Details for: SNAI2

Gene ID: 6591

Symbol: SNAI2

Ensembl ID: ENSG00000019549

Description: snail family transcriptional repressor 2

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Intracellular signaling by second messengers
    (R-HSA-9006925)
  • Mitf-m-regulated melanocyte development
    (R-HSA-9730414)
  • Pip3 activates akt signaling
    (R-HSA-1257604)
  • Pten regulation
    (R-HSA-6807070)
  • Regulation of pten gene transcription
    (R-HSA-8943724)
  • Signal transduction
    (R-HSA-162582)
  • Transcriptional and post-translational regulation of mitf-m expression and activity
    (R-HSA-9856649)
  • Aortic valve morphogenesis
    (GO:0003180)
  • Cartilage morphogenesis
    (GO:0060536)
  • Cell migration involved in endocardial cushion formation
    (GO:0003273)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to ionizing radiation
    (GO:0071479)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Cytoplasm
    (GO:0005737)
  • Desmosome disassembly
    (GO:0035921)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Endothelial cell migration
    (GO:0043542)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Epithelium development
    (GO:0060429)
  • Hematopoietic stem cell proliferation
    (GO:0071425)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of anoikis
    (GO:2000811)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell adhesion involved in substrate-bound cell migration
    (GO:0006933)
  • Negative regulation of cell adhesion mediated by integrin
    (GO:0033629)
  • Negative regulation of chondrocyte differentiation
    (GO:0032331)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of hematopoietic stem cell proliferation
    (GO:1902034)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Negative regulation of keratinocyte proliferation
    (GO:0010839)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of vitamin d biosynthetic process
    (GO:0010957)
  • Negative regulation of vitamin d receptor signaling pathway
    (GO:0070563)
  • Neural crest cell development
    (GO:0014032)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Osteoblast differentiation
    (GO:0001649)
  • Pigmentation
    (GO:0043473)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Protein binding
    (GO:0005515)
  • Regulation of bicellular tight junction assembly
    (GO:2000810)
  • Regulation of branching involved in salivary gland morphogenesis
    (GO:0060693)
  • Regulation of chemokine production
    (GO:0032642)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • White fat cell differentiation
    (GO:0050872)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.6760
    Cell Significance Index: -19.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.0211
    Cell Significance Index: -15.5900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.6804
    Cell Significance Index: 41.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.6281
    Cell Significance Index: 27.1900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.3039
    Cell Significance Index: 12.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.8770
    Cell Significance Index: 60.2200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.6806
    Cell Significance Index: 15.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1814
    Cell Significance Index: 33.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0622
    Cell Significance Index: 26.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7715
    Cell Significance Index: 48.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5304
    Cell Significance Index: 20.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4865
    Cell Significance Index: 16.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0920
    Cell Significance Index: 139.9900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.8688
    Cell Significance Index: 5.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8175
    Cell Significance Index: 112.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7763
    Cell Significance Index: 5.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6499
    Cell Significance Index: 18.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5758
    Cell Significance Index: 254.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5054
    Cell Significance Index: 4.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4768
    Cell Significance Index: 33.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4153
    Cell Significance Index: 51.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4069
    Cell Significance Index: 14.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3418
    Cell Significance Index: 5.7200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3377
    Cell Significance Index: 3.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2657
    Cell Significance Index: 4.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2446
    Cell Significance Index: 3.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2208
    Cell Significance Index: 25.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1708
    Cell Significance Index: 8.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1642
    Cell Significance Index: 29.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0892
    Cell Significance Index: 10.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0554
    Cell Significance Index: 34.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0369
    Cell Significance Index: 0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0178
    Cell Significance Index: 3.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.3800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0075
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0156
    Cell Significance Index: -10.7800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0163
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0167
    Cell Significance Index: -3.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0198
    Cell Significance Index: -14.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0217
    Cell Significance Index: -16.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0225
    Cell Significance Index: -14.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0252
    Cell Significance Index: -13.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0345
    Cell Significance Index: -15.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0345
    Cell Significance Index: -12.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0366
    Cell Significance Index: -7.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0398
    Cell Significance Index: -5.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0485
    Cell Significance Index: -13.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0948
    Cell Significance Index: -1.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0964
    Cell Significance Index: -5.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1049
    Cell Significance Index: -15.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1152
    Cell Significance Index: -3.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1248
    Cell Significance Index: -12.7500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1292
    Cell Significance Index: -0.6800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1297
    Cell Significance Index: -1.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1318
    Cell Significance Index: -15.5400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1322
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1538
    Cell Significance Index: -17.6200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1646
    Cell Significance Index: -0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1659
    Cell Significance Index: -7.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1702
    Cell Significance Index: -17.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1889
    Cell Significance Index: -14.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2206
    Cell Significance Index: -14.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2207
    Cell Significance Index: -9.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2514
    Cell Significance Index: -19.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2680
    Cell Significance Index: -16.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3043
    Cell Significance Index: -13.2300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3171
    Cell Significance Index: -3.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3207
    Cell Significance Index: -19.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3280
    Cell Significance Index: -8.4300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3491
    Cell Significance Index: -1.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3552
    Cell Significance Index: -16.5600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3589
    Cell Significance Index: -5.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3649
    Cell Significance Index: -16.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3735
    Cell Significance Index: -9.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3828
    Cell Significance Index: -21.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3870
    Cell Significance Index: -17.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3904
    Cell Significance Index: -20.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4203
    Cell Significance Index: -15.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4518
    Cell Significance Index: -17.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4765
    Cell Significance Index: -11.9000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4879
    Cell Significance Index: -1.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4943
    Cell Significance Index: -17.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5153
    Cell Significance Index: -13.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5167
    Cell Significance Index: -15.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5370
    Cell Significance Index: -17.5800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5379
    Cell Significance Index: -6.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5415
    Cell Significance Index: -14.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5620
    Cell Significance Index: -17.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5654
    Cell Significance Index: -14.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5743
    Cell Significance Index: -16.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5829
    Cell Significance Index: -9.9900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5863
    Cell Significance Index: -3.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNAI2 is a transcriptional repressor that belongs to the snail family of proteins. It is characterized by its ability to bind to specific DNA sequences and regulate gene expression. SNAI2 has a unique zinc finger motif that allows it to bind to E-boxes, a type of DNA sequence that is commonly found in promoter regions of target genes. Its expression is often regulated by various signaling pathways, including the Notch signaling pathway and the Wnt/β-catenin pathway. SNAI2 is also known to interact with other proteins, including p53 and Akt, which are involved in cell survival and apoptosis. **Pathways and Functions** SNAI2 is involved in various cellular processes, including: 1. **Epithelial-to-mesenchymal transition (EMT)**: SNAI2 promotes EMT by regulating the expression of genes involved in this process, such as vimentin and N-cadherin. 2. **Cell migration**: SNAI2 is involved in cell migration by regulating the expression of genes involved in this process, such as matrix metalloproteinases (MMPs) and integrins. 3. **Cell differentiation**: SNAI2 regulates cell differentiation by controlling the expression of genes involved in this process, such as osteoblast-specific genes. 4. **Cell adhesion**: SNAI2 negatively regulates cell adhesion by inhibiting the expression of genes involved in cell adhesion, such as N-cadherin and β-catenin. 5. **Apoptosis**: SNAI2 negatively regulates apoptosis by inhibiting the expression of genes involved in apoptosis, such as pro-apoptotic proteins. **Clinical Significance** SNAI2 has been implicated in various diseases, including: 1. **Cancer**: SNAI2 is overexpressed in many types of cancer, including breast, lung, and pancreatic cancer. Its overexpression is associated with poor prognosis and reduced survival rates. 2. **Cardiovascular disease**: SNAI2 is involved in the development of aortic valve stenosis and other cardiovascular diseases. Its expression is associated with cardiac remodeling and fibrosis. 3. **Neurological disorders**: SNAI2 is involved in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its expression is associated with neuroinflammation and neuronal damage. 4. **Reproductive disorders**: SNAI2 is involved in the development of reproductive disorders, such as endometriosis and infertility. Its expression is associated with uterine remodeling and fibrosis. In conclusion, SNAI2 is a complex protein that plays a crucial role in regulating various cellular processes. Its expression is often associated with negative regulation of cellular processes, but it also has positive regulatory roles in certain contexts. Further research is needed to understand the full extent of SNAI2's functions and its implications in human disease.

