Details for: KRT6A

Gene ID: 3853

Symbol: KRT6A

Ensembl ID: ENSG00000205420

Description: keratin 6A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 54.3431
    Cell Significance Index: 466.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.9997
    Cell Significance Index: 26.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7610
    Cell Significance Index: 77.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7042
    Cell Significance Index: 41.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6976
    Cell Significance Index: 9.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4901
    Cell Significance Index: 216.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4691
    Cell Significance Index: 6.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1655
    Cell Significance Index: 1.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0195
    Cell Significance Index: 3.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0207
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0278
    Cell Significance Index: -15.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0530
    Cell Significance Index: -24.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0838
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0970
    Cell Significance Index: -16.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1083
    Cell Significance Index: -21.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1202
    Cell Significance Index: -15.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1296
    Cell Significance Index: -15.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1362
    Cell Significance Index: -18.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1439
    Cell Significance Index: -14.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1563
    Cell Significance Index: -20.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1712
    Cell Significance Index: -19.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2187
    Cell Significance Index: -8.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2330
    Cell Significance Index: -5.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2353
    Cell Significance Index: -14.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2465
    Cell Significance Index: -17.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2720
    Cell Significance Index: -18.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2968
    Cell Significance Index: -22.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3082
    Cell Significance Index: -14.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3283
    Cell Significance Index: -8.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3386
    Cell Significance Index: -17.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3445
    Cell Significance Index: -19.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4030
    Cell Significance Index: -10.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4399
    Cell Significance Index: -19.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4921
    Cell Significance Index: -15.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4966
    Cell Significance Index: -6.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5221
    Cell Significance Index: -18.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5516
    Cell Significance Index: -25.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5596
    Cell Significance Index: -18.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5641
    Cell Significance Index: -19.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5882
    Cell Significance Index: -16.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5916
    Cell Significance Index: -7.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5927
    Cell Significance Index: -9.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6063
    Cell Significance Index: -19.3100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.6127
    Cell Significance Index: -4.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6199
    Cell Significance Index: -16.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6298
    Cell Significance Index: -18.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6421
    Cell Significance Index: -15.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6535
    Cell Significance Index: -17.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6857
    Cell Significance Index: -17.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6890
    Cell Significance Index: -19.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7001
    Cell Significance Index: -15.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7115
    Cell Significance Index: -7.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7246
    Cell Significance Index: -18.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7570
    Cell Significance Index: -14.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7672
    Cell Significance Index: -14.1800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.8093
    Cell Significance Index: -6.6900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.8130
    Cell Significance Index: -8.0200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.8144
    Cell Significance Index: -10.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.8308
    Cell Significance Index: -9.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8338
    Cell Significance Index: -21.3000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.8357
    Cell Significance Index: -8.6200
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.8454
    Cell Significance Index: -6.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8474
    Cell Significance Index: -13.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8668
    Cell Significance Index: -21.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8730
    Cell Significance Index: -20.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8744
    Cell Significance Index: -18.2500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.9000
    Cell Significance Index: -9.1800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.9128
    Cell Significance Index: -11.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9130
    Cell Significance Index: -19.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9185
    Cell Significance Index: -19.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9272
    Cell Significance Index: -18.2500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.9283
    Cell Significance Index: -6.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9350
    Cell Significance Index: -6.3400
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.9378
    Cell Significance Index: -7.1400
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.9395
    Cell Significance Index: -8.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9488
    Cell Significance Index: -18.7600
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.9817
    Cell Significance Index: -8.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.9858
    Cell Significance Index: -16.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0281
    Cell Significance Index: -21.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0387
    Cell Significance Index: -17.9600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -1.0401
    Cell Significance Index: -15.5600
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.0922
    Cell Significance Index: -11.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.0937
    Cell Significance Index: -22.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.0940
    Cell Significance Index: -18.7000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.0956
    Cell Significance Index: -12.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1088
    Cell Significance Index: -22.2600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.1275
    Cell Significance Index: -19.3700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.1353
    Cell Significance Index: -14.2600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1386
    Cell Significance Index: -15.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1448
    Cell Significance Index: -19.1600
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -1.1468
    Cell Significance Index: -11.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.1484
    Cell Significance Index: -14.5300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.1607
    Cell Significance Index: -12.3300
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -1.1623
    Cell Significance Index: -11.4100
  • Cell Name: basophil (CL0000767)
    Fold Change: -1.1693
    Cell Significance Index: -10.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KRT6A is a type II keratin protein, which distinguishes it from type I keratins, such as KRT1 and KRT5. The type II keratins, including KRT6A, are characterized by their ability to form dimers and interact with other keratin proteins to form intermediate filaments. These filaments provide mechanical stability and resistance to mechanical stress, allowing epithelial cells to withstand various environmental challenges. KRT6A is also highly expressed in stratified epithelial cells, which differentiate into multiple layers to form the epidermis, a multi-layered epithelial tissue. **Pathways and Functions** KRT6A participates in several key cellular pathways, including: 1. **Cell differentiation**: KRT6A is essential for the proper differentiation of epithelial cells into their specialized forms, such as keratinocytes and stratified epithelial cells. 2. **Morphogenesis of an epithelium**: KRT6A plays a critical role in the development and organization of epithelial tissues, including the formation of the epidermis and other epithelial layers. 3. **Wound healing**: KRT6A is upregulated in response to tissue injury, facilitating the repair of epithelial barriers and promoting the regeneration of damaged tissues. 4. **Antimicrobial response**: KRT6A is involved in the innate immune response to antimicrobial peptides, which help to protect against bacterial infections. 5. **Cell cycle regulation**: KRT6A can regulate cell population proliferation, influencing the growth and development of epithelial tissues. **Clinical Significance** Dysregulation of KRT6A has been implicated in various diseases, including: 1. **Epidermolysis bullosa**: A group of genetic disorders characterized by blistering skin and mucous membranes, often caused by mutations in the KRT5 and KRT14 genes, which encode type I keratins. 2. **Cancer**: Aberrant expression of KRT6A has been observed in various types of cancer, including squamous cell carcinoma and basal cell carcinoma. 3. **Neurological disorders**: KRT6A has been implicated in the pathogenesis of certain neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 4. **Wound healing disorders**: Impaired KRT6A expression has been linked to delayed wound healing and impaired tissue regeneration. In conclusion, KRT6A is a critical component of intermediate filaments in stratified epithelial cells, playing a vital role in maintaining epithelial integrity, cell differentiation, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of KRT6A in maintaining tissue homeostasis and overall health.

