Details for: TEAD3

Gene ID: 7005

Symbol: TEAD3

Ensembl ID: ENSG00000007866

Description: TEA domain transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.7009
    Cell Significance Index: -18.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.6718
    Cell Significance Index: -18.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7127
    Cell Significance Index: -17.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9310
    Cell Significance Index: -15.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9209
    Cell Significance Index: -18.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7947
    Cell Significance Index: -18.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8427
    Cell Significance Index: -8.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6062
    Cell Significance Index: 69.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7636
    Cell Significance Index: 91.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1778
    Cell Significance Index: 191.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1367
    Cell Significance Index: 30.9400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.0060
    Cell Significance Index: 8.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9010
    Cell Significance Index: 25.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8289
    Cell Significance Index: 11.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6927
    Cell Significance Index: 31.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6925
    Cell Significance Index: 75.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6880
    Cell Significance Index: 11.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6747
    Cell Significance Index: 133.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6596
    Cell Significance Index: 14.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6091
    Cell Significance Index: 12.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5734
    Cell Significance Index: 56.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5114
    Cell Significance Index: 14.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4004
    Cell Significance Index: 54.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3917
    Cell Significance Index: 27.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3602
    Cell Significance Index: 325.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3577
    Cell Significance Index: 43.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3575
    Cell Significance Index: 27.4400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.3544
    Cell Significance Index: 1.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3086
    Cell Significance Index: 55.6400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2752
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2655
    Cell Significance Index: 1.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2285
    Cell Significance Index: 101.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1512
    Cell Significance Index: 7.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1452
    Cell Significance Index: 27.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1401
    Cell Significance Index: 2.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1243
    Cell Significance Index: 56.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1205
    Cell Significance Index: 1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1077
    Cell Significance Index: 58.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0970
    Cell Significance Index: 3.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0924
    Cell Significance Index: 2.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0598
    Cell Significance Index: 1.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0523
    Cell Significance Index: 2.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0519
    Cell Significance Index: 35.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0500
    Cell Significance Index: 94.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0365
    Cell Significance Index: 4.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0352
    Cell Significance Index: 0.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0349
    Cell Significance Index: 4.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0333
    Cell Significance Index: 2.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0257
    Cell Significance Index: 1.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0185
    Cell Significance Index: 1.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0099
    Cell Significance Index: 0.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0052
    Cell Significance Index: 8.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0050
    Cell Significance Index: 6.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0040
    Cell Significance Index: 2.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0140
    Cell Significance Index: -1.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0238
    Cell Significance Index: -17.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0305
    Cell Significance Index: -5.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0308
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0379
    Cell Significance Index: -4.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0493
    Cell Significance Index: -1.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0502
    Cell Significance Index: -18.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0518
    Cell Significance Index: -14.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0525
    Cell Significance Index: -6.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0646
    Cell Significance Index: -0.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0691
    Cell Significance Index: -0.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0779
    Cell Significance Index: -15.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0949
    Cell Significance Index: -19.9900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1169
    Cell Significance Index: -1.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1192
    Cell Significance Index: -2.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1238
    Cell Significance Index: -12.6500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1252
    Cell Significance Index: -1.4600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1390
    Cell Significance Index: -2.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1545
    Cell Significance Index: -18.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1679
    Cell Significance Index: -9.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1798
    Cell Significance Index: -1.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1862
    Cell Significance Index: -4.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2057
    Cell Significance Index: -16.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2085
    Cell Significance Index: -2.6700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2109
    Cell Significance Index: -1.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2339
    Cell Significance Index: -3.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2344
    Cell Significance Index: -3.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2429
    Cell Significance Index: -14.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2562
    Cell Significance Index: -5.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2623
    Cell Significance Index: -16.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2736
    Cell Significance Index: -18.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2881
    Cell Significance Index: -2.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2905
    Cell Significance Index: -15.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2919
    Cell Significance Index: -17.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3008
    Cell Significance Index: -8.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3084
    Cell Significance Index: -5.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TEAD3 is a transcription factor that belongs to the TEA (TEA/ATTS) family of proteins, which are characterized by the presence of a TEA domain. This domain is responsible for the interaction with specific DNA sequences and the recruitment of coactivators and corepressors. TEAD3 is a transcriptional regulator that interacts with RNA polymerase II to enhance or repress gene expression. The gene is highly conserved across species, suggesting its essential role in fundamental biological processes. **Pathways and Functions:** TEAD3 is involved in various signaling pathways, including asymmetric neuroblast division, Hippo signaling, and Runx3-mediated transcription. The gene plays a critical role in embryonic organ development, female pregnancy, and gene expression regulation. TEAD3 interacts with other transcription factors, such as Runx3 and Yap1, to regulate the expression of target genes involved in cell growth, differentiation, and survival. The gene is also involved in the regulation of transcription by RNA polymerase II, which is essential for the expression of genes involved in cell proliferation and differentiation. **Clinical Significance:** Dysregulation of TEAD3 has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example, TEAD3 overexpression has been observed in certain types of cancer, such as breast cancer and lung cancer, where it promotes cell proliferation and metastasis. In cardiovascular disease, TEAD3 has been shown to contribute to the development of atherosclerosis and cardiac hypertrophy. Furthermore, TEAD3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and function. In conclusion, TEAD3 is a critical transcriptional regulator involved in various cellular processes, including development, cell differentiation, and disease. Further research is necessary to fully understand the mechanisms of TEAD3 and its role in different diseases, with the ultimate goal of developing therapeutic strategies to modulate TEAD3 activity and prevent or treat diseases associated with its dysregulation. **Implications for Research and Therapy:** 1. Understanding the mechanisms of TEAD3 regulation and its role in different diseases will provide valuable insights into the development of novel therapeutic strategies. 2. TEAD3 may serve as a biomarker for disease diagnosis and prognosis. 3. Targeting TEAD3 activity may provide a new approach for treating diseases associated with its dysregulation. 4. Further research is necessary to fully understand the role of TEAD3 in different tissues and organs and to identify potential therapeutic targets. **References:** * [Insert references to relevant studies on TEAD3 and its role in different diseases] **Note:** This article is a summary of the TEAD3 gene and its functions, and it is not intended to be a comprehensive review of the literature. Further research is necessary to fully understand the mechanisms of TEAD3 and its role in different diseases.

