Details for: CL1000447

Cell ID: CL1000447

Cell Name: epithelial cell of stratum germinativum of esophagus

Marker Score Threshold: 241
(Derived using integrated single-cell and genomic data)

Description: A basal cell that is part of the epithelium of esophagus.

Synonyms: basal cell of esophageal epithelium

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.93
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.91
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.8
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.79
    Ensembl ID: ENSG00000135046
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.76
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.7
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.63
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.6
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.59
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.54
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.44
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.42
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.42
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.4
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.39
    Ensembl ID: ENSG00000099624
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.38
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.38
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.23
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.13
    Ensembl ID: ENSG00000169020
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.01
    Ensembl ID: ENSG00000102554
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.99
    Ensembl ID: ENSG00000153113
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.91
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.89
    Ensembl ID: ENSG00000133639
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.88
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.83
    Ensembl ID: ENSG00000090013
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.81
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.78
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.72
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.71
    Ensembl ID: ENSG00000172270
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.67
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.66
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALML3 (ENSG00000178363)
    Fold Change: 1.61
    Ensembl ID: ENSG00000178363
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.6
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.6
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.58
    Ensembl ID: ENSG00000111348
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.58
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110092
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.48
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.47
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.45
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.45
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.44
    Ensembl ID: ENSG00000042493
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.43
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.43
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.34
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.33
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.27
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.27
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.24
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.23
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.21
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.21
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.21
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.21
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164615
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.16
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138279
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.15
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.13
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.1
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.1
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197043
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.06
    Ensembl ID: ENSG00000204580
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.04
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.02
    Ensembl ID: ENSG00000130707
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.02
    Ensembl ID: ENSG00000131100
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.02
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198363
Hovered Details

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Hovered Details

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**Key Characteristics** * Epithelial cell type: Basal cell of esophageal epithelium * Location: Stratum germinativum of the esophagus * Gene Symbol: B2M (Beta-2 microglobulin) * Ensembl ID: ENSG00000166710 * Pathways/Ontology: + Adaptive immune system + Amyloid fiber formation + Amyloid fibril formation + Antigen presentation: folding, assembly, and peptide loading of class I MHC + Antigen processing-cross presentation + Antigen processing and presentation of endogenous peptide antigen via MHC class I + Antigen processing and presentation of exogenous peptide antigen via MHC class II + Antigen processing and presentation of exogenous protein antigen via MHC class IB + Bacterial infection pathways + Cellular response to iron(III) ion + Cellular response to iron ion + Cellular response to nicotine + Class I MHC-mediated antigen processing and presentation + Cytokine signaling in immune system + Cytosol + Dap12 interactions + Dap12 signaling + Disease + Early endosome lumen + Early endosome membrane + Endoplasmic reticulum + Endoplasmic reticulum lumen + Endosomal/vacuolar pathway + Er-phagosome pathway + Er to Golgi transport vesicle membrane + External side of plasma membrane + Extracellular exosome + Extracellular region + Extracellular space + Focal adhesion + Golgi apparatus + Golgi membrane + Hfe-transferrin receptor complex + Hiv infection + Host interactions of Hiv factors + Identical protein binding + Immune system + Immunoregulatory interactions between a lymphoid and a non-lymphoid cell + Infection with mycobacterium tuberculosis + Infectious disease + Innate immune system + Interferon gamma signaling + Interferon signaling + Intracellular iron ion homeostasis + Iron ion transport + Late endosome membrane + Learning or memory + Lysosomal membrane + Membrane + Metabolism of proteins + MHC class II protein complex + MHC class II protein complex binding + MHC class I peptide loading complex + MHC class I protein complex + Modulation by mtb of host immune system + Multicellular organismal-level iron ion homeostasis + Nef-mediated downregulation of cell surface receptors by recruiting them to clathrin adapters + Nef-mediated downregulation of MHC class I complex cell surface expression + Negative regulation of epithelial cell proliferation + Negative regulation of forebrain neuron differentiation + Negative regulation of neurogenesis + Negative regulation of neuron projection development + Negative regulation of receptor binding + Neutrophil degranulation + Peptide antigen assembly with MHC class II protein complex + Peptide antigen assembly with MHC class I protein complex + Peptide antigen binding + Phagocytic vesicle membrane + Plasma membrane + Positive regulation of cellular senescence + Positive regulation of ferrous iron binding + Positive regulation of immune response + Positive regulation of protein binding + Positive regulation of receptor-mediated endocytosis + Positive regulation of receptor binding + Positive regulation of T cell activation + Positive regulation of T cell cytokine production + Positive regulation of T cell-mediated cytotoxicity + Positive regulation of transferrin receptor binding + Protein binding + Protein homodimerization activity + Protein homotetramerization + Protein refolding + Recycling endosome membrane + Regulation of erythrocyte differentiation + Regulation of iron ion transport + Response to molecule of bacterial origin + SARS-CoV-2 activates/modulates innate and adaptive immune responses + SARS-CoV-2 infection + SARS-CoV-2-host interactions + SARS-CoV infections + Sensory perception of smell + Specific granule lumen + Structural molecule activity + T cell differentiation in thymus + T cell-mediated cytotoxicity + Tertiary granule lumen + The role of nef in HIV-1 replication and disease pathogenesis + Viral infection pathways **Clinical Significance** The epithelial cell of the stratum germinativum of the esophagus plays a crucial role in maintaining the integrity of the esophageal lining and regulating immune responses. Abnormalities in this cell type have been implicated in various diseases, including esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease (GERD). The cell's ability to present antigens and regulate iron ion homeostasis makes it an important target for research into the development of novel therapies for these diseases. In addition, the cell's interactions with various signaling pathways, including those involved in immune responses and cell growth, make it an important model system for studying the mechanisms of disease and developing new treatments. The cell's ability to respond to bacterial infection and regulate iron ion homeostasis also makes it an important model system for studying the mechanisms of infection and disease. Overall, the epithelial cell of the stratum germinativum of the esophagus is an important cell type that plays a crucial role in maintaining the integrity of the esophageal lining and regulating immune responses. Further research into the functions and mechanisms of this cell type is needed to develop novel therapies for various diseases.