Details for: NNMT
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 225.9471
Cell Significance Index: -35.1500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 104.5279
Cell Significance Index: -43.0600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 67.2707
Cell Significance Index: -31.7600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 28.5128
Cell Significance Index: -35.1600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 12.5589
Cell Significance Index: 211.5600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.8937
Cell Significance Index: 192.5100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 10.4346
Cell Significance Index: 70.7000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 10.1487
Cell Significance Index: 260.8700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 9.3683
Cell Significance Index: 268.5500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5681
Cell Significance Index: -33.8100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 7.0744
Cell Significance Index: 172.6100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.2912
Cell Significance Index: 37.3900 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.0331
Cell Significance Index: 31.6700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.8022
Cell Significance Index: 54.6900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 2.1469
Cell Significance Index: 30.8300 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.7591
Cell Significance Index: 10.1300 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.6379
Cell Significance Index: 10.3000 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.5907
Cell Significance Index: 20.0300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2467
Cell Significance Index: 92.9200 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.9710
Cell Significance Index: 6.0800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8531
Cell Significance Index: 40.1000 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.7505
Cell Significance Index: 5.3900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.6836
Cell Significance Index: 10.0900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.6193
Cell Significance Index: 5.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6153
Cell Significance Index: 84.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.5339
Cell Significance Index: 68.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5186
Cell Significance Index: 186.0000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.4936
Cell Significance Index: 24.9400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4547
Cell Significance Index: 344.1800 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.3377
Cell Significance Index: 1.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3110
Cell Significance Index: 169.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.2894
Cell Significance Index: 17.7400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2218
Cell Significance Index: 1.3400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1500
Cell Significance Index: 66.3000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0949
Cell Significance Index: 18.0600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0834
Cell Significance Index: 75.3300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0560
Cell Significance Index: 0.4700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0534
Cell Significance Index: 6.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0490
Cell Significance Index: 30.6200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0125
Cell Significance Index: 2.5100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0001
Cell Significance Index: -0.0700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0056
Cell Significance Index: -0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0068
Cell Significance Index: -12.7700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0094
Cell Significance Index: -6.9400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0122
Cell Significance Index: -1.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0145
Cell Significance Index: -1.6900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0229
Cell Significance Index: -3.9100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0230
Cell Significance Index: -42.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0273
Cell Significance Index: -20.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0278
Cell Significance Index: -42.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0320
Cell Significance Index: -43.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0493
Cell Significance Index: -27.8000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0627
Cell Significance Index: -28.4600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0717
Cell Significance Index: -14.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0755
Cell Significance Index: -13.6100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0813
Cell Significance Index: -11.8200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0966
Cell Significance Index: -11.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1014
Cell Significance Index: -29.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1019
Cell Significance Index: -21.4700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1226
Cell Significance Index: -19.9400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1387
Cell Significance Index: -6.2900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1478
Cell Significance Index: -10.4500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1623
Cell Significance Index: -16.0600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2075
Cell Significance Index: -15.9300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2299
Cell Significance Index: -8.0800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.2415
Cell Significance Index: -26.2700 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: -0.2418
Cell Significance Index: -1.7900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2536
Cell Significance Index: -17.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2545
Cell Significance Index: -29.1600 - Cell Name: fibroblast of the aortic adventitia (CL0002547)
Fold Change: -0.2576
Cell Significance Index: -2.6000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2686
Cell Significance Index: -30.6600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2898
Cell Significance Index: -13.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2900
Cell Significance Index: -34.2000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3315
Cell Significance Index: -34.5200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.3679
Cell Significance Index: -25.4500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3859
Cell Significance Index: -5.9700 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: -0.3938
Cell Significance Index: -1.3700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4543
Cell Significance Index: -13.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4684
Cell Significance Index: -28.7900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4961
Cell Significance Index: -29.7900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5029
Cell Significance Index: -12.5700 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.5178
Cell Significance Index: -4.1200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5291
Cell Significance Index: -27.7800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5452
Cell Significance Index: -34.3600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5795
Cell Significance Index: -14.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5948
Cell Significance Index: -30.9800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6048
Cell Significance Index: -33.9400 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.6213
Cell Significance Index: -5.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6734
Cell Significance Index: -18.8200 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7397
Cell Significance Index: -4.5500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7985
Cell Significance Index: -41.4800 - Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.8270
Cell Significance Index: -6.8400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8475
Cell Significance Index: -29.6900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8546
Cell Significance Index: -37.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8595
Cell Significance Index: -31.5500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8642
Cell Significance Index: -30.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.8728
Cell Significance Index: -18.2700 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.8974
Cell Significance Index: -3.3800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9093
Cell Significance Index: -24.2800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.9831
Cell Significance Index: -16.2000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1979671060
Symbol: NNMT_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8182091
Title: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
PubMed ID: 8182091
PubMed ID: 8575745
Title: Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization.
PubMed ID: 8575745
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11271497
Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.
PubMed ID: 11271497
DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23455543
Title: NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
PubMed ID: 23455543
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26571212
Title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
PubMed ID: 26571212
DOI: 10.1038/ncb3264
PubMed ID: 30044909
Title: Citrullination Inactivates Nicotinamide- N-methyltransferase.
PubMed ID: 30044909
PubMed ID: 31043742
Title: Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
PubMed ID: 31043742
PubMed ID: 21823666
Title: Structural basis of substrate recognition in human nicotinamide N-methyltransferase.
PubMed ID: 21823666
DOI: 10.1021/bi2007614
Sequence Information:
- Length: 264
- Mass: 29574
- Checksum: 280B12748F4488AC
- Sequence:
MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.