IGLV2 23 | ENSG00000211660 | NCBI 28813

Details for: IGLV2 23

Gene ID: 28813

Symbol: IGLV2 23

Ensembl ID: ENSG00000211660

Description: immunoglobulin lambda variable 2-23

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.4977
Cell Significance Index: 7.7000
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4089
Cell Significance Index: 4.5700
Cell Name: blood cell (CL0000081)
Fold Change: 0.1279
Cell Significance Index: 1.0900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0933
Cell Significance Index: 1.3600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0105
Cell Significance Index: 1.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0051
Cell Significance Index: -3.8700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0382
Cell Significance Index: -3.9000
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0405
Cell Significance Index: -0.5900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0550
Cell Significance Index: -4.2200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0678
Cell Significance Index: -8.7600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0714
Cell Significance Index: -12.2000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0742
Cell Significance Index: -3.4600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0795
Cell Significance Index: -1.1300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0840
Cell Significance Index: -5.1500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0974
Cell Significance Index: -2.6100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1006
Cell Significance Index: -11.5200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1171
Cell Significance Index: -8.7300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1471
Cell Significance Index: -5.4000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1544
Cell Significance Index: -3.8500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1558
Cell Significance Index: -7.0600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1566
Cell Significance Index: -1.7800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1664
Cell Significance Index: -4.9000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1751
Cell Significance Index: -2.0600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1761
Cell Significance Index: -11.1000
Cell Name: enterocyte (CL0000584)
Fold Change: -0.1773
Cell Significance Index: -1.1000
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1852
Cell Significance Index: -2.5200
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1893
Cell Significance Index: -2.1200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1929
Cell Significance Index: -2.2800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2002
Cell Significance Index: -5.1000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2027
Cell Significance Index: -4.9100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2067
Cell Significance Index: -3.5100
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.2201
Cell Significance Index: -2.2700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2237
Cell Significance Index: -7.8600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2253
Cell Significance Index: -3.7700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2322
Cell Significance Index: -3.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2339
Cell Significance Index: -12.1500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2400
Cell Significance Index: -4.4400
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2508
Cell Significance Index: -1.6700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2573
Cell Significance Index: -5.0300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2579
Cell Significance Index: -3.1900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2610
Cell Significance Index: -7.5200
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2814
Cell Significance Index: -4.8100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2911
Cell Significance Index: -4.1800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2913
Cell Significance Index: -4.0400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2920
Cell Significance Index: -4.2000
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2931
Cell Significance Index: -2.7200
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2968
Cell Significance Index: -3.8400
Cell Name: adipocyte (CL0000136)
Fold Change: -0.2973
Cell Significance Index: -3.9600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2977
Cell Significance Index: -5.0200
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3026
Cell Significance Index: -4.4300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3030
Cell Significance Index: -3.8400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3038
Cell Significance Index: -8.7100
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.3082
Cell Significance Index: -3.4500
Cell Name: B cell (CL0000236)
Fold Change: -0.3123
Cell Significance Index: -3.6900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3136
Cell Significance Index: -3.5500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3182
Cell Significance Index: -3.3500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3209
Cell Significance Index: -4.4000
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3259
Cell Significance Index: -4.8100
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.3297
Cell Significance Index: -2.6500
Cell Name: monocyte (CL0000576)
Fold Change: -0.3363
Cell Significance Index: -3.8700
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3367
Cell Significance Index: -3.4400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3419
Cell Significance Index: -8.5400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3443
Cell Significance Index: -3.6600
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.3486
