Details for: SPRR1A

Gene ID: 6698

Symbol: SPRR1A

Ensembl ID: ENSG00000169474

Description: small proline rich protein 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 5.5547
    Cell Significance Index: 42.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5030
    Cell Significance Index: 372.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4070
    Cell Significance Index: 229.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3867
    Cell Significance Index: 81.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1702
    Cell Significance Index: 1.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1228
    Cell Significance Index: 1.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0730
    Cell Significance Index: 3.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0713
    Cell Significance Index: 1.9900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0611
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0595
    Cell Significance Index: 37.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0393
    Cell Significance Index: 4.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0113
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0114
    Cell Significance Index: -1.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0181
    Cell Significance Index: -7.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0232
    Cell Significance Index: -4.1800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0268
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0304
    Cell Significance Index: -3.7400
  • Cell Name: deuterosomal cell (CL4033044)
    Fold Change: -0.0329
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0340
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0382
    Cell Significance Index: -4.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0408
    Cell Significance Index: -1.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0440
    Cell Significance Index: -0.5100
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0458
    Cell Significance Index: -0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0608
    Cell Significance Index: -0.8300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0618
    Cell Significance Index: -0.3000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0624
    Cell Significance Index: -0.2900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0963
    Cell Significance Index: -0.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1022
    Cell Significance Index: -3.7500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1299
    Cell Significance Index: -1.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1733
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1768
    Cell Significance Index: -2.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1832
    Cell Significance Index: -8.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1918
    Cell Significance Index: -2.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2046
    Cell Significance Index: -6.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2240
    Cell Significance Index: -5.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2291
    Cell Significance Index: -2.1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2302
    Cell Significance Index: -2.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2788
    Cell Significance Index: -4.6900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2839
    Cell Significance Index: -0.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2859
    Cell Significance Index: -7.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2983
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3004
    Cell Significance Index: -8.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3242
    Cell Significance Index: -8.8300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3605
    Cell Significance Index: -4.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4005
    Cell Significance Index: -8.7700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4169
    Cell Significance Index: -4.3000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4556
    Cell Significance Index: -9.0900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.5012
    Cell Significance Index: -8.6100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5022
    Cell Significance Index: -3.6500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.5024
    Cell Significance Index: -5.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5037
    Cell Significance Index: -8.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5070
    Cell Significance Index: -9.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5343
    Cell Significance Index: -6.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5409
    Cell Significance Index: -8.7600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.5627
    Cell Significance Index: -5.9300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5684
    Cell Significance Index: -8.2900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5726
    Cell Significance Index: -4.9200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5869
    Cell Significance Index: -8.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5898
    Cell Significance Index: -8.3800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.5954
    Cell Significance Index: -6.6600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.6075
    Cell Significance Index: -7.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6142
    Cell Significance Index: -8.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6173
    Cell Significance Index: -8.8400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6270
    Cell Significance Index: -8.6700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6312
    Cell Significance Index: -8.2400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6360
    Cell Significance Index: -8.3700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.6408
    Cell Significance Index: -6.0500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.6413
    Cell Significance Index: -6.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6427
    Cell Significance Index: -8.5400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6445
