Details for: IGFBP6

Gene ID: 3489

Symbol: IGFBP6

Ensembl ID: ENSG00000167779

Description: insulin like growth factor binding protein 6

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Cell migration
    (GO:0016477)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibronectin binding
    (GO:0001968)
  • Identical protein binding
    (GO:0042802)
  • Insulin-like growth factor binary complex
    (GO:0042568)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of stress-activated mapk cascade
    (GO:0032874)
  • Protein binding
    (GO:0005515)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.7425
    Cell Significance Index: -24.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.1158
    Cell Significance Index: -22.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.5092
    Cell Significance Index: -29.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.8054
    Cell Significance Index: -22.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.8473
    Cell Significance Index: -22.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.6560
    Cell Significance Index: -24.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6536
    Cell Significance Index: 190.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.3831
    Cell Significance Index: 54.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1023
    Cell Significance Index: -24.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8376
    Cell Significance Index: -17.9300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 5.7972
    Cell Significance Index: 33.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.8042
    Cell Significance Index: 615.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.4941
    Cell Significance Index: 30.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.1471
    Cell Significance Index: 80.9400
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 3.4603
    Cell Significance Index: 34.9200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.4764
    Cell Significance Index: 16.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3050
    Cell Significance Index: 35.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2937
    Cell Significance Index: 41.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2088
    Cell Significance Index: 166.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1373
    Cell Significance Index: 24.6400
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.0919
    Cell Significance Index: 5.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7923
    Cell Significance Index: 150.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4592
    Cell Significance Index: 45.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3804
    Cell Significance Index: 343.4900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.3712
    Cell Significance Index: 4.1000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2742
    Cell Significance Index: 1.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2714
    Cell Significance Index: 2.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2295
    Cell Significance Index: 37.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1813
    Cell Significance Index: 9.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1623
    Cell Significance Index: 18.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1027
    Cell Significance Index: 2.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0922
    Cell Significance Index: 10.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0633
    Cell Significance Index: 0.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0523
    Cell Significance Index: 0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0499
    Cell Significance Index: 10.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0422
    Cell Significance Index: 26.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0348
    Cell Significance Index: 12.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0317
    Cell Significance Index: 3.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0301
    Cell Significance Index: 5.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0136
    Cell Significance Index: 7.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0080
    Cell Significance Index: 5.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0065
    Cell Significance Index: 4.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0179
    Cell Significance Index: -27.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0199
    Cell Significance Index: -8.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0205
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0270
    Cell Significance Index: -5.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0277
    Cell Significance Index: -12.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0336
    Cell Significance Index: -24.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0341
    Cell Significance Index: -0.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0352
    Cell Significance Index: -0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0387
    Cell Significance Index: -11.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0436
    Cell Significance Index: -24.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0448
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0492
    Cell Significance Index: -30.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0547
    Cell Significance Index: -3.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0621
    Cell Significance Index: -0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0909
    Cell Significance Index: -13.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1103
    Cell Significance Index: -6.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1196
    Cell Significance Index: -15.4500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1213
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1284
    Cell Significance Index: -27.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1306
    Cell Significance Index: -22.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1331
    Cell Significance Index: -15.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1421
    Cell Significance Index: -6.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1428
    Cell Significance Index: -8.5700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1556
    Cell Significance Index: -1.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1609
    Cell Significance Index: -11.9900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1636
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1701
    Cell Significance Index: -1.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1751
    Cell Significance Index: -13.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1811
    Cell Significance Index: -3.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1942
    Cell Significance Index: -2.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1960
    Cell Significance Index: -10.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1999
    Cell Significance Index: -23.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2190
    Cell Significance Index: -22.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2435
    Cell Significance Index: -5.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2459
    Cell Significance Index: -5.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2507
    Cell Significance Index: -5.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2511
    Cell Significance Index: -19.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2522
    Cell Significance Index: -17.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2884
    Cell Significance Index: -18.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3308
    Cell Significance Index: -21.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3412
    Cell Significance Index: -20.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3440
    Cell Significance Index: -23.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3614
    Cell Significance Index: -9.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4108
    Cell Significance Index: -19.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4299
    Cell Significance Index: -22.3300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.4418
    Cell Significance Index: -4.1000
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.4419
    Cell Significance Index: -5.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4473
    Cell Significance Index: -12.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4674
    Cell Significance Index: -26.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4982
    Cell Significance Index: -11.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5285
    Cell Significance Index: -21.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5341
    Cell Significance Index: -7.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5462
    Cell Significance Index: -20.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGFBP6 is a 22-kDa protein that belongs to the IGFBP family, which consists of six members. IGFBP6 is characterized by its ability to bind to IGFs, particularly IGF-I and IGF-II, and modulate their activity. Unlike other IGFBPs, IGFBP6 does not have a high affinity for IGFs and instead, exhibits a more selective binding profile. This unique property allows IGFBP6 to regulate IGF signaling pathways in a more nuanced manner. **Pathways and Functions:** IGFBP6 is involved in various signaling pathways, including: 1. **Cell migration**: IGFBP6 regulates cell migration by modulating the activity of IGFs, which are known to promote cell migration and invasion. 2. **Extracellular region**: IGFBP6 is involved in the regulation of extracellular matrix proteins, such as fibronectin, and modulate cell adhesion and migration. 3. **Negative regulation of canonical Wnt signaling pathway**: IGFBP6 inhibits the canonical Wnt signaling pathway, which is involved in cell proliferation and differentiation. 4. **Positive regulation of MAPK cascade**: IGFBP6 activates the MAPK cascade, which is involved in cell proliferation, differentiation, and survival. 5. **Regulation of IGF transport and uptake**: IGFBP6 regulates the transport and uptake of IGFs by cells, modulating their availability and activity. **Clinical Significance:** IGFBP6 has been implicated in various diseases, including: 1. **Cancer**: IGFBP6 has been shown to promote cell migration and invasion in various cancer types, including prostate, breast, and lung cancer. 2. **Inflammatory diseases**: IGFBP6 has been implicated in the regulation of inflammatory responses and may play a role in the pathogenesis of inflammatory diseases, such as atherosclerosis. 3. **Reproductive disorders**: IGFBP6 has been shown to regulate decidual cell function and may play a role in the pathogenesis of reproductive disorders, such as recurrent pregnancy loss. In conclusion, IGFBP6 is a multifaceted regulator of cell migration, growth, and signaling, with implications for various diseases. Further research is needed to fully elucidate the mechanisms of IGFBP6 and its clinical significance.