Genular Protein ID: 783660770

Symbol: TEAD3_HUMAN

Name: Transcriptional enhancer factor TEF-5

UniProtKB Accession Codes:

Q99594 O95910 Q5BJG7 Q8N6Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9148898

Title: Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

PubMed ID: 9148898

DOI: 10.1074/jbc.272.20.12928

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18579750

Title: TEAD mediates YAP-dependent gene induction and growth control.

PubMed ID: 18579750

DOI: 10.1101/gad.1664408

PubMed ID: 19324877

Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

PubMed ID: 19324877

DOI: 10.1074/jbc.m900843200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 435
  • Mass: 48676
  • Checksum: 9F8E7900EB13D4DC
  • Sequence:
    • MASNSWNASS SPGEAREDGP EGLDKGLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL 
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK KVREYQVGIK AMNLDQVSKD 
KALQSMASMS SAQIVSASVL QNKFSPPSPL PQAVFSTSSR FWSSPPLLGQ QPGPSQDIKP 
FAQPAYPIQP PLPPTLSSYE PLAPLPSAAA SVPVWQDRTI ASSRLRLLEY SAFMEVQRDP 
DTYSKHLFVH IGQTNPAFSD PPLEAVDVRQ IYDKFPEKKG GLKELYEKGP PNAFFLVKFW 
ADLNSTIQEG PGAFYGVSSQ YSSADSMTIS VSTKVCSFGK QVVEKVETEY ARLENGRFVY 
RIHRSPMCEY MINFIHKLKH LPEKYMMNSV LENFTILQVV TSRDSQETLL VIAFVFEVST 
SEHGAQHHVY KLVKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.