Details for: DNAH11

Gene ID: 8701

Symbol: DNAH11

Ensembl ID: ENSG00000105877

Description: dynein axonemal heavy chain 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.2994
    Cell Significance Index: -15.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.3800
    Cell Significance Index: -15.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4092
    Cell Significance Index: -15.3000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.8734
    Cell Significance Index: 43.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0094
    Cell Significance Index: -8.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3548
    Cell Significance Index: 132.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6907
    Cell Significance Index: 37.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2779
    Cell Significance Index: 31.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1756
    Cell Significance Index: 7.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8164
    Cell Significance Index: 62.6500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.8159
    Cell Significance Index: 8.0800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.7707
    Cell Significance Index: 7.5400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6960
    Cell Significance Index: 11.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6112
    Cell Significance Index: 17.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6007
    Cell Significance Index: 87.3200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.5835
    Cell Significance Index: 3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.5107
    Cell Significance Index: 53.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4096
    Cell Significance Index: 66.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3172
    Cell Significance Index: 113.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2521
    Cell Significance Index: 137.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2395
    Cell Significance Index: 14.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2388
    Cell Significance Index: 6.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2256
    Cell Significance Index: 42.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2247
    Cell Significance Index: 13.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2119
    Cell Significance Index: 20.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1463
    Cell Significance Index: 3.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1381
    Cell Significance Index: 5.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1336
    Cell Significance Index: 5.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1128
    Cell Significance Index: 22.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1016
    Cell Significance Index: 29.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0917
    Cell Significance Index: 58.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0667
    Cell Significance Index: 125.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0623
    Cell Significance Index: 0.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0497
    Cell Significance Index: 5.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0409
    Cell Significance Index: 62.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0361
    Cell Significance Index: 24.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0207
    Cell Significance Index: 0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0196
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0183
    Cell Significance Index: 33.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0085
    Cell Significance Index: 1.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0080
    Cell Significance Index: 3.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0066
    Cell Significance Index: -2.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0240
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0244
    Cell Significance Index: -18.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0270
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0282
    Cell Significance Index: -17.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0319
    Cell Significance Index: -18.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0364
    Cell Significance Index: -6.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0573
    Cell Significance Index: -1.6500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0577
    Cell Significance Index: -0.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0641
    Cell Significance Index: -4.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0655
    Cell Significance Index: -8.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0714
    Cell Significance Index: -12.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0734
    Cell Significance Index: -8.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0771
    Cell Significance Index: -2.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0824
    Cell Significance Index: -2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0881
    Cell Significance Index: -9.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0892
    Cell Significance Index: -18.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0991
    Cell Significance Index: -11.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1064
    Cell Significance Index: -14.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1071
    Cell Significance Index: -2.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1156
    Cell Significance Index: -14.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1156
    Cell Significance Index: -1.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1337
    Cell Significance Index: -3.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1352
    Cell Significance Index: -9.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1378
    Cell Significance Index: -16.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1483
    Cell Significance Index: -3.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1617
    Cell Significance Index: -7.5400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1638
    Cell Significance Index: -1.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1684
    Cell Significance Index: -8.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1866
    Cell Significance Index: -12.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1919
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1949
    Cell Significance Index: -5.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2032
    Cell Significance Index: -12.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2032
    Cell Significance Index: -5.5300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2036
    Cell Significance Index: -2.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2070
    Cell Significance Index: -15.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2149
    Cell Significance Index: -7.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2375
    Cell Significance Index: -15.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2438
    Cell Significance Index: -11.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2600
    Cell Significance Index: -16.3900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2681
    Cell Significance Index: -3.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2741
    Cell Significance Index: -4.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2800
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3477
    Cell Significance Index: -12.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3588
    Cell Significance Index: -18.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3699
    Cell Significance Index: -12.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3956
    Cell Significance Index: -12.6000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4116
    Cell Significance Index: -5.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4135
    Cell Significance Index: -15.1800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.4168
    Cell Significance Index: -3.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4236
    Cell Significance Index: -14.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4466
    Cell Significance Index: -6.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4550
    Cell Significance Index: -8.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4682
    Cell Significance Index: -6.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4864
    Cell Significance Index: -13.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAH11 is a member of the dynein heavy chain family, which is composed of four subunits (α, β, γ, and δ). The β subunit (DYH11_HUMAN) is specifically expressed in various cell types, including ciliated cells, cardiac myocytes, and retinal cells. DNAH11 exhibits a high degree of sequence similarity to other dynein heavy chains, suggesting a conserved evolutionary history. The gene is composed of 12 exons and 11 introns, with a total length of approximately 3.5 kilobases. **Pathways and Functions:** DNAH11 is involved in various cellular processes, including: 1. **Motile Cilium Function:** DNAH11 plays a critical role in the structure and function of motile cilia, which are essential for cell motility, development, and maintenance of tissue homeostasis. The gene contributes to the regulation of cilium beat frequency, axoneme dynamics, and microtubule motor activity. 2. **Axoneme Dynamics:** DNAH11 is part of the dynein complex, which is responsible for the movement of axonemes along microtubules. The gene's product interacts with other dynein subunits to regulate axoneme dynamics and microtubule motor activity. 3. **Microtubule Motor Activity:** DNAH11 is involved in the regulation of microtubule motor activity, which is essential for cell motility and movement. 4. **Cell Signaling:** DNAH11 may also contribute to cell signaling pathways, including those involved in learning and memory. **Significantly Expressed Cells:** DNAH11 is expressed in various cell types, including: 1. Ciliated cells 2. Regular atrial cardiac myocytes 3. Retinal rod cells 4. Ciliated columnar cells of the tracheobronchial tree 5. Lung ciliated cells 6. Skeletal muscle fibers 7. Retinal bipolar neurons 8. Basal epithelial cells of the prostatic duct 9. Retinal cone cells 10. Multi-ciliated epithelial cells **Clinical Significance:** Dysregulation of DNAH11 has been implicated in various diseases, including: 1. **Primary Ciliary Dyskinesia (PCD):** PCD is a rare genetic disorder characterized by defective motile cilia, leading to respiratory and reproductive complications. 2. **Muciliary Clearance Disorder:** This condition is characterized by impaired muciliary clearance, leading to respiratory and gastrointestinal complications. 3. **Left-Right Asymmetry Disorders:** Dysregulation of DNAH11 has been implicated in left-right asymmetry disorders, including situs inversus and heterotaxy. 4. **Neurological Disorders:** DNAH11 has been linked to neurological disorders, including learning and memory impairments. In conclusion, DNAH11 is a critical gene involved in the structure and function of motile cilia and axoneme dynamics. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and overall health. Further research is needed to fully understand the functions and significance of DNAH11 and its role in human disease.