Genular Protein ID: 2190835605

Symbol: SNAI2_HUMAN

Name: Zinc finger protein SNAI2

UniProtKB Accession Codes:

O43623 B2R6P6 Q53FC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10866665

Title: Human Slug is a repressor that localizes to sites of active transcription.

PubMed ID: 10866665

DOI: 10.1128/mcb.20.14.5087-5095.2000

PubMed ID: 9721220

Title: Human SLUG gene organization, expression, and chromosome map location on 8q.

PubMed ID: 9721220

DOI: 10.1006/geno.1998.5367

PubMed ID: 10479723

Title: Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.

PubMed ID: 10479723

DOI: 10.1016/s1383-5726(99)00002-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11912130

Title: The SLUG zinc-finger protein represses E-cadherin in breast cancer.

PubMed ID: 11912130

PubMed ID: 12444107

Title: SLUG (SNAI2) deletions in patients with Waardenburg disease.

PubMed ID: 12444107

DOI: 10.1093/hmg/11.25.3231

PubMed ID: 12955764

Title: Deletion of the SLUG (SNAI2) gene results in human piebaldism.

PubMed ID: 12955764

DOI: 10.1002/ajmg.a.20345

PubMed ID: 15734731

Title: Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.

PubMed ID: 15734731

DOI: 10.1074/jbc.m501375200

PubMed ID: 16707493

Title: Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes.

PubMed ID: 16707493

DOI: 10.1074/jbc.m509731200

PubMed ID: 19756381

Title: Slug gene expression supports human osteoblast maturation.

PubMed ID: 19756381

DOI: 10.1007/s00018-009-0149-5

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 21182836

Title: Slug contributes to the regulation of CXCL12 expression in human osteoblasts.

PubMed ID: 21182836

DOI: 10.1016/j.yexcr.2010.12.011

PubMed ID: 22727060

Title: Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation.

PubMed ID: 22727060

DOI: 10.1111/j.1742-4658.2012.08674.x

PubMed ID: 25827072

Title: FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.

PubMed ID: 25827072

DOI: 10.1016/j.canlet.2015.03.037

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

Sequence Information:

  • Length: 268
  • Mass: 29986
  • Checksum: 63F068C8E6B275D4
  • Sequence:
    • MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS GAYSPITVWT 
TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP 
HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQSRKSFS CKYCDKEYVS LGALKMHIRT 
HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK 
YQCKNCSKTF SRMSLLHKHE ESGCCVAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.