Details for: MATN2

Gene ID: 4147

Symbol: MATN2

Ensembl ID: ENSG00000132561

Description: matrilin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.0043
    Cell Significance Index: -26.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.0150
    Cell Significance Index: -26.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.0913
    Cell Significance Index: -23.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.0191
    Cell Significance Index: -26.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.2371
    Cell Significance Index: -27.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.7396
    Cell Significance Index: -23.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.8256
    Cell Significance Index: -26.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5549
    Cell Significance Index: -28.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.2557
    Cell Significance Index: 118.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8002
    Cell Significance Index: -19.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8245
    Cell Significance Index: -26.9300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.5123
    Cell Significance Index: 32.3900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 4.5722
    Cell Significance Index: 22.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2650
    Cell Significance Index: 24.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2373
    Cell Significance Index: 74.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1371
    Cell Significance Index: 123.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8737
    Cell Significance Index: 788.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8505
    Cell Significance Index: 24.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8151
    Cell Significance Index: 17.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7278
    Cell Significance Index: 51.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6524
    Cell Significance Index: 41.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5374
    Cell Significance Index: 192.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5070
    Cell Significance Index: 100.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4647
    Cell Significance Index: 5.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4617
    Cell Significance Index: 92.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4593
    Cell Significance Index: 317.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4506
    Cell Significance Index: 6.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4283
    Cell Significance Index: 189.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4267
    Cell Significance Index: 58.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4198
    Cell Significance Index: 29.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3633
    Cell Significance Index: 7.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3256
    Cell Significance Index: 9.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3148
    Cell Significance Index: 31.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2944
    Cell Significance Index: 7.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2686
    Cell Significance Index: 13.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2348
    Cell Significance Index: 6.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1917
    Cell Significance Index: 8.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1704
    Cell Significance Index: 3.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1597
    Cell Significance Index: 28.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1475
    Cell Significance Index: 9.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1244
    Cell Significance Index: 4.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1058
    Cell Significance Index: 1.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0674
    Cell Significance Index: 12.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0528
    Cell Significance Index: 0.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0470
    Cell Significance Index: 25.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0388
    Cell Significance Index: 59.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0313
    Cell Significance Index: 58.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0160
    Cell Significance Index: 29.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0044
    Cell Significance Index: 5.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0021
    Cell Significance Index: -0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0352
    Cell Significance Index: -26.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0357
    Cell Significance Index: -26.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0366
    Cell Significance Index: -27.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0367
    Cell Significance Index: -0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0462
    Cell Significance Index: -20.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0469
    Cell Significance Index: -29.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0471
    Cell Significance Index: -6.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0511
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0624
    Cell Significance Index: -7.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0812
    Cell Significance Index: -23.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1051
    Cell Significance Index: -13.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1180
    Cell Significance Index: -1.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1208
    Cell Significance Index: -9.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1222
    Cell Significance Index: -14.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1263
    Cell Significance Index: -3.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1380
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1404
    Cell Significance Index: -23.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1452
    Cell Significance Index: -30.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1689
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1793
    Cell Significance Index: -20.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1851
    Cell Significance Index: -23.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1995
    Cell Significance Index: -20.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2207
    Cell Significance Index: -3.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2219
    Cell Significance Index: -23.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2451
    Cell Significance Index: -28.9100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2795
    Cell Significance Index: -3.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2955
    Cell Significance Index: -13.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3076
    Cell Significance Index: -16.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3177
    Cell Significance Index: -19.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3311
    Cell Significance Index: -18.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3330
    Cell Significance Index: -26.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3357
    Cell Significance Index: -14.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3478
    Cell Significance Index: -5.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3527
    Cell Significance Index: -26.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3532
    Cell Significance Index: -8.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3870
    Cell Significance Index: -8.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3888
    Cell Significance Index: -6.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4128
    Cell Significance Index: -15.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4360
    Cell Significance Index: -22.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4375
    Cell Significance Index: -28.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4460
    Cell Significance Index: -6.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4685
    Cell Significance Index: -13.4300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4765
    Cell Significance Index: -6.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4994
    Cell Significance Index: -25.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5567
    Cell Significance Index: -13.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5905
    Cell Significance Index: -6.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6092
    Cell Significance Index: -28.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6318
    Cell Significance Index: -16.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MATN2 is widely expressed in various cell types, including interstitial cells of the ovary, skeletal muscle satellite cells, cardiac neurons, and fibroblasts. 2. **Protein Structure:** MATN2 is a type of matrilin, a family of ECM proteins that form complexes with other proteins to regulate ECM organization and function. 3. **ECM Organization:** MATN2 plays a critical role in the organization and structure of the ECM, particularly in basement membrane formation and extracellular matrix structural constituents. 4. **Cell Migration:** MATN2 is involved in regulating cell migration, including glial cell migration, neuron migration, and axon guidance. 5. **Pathway Involvement:** MATN2 is implicated in several key pathways, including calcium ion binding, collagen-containing extracellular matrix, and response to axon injury. **Pathways and Functions:** 1. **Axon Guidance:** MATN2 regulates axon guidance by interacting with other ECM proteins and signaling molecules to facilitate axonal growth and branching. 2. **Basement Membrane Formation:** MATN2 is involved in the formation and maintenance of basement membranes, which provide structural support and regulate cell migration. 3. **Extracellular Matrix Organization:** MATN2 regulates ECM organization and function by interacting with other ECM proteins and signaling molecules to maintain the integrity of the ECM. 4. **Cell Migration:** MATN2 is involved in regulating cell migration, including glial cell migration, neuron migration, and axon guidance. 5. **Response to Axon Injury:** MATN2 plays a critical role in the response to axon injury, including axon regeneration and repair. **Clinical Significance:** 1. **Neurological Disorders:** MATN2 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Musculoskeletal Diseases:** MATN2 dysregulation has been linked to musculoskeletal diseases, including osteoarthritis and muscular dystrophy. 3. **Cancer:** MATN2 has been implicated in cancer progression and metastasis, particularly in breast and lung cancers. 4. **Cardiovascular Diseases:** MATN2 dysregulation has been linked to cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 5. **Therapeutic Potential:** Understanding the functions and significance of MATN2 has significant implications for the development of novel therapeutic strategies for various diseases, including neurological disorders, musculoskeletal diseases, and cancer. In conclusion, MATN2 is a multifaceted gene that plays a critical role in the organization and structure of the extracellular matrix and cellular migration. Understanding the functions and significance of MATN2 is essential for elucidating its role in various diseases and developing novel therapeutic strategies.

