Details for: SFRP1

Gene ID: 6422

Symbol: SFRP1

Ensembl ID: ENSG00000104332

Description: secreted frizzled related protein 1

Associated with

  • Negative regulation of tcf-dependent signaling by wnt ligand antagonists
    (R-HSA-3772470)
  • Signaling by wnt
    (R-HSA-195721)
  • Signal transduction
    (R-HSA-162582)
  • Tcf dependent signaling in response to wnt
    (R-HSA-201681)
  • Bmp signaling pathway
    (GO:0030509)
  • Bone trabecula formation
    (GO:0060346)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to estrogen stimulus
    (GO:0071391)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to heparin
    (GO:0071504)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to prostaglandin e stimulus
    (GO:0071380)
  • Cellular response to starvation
    (GO:0009267)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to vitamin d
    (GO:0071305)
  • Cellular response to x-ray
    (GO:0071481)
  • Convergent extension involved in somitogenesis
    (GO:0090246)
  • Cysteine-type endopeptidase activity
    (GO:0004197)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral axis specification
    (GO:0009950)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Female gonad development
    (GO:0008585)
  • Frizzled binding
    (GO:0005109)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Hematopoietic stem cell differentiation
    (GO:0060218)
  • Heparin binding
    (GO:0008201)
  • Identical protein binding
    (GO:0042802)
  • Male gonad development
    (GO:0008584)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of b cell differentiation
    (GO:0045578)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of bone remodeling
    (GO:0046851)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of ossification
    (GO:0030279)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of osteoblast proliferation
    (GO:0033689)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Neural crest cell fate commitment
    (GO:0014034)
  • Non-canonical wnt signaling pathway
    (GO:0035567)
  • Osteoblast differentiation
    (GO:0001649)
  • Osteoclast differentiation
    (GO:0030316)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of cell-matrix adhesion
    (GO:0001954)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902043)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of focal adhesion assembly
    (GO:0051894)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of stress fiber assembly
    (GO:0051496)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
    (GO:0060527)
  • Protein binding
    (GO:0005515)
  • Regulation of angiogenesis
    (GO:0045765)
  • Regulation of branching involved in prostate gland morphogenesis
    (GO:0060687)
  • Regulation of cell cycle process
    (GO:0010564)
  • Regulation of neuron projection development
    (GO:0010975)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stromal-epithelial cell signaling involved in prostate gland development
    (GO:0044345)
  • Ureteric bud development
    (GO:0001657)
  • Wnt-protein binding
    (GO:0017147)
  • Wnt signaling pathway involved in somitogenesis
    (GO:0090244)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4728
    Cell Significance Index: -23.7600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 14.7475
    Cell Significance Index: 71.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1919
    Cell Significance Index: -15.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.6061
    Cell Significance Index: 263.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.3931
    Cell Significance Index: 696.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.9384
    Cell Significance Index: 63.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.4871
    Cell Significance Index: 72.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3289
    Cell Significance Index: 155.2100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.4294
    Cell Significance Index: 12.1200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.8964
    Cell Significance Index: 21.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6330
    Cell Significance Index: 46.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5891
    Cell Significance Index: 218.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5800
    Cell Significance Index: 698.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0073
    Cell Significance Index: 738.5300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.3913
    Cell Significance Index: 2.3100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.3213
    Cell Significance Index: 6.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2106
    Cell Significance Index: 7.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1342
    Cell Significance Index: 3.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0977
    Cell Significance Index: 5.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0823
    Cell Significance Index: 5.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0566
    Cell Significance Index: 0.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0253
    Cell Significance Index: 46.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0239
    Cell Significance Index: 0.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0204
    Cell Significance Index: 1.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0183
    Cell Significance Index: 11.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0086
    Cell Significance Index: 16.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0048
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0175
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0187
    Cell Significance Index: -11.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0189
    Cell Significance Index: -1.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0216
    Cell Significance Index: -33.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0276
    Cell Significance Index: -15.0900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0285
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -42.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0348
    Cell Significance Index: -19.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0394
    Cell Significance Index: -29.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0622
    Cell Significance Index: -28.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0623
    Cell Significance Index: -22.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0633
    Cell Significance Index: -13.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0758
    Cell Significance Index: -21.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0913
    Cell Significance Index: -18.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1024
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1109
    Cell Significance Index: -18.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1179
    Cell Significance Index: -21.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1240
    Cell Significance Index: -15.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1260