Genular Protein ID: 2923364751

Symbol: IBP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

P24592 Q14492

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1709161

Title: Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.

PubMed ID: 1709161

DOI: 10.1016/s0021-9258(18)31549-7

PubMed ID: 10087296

Title: Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene.

PubMed ID: 10087296

DOI: 10.1007/s003359901005

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1719383

Title: Isolation and molecular cloning of insulin-like growth factor-binding protein-6.

PubMed ID: 1719383

DOI: 10.1210/mend-5-7-938

PubMed ID: 1697583

Title: Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

PubMed ID: 1697583

DOI: 10.1016/s0021-9258(18)77200-1

PubMed ID: 2551732

Title: Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II.

PubMed ID: 2551732

DOI: 10.1016/0014-5793(89)81101-9

PubMed ID: 2154495

Title: Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts.

PubMed ID: 2154495

DOI: 10.1016/s0021-9258(19)39711-x

PubMed ID: 1850257

Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

PubMed ID: 1850257

DOI: 10.1016/0006-291x(91)90911-p

PubMed ID: 9572875

Title: Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6.

PubMed ID: 9572875

DOI: 10.1021/bi972894e

PubMed ID: 10329650

Title: The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.

PubMed ID: 10329650

DOI: 10.1074/jbc.274.21.14587

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24003225

Title: Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.

PubMed ID: 24003225

DOI: 10.1074/jbc.m113.510826

Sequence Information:

  • Length: 240
  • Mass: 25322
  • Checksum: 285308231C025009
  • Sequence:
    • MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG GSPAEGCAEA 
EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES 
KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR 
GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.