Details for: ERF

Gene ID: 2077

Symbol: ERF

Ensembl ID: ENSG00000105722

Description: ETS2 repressor factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.65
    Marker Score: 1733
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.38
    Marker Score: 1477
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.36
    Marker Score: 462
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1515
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1945
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1
    Marker Score: 2462
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71739
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47962
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.95
    Marker Score: 407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.92
    Marker Score: 5479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14206
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5126
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.88
    Marker Score: 826
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.87
    Marker Score: 580
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1761
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5247
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29353
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.86
    Marker Score: 1721
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.86
    Marker Score: 4210
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.81
    Marker Score: 635
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1306
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8
    Marker Score: 1403
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.79
    Marker Score: 1340.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.79
    Marker Score: 6852
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1856
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.79
    Marker Score: 6915
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.78
    Marker Score: 826
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 235
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.75
    Marker Score: 180
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.73
    Marker Score: 662
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 236
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.72
    Marker Score: 314
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 762
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.71
    Marker Score: 714
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.71
    Marker Score: 1250
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.7
    Marker Score: 256
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 443
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 667
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1823
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 606
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.66
    Marker Score: 1377
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.65
    Marker Score: 691
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.64
    Marker Score: 547
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.64
    Marker Score: 745.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 303
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.63
    Marker Score: 659
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.62
    Marker Score: 2602
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.62
    Marker Score: 145
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 365
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.6
    Marker Score: 275
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.6
    Marker Score: 866
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.59
    Marker Score: 6639
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.59
    Marker Score: 905
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.58
    Marker Score: 2773
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 426
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.56
    Marker Score: 351
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.56
    Marker Score: 2151
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5530.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.54
    Marker Score: 248
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.54
    Marker Score: 652
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.54
    Marker Score: 1319
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.54
    Marker Score: 580
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.54
    Marker Score: 536
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.53
    Marker Score: 502
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.53
    Marker Score: 453
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.53
    Marker Score: 1246
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.53
    Marker Score: 646
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.52
    Marker Score: 330
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 553
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.52
    Marker Score: 946.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.52
    Marker Score: 3374
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.52
    Marker Score: 151
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.51
    Marker Score: 145
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.51
    Marker Score: 281
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.51
    Marker Score: 808
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.51
    Marker Score: 99
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.5
    Marker Score: 227
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 331
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.5
    Marker Score: 129
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.49
    Marker Score: 427
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.49
    Marker Score: 99
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 216
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.49
    Marker Score: 224
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.49
    Marker Score: 112

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Other Information

## Summary ERF is a protein that acts as a repressor of transcription by binding to DNA and blocking the binding of RNA polymerase to specific promoter regions. It is expressed in a variety of cell types, including epithelial cells, stem cells, and cancer cells. ## Key characteristics * ERF is a protein that is highly expressed in cells that are committed to a specific cell fate. * ERF binds to DNA in a sequence-specific manner, and this binding blocks the binding of RNA polymerase to specific promoter regions. * ERF is a key regulator of cell differentiation, proliferation, and apoptosis. * It is also involved in the regulation of stem cell activity and cancer development. ## Pathways and functions * ERF is involved in a variety of cellular processes, including cell differentiation, cellular responses to stimuli, cellular responses to stress, and cellular senescence. * It is also involved in the regulation of stem cell activity and cancer development. * ERF works by binding to DNA and blocking the binding of RNA polymerase to specific promoter regions. This prevents the initiation of transcription, which leads to the repression of gene expression. ## Clinical significance ERF is a promising target for cancer therapy. Inhibition of ERF has been shown to be effective in inhibiting cancer cell growth and metastasis. This is a promising approach for the treatment of a variety of cancers, including breast cancer, lung cancer, and prostate cancer. ## Conclusion ERF is a key regulator of cell differentiation, proliferation, and apoptosis. It is also involved in the regulation of stem cell activity and cancer development. ERF is a promising target for cancer therapy, and inhibitors of ERF are currently being investigated as potential treatments for cancer.

Genular Protein ID: 4068473805

Symbol: ERF_HUMAN

Name: ETS domain-containing transcription factor ERF

UniProtKB Accession Codes:

P50548 B2RAP1 B7Z4R0 Q59G38 Q9UPI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7588608

Title: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

PubMed ID: 7588608

DOI: 10.1002/j.1460-2075.1995.tb00160.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192842

Title: Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).

PubMed ID: 9192842

DOI: 10.1006/geno.1997.4730

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23354439

Title: Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.

PubMed ID: 23354439

DOI: 10.1038/ng.2539

PubMed ID: 27738187

Title: Chitayat syndrome: hyperphalangism, characteristic facies, hallux valgus and bronchomalacia results from a recurrent c.266A>G p.(Tyr89Cys) variant in the ERF gene.

PubMed ID: 27738187

DOI: 10.1136/jmedgenet-2016-104143

Sequence Information:

  • Length: 548
  • Mass: 58703
  • Checksum: 01242339B8D328ED
  • Sequence:
    • MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG DYGEFVIKDP 
DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK RFTYKFNFNK LVLVNYPFID 
VGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS EVLSPTEDPR SPPACSSSSS SLFSAVVARR 
LGRGSVSDCS DGTSELEEPL GEDPRARPPG PPDLGAFRGP PLARLPHDPG VFRVYPRPRG 
GPEPLSPFPV SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG 
SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL PPMAPETPPV 
PSSASSSSSS SSSPFKFKLQ PPPLGRRQRA AGEKAVAGAD KSGGSAGGLA EGAGALAPPP 
PPPQIKVEPI SEGESEEVEV TDISDEDEED GEVFKTPRAP PAPPKPEPGE APGASQCMPL 
KLRFKRRWSE DCRLEGGGGP AGGFEDEGED KKVRGEGPGE AGGPLTPRRV SSDLQHATAQ 
LSLEHRDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.