Genular Protein ID: 2482667844

Symbol: K2C6A_HUMAN

Name: Keratin, type II cytoskeletal 6A

UniProtKB Accession Codes:

P02538 A4QPC1 P48667 Q08AR4 Q6NT67 Q96CL4

Database IDs:

AGR 1 Allergome 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 16 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7543104

Title: Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

PubMed ID: 7543104

DOI: 10.1074/jbc.270.31.18581

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6191871

Title: The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins.

PubMed ID: 6191871

DOI: 10.1016/0092-8674(83)90034-x

PubMed ID: 15731013

Title: Identification of trichoplein, a novel keratin filament-binding protein.

PubMed ID: 15731013

DOI: 10.1242/jcs.01667

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22668561

Title: Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.

PubMed ID: 22668561

DOI: 10.1684/ejd.2012.1773

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26758872

Title: Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.

PubMed ID: 26758872

DOI: 10.1093/hmg/ddw001

PubMed ID: 7545493

Title: Mutation of a type II keratin gene (K6a) in pachyonychia congenita.

PubMed ID: 7545493

DOI: 10.1038/ng0795-363

PubMed ID: 10232400

Title: A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1.

PubMed ID: 10232400

DOI: 10.1111/j.1600-0625.1999.tb00356.x

PubMed ID: 11886499

Title: Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.

PubMed ID: 11886499

DOI: 10.1046/j.0022-202x.2001.01565.x

PubMed ID: 15387942

Title: [A de nono I462S mutation in the KRT6A gene is associated with pachyonychia congenita type I].

PubMed ID: 15387942

PubMed ID: 15840119

Title: A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a.

PubMed ID: 15840119

DOI: 10.1111/j.1365-2133.2005.06473.x

PubMed ID: 16250206

Title: The genetic basis of pachyonychia congenita.

PubMed ID: 16250206

DOI: 10.1111/j.1087-0024.2005.10204.x

PubMed ID: 17719747

Title: A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.

PubMed ID: 17719747

DOI: 10.1016/j.jdermsci.2007.07.003

PubMed ID: 17309457

Title: A novel missense mutation L468Q of keratin 6a in pachyonychia congenita type 1.

PubMed ID: 17309457

DOI: 10.1111/j.1468-3083.2006.01930.x

PubMed ID: 18489596

Title: Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families.

PubMed ID: 18489596

DOI: 10.1111/j.1365-2133.2008.08603.x

PubMed ID: 19416275

Title: Novel and recurrent keratin 6A (KRT6A) mutations in Chinese patients with pachyonychia congenita type 1.

PubMed ID: 19416275

DOI: 10.1111/j.1365-2133.2009.09062.x

PubMed ID: 21326300

Title: A large mutational study in pachyonychia congenita.

PubMed ID: 21326300

DOI: 10.1038/jid.2011.20

Sequence Information:

  • Length: 564
  • Mass: 60045
  • Checksum: 26708916C7DC923A
  • Sequence:
    • MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSVSVSR SRGSGGLGGA CGGAGFGSRS 
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPTIQRVR AEEREQIKTL NNKFASFIDK 
VRFLEQQNKV LETKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR 
GMQDLVEDFK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 
EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCANLQAAIA DAEQRGEMAL 
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 
VGQVNISVVQ STVSSGYGGA SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRAIGGGLS 
SVGGGSSTIK YTTTSSSSRK SYKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.