Genular Protein ID: 819046890

Symbol: DYH11_HUMAN

Name: Axonemal beta dynein heavy chain 11

UniProtKB Accession Codes:

Q96DT5 Q9UJ82

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 12 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12142464

Title: Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.

PubMed ID: 12142464

DOI: 10.1073/pnas.152337699

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 18022865

Title: Primary ciliary dyskinesia associated with normal axoneme ultrastructure is caused by DNAH11 mutations.

PubMed ID: 18022865

DOI: 10.1002/humu.20656

PubMed ID: 25186273

Title: Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.

PubMed ID: 25186273

DOI: 10.1183/09031936.00052014

PubMed ID: 31178125

Title: Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

PubMed ID: 31178125

DOI: 10.1016/j.ajhg.2019.04.015

PubMed ID: 33139725

Title: CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

PubMed ID: 33139725

DOI: 10.1038/s41467-020-19113-0

Sequence Information:

  • Length: 4516
  • Mass: 520369
  • Checksum: 4F4F149CE7FF82D7
  • Sequence:
    • MAAQVAAREA RDFREAPTLR LTSGAGLEAV GAVELEEEEE NEEEAAARRA RSFAQDARVR 
FLGGRLAMML GFTEEKWSQY LESEDNRQVL GEFLESTSPA CLVFSFAASG RLAASQEIPR 
DANHKLVFIS KKITESIGVN DFSQVVLFGE LPALSLGHVS AFLDEILVPV LSNKNNHKSW 
SCFTSQDMEY HIEVMKKKMY IFRGKMSRRT LLPIPTVAGK MDLDQNCSEN KPPSNERIIL 
HAIESVVIEW SHQIQEIIER DSVQRLLNGL HLSPQAELDF WMMRRENLSC IYDQLQAPVV 
LKMVKILTTK QSSYFPTLKD IFLAVENALL EAQDVELYLR PLRRHIQCLQ ETEFPQTRIL 
IAPLFHTICL IWSHSKFYNT PARVIVLLQE FCNLFINQAT AYLSPEDLLR GEIEESLEKV 
QVAVNILKTF KNSFFNYRKK LASYFMGRKL RPWDFQSHLV FCRFDKFLDR LIKIEDIFAT 
TLEFEKLERL EFGGTKGAIL NGQVHEMSEE LMELCKLFKQ STYDPSDCTN MEFESDYVAF 
KSKTLEFDRR LGTIICEAFF NCNGLEAAFK LLTIFGNFLE KPVVMEIFSL HYSTLVHMFN 
TELDVCKQLY NEHMKQIECG HVVLNKNMPF TSGNMKWAQQ VLQRLQMFWS NFASLRYLFL 
GNPDHALVYQ KYVEMTTLLD QFESRIYNEW KSNVDEICEF NLNQPLVKFS AINGLLCVNF 
DPKLVAVLRE VKYLLMLKKQ DIPDSALAIF KKRNTILKYI GNLDLLVQGY NKLKQTLLEV 
EYPLIEDELR AIDEQLTAAT TWLTWQDDCW GYIERVRAAT SELEHRVERT QKNVKVIQQT 
