Details for: MSR1

Gene ID: 4481

Symbol: MSR1

Ensembl ID: ENSG00000038945

Description: macrophage scavenger receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 32.0577
    Cell Significance Index: -16.4900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 18.1031
    Cell Significance Index: 47.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9591
    Cell Significance Index: -14.7500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 7.3563
    Cell Significance Index: 103.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3146
    Cell Significance Index: -13.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.9189
    Cell Significance Index: 76.1000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 3.5151
    Cell Significance Index: 43.4800
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.8652
    Cell Significance Index: 9.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3736
    Cell Significance Index: 16.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3385
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2982
    Cell Significance Index: 56.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2981
    Cell Significance Index: 5.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2871
    Cell Significance Index: 4.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2372
    Cell Significance Index: 4.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1895
    Cell Significance Index: 18.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1756
    Cell Significance Index: 8.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1738
    Cell Significance Index: 156.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1281
    Cell Significance Index: 25.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0923
    Cell Significance Index: 2.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0843
    Cell Significance Index: 13.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 4.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0007
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0037
    Cell Significance Index: -2.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0079
    Cell Significance Index: -0.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0110
    Cell Significance Index: -1.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0135
    Cell Significance Index: -1.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0209
    Cell Significance Index: -7.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0235
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0239
    Cell Significance Index: -17.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0248
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0257
    Cell Significance Index: -7.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0283
    Cell Significance Index: -12.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0305
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0463
    Cell Significance Index: -9.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0464
    Cell Significance Index: -8.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0512
    Cell Significance Index: -1.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0545
    Cell Significance Index: -0.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0590
    Cell Significance Index: -3.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0781
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0809
    Cell Significance Index: -17.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0915
    Cell Significance Index: -15.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0947
    Cell Significance Index: -6.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1013
    Cell Significance Index: -12.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1016
    Cell Significance Index: -11.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1025
    Cell Significance Index: -14.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1242
    Cell Significance Index: -16.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1378
    Cell Significance Index: -8.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1407
    Cell Significance Index: -14.6500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1543
    Cell Significance Index: -2.0500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1574
    Cell Significance Index: -1.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1614
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1651
    Cell Significance Index: -18.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1673
    Cell Significance Index: -3.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1867
    Cell Significance Index: -23.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1908
    Cell Significance Index: -15.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2005
    Cell Significance Index: -4.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2057
    Cell Significance Index: -13.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2148
    Cell Significance Index: -16.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2242
    Cell Significance Index: -12.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2257
    Cell Significance Index: -10.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2385
    Cell Significance Index: -10.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2497
    Cell Significance Index: -15.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2520
    Cell Significance Index: -2.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2587
    Cell Significance Index: -16.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2608
    Cell Significance Index: -13.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2609
    Cell Significance Index: -6.9800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2881
    Cell Significance Index: -2.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2887
    Cell Significance Index: -15.0400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3063
    Cell Significance Index: -4.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3063
    Cell Significance Index: -13.5500
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.3109
    Cell Significance Index: -3.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3259
    Cell Significance Index: -17.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3287
    Cell Significance Index: -7.0000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3448
    Cell Significance Index: -3.5200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3465
    Cell Significance Index: -4.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3555
    Cell Significance Index: -13.4600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3672
    Cell Significance Index: -3.2100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3871
    Cell Significance Index: -6.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3990
    Cell Significance Index: -7.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4127
    Cell Significance Index: -19.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4147
    Cell Significance Index: -6.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4159
    Cell Significance Index: -14.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4345
    Cell Significance Index: -15.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4402
    Cell Significance Index: -16.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4426
    Cell Significance Index: -14.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4523
    Cell Significance Index: -12.1200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4594
    Cell Significance Index: -4.1400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.4618
    Cell Significance Index: -5.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4634
    Cell Significance Index: -14.7600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4644
    Cell Significance Index: -5.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4668
    Cell Significance Index: -12.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4722
    Cell Significance Index: -29.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MSR1 is a member of the scavenger receptor family, characterized by its ability to bind to a wide range of ligands, including: 1. Lipids: MSR1 can bind to cholesterol, phospholipids, and other lipid molecules, facilitating their uptake and transport. 2. Proteins: MSR1 can recognize and bind to various proteins, including amyloid-beta, which is involved in Alzheimer's disease. 3. Cellular debris: MSR1 can engulf and clear cellular debris, such as apoptotic cells and dead bacteria. MSR1's structure consists of a large ectodomain with a lectin-like domain, which mediates ligand binding, and a transmembrane domain that anchors the receptor to the plasma membrane. **Pathways and Functions** MSR1 plays a critical role in various cellular processes, including: 1. **Lipid metabolism**: MSR1 facilitates the uptake and transport of lipids, including cholesterol, which is essential for maintaining cellular membrane homeostasis. 2. **Amyloid-beta clearance**: MSR1 recognizes and binds to amyloid-beta, facilitating its clearance from the brain and reducing the risk of Alzheimer's disease. 3. **Scavenging**: MSR1 can engulf and clear cellular debris, including dead bacteria and apoptotic cells, which helps maintain tissue homeostasis and prevent inflammation. 4. **Phagocytosis**: MSR1 can participate in phagocytic processes, including the recognition and uptake of pathogens. **Clinical Significance** Dysregulation of MSR1 has been implicated in various diseases, including: 1. **Atherosclerosis**: MSR1's role in lipid metabolism and scavenging of low-density lipoprotein particles makes it a potential target for therapeutic interventions in atherosclerosis. 2. **Alzheimer's disease**: MSR1's involvement in amyloid-beta clearance suggests that it may play a role in the pathogenesis of Alzheimer's disease, and its dysregulation may contribute to disease progression. 3. **Cardiovascular disease**: MSR1's role in lipid metabolism and scavenging of cellular debris makes it a potential target for therapeutic interventions in cardiovascular disease. In conclusion, MSR1 is a critical receptor involved in lipid metabolism, amyloid-beta clearance, and scavenging of cellular debris. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and therapeutic potential of MSR1.

Genular Protein ID: 1415636702

Symbol: MSRE_HUMAN

Name: Macrophage scavenger receptor types I and II

UniProtKB Accession Codes:

P21757 D3DSP3 O60505 P21759 Q45F10

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2251254

Title: Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

PubMed ID: 2251254

DOI: 10.1073/pnas.87.23.9133

PubMed ID: 9548586

Title: A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake.

PubMed ID: 9548586

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8093617

Title: Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene.

PubMed ID: 8093617

DOI: 10.1016/s0021-9258(18)53970-3

PubMed ID: 8900177

Title: Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain.

PubMed ID: 8900177

DOI: 10.1074/jbc.271.43.26924

PubMed ID: 12244320

Title: Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.

PubMed ID: 12244320

DOI: 10.1038/ng994

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21791690

Title: Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma.

PubMed ID: 21791690

DOI: 10.1001/jama.2011.1029

PubMed ID: 25965346

Title: SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation.

PubMed ID: 25965346

DOI: 10.1371/journal.pone.0126576

Sequence Information:

  • Length: 451
  • Mass: 49762
  • Checksum: 915C03B56653BB41
  • Sequence:
    • MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV 
FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN 
MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL 
ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI 
KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG 
PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE 
GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF 
GRESSIEECK IRQWGTRACS HSEDAGVTCT L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.