Details for: PCA3

Gene ID: 50652

Symbol: PCA3

Ensembl ID: ENSG00000225937

Description: prostate cancer associated 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 6.7240
    Cell Significance Index: 212.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.6778
    Cell Significance Index: 3641.0100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.1616
    Cell Significance Index: 12.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9459
    Cell Significance Index: 58.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8542
    Cell Significance Index: 387.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.7101
    Cell Significance Index: 73.9400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.6600
    Cell Significance Index: 8.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4981
    Cell Significance Index: 937.8800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4098
    Cell Significance Index: 4.7200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.3007
    Cell Significance Index: 3.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2938
    Cell Significance Index: 55.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2356
    Cell Significance Index: 5.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2265
    Cell Significance Index: 10.5600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.2002
    Cell Significance Index: 2.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2001
    Cell Significance Index: 4.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1530
    Cell Significance Index: 15.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1484
    Cell Significance Index: 228.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1468
    Cell Significance Index: 132.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1226
    Cell Significance Index: 3.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1187
    Cell Significance Index: 7.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1159
    Cell Significance Index: 41.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1097
    Cell Significance Index: 3.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0861
    Cell Significance Index: 14.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0779
    Cell Significance Index: 8.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0697
    Cell Significance Index: 3.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0575
    Cell Significance Index: 3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0568
    Cell Significance Index: 1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0532
    Cell Significance Index: 10.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0401
    Cell Significance Index: 1.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0400
    Cell Significance Index: 73.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0392
    Cell Significance Index: 7.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0299
    Cell Significance Index: 4.3500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0269
    Cell Significance Index: 0.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0210
    Cell Significance Index: 1.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0176
    Cell Significance Index: 0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0156
    Cell Significance Index: 4.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0047
    Cell Significance Index: 2.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0006
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0042
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0074
    Cell Significance Index: -3.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0085
    Cell Significance Index: -6.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0108
    Cell Significance Index: -5.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0133
    Cell Significance Index: -2.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0169
    Cell Significance Index: -1.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0208
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0230
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0262
    Cell Significance Index: -4.4700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0364
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0386
    Cell Significance Index: -4.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0394
    Cell Significance Index: -0.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0396
    Cell Significance Index: -5.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0432
    Cell Significance Index: -2.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0442
    Cell Significance Index: -6.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0443
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0443
    Cell Significance Index: -3.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0454
    Cell Significance Index: -1.7200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0457
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0475
    Cell Significance Index: -5.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0481
    Cell Significance Index: -3.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0515
    Cell Significance Index: -6.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0621
    Cell Significance Index: -6.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0627
    Cell Significance Index: -3.5200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0666
    Cell Significance Index: -0.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0681
    Cell Significance Index: -3.5400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0752
    Cell Significance Index: -1.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0756
    Cell Significance Index: -1.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0825
    Cell Significance Index: -6.1500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0859
    Cell Significance Index: -1.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0881
    Cell Significance Index: -2.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0909
    Cell Significance Index: -2.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1008
    Cell Significance Index: -3.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1085
    Cell Significance Index: -3.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1156
    Cell Significance Index: -6.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1176
    Cell Significance Index: -5.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1187
    Cell Significance Index: -3.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1269
    Cell Significance Index: -5.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1285
    Cell Significance Index: -6.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1333
    Cell Significance Index: -3.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1423
    Cell Significance Index: -4.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1454
    Cell Significance Index: -2.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1467
    Cell Significance Index: -3.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1471
    Cell Significance Index: -2.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1548
    Cell Significance Index: -4.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1581
    Cell Significance Index: -3.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1605
    Cell Significance Index: -3.8500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1686
    Cell Significance Index: -1.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1808
    Cell Significance Index: -3.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1825
    Cell Significance Index: -1.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1856
    Cell Significance Index: -6.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1867
    Cell Significance Index: -2.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1899
    Cell Significance Index: -5.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1907
    Cell Significance Index: -4.1200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1908
    Cell Significance Index: -1.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1912
    Cell Significance Index: -4.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA gene:** The PCA3 gene is a non-coding RNA, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including microRNA-mediated suppression of tumor suppressor genes. 2. **Widespread expression:** PCA3 is expressed in multiple tissues, including the prostate, lens of the eye, retina, and smooth muscle cells. This suggests a potential role for PCA3 in the development and progression of various types of cancer. 3. **Prostate cancer association:** PCA3 has been strongly associated with prostate cancer, with increased expression levels observed in prostate cancer cells compared to normal prostate tissue. 4. **Regulatory function:** PCA3 regulates gene expression through microRNA-mediated suppression of tumor suppressor genes, which can contribute to cancer development and progression. **Pathways and Functions:** 1. **MicroRNA-mediated regulation:** PCA3 regulates gene expression through the suppression of microRNAs, which are small non-coding RNAs that play a crucial role in regulating gene expression. 2. **Tumor suppressor gene regulation:** PCA3 suppresses the expression of tumor suppressor genes, such as PTEN and TP53, which are involved in preventing cancer development and progression. 3. **Cell cycle regulation:** PCA3 may regulate cell cycle progression by modulating the expression of cell cycle regulators, such as CDK4 and CDK6. 4. **Apoptosis regulation:** PCA3 may regulate apoptosis (programmed cell death) by modulating the expression of pro-apoptotic and anti-apoptotic genes. **Clinical Significance:** 1. **Prostate cancer diagnosis:** PCA3 has been investigated as a potential diagnostic biomarker for prostate cancer. Elevated PCA3 expression levels have been observed in prostate cancer cells compared to normal prostate tissue. 2. **Prognostic marker:** PCA3 may serve as a prognostic marker for prostate cancer, with increased expression levels associated with more aggressive disease. 3. **Cancer therapy:** PCA3 may be a target for cancer therapy, with potential therapeutic applications in the development of cancer-specific microRNAs or small molecule inhibitors. 4. **Cancer risk prediction:** PCA3 may be used to predict cancer risk in individuals with a family history of prostate cancer or other cancers. In conclusion, the PCA3 gene is a non-coding RNA gene that plays a significant role in the development and progression of prostate cancer. Its widespread expression pattern and regulatory function suggest a potential role in the development of multiple types of cancer. Further research is needed to fully understand the molecular mechanisms underlying PCA3's involvement in cancer and to explore its potential as a diagnostic biomarker, prognostic marker, and therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.