Genular Protein ID: 2791166853

Symbol: MATN2_HUMAN

Name: Matrilin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11124542

Title: Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genes.

PubMed ID: 11124542

DOI: 10.1159/000056797

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9083061

Title: Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily.

PubMed ID: 9083061

DOI: 10.1074/jbc.272.14.9268

Sequence Information:

  • Length: 956
  • Mass: 106837
  • Checksum: D0868FBF62744EF2
  • Sequence:
  • MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS CENKRADLVF 
    IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV 
    ERAVKRMRHL STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV 
    AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH 
    MCSTLEHNCA HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 
    FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT 
    KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC RRINYCALNK PGCEHECVNM 
    EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ DHGCEQLCLN TEDSFVCQCS EGFLINEDLK 
    TCSRVDYCLL SDHGCEYSCV NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC 
    VSSEDSFVCQ CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFRLAE 
    DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT EGPIDLVFVI 
    DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS TQVHTEFTLR NFNSAKDMKK 
    AVAHMKYMGK GSMTGLALKH MFERSFTQGE GARPLSTRVP RAAIVFTDGR AQDDVSEWAS 
    KAKANGITMY AVGVGKAIEE ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED 
    SDGRQDSPAG ELPKTVQQPT ESEPVTINIQ DLLSCSNFAV QHRYLFEEDN LLRSTQKLSH 
    STKPSGSPLE EKHDQCKCEN LIMFQNLANE EVRKLTQRLE EMTQRMEALE NRLRYR

Genular Protein ID: 1148978182

Symbol: Q8N2G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 451
  • Mass: 50150
  • Checksum: 0FF171E6268674E5
  • Sequence:
  • MEKMLAGCFL LILGQIVLLP AEARERSRGR SISRGRHART HPQTALLESS CENKRADLVF 
    IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV 
    ERAVKRMRHP STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV 
    AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH 
    MCSTLEHNCA HFCINIPGSY VCRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS 
    FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT 
    KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC RRINYCALNK PGCEHECVNM 
    EESYYCRCHR GYTLDPNGKT CSRECTLGVG C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.