Details for: NNMT

Gene ID: 4837

Symbol: NNMT

Ensembl ID: ENSG00000166741

Description: nicotinamide N-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.9471
    Cell Significance Index: -35.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.5279
    Cell Significance Index: -43.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.2707
    Cell Significance Index: -31.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.5128
    Cell Significance Index: -35.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 12.5589
    Cell Significance Index: 211.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.8937
    Cell Significance Index: 192.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 10.4346
    Cell Significance Index: 70.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 10.1487
    Cell Significance Index: 260.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.3683
    Cell Significance Index: 268.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5681
    Cell Significance Index: -33.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.0744
    Cell Significance Index: 172.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.2912
    Cell Significance Index: 37.3900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.0331
    Cell Significance Index: 31.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.8022
    Cell Significance Index: 54.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.1469
    Cell Significance Index: 30.8300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.7591
    Cell Significance Index: 10.1300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6379
    Cell Significance Index: 10.3000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.5907
    Cell Significance Index: 20.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2467
    Cell Significance Index: 92.9200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.9710
    Cell Significance Index: 6.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8531
    Cell Significance Index: 40.1000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.7505
    Cell Significance Index: 5.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6836
    Cell Significance Index: 10.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6193
    Cell Significance Index: 5.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6153
    Cell Significance Index: 84.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5339
    Cell Significance Index: 68.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5186
    Cell Significance Index: 186.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4936
    Cell Significance Index: 24.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4547
    Cell Significance Index: 344.1800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3377
    Cell Significance Index: 1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3110
    Cell Significance Index: 169.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2894
    Cell Significance Index: 17.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2218
    Cell Significance Index: 1.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1500
    Cell Significance Index: 66.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0949
    Cell Significance Index: 18.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0834
    Cell Significance Index: 75.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0560
    Cell Significance Index: 0.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0534
    Cell Significance Index: 6.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0490
    Cell Significance Index: 30.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0125
    Cell Significance Index: 2.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0056
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0122
    Cell Significance Index: -1.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0145
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0229
    Cell Significance Index: -3.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0230
    Cell Significance Index: -42.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0273
    Cell Significance Index: -20.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0278
    Cell Significance Index: -42.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0320
    Cell Significance Index: -43.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0493
    Cell Significance Index: -27.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0627
    Cell Significance Index: -28.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0717
    Cell Significance Index: -14.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0755
    Cell Significance Index: -13.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0813
    Cell Significance Index: -11.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0966
    Cell Significance Index: -11.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1014
    Cell Significance Index: -29.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1019
    Cell Significance Index: -21.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1226
    Cell Significance Index: -19.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1387
    Cell Significance Index: -6.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1478
    Cell Significance Index: -10.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1623
    Cell Significance Index: -16.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2075
    Cell Significance Index: -15.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2299
    Cell Significance Index: -8.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2415
    Cell Significance Index: -26.2700
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.2418
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2536
    Cell Significance Index: -17.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2545
    Cell Significance Index: -29.1600
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.2576
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2686
    Cell Significance Index: -30.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2898
    Cell Significance Index: -13.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2900
    Cell Significance Index: -34.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3315
    Cell Significance Index: -34.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3679
    Cell Significance Index: -25.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3859
    Cell Significance Index: -5.9700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.3938
    Cell Significance Index: -1.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4543
    Cell Significance Index: -13.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4684
    Cell Significance Index: -28.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4961
    Cell Significance Index: -29.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5029
    Cell Significance Index: -12.5700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5178
    Cell Significance Index: -4.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5291
    Cell Significance Index: -27.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5452
    Cell Significance Index: -34.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5795
    Cell Significance Index: -14.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5948
    Cell Significance Index: -30.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6048
    Cell Significance Index: -33.9400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.6213
    Cell Significance Index: -5.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6734
    Cell Significance Index: -18.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7397
    Cell Significance Index: -4.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7985
    Cell Significance Index: -41.4800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.8270
    Cell Significance Index: -6.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8475
    Cell Significance Index: -29.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8546
    Cell Significance Index: -37.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8595
    Cell Significance Index: -31.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8642
    Cell Significance Index: -30.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8728
    Cell Significance Index: -18.2700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.8974
    Cell Significance Index: -3.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9093
    Cell Significance Index: -24.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9831
    Cell Significance Index: -16.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NNMT gene is a human gene with an Ensembl ID of ENSG00000166741. It is involved in several metabolic pathways, including: 1. Metabolism of vitamins and cofactors 2. Metabolism of amino acids and derivatives 3. Metabolism of water-soluble vitamins and cofactors 4. Nicotinamide metabolic process 5. Nicotinamide n-methyltransferase activity 6. Nad biosynthesis via nicotinamide riboside salvage pathway The NNMT enzyme is a N-methyltransferase that catalyzes the transfer of a methyl group from nicotinamide to various substrates, including nicotinamide riboside, nicotinic acid, and other compounds. This enzymatic activity is critical for the regulation of various cellular processes, including protein deacetylation, gluconeogenesis, and the salvage pathway of nicotinamide riboside. **Pathways and Functions:** The NNMT gene is involved in several key metabolic pathways, including: 1. **Nicotinamide Metabolic Process:** NNMT catalyzes the transfer of a methyl group from nicotinamide to nicotinamide riboside, resulting in the formation of nicotinamide mononucleotide (NMN). NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), which plays a critical role in energy metabolism and cellular homeostasis. 2. **Nad Biosynthesis via Nicotinamide Riboside Salvage Pathway:** NNMT is involved in the salvage pathway of nicotinamide riboside, which is a critical pathway for the regeneration of NAD+ from NMN. 3. **Metabolism of Vitamins and Cofactors:** NNMT is involved in the metabolism of various vitamins and cofactors, including nicotinic acid, pantothenic acid, and biotin. 4. **Metabolism of Amino Acids and Derivatives:** NNMT is involved in the metabolism of various amino acids and derivatives, including glycine, proline, and glutamine. **Clinical Significance:** The NNMT gene has been implicated in several diseases and conditions, including: 1. **Atherosclerosis:** NNMT has been shown to play a critical role in the regulation of lipid metabolism and the development of atherosclerosis. 2. **Type 2 Diabetes:** NNMT has been implicated in the regulation of gluconeogenesis and the development of type 2 diabetes. 3. **Cancer:** NNMT has been shown to play a critical role in the regulation of protein deacetylation and the development of cancer. 4. **Neurological Disorders:** NNMT has been implicated in the regulation of NAD+ metabolism and the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the NNMT gene is a critical regulator of metabolic pathways and cellular processes, and its dysregulation has been implicated in several diseases and conditions. Further research is needed to fully understand the role of NNMT in human health and disease.