MRGWARCVLP PRREHRREAA FTLEDKGDLF TKKYKLIQGD GCKIHNLVEE NRKLFKANPS 
LDTWKIYVEF IDDIVVEGFF QAIMHDLDFF LKNTEKQLKP APFFQAQMIL LPPEIVFKPS 
LDREAGDGFY DLVEEMLCNS FRMSAQMNRI ATHLEIKNYQ NDMDNMLGLA EVRQEIMNRV 
VNVINKVLDF RNTLETHTYL WVDDRAEFMK HFLLYGHAVS SDEMDAHANE EIPEQPPTLE 
QFKEQIDIYE ALYVQMSKFE DFRVFDSWFK VDMKPFKVSL LTIIKKWSWM FQEHLLRFVI 
DSLNELQEFI KETDSGLQRE LNEGDHDGLV DIMVHLLAVR SRQRATDELF EPLKETITLL 
ESYGQKMPEQ VYIQLEELPE RWETTKKIAA TVRHEVSPLH NAEVTLIRKK CILFDAKQAE 
FRERFRHYAP LGFNAENPYT ALDKANEELE ALEEEMLQMQ ESTRLFEVAL PEYKQMKQCR 
KEIKLLKGLW DVIIYVRRSI DNWTKTQWRQ IHVEQMDVEL RRFAKEIWSL NKEVRVWDAY 
TGLEGTVKDM TASLRAITEL QSPALRDRHW HQLMKAIGVK FLINEATTLA DLLALRLHRV 
EDDVRRIVDK AVKELGTEKV ITEISQTWAT MKFSYEVHYR TGIPLLKSDE QLFETLEHNQ 
VQLQTLLQSK YVEYFIEQVL SWQNKLNIAD LVIFTWMEVQ RTWSHLESIF VCSEDIRIQL 
VKDARRFDGV DAEFKELMFK TAKVENVLEA TCRPNLYEKL KDLQSRLSLC EKALAEYLET 
KRIAFPRFYF VSSADLLDIL SKGAQPKQVT CHLAKLFDSI ADLQFEDNQD VSAHRAVGMY 
SKEKEYVPFQ AECECVGHVE TWLLQLEQTM QETVRHSITE AIVAYEEKPR ELWIFDFPAQ 
VALTSSQIWW TTDVGIAFSR LEEGYETALK DFHKKQISQL NTLITLLLGE LPPGDRQKIM 
TICTIDVHAR DVVAKLISQK VVSPQAFTWL SQLRHRWEDT QKHCFVNICD AQFQYFYEYL 
GNSPRLVITP LTDRCYITLT QSLHLTMSGA PAGPAGTGKT ETTKDLGRAL GMMVYVFNCS 
EQMDYKSIGN IYKGLVQTGA WGCFDEFNRI SVEVLSVVAV QVKMIHDAIR NRKKRFVFLG 
EAITLKPSVG IFITMNPGYA GRTELPENLK ALFRPCAMVA PDIELICEIL LVAEGFVDAR 
ALARKFITLY TLCKELLSKQ DHYDWGLRAI KSVLVVAGSL KRGDKNRPED QVLMRALRDF 
NMPKIVTDDI PVFLGLVGDL FPALDVPRRR KLHFEQMVRQ STLELRLQPE ESFILKVVQL 
EELLAVRHSV FVVGNAGTGK SKILRTLNRT YVNMKQKPVW NDLNPKAVTT DELFGFIHHA 
TREWKDGKIV YSYFIGLFSS ILREQANLKH DGPKWIVLDG DIDPMWIESL NTVMDDNKVL 
TLASNERIAL TPFMRLLFEI HHLRSATPAT VSRAGILYVN PQDLGWNPYV ASWIDRRRHQ 
SEKANLTILF DKYVPACLDK LRTSFKTITS IPESSLVQTL CVLLECLLTP ENVPSDSPKE 
VYEVYFVFAC IWAFGGTLLQ DQISDYQADF SRWWQKEMKA VKFPSQGTIF DYYVDHKTKK 
LLPWADKIAQ FTMDPDVPLQ TVLVHTTETA RLRYFMELLL EKGKPLMLVG NAGVGKTVFV 
GDTLASLSED YIVSRVPFNY YTTSTALQKI LEKPLEKKAG HNYGPGGNKK LIYFIDDMNM 
PEVDLYGTVQ PHTLIRQHID YGHWYDRQKV MLKEIHNCQY VACMNPMVGS FTINPRLQRH 
FTVFAFNFPS LDALNTIYGQ IFSFHFQQQA FAPSILRSGP TLIQATIAFH QTMMCNFLPT 
