Gene GPX2 - ENSG00000176153 | NCBI Gene ID: 2877

Details for: GPX2

Gene ID: 2877

Symbol: GPX2

Ensembl ID: ENSG00000176153

Description: glutathione peroxidase 2

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Fatty acid metabolism
(R-HSA-8978868)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Rna polymerase ii transcription
(R-HSA-73857)
Synthesis of 5-eicosatetraenoic acids
(R-HSA-2142688)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-HSA-2142712)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-HSA-2142770)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular oxidant detoxification
(GO:0098869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Glutathione peroxidase activity
(GO:0004602)
Intercellular bridge
(GO:0045171)
Mitotic spindle
(GO:0072686)
Phospholipid-hydroperoxide glutathione peroxidase activity
(GO:0047066)
Response to oxidative stress
(GO:0006979)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.89
Marker Score: 24831
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.28
Marker Score: 27714.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.02
Marker Score: 2382
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.64
Marker Score: 3891
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.54
Marker Score: 2123
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.43
Marker Score: 18101
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.36
Marker Score: 5353
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.27
Marker Score: 7125
Cell Name: malignant cell (CL0001064)
Fold Change: 2.26
Marker Score: 30323
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.23
Marker Score: 2137
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.2
Marker Score: 1157
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.19
Marker Score: 17126
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.09
Marker Score: 6008
Cell Name: stem cell (CL0000034)
Fold Change: 1.91
Marker Score: 4537.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.88
Marker Score: 707
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.7
Marker Score: 587
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.61
Marker Score: 13881
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.59
Marker Score: 1582
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.58
Marker Score: 381
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.49
Marker Score: 994
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.48
Marker Score: 1562.5
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.4
Marker Score: 283
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 864
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.18
Marker Score: 820
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.18
Marker Score: 338
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1
Marker Score: 2696.5
Cell Name: enterocyte (CL0000584)
Fold Change: 1.1
Marker Score: 5259
Cell Name: precursor cell (CL0011115)
Fold Change: 1.08
Marker Score: 263
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.06
Marker Score: 306
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.05
Marker Score: 437
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71810
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.98
Marker Score: 369
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5339
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.93
Marker Score: 231
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.9
Marker Score: 3893
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.86
Marker Score: 627
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.85
Marker Score: 5462
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.83
Marker Score: 916
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.82
Marker Score: 383
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1313
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.8
Marker Score: 4281
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.79
Marker Score: 6892
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.79
Marker Score: 2727
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 595
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3073
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 658
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.71
Marker Score: 283
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.67
Marker Score: 597
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.66
Marker Score: 645
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 435
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.64
Marker Score: 392
Cell Name: paneth cell (CL0000510)
Fold Change: 0.62
Marker Score: 431
Cell Name: parietal cell (CL0000162)
Fold Change: 0.61
Marker Score: 171
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.59
Marker Score: 528.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.59
Marker Score: 272
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.59
Marker Score: 612
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.58
Marker Score: 725
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.57
Marker Score: 882
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.56
Marker Score: 290
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 439
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.55
Marker Score: 205
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.55
Marker Score: 149
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.55
Marker Score: 8536
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.54
Marker Score: 141
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.54
Marker Score: 573
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.52
Marker Score: 217
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.51
Marker Score: 435
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.51
Marker Score: 134
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 0.5
Marker Score: 159
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.5
Marker Score: 149
Cell Name: secretory cell (CL0000151)
Fold Change: 0.49
Marker Score: 903
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.49
Marker Score: 940
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.49
Marker Score: 213
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 470
Cell Name: peptic cell (CL0000155)
Fold Change: 0.48
Marker Score: 201
Cell Name: club cell (CL0000158)
Fold Change: 0.48
Marker Score: 556
Cell Name: germ cell (CL0000586)
Fold Change: 0.46
Marker Score: 810
Cell Name: basal cell (CL0000646)
Fold Change: 0.46
Marker Score: 592
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.45
Marker Score: 392
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.4
Marker Score: 275
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.39
Marker Score: 142
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.38
Marker Score: 218
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.38
Marker Score: 141.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.38
Marker Score: 119
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 367
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.36
Marker Score: 410
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.36
Marker Score: 177
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.35
Marker Score: 100

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**Key characteristics** * GPX2 is a member of the glutathione peroxidase family of enzymes. * It is a protein of approximately 120 kDa. * It is found in the cytosol of cells. * It is a key regulator of cellular metabolism. **Pathways and functions** GPX2 is involved in a variety of pathways, including: * Arachidonic acid metabolism * Cellular responses to stimuli * Cellular responses to stress * Detoxification of reactive oxygen species * Electron transfer activity * Fatty acid metabolism **Clinical significance** GPX2 is a potential therapeutic target for a variety of diseases, including: * Cancer * Cardiovascular disease * Stroke * Diabetes * Neurodegenerative diseases **Expression** GPX2 is significantly expressed in cells of the skin, eyes, and lungs. It is also expressed in cells in the gastrointestinal tract, liver, and kidney. **Protein function** GPX2 is a key regulator of cellular metabolism. It helps to protect cells from damage by ROS and other molecules that can cause oxidative stress. GPX2 does this by catalyzing the reduction of hydrogen peroxide to water. This process helps to prevent the formation of hydroxyl radicals, which can damage DNA, proteins, and lipids. **Clinical significance** GPX2 is a potential therapeutic target for a variety of diseases. For example, clinical trials are currently underway to evaluate the use of GPX2 inhibitors as a treatment for cancer, cardiovascular disease, and stroke.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glutathione peroxidase 2

Genular Protein ID: 2142087548

Symbol: GPX2_HUMAN

Name: Glutathione peroxidase 2

UniProtKB Accession Codes:

P18283 Q6PJ52 Q8WWI7 Q9NRP9

Database IDs:

Citations:

PubMed ID: 2388849

Title: A human cDNA sequence of a novel glutathione peroxidase-related protein.

PubMed ID: 2388849

DOI: 10.1093/nar/18.15.4619

PubMed ID: 8428933

Title: Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

PubMed ID: 8428933

DOI: 10.1016/s0021-9258(18)53812-6

PubMed ID: 10806356

Title: Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents.

PubMed ID: 10806356

DOI: 10.1016/s0378-1119(00)00137-2

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 36608588

Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.

PubMed ID: 36608588

DOI: 10.1016/j.redox.2022.102593

Sequence Information:

Length: 190
Mass: 21954
Checksum: FC8C4E69C4DE83A0
Sequence:

MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 
LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK 
DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 
DIKRLLKVAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GPX2

Associated with

Cells (max top 100)

Other Information

A human cDNA sequence of a novel glutathione peroxidase-related protein. PubMed ID: 2388849

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. PubMed ID: 8428933

Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents. PubMed ID: 10806356

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides. PubMed ID: 36608588