Details for: KRT6A

Gene ID: 3853

Symbol: KRT6A

Ensembl ID: ENSG00000205420

Description: keratin 6A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.32
    Marker Score: 25916
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.01
    Marker Score: 25904
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.87
    Marker Score: 2396
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.39
    Marker Score: 4344.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.06
    Marker Score: 27673
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.9
    Marker Score: 459
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.73
    Marker Score: 1819
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.55
    Marker Score: 1054
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.52
    Marker Score: 928
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.26
    Marker Score: 1424
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1453
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.96
    Marker Score: 756
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.93
    Marker Score: 1530
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.77
    Marker Score: 364
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.7
    Marker Score: 4537.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.69
    Marker Score: 759
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 325
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.65
    Marker Score: 4816
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.64
    Marker Score: 365
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.59
    Marker Score: 414
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.53
    Marker Score: 620
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.53
    Marker Score: 175
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.53
    Marker Score: 349
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.51
    Marker Score: 173
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 964
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.5
    Marker Score: 907
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.49
    Marker Score: 1199
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.48
    Marker Score: 426
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.42
    Marker Score: 156
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.38
    Marker Score: 255
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 382
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.33
    Marker Score: 532
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.31
    Marker Score: 207
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 279
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.27
    Marker Score: 381.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.27
    Marker Score: 365
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.26
    Marker Score: 740
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.25
    Marker Score: 227
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 227
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.22
    Marker Score: 44
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.21
    Marker Score: 59.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.2
    Marker Score: 1761
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2
    Marker Score: 404
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.19
    Marker Score: 3000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.19
    Marker Score: 891
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.19
    Marker Score: 212
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1058
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 174
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.16
    Marker Score: 138
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.15
    Marker Score: 272
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.15
    Marker Score: 539.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.13
    Marker Score: 116
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.13
    Marker Score: 631
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.13
    Marker Score: 45.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 389
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 149

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Other Information

**Key characteristics:** - KRT6A is a transmembrane protein with a molecular weight of approximately 130 kDa. - It belongs to the keratin family of structural proteins, which are essential for the integrity of epithelial cells. - KRT6A is a cytoskeletal protein that helps to maintain the structural integrity of the skin epidermis. - It is also involved in cell differentiation and the formation of the cornified envelope, a protective barrier that surrounds the skin. **Pathways and functions:** - KRT6A is involved in the antimicrobial humoral immune response mediated by antimicrobial peptides. - It is expressed in epithelial cells of the skin, where it helps to protect the body from infection. - It is also expressed in immune cells, where it helps to activate the immune response. - KRT6A is involved in cell differentiation and the formation of the cornified envelope. - It is also involved in the killing of cells of another organism. - It is a structural component of the skin epidermis, providing strength and elasticity. **Clinical significance:** Mutations in KRT6A have been linked to a number of skin disorders, including psoriasis, eczema, and skin cancer. These disorders are characterized by abnormal skin growth and differentiation, and they can be treated with topical treatments that target KRT6A.

Genular Protein ID: 2482667844

Symbol: K2C6A_HUMAN

Name: Keratin, type II cytoskeletal 6A

UniProtKB Accession Codes:

P02538 A4QPC1 P48667 Q08AR4 Q6NT67 Q96CL4

Database IDs:

AGR 1 Allergome 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 16 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7543104

Title: Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

PubMed ID: 7543104

DOI: 10.1074/jbc.270.31.18581

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6191871

Title: The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins.

PubMed ID: 6191871

DOI: 10.1016/0092-8674(83)90034-x

PubMed ID: 15731013

Title: Identification of trichoplein, a novel keratin filament-binding protein.

PubMed ID: 15731013

DOI: 10.1242/jcs.01667

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22668561

Title: Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.

PubMed ID: 22668561

DOI: 10.1684/ejd.2012.1773

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26758872

Title: Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.

PubMed ID: 26758872

DOI: 10.1093/hmg/ddw001

PubMed ID: 7545493

Title: Mutation of a type II keratin gene (K6a) in pachyonychia congenita.

PubMed ID: 7545493

DOI: 10.1038/ng0795-363

PubMed ID: 10232400

Title: A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1.

PubMed ID: 10232400

DOI: 10.1111/j.1600-0625.1999.tb00356.x

PubMed ID: 11886499

Title: Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.

PubMed ID: 11886499

DOI: 10.1046/j.0022-202x.2001.01565.x

PubMed ID: 15387942

Title: [A de nono I462S mutation in the KRT6A gene is associated with pachyonychia congenita type I].

PubMed ID: 15387942

PubMed ID: 15840119

Title: A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a.

PubMed ID: 15840119

DOI: 10.1111/j.1365-2133.2005.06473.x

PubMed ID: 16250206

Title: The genetic basis of pachyonychia congenita.

PubMed ID: 16250206

DOI: 10.1111/j.1087-0024.2005.10204.x

PubMed ID: 17719747

Title: A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.

PubMed ID: 17719747

DOI: 10.1016/j.jdermsci.2007.07.003

PubMed ID: 17309457

Title: A novel missense mutation L468Q of keratin 6a in pachyonychia congenita type 1.

PubMed ID: 17309457

DOI: 10.1111/j.1468-3083.2006.01930.x

PubMed ID: 18489596

Title: Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families.

PubMed ID: 18489596

DOI: 10.1111/j.1365-2133.2008.08603.x

PubMed ID: 19416275

Title: Novel and recurrent keratin 6A (KRT6A) mutations in Chinese patients with pachyonychia congenita type 1.

PubMed ID: 19416275

DOI: 10.1111/j.1365-2133.2009.09062.x

PubMed ID: 21326300

Title: A large mutational study in pachyonychia congenita.

PubMed ID: 21326300

DOI: 10.1038/jid.2011.20

Sequence Information:

  • Length: 564
  • Mass: 60045
  • Checksum: 26708916C7DC923A
  • Sequence:
    • MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSVSVSR SRGSGGLGGA CGGAGFGSRS 
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPTIQRVR AEEREQIKTL NNKFASFIDK 
VRFLEQQNKV LETKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR 
GMQDLVEDFK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 
EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCANLQAAIA DAEQRGEMAL 
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 
VGQVNISVVQ STVSSGYGGA SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRAIGGGLS 
SVGGGSSTIK YTTTSSSSRK SYKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.