    Cell Significance Index: -8.3000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6476
    Cell Significance Index: -8.8800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.6501
    Cell Significance Index: -5.8800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.6520
    Cell Significance Index: -5.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6552
    Cell Significance Index: -6.7800
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.6574
    Cell Significance Index: -6.0400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6593
    Cell Significance Index: -8.4700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.6638
    Cell Significance Index: -6.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6720
    Cell Significance Index: -8.2600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6757
    Cell Significance Index: -8.2200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.6765
    Cell Significance Index: -8.5600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6781
    Cell Significance Index: -8.8500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.6793
    Cell Significance Index: -6.7800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6821
    Cell Significance Index: -8.0600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.6830
    Cell Significance Index: -6.0700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6831
    Cell Significance Index: -8.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.6846
    Cell Significance Index: -8.0900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.6923
    Cell Significance Index: -6.7800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6946
    Cell Significance Index: -7.9500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6962
    Cell Significance Index: -8.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6971
    Cell Significance Index: -7.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7016
    Cell Significance Index: -8.3900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7022
    Cell Significance Index: -8.0800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.7043
    Cell Significance Index: -8.9200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.7047
    Cell Significance Index: -7.6400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.7049
    Cell Significance Index: -7.6800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7064
    Cell Significance Index: -8.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7068
    Cell Significance Index: -8.8300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7127
    Cell Significance Index: -8.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein**: SPRR1A is a type of small proline-rich protein, characterized by its high content of proline residues, which confer unique structural properties to the protein. 2. **Epithelial specificity**: SPRR1A is predominantly expressed in epithelial cells, including keratinocytes, squamous epithelial cells, and stratified epithelial cells. 3. **Keratinization and cornified envelope formation**: SPRR1A is essential for the proper formation of the cornified envelope, a critical structure in skin and epithelial tissues that provides mechanical strength and barrier function. 4. **Peptide cross-linking**: SPRR1A participates in peptide cross-linking, a process that secures the integrity of the epithelial barrier. **Pathways and Functions:** 1. **Keratinization pathway**: SPRR1A regulates keratinization, a process of cellular differentiation in epithelial cells, by interacting with keratin proteins and influencing their assembly and cross-linking. 2. **Cornified envelope formation pathway**: SPRR1A contributes to the formation of the cornified envelope by interacting with other proteins, such as filaggrin, and facilitating the assembly of the envelope's structural components. 3. **Peptide cross-linking pathway**: SPRR1A participates in peptide cross-linking, a process that secures the integrity of the epithelial barrier by forming covalent bonds between keratin proteins. 4. **Epithelial homeostasis**: SPRR1A maintains epithelial homeostasis by regulating the expression of genes involved in epithelial development, differentiation, and maintenance. **Clinical Significance:** 1. **Atopic dermatitis**: Mutations in SPRR1A have been associated with atopic dermatitis, a chronic skin condition characterized by impaired skin barrier function and increased susceptibility to infections. 2. **Epidermolysis bullosa**: SPRR1A mutations have also been linked to epidermolysis bullosa, a group of genetic disorders characterized by skin blistering and fragility. 3. **Cancer**: Alterations in SPRR1A expression have been observed in various types of cancer, including squamous cell carcinoma and basal cell carcinoma, suggesting its potential role in tumorigenesis. 4. **Regenerative medicine**: SPRR1A's role in epithelial homeostasis and differentiation makes it a promising target for regenerative medicine applications, such as wound healing and tissue engineering. In conclusion, the SPRR1A gene plays a vital role in maintaining epithelial homeostasis and barrier function, and its dysregulation has been implicated in various diseases, including atopic dermatitis, epidermolysis bullosa, and cancer. Further research is necessary to fully elucidate the molecular mechanisms underlying SPRR1A's functions and to explore its therapeutic potential.

Genular Protein ID: 248995260

Symbol: SPR1A_HUMAN

Name: Cornifin-A

UniProtKB Accession Codes:

P35321 B1AN47 D3DV31 Q2M303 Q9UDG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8325635

Title: Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.

PubMed ID: 8325635

DOI: 10.1006/geno.1993.1240

PubMed ID: 8018055

Title: Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.

PubMed ID: 8018055

DOI: 10.1016/0003-9969(94)90051-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7829876

Title: The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.

PubMed ID: 7829876

DOI: 10.1111/1523-1747.ep12612759

Sequence Information:

  • Length: 89
  • Mass: 9877
  • Checksum: C79E79931794D3D4
  • Sequence:
    • MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH PKVPEPCQPK 
VPEPCQPKVP EPCPSTVTPA PAQQKTKQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.