Details for: AQP7

Gene ID: 364

Symbol: AQP7

Ensembl ID: ENSG00000165269

Description: aquaporin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: club cell (CL0000158)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: macrophage (CL0000235)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: B cell (CL0000236)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: basal cell (CL0000646)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: podocyte (CL0000653)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: N/A
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AQP7 is a type I transmembrane protein, consisting of six transmembrane segments and a pore loop that allows for the selective transport of water, glycerol, and small molecules. Its expression is widespread across various cell types, including adipocytes, cardiac myocytes, and neurons. AQP7 has been shown to be highly expressed in the heart, liver, and pancreas, where it plays a critical role in maintaining cellular homeostasis and regulating fluid balance. **Pathways and Functions:** AQP7 is involved in various cellular processes, including: 1. **Aquaporin-mediated transport**: AQP7 facilitates the transport of water, glycerol, and small molecules across cellular membranes, playing a crucial role in maintaining cellular homeostasis and regulating fluid balance. 2. **Glycerol channel activity**: AQP7 acts as a glycerol channel, allowing for the selective transport of glycerol across cellular membranes. 3. **Transport of small molecules**: AQP7 can transport small molecules, such as urea, across cellular membranes. 4. **Urea transmembrane transport**: AQP7 plays a critical role in the transport of urea across cellular membranes, which is essential for maintaining cellular homeostasis and regulating fluid balance. **Clinical Significance:** AQP7 has been implicated in various physiological and pathological processes, including: 1. **Cardiac function**: AQP7 has been shown to play a critical role in maintaining cardiac function, particularly in the regulation of fluid balance and electrolyte transport. 2. **Diabetes**: AQP7 has been implicated in the pathogenesis of diabetes, particularly in the regulation of glycerol transport and glucose metabolism. 3. **Liver disease**: AQP7 has been shown to play a critical role in maintaining liver function, particularly in the regulation of fluid balance and bile transport. 4. **Cancer**: AQP7 has been implicated in the pathogenesis of various cancers, particularly in the regulation of glycerol transport and cell growth. In conclusion, Aquaporin 7 (AQP7) is a multifaceted protein that plays a crucial role in maintaining cellular homeostasis and regulating fluid balance across various cell types. Its clinical significance is evident in various physiological and pathological processes, including cardiac function, diabetes, liver disease, and cancer. Further research is needed to fully elucidate the mechanisms of AQP7 and its role in human disease. **References:** * [Insert references to relevant research articles and studies] As an expert immunologist, I would like to emphasize the importance of continued research into the role of AQP7 in human disease and its potential as a therapeutic target.

Genular Protein ID: 2234081453

Symbol: AQP7_HUMAN

Name: Aquaporin-7

UniProtKB Accession Codes:

O14520 Q08E94 Q5T5L9 Q8NHM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405233

Title: Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.

PubMed ID: 9405233

DOI: 10.1006/bbrc.1997.7769

PubMed ID: 11952783

Title: Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.

PubMed ID: 11952783

DOI: 10.1046/j.1432-1033.2002.02821.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28042826

Title: Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.

PubMed ID: 28042826

DOI: 10.3390/ijms18010066

PubMed ID: 27832861

Title: Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation.

PubMed ID: 27832861

DOI: 10.1016/j.metabol.2016.09.004

PubMed ID: 30423801

Title: Molecular Basis of Aquaporin-7 Permeability Regulation by pH.

PubMed ID: 30423801

DOI: 10.3390/cells7110207

PubMed ID: 30420639

Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.

PubMed ID: 30420639

DOI: 10.1038/s41467-018-07176-z

PubMed ID: 17566090

Title: Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes.

PubMed ID: 17566090

DOI: 10.1210/jc.2007-0531

Sequence Information:

  • Length: 342
  • Mass: 37232
  • Checksum: 8A05F92B977D2F93
  • Sequence:
    • MVQASGHRRS TRGSKMVSWS VIAKIQEILQ RKMVREFLAE FMSTYVMMVF GLGSVAHMVL 
NKKYGSYLGV NLGFGFGVTM GVHVAGRISG AHMNAAVTFA NCALGRVPWR KFPVYVLGQF 
LGSFLAAATI YSLFYTAILH FSGGQLMVTG PVATAGIFAT YLPDHMTLWR GFLNEAWLTG 
MLQLCLFAIT DQENNPALPG TEALVIGILV VIIGVSLGMN TGYAINPSRD LPPRIFTFIA 
GWGKQVFSNG ENWWWVPVVA PLLGAYLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 
LPKMGSHEPT ISPLTPVSVS PANRSSVHPA PPLHESMALE HF

Genular Protein ID: 3892593335

Symbol: Q6P5T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P5T0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 216
  • Mass: 23334
  • Checksum: BB2E487C1677749A
  • Sequence:
    • MVLNKKYGSY LGVNLGFGFG VTMGVHVAGR ISGAHMNAAV TFANCALGRV PWRKFPVYVL 
GQFLGSFLAA ATIYSLFYTA ILHFSGGQLM VTGPVATAGI FATYLPDHMT LWRGFLNEAW 
LTGMLQLCLF AITDQENNPA LPGTEALVIG ILVVIIGVSL GMNTGYAINP SRDLPPRIFT 
FIAGWGKQVF RWHHLPGLHW LHHPTGAPEI GGFCGV

Genular Protein ID: 3919948552

Symbol: B7Z4U2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4U2

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 257
  • Mass: 28061
  • Checksum: DAEF1AB9FF4B7585
  • Sequence:
    • MVQASGHRRS TRGSKMVSWS VIAKIQEILQ RKMVREFLAE FMSTYVMMVF GLGSVAHMVL 
NKKYGSYLGV NLGFGFGVTM GVHVAGRISG AHMNAAVTFA NCALGRVPWR KFPVYVLGQF 
LGSFLAAATI YSLFYTAILH FSGGQLMVTG PVATAGIFAT YLPDHMTLWR GFLNEAWLTG 
MLQLCLFAIT DQENNPALPG TEALVIGILV VIIGVSLGMN TGYAINPSRD LPPRIFTFIA 
GWGKQVFRYC PCPGPFL

Genular Protein ID: 3481219000

Symbol: Q5T5M0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T5M0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 256
  • Mass: 27880
  • Checksum: FC33793AD7CF8E1B
  • Sequence:
    • MGSGHCLRST RGSKMVSWSV IAKIQEILQR KMVREFLAEF MSTYVMMVFG LGSVAHMVLN 
KKYGSYLGVN LGFGFGVTMG VHVAGRISGA HMNAAVTFAN CALGRVPWRK FPVYVLGQFL 
GSFLAAATIY SLFYTAILHF SGGQLMVTGP VATAGIFATY LPDHMTLWRG FLNEAWLTGM 
LQLCLFAITD QENNPALPGT EALVIGILVV IIGVSLGMNT GYAINPSRDL PPRIFTFIAG 
WGKQVFRYCP CPGPFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.