Details for: CL0000451

Cell ID: CL0000451

Cell Name: dendritic cell

Marker Score Threshold: 686
(Derived using integrated single-cell and genomic data)

Description: A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).

Synonyms: interdigitating cell, veiled cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 6.98
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.56
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.43
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.89
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.72
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.58
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.52
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.37
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.35
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.34
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.32
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.21
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.21
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.19
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.99
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.99
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.94
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.94
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.83
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.83
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.78
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.76
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.74
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.7
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.7
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.7
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.66
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.66
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.63
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.63
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.63
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.62
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.62
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.62
    Ensembl ID: ENSG00000198898
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.61
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.61
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.58
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.57
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.52
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.52
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.48
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.47
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.45
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.45
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.42
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.42
    Ensembl ID: ENSG00000087088
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.41
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.35
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.32
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.32
    Ensembl ID: ENSG00000042493
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.27
    Ensembl ID: ENSG00000085224
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.27
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.26
    Ensembl ID: ENSG00000023445
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.26
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.25
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.23
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000141480
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.22
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.21
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.18
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.17
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.17
    Ensembl ID: ENSG00000015475
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.14
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.13
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.13
    Ensembl ID: ENSG00000131100
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.11
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.11
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.11
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.1
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.06
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100412
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.01
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.01
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.01
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1
    Ensembl ID: ENSG00000196975
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1
    Ensembl ID: ENSG00000147872
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Hematopoietic Origin**: Dendritic cells are derived from hematopoietic stem cells, which can differentiate into various blood cells, including immune cells. 2. **Antigen Uptake and Processing**: Dendritic cells have the ability to uptake and process antigens, which are then presented to T cells via MHC class I and II molecules. 3. **T Cell Activation**: Dendritic cells are specialized in activating T cells, which is essential for initiating an immune response. 4. **Lineage-Negative**: Dendritic cells are lineage-negative cells, meaning they do not express certain surface markers such as CD3, CD19, CD34, or CD56. 5. **Specialized Tissue Residency**: Dendritic cells are found in various tissues, including the skin, lungs, and lymph nodes. 6. **Metabolic and Protein Synthesis**: Dendritic cells are involved in metabolic processes such as glycolysis and protein synthesis, which are essential for their function. **Clinical Significance** 1. **Immunotherapy**: Dendritic cells are being explored as a potential therapeutic tool for cancer treatment, as they can be loaded with tumor antigens and used to stimulate an immune response against cancer cells. 2. **Vaccine Development**: Dendritic cells are being used as a tool to develop vaccines, as they can be loaded with antigens and used to stimulate an immune response against pathogens. 3. **Autoimmune Diseases**: Dendritic cells are involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and are being explored as a potential therapeutic target. 4. **Infectious Diseases**: Dendritic cells play a crucial role in the immune response to infectious diseases, such as tuberculosis and HIV, and are being explored as a potential therapeutic target. 5. **Cancer Immunotherapy**: Dendritic cells are being explored as a potential therapeutic tool for cancer treatment, as they can be loaded with tumor antigens and used to stimulate an immune response against cancer cells. In conclusion, dendritic cells are a critical component of the immune system, playing a central role in the initiation of immune responses. Their unique characteristics, including their ability to uptake, process, and present antigens, make them an attractive target for therapeutic interventions in various diseases.