Details for: ERF

Gene ID: 2077

Symbol: ERF

Ensembl ID: ENSG00000105722

Description: ETS2 repressor factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.7664
    Cell Significance Index: -21.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.0193
    Cell Significance Index: -20.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.3320
    Cell Significance Index: -21.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4761
    Cell Significance Index: -18.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.9646
    Cell Significance Index: -22.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4136
    Cell Significance Index: -18.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8514
    Cell Significance Index: -22.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0557
    Cell Significance Index: -21.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6259
    Cell Significance Index: -22.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5316
    Cell Significance Index: -16.9900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.9132
    Cell Significance Index: 5.6900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.7297
    Cell Significance Index: 26.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2006
    Cell Significance Index: 32.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0590
    Cell Significance Index: 16.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0585
    Cell Significance Index: 18.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9675
    Cell Significance Index: 27.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9559
    Cell Significance Index: 20.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9503
    Cell Significance Index: 858.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8547
    Cell Significance Index: 9.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8525
    Cell Significance Index: 44.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8379
    Cell Significance Index: 50.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7455
    Cell Significance Index: 81.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7453
    Cell Significance Index: 33.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7229
    Cell Significance Index: 37.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6030
    Cell Significance Index: 98.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5781
    Cell Significance Index: 255.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4792
    Cell Significance Index: 22.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4781
    Cell Significance Index: 13.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4496
    Cell Significance Index: 57.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4452
    Cell Significance Index: 57.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3964
    Cell Significance Index: 27.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3066
    Cell Significance Index: 37.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2589
    Cell Significance Index: 35.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2323
    Cell Significance Index: 46.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2226
    Cell Significance Index: 16.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2127
    Cell Significance Index: 15.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2042
    Cell Significance Index: 36.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1794
    Cell Significance Index: 3.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1763
    Cell Significance Index: 33.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1551
    Cell Significance Index: 5.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1508
    Cell Significance Index: 14.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1252
    Cell Significance Index: 68.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1027
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0988
    Cell Significance Index: 2.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0494
    Cell Significance Index: 0.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0391
    Cell Significance Index: 14.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0320
    Cell Significance Index: 1.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0029
    Cell Significance Index: 2.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0118
    Cell Significance Index: -22.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0158
    Cell Significance Index: -29.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0186
    Cell Significance Index: -28.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0214
    Cell Significance Index: -29.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0240
    Cell Significance Index: -17.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0257
    Cell Significance Index: -1.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0288
    Cell Significance Index: -1.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0315
    Cell Significance Index: -19.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0403
    Cell Significance Index: -1.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0422
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0464
    Cell Significance Index: -7.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0492
    Cell Significance Index: -22.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0528
    Cell Significance Index: -0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0536
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0643
    Cell Significance Index: -7.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0650
    Cell Significance Index: -0.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0741
    Cell Significance Index: -21.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0793
    Cell Significance Index: -2.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0893
    Cell Significance Index: -10.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0971
    Cell Significance Index: -11.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1013
    Cell Significance Index: -1.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1040
    Cell Significance Index: -20.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1057
    Cell Significance Index: -6.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1161
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1178
    Cell Significance Index: -24.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1325
    Cell Significance Index: -10.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1367
    Cell Significance Index: -3.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1406
    Cell Significance Index: -20.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1503
    Cell Significance Index: -6.1600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1686
    Cell Significance Index: -1.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1983
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2091
    Cell Significance Index: -16.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2270
    Cell Significance Index: -6.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2680
    Cell Significance Index: -16.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2686
    Cell Significance Index: -15.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2995
    Cell Significance Index: -6.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3034
    Cell Significance Index: -11.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3120
    Cell Significance Index: -16.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3257
    Cell Significance Index: -5.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3454
    Cell Significance Index: -12.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3477
    Cell Significance Index: -21.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4019
    Cell Significance Index: -5.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4243
    Cell Significance Index: -11.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4492
    Cell Significance Index: -6.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4697
    Cell Significance Index: -3.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4858
    Cell Significance Index: -12.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** ERF belongs to the ETS family of transcription factors, characterized by the presence of an ETS domain, which is essential for DNA binding and transcriptional regulation. 2. **Cellular expression:** ERF is widely expressed in various cell types, including conjunctival epithelial cells, skeletal muscle satellite stem cells, and bladder urothelial cells, highlighting its importance in tissue development and maintenance. 3. **Transcriptional regulation:** ERF acts as a transcriptional repressor, regulating the expression of target genes involved in cell differentiation, stress responses, and senescence. 4. **DNA binding:** ERF exhibits sequence-specific DNA binding activity, allowing it to regulate gene expression in response to specific DNA sequences. **Pathways and Functions:** 1. **Cell differentiation:** ERF plays a crucial role in regulating cell differentiation, particularly in the development of conjunctival epithelial cells and skeletal muscle satellite stem cells. 2. **Stress responses:** ERF is involved in regulating cellular responses to stress, including DNA damage and oxidative stress, by modulating the expression of stress-related genes. 3. **Senescence:** ERF contributes to the regulation of cellular senescence, a state of permanent cell cycle arrest, by controlling the expression of senescence-associated genes. 4. **Transcriptional regulation:** ERF acts as a negative regulator of transcription, inhibiting the expression of target genes involved in cell proliferation and differentiation. **Clinical Significance:** 1. **Immunological disorders:** ERF has been implicated in the development of various immunological disorders, including cancer, autoimmune diseases, and inflammatory diseases. 2. **Tissue engineering:** ERF's role in regulating cell differentiation and senescence makes it a potential target for tissue engineering applications, particularly in the development of regenerative therapies. 3. **Cancer research:** ERF's involvement in regulating cell proliferation and differentiation has led to its investigation as a potential oncogene, with implications for cancer therapy. 4. **Neurological disorders:** ERF's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells has raised interest in its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. In conclusion, the ETS2 Repressor Factor is a complex transcription factor that plays a critical role in regulating various cellular processes, including cell differentiation, stress responses, and senescence. Its clinical significance extends to immunological disorders, tissue engineering, cancer research, and neurological disorders, highlighting the need for further investigation into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 4068473805

