Details for: TFAP2C

Gene ID: 7022

Symbol: TFAP2C

Ensembl ID: ENSG00000087510

Description: transcription factor AP-2 gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.6840
    Cell Significance Index: -12.1100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.4936
    Cell Significance Index: 10.3900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.8752
    Cell Significance Index: 3.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5650
    Cell Significance Index: 181.4100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.9872
    Cell Significance Index: 4.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9209
    Cell Significance Index: 51.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6083
    Cell Significance Index: -3.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4703
    Cell Significance Index: 41.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3849
    Cell Significance Index: 263.5600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1.3273
    Cell Significance Index: 9.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1569
    Cell Significance Index: 511.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9600
    Cell Significance Index: 49.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9571
    Cell Significance Index: 94.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8604
    Cell Significance Index: 40.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8504
    Cell Significance Index: 767.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7531
    Cell Significance Index: 10.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7462
    Cell Significance Index: 20.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5338
    Cell Significance Index: 7.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5082
    Cell Significance Index: 65.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4690
    Cell Significance Index: 76.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4270
    Cell Significance Index: 19.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3981
    Cell Significance Index: 2.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3776
    Cell Significance Index: 41.0700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2945
    Cell Significance Index: 1.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2681
    Cell Significance Index: 32.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2603
    Cell Significance Index: 4.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2396
    Cell Significance Index: 10.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2375
    Cell Significance Index: 42.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1723
    Cell Significance Index: 11.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1467
    Cell Significance Index: 10.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0882
    Cell Significance Index: 48.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0761
    Cell Significance Index: 4.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0654
    Cell Significance Index: 8.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0180
    Cell Significance Index: 0.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0063
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0140
    Cell Significance Index: -0.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0146
    Cell Significance Index: -0.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0201
    Cell Significance Index: -14.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0207
    Cell Significance Index: -2.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0221
    Cell Significance Index: -7.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0529
    Cell Significance Index: -15.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0531
    Cell Significance Index: -10.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0737
    Cell Significance Index: -14.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0750
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0768
    Cell Significance Index: -0.5800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0800
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0825
    Cell Significance Index: -14.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0916
    Cell Significance Index: -10.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0926
    Cell Significance Index: -2.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0929
    Cell Significance Index: -13.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0990
    Cell Significance Index: -3.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1012
    Cell Significance Index: -5.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1195
    Cell Significance Index: -13.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1233
    Cell Significance Index: -1.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1302
    Cell Significance Index: -6.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1304
    Cell Significance Index: -13.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1424
    Cell Significance Index: -14.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1497
    Cell Significance Index: -9.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1500
    Cell Significance Index: -8.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1653
    Cell Significance Index: -2.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1656
    Cell Significance Index: -1.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1818
    Cell Significance Index: -2.7400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1910
    Cell Significance Index: -2.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2103
    Cell Significance Index: -14.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2281
    Cell Significance Index: -14.0200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2297
    Cell Significance Index: -3.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2327
    Cell Significance Index: -12.1200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2327
    Cell Significance Index: -2.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2356
    Cell Significance Index: -18.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2597
    Cell Significance Index: -16.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2606
    Cell Significance Index: -6.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2689
    Cell Significance Index: -4.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2694
    Cell Significance Index: -9.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3047
    Cell Significance Index: -6.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3063
    Cell Significance Index: -3.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3459
    Cell Significance Index: -7.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3469
    Cell Significance Index: -9.2800
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.3567
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3626
    Cell Significance Index: -16.0400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3724
    Cell Significance Index: -3.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3740
    Cell Significance Index: -8.6400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3855
    Cell Significance Index: -6.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3926
    Cell Significance Index: -2.6600
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.4039
    Cell Significance Index: -2.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4158
    Cell Significance Index: -14.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4242
    Cell Significance Index: -16.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Diverse Expression Patterns:** TFAP2C is expressed in a wide range of cell types, including cardiac endothelial cells, placental villous trophoblasts, granulocyte monocyte progenitor cells, and stem cells from various tissues. 2. **Transcriptional Regulation:** TFAP2C acts as a transcriptional activator or repressor, modulating the expression of genes involved in cell cycle regulation, growth factor signaling, and other cellular processes. 3. **AP-2 Family Interactions:** TFAP2C interacts with other members of the AP-2 family to regulate the expression of target genes, highlighting its role in coordinating cellular responses to various stimuli. 4. **Sumoylation and Protein Modification:** TFAP2C is subject to sumoylation, a post-translational modification that regulates its activity and interactions with other proteins. **Pathways and Functions:** 1. **Cell Cycle Regulation:** TFAP2C regulates the expression of cell cycle-related genes, influencing cell proliferation and differentiation. 2. **Growth Factor Signaling:** TFAP2C modulates the expression of growth factor receptors and signaling molecules, influencing cell growth and survival. 3. **Neural Development:** TFAP2C is involved in the specification of primordial germ cells and the development of the neural plate border. 4. **Immunological Regulation:** TFAP2C regulates the expression of genes involved in immune cell development and function, including the specification of immature innate lymphoid cells. 5. **Epigenetic Regulation:** TFAP2C interacts with epigenetic regulators to modulate gene expression, influencing chromatin structure and transcriptional activity. **Clinical Significance:** 1. **Cancer Therapy:** TFAP2C's role in regulating cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Neurological Disorders:** Dysregulation of TFAP2C has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cardiovascular Disease:** TFAP2C's involvement in cardiac development and function makes it a potential therapeutic target for cardiovascular disease. 4. **Immunological Disorders:** TFAP2C's role in regulating immune cell development and function highlights its potential as a therapeutic target for immunological disorders. In conclusion, TFAP2C is a multifaceted transcription factor that plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its diverse expression patterns and interactions with other transcription factors underscore its importance in maintaining tissue homeostasis. Further research is needed to fully elucidate the functions of TFAP2C and its potential as a therapeutic target in various diseases.

Genular Protein ID: 2840926360

Symbol: AP2C_HUMAN

Name: Transcription factor AP-2 gamma

UniProtKB Accession Codes:

Q92754 B4DWK3 O00685 O00730 Q86V30 Q8IVB6 Q9P1X2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661133

Title: Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.

PubMed ID: 8661133

DOI: 10.1006/geno.1996.0351

PubMed ID: 9113991

Title: Identification of ERF-1 as a member of the AP2 transcription factor family.

PubMed ID: 9113991

DOI: 10.1073/pnas.94.9.4342

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11694877

Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

PubMed ID: 11694877

DOI: 10.1038/ng768

PubMed ID: 11744733

Title: Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.

PubMed ID: 11744733

DOI: 10.1074/jbc.m110850200

PubMed ID: 12072434

Title: Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

PubMed ID: 12072434

DOI: 10.1074/jbc.m202780200

PubMed ID: 12586840

Title: Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

PubMed ID: 12586840

DOI: 10.1074/jbc.m208144200

PubMed ID: 15548692

Title: Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.

PubMed ID: 15548692

DOI: 10.1158/0008-5472.can-04-2055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19115315

Title: The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.

PubMed ID: 19115315

DOI: 10.1002/jcb.22002

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24413532

Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.

PubMed ID: 24413532

DOI: 10.1158/0008-5472.can-13-2020

Sequence Information:

  • Length: 450
  • Mass: 49177
  • Checksum: 2D4F5FBC269A34A8
  • Sequence:
    • MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF 
PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR 
PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV 
DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY 
KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK 
EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL 
IVIDKSYMNP GDQSPADSNK TLEKMEKHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.