Gene TFAP2C - ENSG00000087510 | NCBI Gene ID: 7022

Details for: TFAP2C

Gene ID: 7022

Symbol: TFAP2C

Ensembl ID: ENSG00000087510

Description: transcription factor AP-2 gamma

Associated with

Activation of the tfap2 (ap-2) family of transcription factors
(R-HSA-8866907)
Developmental biology
(R-HSA-1266738)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of activity of tfap2 (ap-2) family transcription factors
(R-HSA-8866904)
Post-translational protein modification
(R-HSA-597592)
Reproduction
(R-HSA-1474165)
Rna polymerase ii transcription
(R-HSA-73857)
Specification of primordial germ cells
(R-HSA-9827857)
Specification of the neural plate border
(R-HSA-9834899)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription factors
(R-HSA-3232118)
Tfap2 (ap-2) family regulates transcription of cell cycle factors
(R-HSA-8866911)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-HSA-8866910)
Tfap2 (ap-2) family regulates transcription of other transcription factors
(R-HSA-8866906)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Anatomical structure development
(GO:0048856)
Cell-cell signaling
(GO:0007267)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Male gonad development
(GO:0008584)
Mitochondrion
(GO:0005739)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.65
Marker Score: 3130
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.52
Marker Score: 5958
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 850
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.25
Marker Score: 1570.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.25
Marker Score: 2533
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.21
Marker Score: 2463
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.19
Marker Score: 1254
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.18
Marker Score: 401
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4799
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.04
Marker Score: 5119
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251791
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 791
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.99
Marker Score: 1126
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 389
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5318
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.92
Marker Score: 2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.92
Marker Score: 14332
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: malignant cell (CL0001064)
Fold Change: 0.86
Marker Score: 11533
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.85
Marker Score: 7351
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.83
Marker Score: 564
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.77
Marker Score: 506
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 682
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: basal cell (CL0000646)
Fold Change: 0.69
Marker Score: 886
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.68
Marker Score: 1198
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.66
Marker Score: 974
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.64
Marker Score: 536
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.63
Marker Score: 295
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.62
Marker Score: 682
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.62
Marker Score: 412
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.6
Marker Score: 4691.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.59
Marker Score: 355
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.59
Marker Score: 209
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.57
Marker Score: 181
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 365.5
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.57
Marker Score: 469
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.56
Marker Score: 2175
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 231
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.49
Marker Score: 142
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.47
Marker Score: 3488
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.47
Marker Score: 415
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.45
Marker Score: 1291.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.45
Marker Score: 2347
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.44
Marker Score: 99
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.44
Marker Score: 194
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.43
Marker Score: 4837
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.42
Marker Score: 201
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.42
Marker Score: 1022.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.41
Marker Score: 1593
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.41
Marker Score: 203
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.4
Marker Score: 103
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.38
Marker Score: 222
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.38
Marker Score: 262
Cell Name: club cell (CL0000158)
Fold Change: 0.37
Marker Score: 428
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 368
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.36
Marker Score: 224
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.36
Marker Score: 346
Cell Name: acinar cell (CL0000622)
Fold Change: 0.35
Marker Score: 247
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.34
Marker Score: 177
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.34
Marker Score: 99
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.34
Marker Score: 82
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.33
Marker Score: 261
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.33
Marker Score: 103
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.32
Marker Score: 348
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.32
Marker Score: 140
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.31
Marker Score: 2017
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.31
Marker Score: 224
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.3
Marker Score: 485
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.3
Marker Score: 389
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.29
Marker Score: 81
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.29
Marker Score: 159
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.28
Marker Score: 105
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.28
Marker Score: 465
Cell Name: secretory cell (CL0000151)
Fold Change: 0.28
Marker Score: 513
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.27
Marker Score: 94
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.27
Marker Score: 917
Cell Name: reticular cell (CL0000432)
Fold Change: 0.25
Marker Score: 92
Cell Name: mast cell (CL0000097)
Fold Change: 0.25
Marker Score: 143
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.24
Marker Score: 139
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.24
Marker Score: 468
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.24
Marker Score: 458
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.23
Marker Score: 206
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.23
Marker Score: 4857
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.23
Marker Score: 72

Hover over a box to see details here...

