Details for: CL0002480

Cell ID: CL0002480

Cell Name: nasal mucosa goblet cell

Marker Score Threshold: 669
(Derived using integrated single-cell and genomic data)

Description: A goblet cell located in the nasal epithelium.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.37
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.36
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3.31
    Ensembl ID: ENSG00000170017
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.31
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.17
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 3
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.96
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.93
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 2.92
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 2.9
    Ensembl ID: ENSG00000248144
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.77
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.61
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.32
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.31
    Ensembl ID: ENSG00000072778
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.24
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.23
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.22
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.18
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.17
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.15
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 2.12
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.04
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.04
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.97
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.95
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.92
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.88
    Ensembl ID: ENSG00000161905
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.88
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.87
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.82
    Ensembl ID: ENSG00000111275
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.75
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.75
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.73
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.7
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.7
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.7
    Ensembl ID: ENSG00000142599
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.69
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.68
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ALDH3B1 (ENSG00000006534)
    Fold Change: 1.63
    Ensembl ID: ENSG00000006534
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.62
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.6
    Ensembl ID: ENSG00000166825
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.54
    Ensembl ID: ENSG00000120805
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.54
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.53
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.47
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.46
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.45
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.45
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.44
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.42
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP7B (ENSG00000123191)
    Fold Change: 1.41
    Ensembl ID: ENSG00000123191
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.4
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.4
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.37
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.36
    Ensembl ID: ENSG00000137845
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.32
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.29
    Ensembl ID: ENSG00000006756
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165629
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.28
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.26
    Ensembl ID: ENSG00000060971
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.23
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.22
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.22
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.22
    Ensembl ID: ENSG00000278540
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.21
    Ensembl ID: ENSG00000166747
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000123505
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.21
    Ensembl ID: ENSG00000102699
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.16
    Ensembl ID: ENSG00000035687
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.12
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.11
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.11
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.09
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.06
    Ensembl ID: ENSG00000141480
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.05
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.03
    Ensembl ID: ENSG00000114573
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.01
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1
    Ensembl ID: ENSG00000023330
Hovered Details

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Hovered Details

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**Key Characteristics** The nasal mucosa goblet cell is characterized by the following features: 1. **Location**: Goblet cells are found in the nasal mucosa, specifically in the respiratory epithelium. 2. **Function**: Goblet cells produce and secrete mucins, which are glycoproteins that provide lubrication and protection to the epithelial surface. 3. **Gene expression**: The ALDH1A1 gene is specifically expressed in goblet cells, while ANXA1 and AQP3 genes are also present in these cells. 4. **Cellular structure**: Goblet cells have a distinct morphology, with a large nuclei and a prominent Golgi apparatus. **Clinical Significance** The nasal mucosa goblet cell plays a crucial role in maintaining the health of the respiratory epithelium, and alterations in goblet cell function or number can contribute to various respiratory disorders. Some of the clinical significance of the nasal mucosa goblet cell includes: 1. **Respiratory diseases**: Abnormalities in goblet cell function or number have been implicated in various respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. 2. **Allergies**: Goblet cells play a role in the immune response to allergens, and alterations in goblet cell function or number can contribute to the development of allergic diseases. 3. **Infections**: Goblet cells can produce antimicrobial peptides and proteins that help to clear pathogens from the respiratory epithelium. 4. **Cancer**: Alterations in goblet cell function or number have been implicated in the development of certain types of cancer, including lung and colon cancer. **Pathways/ Ontology** The genes ALDH1A1, ANXA1, and AQP3 are involved in various cellular processes, including: 1. **Cellular detoxification**: ALDH1A1 is involved in the detoxification of aldehydes, which are toxic compounds that can damage cellular components. 2. **Cell signaling**: ANXA1 is involved in cell signaling pathways, including the regulation of immune responses and cell migration. 3. **Water transport**: AQP3 is involved in the transport of water across cell membranes, which is essential for maintaining cellular homeostasis. In conclusion, the nasal mucosa goblet cell is a unique cell type that plays a crucial role in maintaining the health of the respiratory epithelium. Alterations in goblet cell function or number can contribute to various respiratory disorders, and further research is needed to understand the mechanisms underlying these processes.