KKGVTYPSAL TYSSSKSPAA QAGETTKAYQ RPPIPGTTAQ 
PVTLMQLLAV TVAVATPTTL PRPSPSAAST TSIPRPQSVG HRSQEMDLWS TATYTSSQNR 
PRADPGIQRQ DPSGAAFQKP VGADVSLGLV PKEELSTQSL EPVSLGDPNC KIDLSFLIDG 
STSIGKRRFR IQKQLLADVA QALDIGPAGP LMGVVQYGDN PATHFNLKTH TNSRDLKTAI 
EKITQRGGLS NVGRAISFVT KNFFSKANGN RSGAPNVVVV MVDGWPTDKV EEASRLARES 
GINIFFITIE GAAENEKQYV VEPNFANKAV CRTNGFYSLH VQSWFGLHKT LQPLVKRVCD 
TDRLACSKTC LNSADIGFVI DGSSSVGTGN FRTVLQFVTN LTKEFEISDT DTRIGAVQYT 
YEQRLEFGFD KYSSKPDILN AIKRVGYWSG GTSTGAAINF ALEQLFKKSK PNKRKLMILI 
TDGRSYDDVR IPAMAAHLKG VITYAIGVAW AAQEELEVIA THPARDHSFF VDEFDNLHQY 
VPRIIQNICT EFNSQPRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.