Details for: IGFBP6

Gene ID: 3489

Symbol: IGFBP6

Ensembl ID: ENSG00000167779

Description: insulin like growth factor binding protein 6

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Cell migration
    (GO:0016477)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibronectin binding
    (GO:0001968)
  • Identical protein binding
    (GO:0042802)
  • Insulin-like growth factor binary complex
    (GO:0042568)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of stress-activated mapk cascade
    (GO:0032874)
  • Protein binding
    (GO:0005515)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 5.68
    Marker Score: 5952.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.62
    Marker Score: 3087
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.85
    Marker Score: 12288
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.82
    Marker Score: 1176
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8
    Marker Score: 95185
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.78
    Marker Score: 5223
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.48
    Marker Score: 6494
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.38
    Marker Score: 548
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.26
    Marker Score: 563
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.24
    Marker Score: 563
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.99
    Marker Score: 516
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.92
    Marker Score: 1098
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.89
    Marker Score: 1245
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.77
    Marker Score: 761
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.66
    Marker Score: 411
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.63
    Marker Score: 1577
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.61
    Marker Score: 410
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1146
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.55
    Marker Score: 498
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.55
    Marker Score: 17455
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168929
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.37
    Marker Score: 1883
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.27
    Marker Score: 1588
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.25
    Marker Score: 353
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.2
    Marker Score: 756
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.17
    Marker Score: 832
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.14
    Marker Score: 1491
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.1
    Marker Score: 266
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.09
    Marker Score: 540
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.08
    Marker Score: 364
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.01
    Marker Score: 228
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 282
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.98
    Marker Score: 1269
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.97
    Marker Score: 288
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.97
    Marker Score: 637
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.91
    Marker Score: 1125
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.9
    Marker Score: 327
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.89
    Marker Score: 460
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5016
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 837
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.88
    Marker Score: 968
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.87
    Marker Score: 1346
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.86
    Marker Score: 990
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.86
    Marker Score: 3516
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.83
    Marker Score: 875
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 376
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.8
    Marker Score: 188
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.8
    Marker Score: 810
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.79
    Marker Score: 209
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.78
    Marker Score: 229
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565.5
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.73
    Marker Score: 1455
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.72
    Marker Score: 209
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2968
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.71
    Marker Score: 443
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7
    Marker Score: 1718
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.7
    Marker Score: 322
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.7
    Marker Score: 1009
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7
    Marker Score: 726
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.67
    Marker Score: 2396
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.65
    Marker Score: 1260
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.65
    Marker Score: 131
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 181
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.62
    Marker Score: 219
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6
    Marker Score: 233
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.59
    Marker Score: 292
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 555
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.56
    Marker Score: 1505
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.56
    Marker Score: 2754.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.55
    Marker Score: 157
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.54
    Marker Score: 2848
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.54
    Marker Score: 291
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.53
    Marker Score: 565
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.53
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3112
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.51
    Marker Score: 341
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.51
    Marker Score: 118
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.51
    Marker Score: 111
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.51
    Marker Score: 812

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Other Information

## Summary IGFBP6 is a protein that plays a crucial role in regulating cell migration, proliferation, and survival. It is highly expressed in various cell types, including immune cells, stromal cells, and cancer cells. ## Key characteristics * IGFBP6 is a secreted protein that acts as a decoy receptor for insulin-like growth factors (IGFs). * It is a member of the IGFBP family of proteins, which are known for their ability to bind to IGFs and regulate their activity. * IGFBP6 is a key regulator of cell migration by promoting the migration of immune cells and tumor cells. * It is also involved in the regulation of cell proliferation, survival, and differentiation. ## Pathways and functions * IGFBP6 is a key regulator of cell migration by binding to IGFs and promoting their interaction with specific receptors on immune cells. * It also binds to the IGF receptor, which is expressed on various cell types, including immune cells, stromal cells, and cancer cells. * This binding activates the IGF receptor, which triggers a cascade of intracellular events that lead to the activation of MAPK and Akt signaling pathways. * These pathways promote cell migration, proliferation, and survival. * IGFBP6 also plays a role in the regulation of cell population proliferation by promoting the growth of epithelial cells in the prostate. * It does this by binding to the IGFBP1 receptor and inhibiting its interaction with IGFs. ## Clinical significance * IGFBP6 is a potential therapeutic target for cancer and other diseases that are characterized by abnormal cell migration and proliferation. * Inhibition of IGFBP6 has been shown to inhibit cancer cell growth and metastasis. * Clinical trials are currently investigating the use of IGFBP6 inhibitors as a cancer treatment.

Genular Protein ID: 2923364751

Symbol: IBP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

P24592 Q14492

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1709161

Title: Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.

PubMed ID: 1709161

DOI: 10.1016/s0021-9258(18)31549-7

PubMed ID: 10087296

Title: Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene.

PubMed ID: 10087296

DOI: 10.1007/s003359901005

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1719383

Title: Isolation and molecular cloning of insulin-like growth factor-binding protein-6.

PubMed ID: 1719383

DOI: 10.1210/mend-5-7-938

PubMed ID: 1697583

Title: Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

PubMed ID: 1697583

DOI: 10.1016/s0021-9258(18)77200-1

PubMed ID: 2551732

Title: Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II.

PubMed ID: 2551732

DOI: 10.1016/0014-5793(89)81101-9

PubMed ID: 2154495

Title: Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts.

PubMed ID: 2154495

DOI: 10.1016/s0021-9258(19)39711-x

PubMed ID: 1850257

Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

PubMed ID: 1850257

DOI: 10.1016/0006-291x(91)90911-p

PubMed ID: 9572875

Title: Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6.

PubMed ID: 9572875

DOI: 10.1021/bi972894e

PubMed ID: 10329650

Title: The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.

PubMed ID: 10329650

DOI: 10.1074/jbc.274.21.14587

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24003225

Title: Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.

PubMed ID: 24003225

DOI: 10.1074/jbc.m113.510826

Sequence Information:

  • Length: 240
  • Mass: 25322
  • Checksum: 285308231C025009
  • Sequence:
    • MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG GSPAEGCAEA 
EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES 
KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR 
GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.