Details for: NNMT

Gene ID: 4837

Symbol: NNMT

Ensembl ID: ENSG00000166741

Description: nicotinamide N-methyltransferase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.28
    Marker Score: 4,568
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.78
    Marker Score: 128,521
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.72
    Marker Score: 2,448
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.46
    Marker Score: 18,623
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.2
    Marker Score: 8,025
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.2
    Marker Score: 4,398
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.15
    Marker Score: 1,353
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.09
    Marker Score: 8,079
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.02
    Marker Score: 1,720
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.95
    Marker Score: 14,507
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.61
    Marker Score: 11,273
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.54
    Marker Score: 5,064
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.47
    Marker Score: 879
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.44
    Marker Score: 4,124
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.32
    Marker Score: 10,010
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.21
    Marker Score: 3,214
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.2
    Marker Score: 14,176
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.18
    Marker Score: 1,880
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.15
    Marker Score: 483
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.02
    Marker Score: 3,243
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2
    Marker Score: 1,116
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.93
    Marker Score: 705
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.93
    Marker Score: 410
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.89
    Marker Score: 3,348
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.89
    Marker Score: 434
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.87
    Marker Score: 12,181
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.73
    Marker Score: 2,158
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.72
    Marker Score: 1,838
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.69
    Marker Score: 1,701
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.61
    Marker Score: 1,015
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.61
    Marker Score: 455
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.59
    Marker Score: 591
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,149
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.56
    Marker Score: 1,503
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.53
    Marker Score: 432
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.5
    Marker Score: 683
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.49
    Marker Score: 357
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.48
    Marker Score: 366
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.48
    Marker Score: 3,638
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,977
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.46
    Marker Score: 566
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.44
    Marker Score: 448
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.42
    Marker Score: 792
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.37
    Marker Score: 571
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.37
    Marker Score: 1,215
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.36
    Marker Score: 21,860
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.3
    Marker Score: 1,174
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.29
    Marker Score: 334
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.24
    Marker Score: 641
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.24
    Marker Score: 377
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 840
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.17
    Marker Score: 442
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.16
    Marker Score: 628
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.14
    Marker Score: 4,414
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,771
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.13
    Marker Score: 710
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.11
    Marker Score: 445
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2,071
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17,176
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.09
    Marker Score: 14,447
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 688
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 495
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.07
    Marker Score: 345
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.06
    Marker Score: 1,314
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.04
    Marker Score: 507
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.04
    Marker Score: 1,999
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.02
    Marker Score: 269
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.01
    Marker Score: 300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.01
    Marker Score: 277
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1
    Marker Score: 899
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,759
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,984
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 372
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.99
    Marker Score: 619
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.98
    Marker Score: 215
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.98
    Marker Score: 646
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.98
    Marker Score: 332
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.98
    Marker Score: 5,879
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.97
    Marker Score: 980
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 297
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.95
    Marker Score: 392
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.93
    Marker Score: 546
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.93
    Marker Score: 12,557
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.93
    Marker Score: 7,101
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1,834
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.9
    Marker Score: 402
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.88
    Marker Score: 753
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,270
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,960
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.87
    Marker Score: 1,337
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.86
    Marker Score: 9,701

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NNMT gene is a human gene with an Ensembl ID of ENSG00000166741. It is involved in several metabolic pathways, including: 1. Metabolism of vitamins and cofactors 2. Metabolism of amino acids and derivatives 3. Metabolism of water-soluble vitamins and cofactors 4. Nicotinamide metabolic process 5. Nicotinamide n-methyltransferase activity 6. Nad biosynthesis via nicotinamide riboside salvage pathway The NNMT enzyme is a N-methyltransferase that catalyzes the transfer of a methyl group from nicotinamide to various substrates, including nicotinamide riboside, nicotinic acid, and other compounds. This enzymatic activity is critical for the regulation of various cellular processes, including protein deacetylation, gluconeogenesis, and the salvage pathway of nicotinamide riboside. **Pathways and Functions:** The NNMT gene is involved in several key metabolic pathways, including: 1. **Nicotinamide Metabolic Process:** NNMT catalyzes the transfer of a methyl group from nicotinamide to nicotinamide riboside, resulting in the formation of nicotinamide mononucleotide (NMN). NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), which plays a critical role in energy metabolism and cellular homeostasis. 2. **Nad Biosynthesis via Nicotinamide Riboside Salvage Pathway:** NNMT is involved in the salvage pathway of nicotinamide riboside, which is a critical pathway for the regeneration of NAD+ from NMN. 3. **Metabolism of Vitamins and Cofactors:** NNMT is involved in the metabolism of various vitamins and cofactors, including nicotinic acid, pantothenic acid, and biotin. 4. **Metabolism of Amino Acids and Derivatives:** NNMT is involved in the metabolism of various amino acids and derivatives, including glycine, proline, and glutamine. **Clinical Significance:** The NNMT gene has been implicated in several diseases and conditions, including: 1. **Atherosclerosis:** NNMT has been shown to play a critical role in the regulation of lipid metabolism and the development of atherosclerosis. 2. **Type 2 Diabetes:** NNMT has been implicated in the regulation of gluconeogenesis and the development of type 2 diabetes. 3. **Cancer:** NNMT has been shown to play a critical role in the regulation of protein deacetylation and the development of cancer. 4. **Neurological Disorders:** NNMT has been implicated in the regulation of NAD+ metabolism and the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the NNMT gene is a critical regulator of metabolic pathways and cellular processes, and its dysregulation has been implicated in several diseases and conditions. Further research is needed to fully understand the role of NNMT in human health and disease.

Genular Protein ID: 1979671060

Symbol: NNMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P40261

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8182091

Title: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.

PubMed ID: 8182091

DOI: 10.1016/s0021-9258(17)36700-5

PubMed ID: 8575745

Title: Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization.

PubMed ID: 8575745

DOI: 10.1006/geno.1995.9966

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11271497

Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.

PubMed ID: 11271497

DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23455543

Title: NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.

PubMed ID: 23455543

DOI: 10.1038/nchembio.1204

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26571212

Title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

PubMed ID: 26571212

DOI: 10.1038/ncb3264

PubMed ID: 30044909

Title: Citrullination Inactivates Nicotinamide- N-methyltransferase.

PubMed ID: 30044909

DOI: 10.1021/acschembio.8b00578

PubMed ID: 31043742

Title: Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.

PubMed ID: 31043742

DOI: 10.1038/s41586-019-1173-8

PubMed ID: 21823666

Title: Structural basis of substrate recognition in human nicotinamide N-methyltransferase.

PubMed ID: 21823666

DOI: 10.1021/bi2007614

Sequence Information:

  • Length: 264
  • Mass: 29574
  • Checksum: 280B12748F4488AC
  • Sequence:
    • MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI 
DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN 
RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL 
RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ 
SYSSTMANNE GLFSLVARKL SRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.