AIKFHYIFNL RDLSNVFQGI LFASPECLKG PLDLIHLWLH ESARVYGDKL IDKKDCDLFQ 
RRMLETAYKY FEGIDSHMLL QQPLIYCHFA DRGKDPHYMP VKDWEVLKTI LTETLDNYNE 
LNAAMHLVLF EDAMQHVCRI SRILRTPQGC ALLVGVGGSG KQSLSRLAAY LRGLEVFQIT 
LTEGYGIQEL RVDLANLYIR TGAKNMPTVF LLTDAQVLDE SFLVLINDLL ASGEIPDLFS 
DEDVDKIISG IHNEVHALGM VDSRENCWKF FMARVRLQLK IILCFSPVGR TLRVRARKFP 
AIVNCTAIDW FHAWPQEALV SVSRRFIEET KGIEPVHKDS ISLFMAHVHT TVNEMSTRYY 
QNERRHNYTT PKSFLEQISL FKNLLKKKQN EVSEKKERLV NGIQKLKTTA SQVGDLKARL 
ASQEAELQLR NHDAEALITK IGLQTEKVSR EKTIADAEER KVTAIQTEVF QKQRECEADL 
LKAEPALVAA TAALNTLNRV NLSELKAFPN PPIAVTNVTA AVMVLLAPRG RVPKDRSWKA 
AKVFMGKVDD FLQALINYDK EHIPENCLKV VNEHYLKDPE FNPNLIRTKS FAAAGLCAWV 
INIIKFYEVY CDVEPKRQAL AQANLELAAA TEKLEAIRKK LVDLDRNLSR LTASFEKATA 
EKVRCQEEVN QTNKTIKLAN RLVKELEAKK IRWGQSIKSF EAQEKTLCGD VLLTAAFVSY 
VGPFTRQYRQ ELVHCKWVPF LQQKVSIPLT EGLDLISMLT DDATIAAWNN EGLPSDRMST 
ENAAILTHCE RWPLVIDPQQ QGIKWIKNKY GMDLKVTHLG QKGFLNAIET ALAFGDVILI 
ENLEETIDPV LDPLLGRNTI KKGKYIRIGD KECEFNKNFR LILHTKLANP HYKPELQAQT 
TLLNFTVTED GLEAQLLAEV VSIERPDLEK LKLVLTKHQN DFKIELKYLE DDLLLRLSAA 
EGSFLDDTKL VERLEATKTT VAEIEHKVIE AKENERKINE ARECYRPVAA RASLLYFVIN 
DLQKINPLYQ FSLKAFNVLF HRAIEQADKV EDMQGRISIL MESITHAVFL YTSQALFEKD 
KLTFLSQMAF QILLRKKEID PLELDFLLRF TVEHTHLSPV DFLTSQSWSA IKAIAVMEEF 
RGIDRDVEGS AKQWRKWVES ECPEKEKLPQ EWKKKSLIQK LILLRAMRPD RMTYALRNFV 
EEKLGAKYVE RTRLDLVKAF EESSPATPIF FILSPGVDAL KDLEILGKRL GFTIDSGKFH 
NVSLGQGQET VAEVALEKAS KGGHWVILQN VHLVAKWLGT LEKLLERFSQ GSHRDYRVFM 
SAESAPTPDE HIIPQGLLEN SIKITNEPPT GMLANLHAAL YNFDQDTLEI CSKEQEFKSI 
LFSLCYFHAC VAGRLRFGPQ GWSRSYPFNP GDLTICASVL YNYLEANSKV PWEDLRYLFG 
EIMYGGHITD DWDRKLCRVY LEEFMNPSLT EDELMLAPGF AAPPYLDYAG YHQYIEEMLP 
PESPALYGLH PNAEIEFLTV TSNTLFRTLL EMQPRNALSG DELGQSTEEK VKNVLDDILE 
KLPEEFNMAE IMQKNSNRSP YVLVCFQECE RMNILIREIR ISLEQLDLSL KGELALSPAV 
EAQQFALSYD TVPDTWSKLA YPSTYGLAQW FNDLLLRCRE LDTWTQDLTL PAVVWLSGFF 
NPQSFLTAIM QTMARKNEWP LDKTRLTADV TKKTKEDYGH PPREGAYLHG LFMEGARWDT 
QAGTIVEARL KELACPMPVI FAKATPVDRQ ETKQTYECPV YRTKLRGPSY IWTFRLKSEE 
KTAKWVLAGV ALLLEA