Cell Significance Index: -4.8200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3506
Cell Significance Index: -4.5900
Cell Name: peg cell (CL4033014)
Fold Change: -0.3506
Cell Significance Index: -8.1000
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.3550
Cell Significance Index: -4.5600
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.3557
Cell Significance Index: -4.5000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3614
Cell Significance Index: -3.8600
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3662
Cell Significance Index: -3.9400
Cell Name: ionocyte (CL0005006)
Fold Change: -0.3670
Cell Significance Index: -3.8400
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3693
Cell Significance Index: -3.7700
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.3705
Cell Significance Index: -3.6600
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3725
Cell Significance Index: -3.0800
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.3748
Cell Significance Index: -3.9000
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3750
Cell Significance Index: -3.3500
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3758
Cell Significance Index: -3.8200
Cell Name: glial cell (CL0000125)
Fold Change: -0.3760
Cell Significance Index: -4.1200
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.3761
Cell Significance Index: -2.8700
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.3764
Cell Significance Index: -4.2700
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.3812
Cell Significance Index: -3.7600
Cell Name: mast cell (CL0000097)
Fold Change: -0.3815
Cell Significance Index: -5.0200
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3823
Cell Significance Index: -3.6700
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3848
Cell Significance Index: -4.2800
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.3851
Cell Significance Index: -2.7100
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.3857
Cell Significance Index: -4.4500
Cell Name: goblet cell (CL0000160)
Fold Change: -0.3892
Cell Significance Index: -3.5200
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.3905
Cell Significance Index: -5.1000
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3958
Cell Significance Index: -4.9500
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.3986
Cell Significance Index: -3.9000
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3991
Cell Significance Index: -3.6500
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4027
Cell Significance Index: -4.4600
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.4037
Cell Significance Index: -4.9100
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4104
Cell Significance Index: -4.8500
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.4119
Cell Significance Index: -8.5900
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.4169
Cell Significance Index: -4.4200
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4173
Cell Significance Index: -4.6200
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4176
Cell Significance Index: -5.4800
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4195
Cell Significance Index: -5.0600
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4206
Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGLV2-23 is a member of the immunoglobulin lambda (λ) gene family, which is responsible for encoding the variable regions of the lambda light chain of immunoglobulins. The lambda light chain is a crucial component of the antibody molecule, which plays a central role in the adaptive immune response. IGLV2-23 is characterized by its ability to bind to various antigens, including those recognized by the B cell receptor (BCR) and the Fc epsilon receptor (FcεRI). This binding capacity allows IGLV2-23 to participate in immune responses, including the activation of complement and phagocytosis. **Pathways and Functions:** IGLV2-23 is involved in several key immune pathways, including: 1. **Antigen binding and activation of the B cell receptor (BCR):** IGLV2-23 binds to antigens, leading to the activation of the BCR and the generation of second messengers, such as calcium and phospholipids. 2. **Complement activation:** IGLV2-23 can activate the classical complement pathway, leading to the production of C3 and C5 convertases, which ultimately result in the lysis of target cells. 3. **Phagocytosis:** IGLV2-23 can interact with scavenger receptors, such as Fcγ receptors, to facilitate the phagocytosis of pathogens and debris. 4. **Regulation of actin dynamics:** IGLV2-23 can regulate actin dynamics, which is essential for the formation of phagocytic cups and the subsequent engulfment of pathogens. 5. **Calcium mobilization:** IGLV2-23 can mobilize calcium ions, which is essential for the activation of various immune cells, including natural killer cells and T cells. **Clinical Significance:** IGLV2-23 has been implicated in various diseases, including: 1. **Leishmania infection:** IGLV2-23 is significantly expressed in natural killer cells and T cells, which are essential for the defense against Leishmania parasites. 2. **Infectious diseases:** IGLV2-23 has been implicated in the pathogenesis of various infectious diseases, including tuberculosis and malaria. 3. **Autoimmune diseases:** IGLV2-23 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer:** IGLV2-23 has been implicated in the development and progression of various cancers, including leukemia and lymphoma. In conclusion, IGLV2-23 is a gene of significant importance in the adaptive immune system, with implications for our understanding of immune defense against infections and autoimmune diseases. Further research is necessary to fully elucidate the mechanisms by which IGLV2-23 regulates immune responses and to explore its therapeutic potential in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.