Details for: GPX2

Gene ID: 2877

Symbol: GPX2

Ensembl ID: ENSG00000176153

Description: glutathione peroxidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.7881
    Cell Significance Index: -15.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.5924
    Cell Significance Index: -15.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 13.3141
    Cell Significance Index: 691.6300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.7235
    Cell Significance Index: 25.6500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 9.1870
    Cell Significance Index: 69.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7491
    Cell Significance Index: -18.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.9675
    Cell Significance Index: 1075.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.4655
    Cell Significance Index: 50.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.4842
    Cell Significance Index: 551.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.4581
    Cell Significance Index: 202.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7440
    Cell Significance Index: 56.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3261
    Cell Significance Index: 45.3800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.0279
    Cell Significance Index: 30.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.7030
    Cell Significance Index: 77.8800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.1152
    Cell Significance Index: 13.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7508
    Cell Significance Index: 47.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.6349
    Cell Significance Index: 19.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.6188
    Cell Significance Index: 13.9100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.2917
    Cell Significance Index: 9.0900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1723
    Cell Significance Index: 7.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1299
    Cell Significance Index: 1020.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1008
    Cell Significance Index: 218.4500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.0645
    Cell Significance Index: 2.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0335
    Cell Significance Index: 22.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9339
    Cell Significance Index: 177.7300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.7654
    Cell Significance Index: 4.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7351
    Cell Significance Index: 119.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6822
    Cell Significance Index: 21.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5244
    Cell Significance Index: 51.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4987
    Cell Significance Index: 13.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4387
    Cell Significance Index: 6.2500
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.4155
    Cell Significance Index: 3.5800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3744
    Cell Significance Index: 1.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1974
    Cell Significance Index: 3.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1959
    Cell Significance Index: 22.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1945
    Cell Significance Index: 86.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1224
    Cell Significance Index: 14.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0941
    Cell Significance Index: 5.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0758
    Cell Significance Index: 0.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0359
    Cell Significance Index: 24.8600
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0261
    Cell Significance Index: 0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0257
    Cell Significance Index: 0.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0234
    Cell Significance Index: 12.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0117
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0080
    Cell Significance Index: 1.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0020
    Cell Significance Index: -1.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0157
    Cell Significance Index: -3.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0177
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0217
    Cell Significance Index: -15.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0226
    Cell Significance Index: -14.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0260
    Cell Significance Index: -0.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0277
    Cell Significance Index: -9.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0358
    Cell Significance Index: -7.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0407
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0471
    Cell Significance Index: -13.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0481
    Cell Significance Index: -5.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0518
    Cell Significance Index: -2.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0598
    Cell Significance Index: -1.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0727
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0826
    Cell Significance Index: -12.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0915
    Cell Significance Index: -6.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0956
    Cell Significance Index: -13.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1039
    Cell Significance Index: -2.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1052
    Cell Significance Index: -1.1100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1275
    Cell Significance Index: -2.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1277
    Cell Significance Index: -13.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1413
    Cell Significance Index: -14.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1415
    Cell Significance Index: -3.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1451
    Cell Significance Index: -18.7500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1572
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1612
    Cell Significance Index: -12.3700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1749
    Cell Significance Index: -1.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1759
    Cell Significance Index: -10.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1933
    Cell Significance Index: -1.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2012
    Cell Significance Index: -9.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2072
    Cell Significance Index: -16.4100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2134
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2139
    Cell Significance Index: -1.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2142
    Cell Significance Index: -14.4000
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.2231
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2361
    Cell Significance Index: -3.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2367
    Cell Significance Index: -14.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2463
    Cell Significance Index: -2.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2480
    Cell Significance Index: -18.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2543
    Cell Significance Index: -14.2700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2750
    Cell Significance Index: -2.6400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2785
    Cell Significance Index: -2.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2847
    Cell Significance Index: -18.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2849
    Cell Significance Index: -12.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2964
    Cell Significance Index: -13.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3093
    Cell Significance Index: -9.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPX2 exhibits several key characteristics that distinguish it from other glutathione peroxidases. These include: 1. **Phospholipid-hydroperoxide glutathione peroxidase activity**: GPX2 possesses the ability to reduce phospholipid hydroperoxides, a type of ROS, to their corresponding alcohols. This activity is unique among glutathione peroxidases and is essential for maintaining cellular membrane integrity. 2. **High specificity**: GPX2 is highly specific for phospholipid hydroperoxides, allowing it to target specific ROS without generating other reactive intermediates. 3. **Antioxidant activity**: GPX2 has been shown to scavenge ROS, including hydrogen peroxide and lipid hydroperoxides, thereby protecting cells from oxidative damage. 4. **Regulation of cellular metabolism**: GPX2 is involved in the regulation of fatty acid metabolism, which is essential for energy production and cellular homeostasis. **Pathways and Functions** GPX2 is involved in several key pathways, including: 1. **Detoxification of reactive oxygen species**: GPX2 plays a crucial role in the detoxification of ROS, including hydrogen peroxide and lipid hydroperoxides, thereby protecting cells from oxidative damage. 2. **Cellular responses to stimuli**: GPX2 is involved in the regulation of cellular responses to oxidative stress, including the activation of signaling pathways that promote cell survival and apoptosis. 3. **Fatty acid metabolism**: GPX2 is involved in the regulation of fatty acid metabolism, which is essential for energy production and cellular homeostasis. 4. **Electron transfer activity**: GPX2 possesses electron transfer activity, which allows it to reduce phospholipid hydroperoxides and other ROS. **Clinical Significance** GPX2 has been implicated in the pathogenesis of various diseases, including: 1. **Cancer**: GPX2 has been shown to be overexpressed in various types of cancer, including colon, breast, and prostate cancer. Its overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurodegenerative diseases**: GPX2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its dysregulation is associated with oxidative stress and neuronal damage. 3. **Atherosclerosis**: GPX2 has been shown to play a role in the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. 4. **Inflammatory diseases**: GPX2 has been implicated in the pathogenesis of inflammatory diseases, including arthritis and asthma. Its dysregulation is associated with oxidative stress and inflammation. In conclusion, GPX2 is a crucial enzyme involved in the detoxification of ROS and the regulation of cellular metabolism. Its dysregulation has been implicated in the pathogenesis of various diseases, including cancer, neurodegenerative diseases, atherosclerosis, and inflammatory diseases. Further research is needed to fully understand the role of GPX2 in human health and disease.

Genular Protein ID: 2142087548

Symbol: GPX2_HUMAN

Name: Glutathione peroxidase 2

UniProtKB Accession Codes:

P18283 Q6PJ52 Q8WWI7 Q9NRP9

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 39 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2388849

Title: A human cDNA sequence of a novel glutathione peroxidase-related protein.

PubMed ID: 2388849

DOI: 10.1093/nar/18.15.4619

PubMed ID: 8428933

Title: Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

PubMed ID: 8428933

DOI: 10.1016/s0021-9258(18)53812-6

PubMed ID: 10806356

Title: Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents.

PubMed ID: 10806356

DOI: 10.1016/s0378-1119(00)00137-2

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 36608588

Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.

PubMed ID: 36608588

DOI: 10.1016/j.redox.2022.102593

Sequence Information:

  • Length: 190
  • Mass: 21954
  • Checksum: FC8C4E69C4DE83A0
  • Sequence:
    • MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 
LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK 
DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 
DIKRLLKVAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.