Details for: NNMT
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.28
Marker Score: 4,568 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.78
Marker Score: 128,521 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.72
Marker Score: 2,448 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 3.46
Marker Score: 18,623 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.2
Marker Score: 8,025 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.2
Marker Score: 4,398 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.15
Marker Score: 1,353 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.09
Marker Score: 8,079 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 3.02
Marker Score: 1,720 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.95
Marker Score: 14,507 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.61
Marker Score: 11,273 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.54
Marker Score: 5,064 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.47
Marker Score: 879 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.44
Marker Score: 4,124 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.32
Marker Score: 10,010 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.21
Marker Score: 3,214 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.2
Marker Score: 14,176 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.18
Marker Score: 1,880 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.15
Marker Score: 483 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.02
Marker Score: 3,243 - Cell Name: fat cell (CL0000136)
Fold Change: 2
Marker Score: 1,116 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.93
Marker Score: 705 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.93
Marker Score: 410 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.89
Marker Score: 3,348 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.89
Marker Score: 434 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.87
Marker Score: 12,181 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.73
Marker Score: 2,158 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.72
Marker Score: 1,838 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.69
Marker Score: 1,701 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.61
Marker Score: 1,015 - Cell Name: muscle cell (CL0000187)
Fold Change: 1.61
Marker Score: 455 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.59
Marker Score: 591 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1,149 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.56
Marker Score: 1,503 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.53
Marker Score: 432 - Cell Name: interneuron (CL0000099)
Fold Change: 1.5
Marker Score: 683 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.49
Marker Score: 357 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.48
Marker Score: 366 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.48
Marker Score: 3,638 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,977 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.46
Marker Score: 566 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.44
Marker Score: 448 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.42
Marker Score: 792 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.37
Marker Score: 571 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.37
Marker Score: 1,215 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.36
Marker Score: 21,860 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.3
Marker Score: 1,174 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.29
Marker Score: 334 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.24
Marker Score: 641 - Cell Name: ionocyte (CL0005006)
Fold Change: 1.24
Marker Score: 377 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 840 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.17
Marker Score: 442 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.16
Marker Score: 628 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.14
Marker Score: 4,414 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,771 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.13
Marker Score: 710 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.11
Marker Score: 445 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.1
Marker Score: 2,071 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1
Marker Score: 17,176 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.09
Marker Score: 14,447 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.08
Marker Score: 688 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.08
Marker Score: 495 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.07
Marker Score: 345 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.07
Marker Score: 273 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.06
Marker Score: 1,314 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.04
Marker Score: 507 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.04
Marker Score: 1,999 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.02
Marker Score: 269 - Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 1.01
Marker Score: 300 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.01
Marker Score: 277 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1
Marker Score: 899 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,759 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,984 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.99
Marker Score: 372 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.99
Marker Score: 619 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.98
Marker Score: 215 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.98
Marker Score: 646 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.98
Marker Score: 332 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.98
Marker Score: 5,879 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.97
Marker Score: 980 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.95
Marker Score: 297 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,409 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.95
Marker Score: 392 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.94
Marker Score: 2,398 - Cell Name: pericyte (CL0000669)
Fold Change: 0.93
Marker Score: 546 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.93
Marker Score: 12,557 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.93
Marker Score: 7,101 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9
Marker Score: 1,834 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.9
Marker Score: 402 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.88
Marker Score: 753 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,270 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,960 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.87
Marker Score: 1,337 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.86
Marker Score: 9,701
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1979671060
Symbol: NNMT_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8182091
Title: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
PubMed ID: 8182091
PubMed ID: 8575745
Title: Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization.
PubMed ID: 8575745
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11271497
Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.
PubMed ID: 11271497
DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23455543
Title: NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
PubMed ID: 23455543
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26571212
Title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
PubMed ID: 26571212
DOI: 10.1038/ncb3264
PubMed ID: 30044909
Title: Citrullination Inactivates Nicotinamide- N-methyltransferase.
PubMed ID: 30044909
PubMed ID: 31043742
Title: Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
PubMed ID: 31043742
PubMed ID: 21823666
Title: Structural basis of substrate recognition in human nicotinamide N-methyltransferase.
PubMed ID: 21823666
DOI: 10.1021/bi2007614
Sequence Information:
- Length: 264
- Mass: 29574
- Checksum: 280B12748F4488AC
- Sequence:
MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.