**Key Characteristics:** 1. **Diverse Expression Patterns:** TFAP2C is expressed in a wide range of cell types, including cardiac endothelial cells, placental villous trophoblasts, granulocyte monocyte progenitor cells, and stem cells from various tissues. 2. **Transcriptional Regulation:** TFAP2C acts as a transcriptional activator or repressor, modulating the expression of genes involved in cell cycle regulation, growth factor signaling, and other cellular processes. 3. **AP-2 Family Interactions:** TFAP2C interacts with other members of the AP-2 family to regulate the expression of target genes, highlighting its role in coordinating cellular responses to various stimuli. 4. **Sumoylation and Protein Modification:** TFAP2C is subject to sumoylation, a post-translational modification that regulates its activity and interactions with other proteins. **Pathways and Functions:** 1. **Cell Cycle Regulation:** TFAP2C regulates the expression of cell cycle-related genes, influencing cell proliferation and differentiation. 2. **Growth Factor Signaling:** TFAP2C modulates the expression of growth factor receptors and signaling molecules, influencing cell growth and survival. 3. **Neural Development:** TFAP2C is involved in the specification of primordial germ cells and the development of the neural plate border. 4. **Immunological Regulation:** TFAP2C regulates the expression of genes involved in immune cell development and function, including the specification of immature innate lymphoid cells. 5. **Epigenetic Regulation:** TFAP2C interacts with epigenetic regulators to modulate gene expression, influencing chromatin structure and transcriptional activity. **Clinical Significance:** 1. **Cancer Therapy:** TFAP2C's role in regulating cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Neurological Disorders:** Dysregulation of TFAP2C has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cardiovascular Disease:** TFAP2C's involvement in cardiac development and function makes it a potential therapeutic target for cardiovascular disease. 4. **Immunological Disorders:** TFAP2C's role in regulating immune cell development and function highlights its potential as a therapeutic target for immunological disorders. In conclusion, TFAP2C is a multifaceted transcription factor that plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its diverse expression patterns and interactions with other transcription factors underscore its importance in maintaining tissue homeostasis. Further research is needed to fully elucidate the functions of TFAP2C and its potential as a therapeutic target in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor AP-2 gamma

Genular Protein ID: 2840926360

Symbol: AP2C_HUMAN

Name: Transcription factor AP-2 gamma

UniProtKB Accession Codes:

Q92754 B4DWK3 O00685 O00730 Q86V30 Q8IVB6 Q9P1X2

Database IDs:

Citations:

PubMed ID: 8661133

Title: Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.

PubMed ID: 8661133

DOI: 10.1006/geno.1996.0351

PubMed ID: 9113991

Title: Identification of ERF-1 as a member of the AP2 transcription factor family.

PubMed ID: 9113991

DOI: 10.1073/pnas.94.9.4342

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 11744733

Title: Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.

PubMed ID: 11744733

DOI: 10.1074/jbc.m110850200

PubMed ID: 12072434

Title: Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

PubMed ID: 12072434

DOI: 10.1074/jbc.m202780200

PubMed ID: 12586840

Title: Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

PubMed ID: 12586840

DOI: 10.1074/jbc.m208144200

PubMed ID: 15548692

Title: Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.

PubMed ID: 15548692

DOI: 10.1158/0008-5472.can-04-2055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19115315

Title: The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.

PubMed ID: 19115315

DOI: 10.1002/jcb.22002

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24413532

Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.

PubMed ID: 24413532

DOI: 10.1158/0008-5472.can-13-2020

Sequence Information:

Length: 450
Mass: 49177
Checksum: 2D4F5FBC269A34A8
Sequence:

MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF 
PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR 
PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV 
DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY 
KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK 
EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL 
IVIDKSYMNP GDQSPADSNK TLEKMEKHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TFAP2C

Associated with

Cells (max top 100)

Other Information

Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. PubMed ID: 8661133

Identification of ERF-1 as a member of the AP2 transcription factor family. PubMed ID: 9113991

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. PubMed ID: 11694877

Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. PubMed ID: 11744733

Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. PubMed ID: 12072434

Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. PubMed ID: 12586840

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. PubMed ID: 15548692

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. PubMed ID: 19115315

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1. PubMed ID: 24413532