Details for: MYBL2

Gene ID: 4605

Symbol: MYBL2

Ensembl ID: ENSG00000101057

Description: MYB proto-oncogene like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.6767
    Cell Significance Index: -7.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.2951
    Cell Significance Index: -6.6200
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 10.8226
    Cell Significance Index: 8.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0691
    Cell Significance Index: -6.2500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 4.7791
    Cell Significance Index: 11.1500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.0533
    Cell Significance Index: 30.6100
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 3.9306
    Cell Significance Index: 1.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6571
    Cell Significance Index: 195.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2337
    Cell Significance Index: -2.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1469
    Cell Significance Index: 30.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9677
    Cell Significance Index: 95.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6975
    Cell Significance Index: 113.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6279
    Cell Significance Index: 68.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6200
    Cell Significance Index: 6.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5607
    Cell Significance Index: 33.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4435
    Cell Significance Index: 88.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4024
    Cell Significance Index: 10.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3716
    Cell Significance Index: 6.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3214
    Cell Significance Index: 37.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3163
    Cell Significance Index: 10.9900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2642
    Cell Significance Index: 2.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1857
    Cell Significance Index: 5.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1728
    Cell Significance Index: 4.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1413
    Cell Significance Index: 77.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1400
    Cell Significance Index: 2.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1312
    Cell Significance Index: 7.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1056
    Cell Significance Index: 1.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0869
    Cell Significance Index: 1.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0666
    Cell Significance Index: 29.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0603
    Cell Significance Index: 4.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0421
    Cell Significance Index: 1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0416
    Cell Significance Index: 1.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0387
    Cell Significance Index: 6.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0359
    Cell Significance Index: 32.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0306
    Cell Significance Index: 1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0287
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0134
    Cell Significance Index: 0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0099
    Cell Significance Index: 1.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0059
    Cell Significance Index: 0.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0043
    Cell Significance Index: 0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0012
    Cell Significance Index: 0.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0025
    Cell Significance Index: -0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -8.9500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0129
    Cell Significance Index: -0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0185
    Cell Significance Index: -5.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0244
    Cell Significance Index: -4.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0245
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0247
    Cell Significance Index: -3.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0287
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0337
    Cell Significance Index: -7.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0353
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0378
    Cell Significance Index: -4.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0461
    Cell Significance Index: -0.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0675
    Cell Significance Index: -7.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0696
    Cell Significance Index: -0.8800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0718
    Cell Significance Index: -0.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0719
    Cell Significance Index: -1.0300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0724
    Cell Significance Index: -0.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0763
    Cell Significance Index: -5.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0778
    Cell Significance Index: -1.9400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0826
    Cell Significance Index: -1.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0852
    Cell Significance Index: -6.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0856
    Cell Significance Index: -1.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0939
    Cell Significance Index: -4.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1008
    Cell Significance Index: -7.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1010
    Cell Significance Index: -6.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1019
    Cell Significance Index: -6.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1056
    Cell Significance Index: -5.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1066
    Cell Significance Index: -1.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1167
    Cell Significance Index: -7.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1204
    Cell Significance Index: -5.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1267
    Cell Significance Index: -7.7700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1426
    Cell Significance Index: -2.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1501
    Cell Significance Index: -6.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1538
    Cell Significance Index: -4.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1576
    Cell Significance Index: -4.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1720
    Cell Significance Index: -6.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1724
    Cell Significance Index: -8.0400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1725
    Cell Significance Index: -1.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1748
    Cell Significance Index: -6.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1837
    Cell Significance Index: -4.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1883
    Cell Significance Index: -4.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation**: MYBL2 is involved in regulating cell cycle progression, particularly during the G1, S, and G2/M phases. 2. **Transcriptional control**: MYBL2 regulates gene expression by interacting with other transcription factors, such as TFAP2A, to control the transcriptional activity of RNA polymerase II. 3. **Tissue specificity**: MYBL2 is significantly expressed in various cell types, including immune cells, hematopoietic progenitor cells, and certain types of cancer cells. 4. **Proto-oncogenic potential**: MYBL2 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. **Pathways and Functions:** 1. **Cell cycle regulation**: MYBL2 is involved in regulating cell cycle progression by interacting with cyclin-dependent kinases (CDKs) and other cell cycle regulators. 2. **Transcriptional control**: MYBL2 regulates gene expression by interacting with other transcription factors, such as TFAP2A, to control the transcriptional activity of RNA polymerase II. 3. **Polo-like kinase-mediated events**: MYBL2 interacts with polo-like kinases (Plks) to regulate the G2/M transition and mitotic spindle assembly. 4. **Apoptosis regulation**: MYBL2 regulates apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** 1. **Cancer association**: MYBL2 has been implicated in the development and progression of certain types of cancer, including leukemia, lymphoma, and other hematological malignancies. 2. **Immunological disorders**: MYBL2 is significantly expressed in immune cells and has been implicated in the regulation of immune responses, including the development of autoimmune diseases. 3. **Regulatory role in cell differentiation**: MYBL2 plays a regulatory role in cell differentiation, particularly during the development of certain cell types, such as oogonial cells. 4. **Potential therapeutic target**: MYBL2 has been identified as a potential therapeutic target for the treatment of certain types of cancer and immunological disorders. In conclusion, MYBL2 is a transcription factor that plays a crucial role in regulating cell cycle progression, transcriptional control, and apoptosis. Its dysregulation has been implicated in several diseases, including cancer, immunological disorders, and cell differentiation disorders. Further research is needed to fully understand the functions and clinical significance of MYBL2.

Genular Protein ID: 844353820

Symbol: MYBB_HUMAN

Name: Myb-related protein B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3060855

Title: Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.

PubMed ID: 3060855

DOI: 10.1093/nar/16.23.11075

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9840932

Title: The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.

PubMed ID: 9840932

DOI: 10.1038/sj.onc.1202503

PubMed ID: 10095772

Title: Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.

PubMed ID: 10095772

DOI: 10.1046/j.1432-1327.1999.00191.x

PubMed ID: 10770937

Title: Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB.

PubMed ID: 10770937

DOI: 10.1074/jbc.m002055200

PubMed ID: 8062924

Title: Multiple nuclear localization signals of the B-myb gene product.

PubMed ID: 8062924

DOI: 10.1016/0014-5793(94)00733-0

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17671431

Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.

PubMed ID: 17671431

DOI: 10.4161/cc.6.15.4512

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25557911

Title: Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.

PubMed ID: 25557911

DOI: 10.1038/ncomms6800

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 700
  • Mass: 78764
  • Checksum: D91B28B3DAB94061
  • Sequence:
  • MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG QQDWKFLASH 
    FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK YGTKQWTLIA KHLKGRLGKQ 
    CRERWHNHLN PEVKKSCWTE EEDRIICEAH KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI 
    KRKVDTGGFL SESKDCKPPV YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN 
    SEEELAAATT SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL 
    IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS HQQQVLPPRQ 
    PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG SGIGTPPSVL KRQRKRRVAL 
    SPVTENSTSL SFLDSCNSLT PKSTPVKTLP FSPSQFLNFW NKQDTLELES PSLTSTPVCS 
    QKVVVTTPLH RDKTPLHQKH AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH 
    LEEDLKEVLR SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS 
    TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR SHFTTPAPMS 
    SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.