Symbol: ERF_HUMAN

Name: ETS domain-containing transcription factor ERF

UniProtKB Accession Codes:

P50548 B2RAP1 B7Z4R0 Q59G38 Q9UPI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7588608

Title: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

PubMed ID: 7588608

DOI: 10.1002/j.1460-2075.1995.tb00160.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192842

Title: Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).

PubMed ID: 9192842

DOI: 10.1006/geno.1997.4730

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23354439

Title: Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.

PubMed ID: 23354439

DOI: 10.1038/ng.2539

PubMed ID: 27738187

Title: Chitayat syndrome: hyperphalangism, characteristic facies, hallux valgus and bronchomalacia results from a recurrent c.266A>G p.(Tyr89Cys) variant in the ERF gene.

PubMed ID: 27738187

DOI: 10.1136/jmedgenet-2016-104143

Sequence Information:

  • Length: 548
  • Mass: 58703
  • Checksum: 01242339B8D328ED
  • Sequence:
    • MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG DYGEFVIKDP 
DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK RFTYKFNFNK LVLVNYPFID 
VGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS EVLSPTEDPR SPPACSSSSS SLFSAVVARR 
LGRGSVSDCS DGTSELEEPL GEDPRARPPG PPDLGAFRGP PLARLPHDPG VFRVYPRPRG 
GPEPLSPFPV SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG 
SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL PPMAPETPPV 
PSSASSSSSS SSSPFKFKLQ PPPLGRRQRA AGEKAVAGAD KSGGSAGGLA EGAGALAPPP 
PPPQIKVEPI SEGESEEVEV TDISDEDEED GEVFKTPRAP PAPPKPEPGE APGASQCMPL 
KLRFKRRWSE DCRLEGGGGP AGGFEDEGED KKVRGEGPGE AGGPLTPRRV SSDLQHATAQ 
LSLEHRDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.