Genular Protein ID: 2745201395

Symbol: H9NAJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H9NAJ7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 22184204

Title: Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.

PubMed ID: 22184204

DOI: 10.1136/thoraxjnl-2011-200301

Sequence Information:

  • Length: 224
  • Mass: 25401
  • Checksum: BD76A2A31AAF9DC0
  • Sequence:
    • ELWIFDFPAQ VALTSSQIWW TTDVGIAFSR LEEGYETALK DFHKKQISQL NTLITLLLGE 
LPPGDRQKIM TICTIDVHAR DVVAKLISQK VVSPQAFTWL SQLRHRWEDT QKHCFVNICD 
AQFQYFYEYL GNSPRLVITP LTDRCYITLT QSLHLTMSGA PAGPAGTGKT ETTKDLGRAL 
GMMVYVFNCS EQMDYKSIGN IYKGLVQTGA WGCFDEFNRI SVEV

Genular Protein ID: 2205203008

Symbol: Q96NT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96NT7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 333
  • Mass: 37884
  • Checksum: 2ECCF9C5B2ABB721
  • Sequence:
    • MRPDRMTYAL RNFVEEKLGA KYVERTRLDL VKAFEESSPA TPIFFILSPG VDALKDLEIL 
GKRLGFTIDS GKFHNVSLGQ GQETVAEVAL EKASKGGHWV ILQNVHLVAK WLGTLEKLLE 
RFSQGSHRDY RVFMSAESAP TPDEHIIPQG LLENSIKITN EPPTGMLANL HAALYNFDQD 
TLEICSKEQE FKSIFFSLCY FHACVAGRLR FGPQGWSRSY PFNPGDLTIC ASVLYNYLEA 
NSKVPWEDLR YLFGEIMYGG HITDDWDRKL CRVYLEEFVN PSLIEDELML APGFAAPPYL 
DYAGYHQYIE EMLPPESPAL YGLHPNAEIE FRQ

Genular Protein ID: 2948415969

Symbol: H9NAJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

H9NAJ8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1

Citations:

PubMed ID: 22184204

Title: Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.

PubMed ID: 22184204

DOI: 10.1136/thoraxjnl-2011-200301

Sequence Information:

  • Length: 242
  • Mass: 28736
  • Checksum: 88ED9C80C76DD157
  • Sequence:
    • ALDKANEELE ALEEEMLQMQ ESTRLFEVAL PEYKQMKQCR KEIKLLKGLW DVIIYVRRSI 
DNWTKTQWRQ IHVEQMDVEL RRFAKEIWSL NKEVRVWDAY TGLEGTVKDM TASLRAITEL 
QSPALRDRHW HQLMKAIGVK FLINEATTLA DLLALRLHRV EDDVRRIVDK AVKELGTEKV 
ITEISQTWAT MKFSYEVHYR TGIPLLKSDE QLFETLEHNQ VQLQTLLQSK YVEYFIEQVL 
SW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.