Details for: CL0002324

Cell ID: CL0002324

Cell Name: myoepithelial cell of mammary gland

Marker Score Threshold: 4912
(Derived using integrated single-cell and genomic data)

Description: A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM.

Synonyms: basal myoepithelial cell, basal-myoepithelial cell, myoepithelial cell of mammary gland, basal cell of lactiferous duct, myoepithelial cell of lactiferous gland, B-Myo cell, BM, basal

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 4.11
    Ensembl ID: ENSG00000185883
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.89
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.77
    Ensembl ID: ENSG00000184009
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.7
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 3.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 3.23
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.19
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 3.15
    Ensembl ID: ENSG00000164111
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 2.9
    Ensembl ID: ENSG00000196136
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.79
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.76
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.55
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.5
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.42
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.42
    Ensembl ID: ENSG00000142192
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.39
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.35
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.35
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.31
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.27
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.24
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 2.23
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.21
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.2
    Ensembl ID: ENSG00000130203
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.17
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.16
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.11
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 2.06
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.06
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.05
    Ensembl ID: ENSG00000135390
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.02
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.93
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.91
    Ensembl ID: ENSG00000110330
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.85
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.83
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.79
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.77
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.77
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.76
    Ensembl ID: ENSG00000213465
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.75
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.74
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.68
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.67
    Ensembl ID: ENSG00000133639
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.67
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.65
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.62
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.61
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.54
    Ensembl ID: ENSG00000106624
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.52
    Ensembl ID: ENSG00000159403
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.52
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.52
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.49
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.47
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.45
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.42
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.4
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198363
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.38
    Ensembl ID: ENSG00000119138
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.34
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.32
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107262
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.26
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.22
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.21
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.18
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.16
    Ensembl ID: ENSG00000176171
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.13
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.12
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.1
    Ensembl ID: ENSG00000175899
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.1
    Ensembl ID: ENSG00000140299
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.09
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122359
  • Gene Symbol: FAS (ENSG00000026103)
    Fold Change: 1.04
    Ensembl ID: ENSG00000026103
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.04
    Ensembl ID: ENSG00000120805
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198356
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Location**: Myoepithelial cells are located in the basal layer of the mammary gland. 2. **Function**: They contract in response to oxytocin stimulation to facilitate milk secretion during lactation. 3. **Identification**: High levels of CD49f and low levels of EpCAM. 4. **Gene Expression**: ATP6V0C gene is specifically expressed in myoepithelial cells of the mammary gland. 5. **Cellular Processes**: Involved in cell-cell communication, cell adhesion, and regulation of the actin cytoskeleton. **Clinical Significance** 1. **Lactation**: Myoepithelial cells play a crucial role in milk secretion during lactation, and dysfunction can lead to difficulties in milk production. 2. **Breast Cancer**: Abnormalities in myoepithelial cells have been linked to breast cancer, particularly ductal carcinoma in situ (DCIS) and invasive breast cancer. 3. **Breast Development**: Myoepithelial cells are involved in the development of the mammary gland, and abnormalities can lead to breast hypoplasia or hyperplasia. 4. **Gastrointestinal Diseases**: Myoepithelial cells in the gastrointestinal tract can also be involved in diseases such as gastrointestinal motility disorders and inflammatory bowel disease. In conclusion, myoepithelial cells of the mammary gland are specialized cells that play a crucial role in lactation and breast development. Their dysfunction can lead to various clinical conditions, including lactation difficulties, breast cancer, and gastrointestinal diseases.