Genular Protein ID: 1979671060

Symbol: NNMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P40261

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8182091

Title: Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.

PubMed ID: 8182091

DOI: 10.1016/s0021-9258(17)36700-5

PubMed ID: 8575745

Title: Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization.

PubMed ID: 8575745

DOI: 10.1006/geno.1995.9966

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11271497

Title: Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.

PubMed ID: 11271497

DOI: 10.1002/1522-2683(200011)21:17<3785::aid-elps3785>3.0.co;2-2

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23455543

Title: NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.

PubMed ID: 23455543

DOI: 10.1038/nchembio.1204

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26571212

Title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

PubMed ID: 26571212

DOI: 10.1038/ncb3264

PubMed ID: 30044909

Title: Citrullination Inactivates Nicotinamide- N-methyltransferase.

PubMed ID: 30044909

DOI: 10.1021/acschembio.8b00578

PubMed ID: 31043742

Title: Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.

PubMed ID: 31043742

DOI: 10.1038/s41586-019-1173-8

PubMed ID: 21823666

Title: Structural basis of substrate recognition in human nicotinamide N-methyltransferase.

PubMed ID: 21823666

DOI: 10.1021/bi2007614

Sequence Information:

  • Length: 264
  • Mass: 29574
  • Checksum: 280B12748F4488AC
  • Sequence:
    • MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI 
DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN 
RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL 
RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ 
SYSSTMANNE GLFSLVARKL SRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.