Details for: TAGLN

Gene ID: 6876

Symbol: TAGLN

Ensembl ID: ENSG00000149591

Description: transgelin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 200.4562
    Cell Significance Index: -31.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.1014
    Cell Significance Index: -31.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.1202
    Cell Significance Index: -27.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.0942
    Cell Significance Index: -26.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.1300
    Cell Significance Index: -30.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.4109
    Cell Significance Index: -27.1100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 29.0297
    Cell Significance Index: 152.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.7719
    Cell Significance Index: -26.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.3618
    Cell Significance Index: -31.2700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 8.2774
    Cell Significance Index: 48.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9458
    Cell Significance Index: -17.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7166
    Cell Significance Index: -30.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.5699
    Cell Significance Index: 133.7700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 5.5618
    Cell Significance Index: 25.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.2621
    Cell Significance Index: 585.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.0676
    Cell Significance Index: 116.6000
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.2372
    Cell Significance Index: 24.2400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.3432
    Cell Significance Index: 27.1200
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.9247
    Cell Significance Index: 14.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1762
    Cell Significance Index: 223.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0960
    Cell Significance Index: 51.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6692
    Cell Significance Index: 604.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6024
    Cell Significance Index: 12.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3338
    Cell Significance Index: 42.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3166
    Cell Significance Index: 40.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3157
    Cell Significance Index: 51.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2438
    Cell Significance Index: 12.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2372
    Cell Significance Index: 107.6400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.2007
    Cell Significance Index: 0.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1857
    Cell Significance Index: 18.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1660
    Cell Significance Index: 18.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1080
    Cell Significance Index: 13.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1069
    Cell Significance Index: 201.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1067
    Cell Significance Index: 1.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0952
    Cell Significance Index: 0.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0908
    Cell Significance Index: 18.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0903
    Cell Significance Index: 6.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0813
    Cell Significance Index: 9.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0751
    Cell Significance Index: 26.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0702
    Cell Significance Index: 31.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0397
    Cell Significance Index: 7.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0396
    Cell Significance Index: 2.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0280
    Cell Significance Index: 15.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0241
    Cell Significance Index: 0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0140
    Cell Significance Index: 8.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0063
    Cell Significance Index: 4.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0169
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0177
    Cell Significance Index: -3.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0181
    Cell Significance Index: -33.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0188
    Cell Significance Index: -13.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0210
    Cell Significance Index: -32.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0213
    Cell Significance Index: -13.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0256
    Cell Significance Index: -34.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0319
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0323
    Cell Significance Index: -18.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0375
    Cell Significance Index: -27.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0450
    Cell Significance Index: -4.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0739
    Cell Significance Index: -8.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0856
    Cell Significance Index: -5.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0880
    Cell Significance Index: -9.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0984
    Cell Significance Index: -28.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1017
    Cell Significance Index: -21.4300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1065
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1246
    Cell Significance Index: -18.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1427
    Cell Significance Index: -10.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1446
    Cell Significance Index: -8.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1573
    Cell Significance Index: -7.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1902
    Cell Significance Index: -8.8700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1999
    Cell Significance Index: -0.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2254
    Cell Significance Index: -15.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2490
    Cell Significance Index: -29.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2548
    Cell Significance Index: -29.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2821
    Cell Significance Index: -4.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2855
    Cell Significance Index: -6.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3256
    Cell Significance Index: -4.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3419
    Cell Significance Index: -22.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3675
    Cell Significance Index: -29.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3782
    Cell Significance Index: -19.1100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3816
    Cell Significance Index: -2.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4084
    Cell Significance Index: -27.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4704
    Cell Significance Index: -29.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5093
    Cell Significance Index: -13.6000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.5211
    Cell Significance Index: -4.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5221
    Cell Significance Index: -27.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5241
    Cell Significance Index: -32.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5408
    Cell Significance Index: -14.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5500
    Cell Significance Index: -16.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5657
    Cell Significance Index: -13.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5831
    Cell Significance Index: -32.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5979
    Cell Significance Index: -16.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6029
    Cell Significance Index: -16.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6142
    Cell Significance Index: -32.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6637
    Cell Significance Index: -23.0700
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.6719
    Cell Significance Index: -3.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7030
    Cell Significance Index: -22.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7063
    Cell Significance Index: -31.2400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.7177
    Cell Significance Index: -3.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7213
    Cell Significance Index: -25.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7350
    Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAGLN is a small, acidic protein (approximately 47 kDa) that belongs to the transgelin family. It is characterized by its ability to bind to actin filaments, which is essential for its role in cytoskeletal organization and dynamics. TAGLN is also known for its anti-apoptotic properties, as it can inhibit programmed cell death in various cell types. Additionally, TAGLN has been implicated in cell adhesion, migration, and proliferation, highlighting its potential role in tissue development and immune response. **Pathways and Functions:** TAGLN's involvement in various cellular processes can be attributed to its interactions with different signaling pathways. The actin-binding domain of TAGLN is essential for its role in cytoskeletal organization, as it influences the organization and dynamics of actin filaments. This, in turn, affects cell adhesion, migration, and survival. TAGLN's anti-apoptotic properties are mediated through its interaction with anti-apoptotic proteins, such as Bcl-2 family members. Furthermore, TAGLN has been implicated in the regulation of cell proliferation, as it can inhibit the cell cycle progression in various cell types. In addition to its role in cytoskeletal organization and cell survival, TAGLN has been shown to interact with various signaling pathways, including the MAPK/ERK pathway, the PI3K/Akt pathway, and the NF-κB pathway. These interactions suggest that TAGLN plays a complex role in modulating immune response and tissue development. **Clinical Significance:** TAGLN's expression in various cell types involved in tissue development and immune response makes it an attractive candidate for studying various diseases, including cancer, cardiovascular disease, and immune disorders. Dysregulation of TAGLN expression has been implicated in several diseases, including: 1. **Cancer:** TAGLN's anti-apoptotic properties have been exploited by cancer cells to evade programmed cell death, leading to tumor progression and metastasis. 2. **Cardiovascular disease:** TAGLN's role in cytoskeletal organization and cell survival has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Immune disorders:** TAGLN's interaction with immune cells, such as T cells and macrophages, has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, TAGLN's complex role in cellular processes, including cytoskeletal organization, cell survival, and immune response, makes it an attractive candidate for studying various diseases. Further research is needed to fully elucidate the mechanisms by which TAGLN regulates cellular processes and to explore its potential as a therapeutic target for treating various diseases.

Genular Protein ID: 943251141

Symbol: TAGL_HUMAN

Name: Transgelin

UniProtKB Accession Codes:

Q01995 O15542

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1520290

Title: A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts.

PubMed ID: 1520290

DOI: 10.1016/s0006-291x(05)81449-4

PubMed ID: 1872880

Title: Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle.

PubMed ID: 1872880

PubMed ID: 9615232

Title: Expression and cytogenetic localization of the human SM22 gene (TAGLN).

PubMed ID: 9615232

DOI: 10.1006/geno.1998.5267

PubMed ID: 9276683

Title: Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation.

PubMed ID: 9276683

DOI: 10.1093/oxfordjournals.jbchem.a021722

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 201
  • Mass: 22611
  • Checksum: 7AE9E7A9A45602C3
  • Sequence:
    • MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL GFQVWLKNGV 
ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVIKTD MFQTVDLFEG 
KDMAAVQRTL MALGSLAVTK NDGHYRGDPN WFMKKAQEHK REFTESQLQE GKHVIGLQMG 
SNRGASQAGM TGYGRPRQII S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.