    Cell Significance Index: -25.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1314
    Cell Significance Index: -19.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1377
    Cell Significance Index: -16.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1547
    Cell Significance Index: -10.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1915
    Cell Significance Index: -23.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2104
    Cell Significance Index: -24.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2130
    Cell Significance Index: -5.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2190
    Cell Significance Index: -5.3100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2228
    Cell Significance Index: -1.6200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.2282
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2554
    Cell Significance Index: -29.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2559
    Cell Significance Index: -26.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2603
    Cell Significance Index: -5.0800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2675
    Cell Significance Index: -1.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2759
    Cell Significance Index: -28.7300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2996
    Cell Significance Index: -1.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3774
    Cell Significance Index: -9.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3910
    Cell Significance Index: -2.3200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4013
    Cell Significance Index: -2.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4084
    Cell Significance Index: -6.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4191
    Cell Significance Index: -28.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4249
    Cell Significance Index: -22.1300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4305
    Cell Significance Index: -3.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4334
    Cell Significance Index: -26.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4396
    Cell Significance Index: -28.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4874
    Cell Significance Index: -13.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4939
    Cell Significance Index: -10.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5136
    Cell Significance Index: -13.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5145
    Cell Significance Index: -32.4300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.5258
    Cell Significance Index: -7.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6433
    Cell Significance Index: -10.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6592
    Cell Significance Index: -34.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6622
    Cell Significance Index: -29.2900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6645
    Cell Significance Index: -4.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6663
    Cell Significance Index: -8.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7168
    Cell Significance Index: -16.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7308
    Cell Significance Index: -31.7800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7415
    Cell Significance Index: -11.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7571
    Cell Significance Index: -39.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7739
    Cell Significance Index: -19.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7764
    Cell Significance Index: -29.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8254
    Cell Significance Index: -30.3000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8363
    Cell Significance Index: -11.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8386
    Cell Significance Index: -17.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8388
    Cell Significance Index: -24.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8492
    Cell Significance Index: -29.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8495
    Cell Significance Index: -21.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8700
    Cell Significance Index: -43.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8819
    Cell Significance Index: -19.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9169
    Cell Significance Index: -30.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9193
    Cell Significance Index: -22.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9310
    Cell Significance Index: -23.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9513
    Cell Significance Index: -25.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9524
    Cell Significance Index: -25.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SFRP1 is a secreted protein with a molecular weight of approximately 35 kDa. It is a member of the frizzled-related protein family and shares a high degree of sequence homology with other SFRPs. SFRP1 is characterized by its ability to bind to Wnt ligands and Frizzled receptors, as well as its ability to modulate the activity of the Wnt/β-catenin signaling pathway. SFRP1 is also known to interact with other signaling molecules, including BMPs, TGF-β, and FGFs, thereby regulating a wide range of cellular processes. **Pathways and Functions** SFRP1 regulates various signaling pathways involved in development, homeostasis, and disease. The primary pathway modulated by SFRP1 is the Wnt/β-catenin signaling pathway, which plays a crucial role in regulating cell proliferation, differentiation, and survival. SFRP1 inhibits the activation of this pathway by binding to Wnt ligands and Frizzled receptors, thereby preventing the translocation of β-catenin to the nucleus and the subsequent activation of target genes. In addition to its role in the Wnt/β-catenin pathway, SFRP1 regulates other signaling pathways, including: * BMP signaling pathway: SFRP1 inhibits BMP signaling by binding to BMP receptors, thereby preventing the activation of downstream target genes. * TGF-β signaling pathway: SFRP1 inhibits TGF-β signaling by binding to TGF-β receptors, thereby preventing the activation of downstream target genes. * FGF signaling pathway: SFRP1 inhibits FGF signaling by binding to FGF receptors, thereby preventing the activation of downstream target genes. SFRP1 also regulates various cellular processes, including: * Cell proliferation: SFRP1 inhibits cell proliferation by regulating the Wnt/β-catenin signaling pathway. * Cell differentiation: SFRP1 regulates cell differentiation by modulating the Wnt/β-catenin signaling pathway. * Cell survival: SFRP1 regulates cell survival by modulating the Wnt/β-catenin signaling pathway. * Angiogenesis: SFRP1 regulates angiogenesis by modulating the Wnt/β-catenin signaling pathway. * Tissue development: SFRP1 regulates tissue development by modulating the Wnt/β-catenin signaling pathway. **Clinical Significance** SFRP1 has been implicated in various diseases, including: * Cancer: SFRP1 is overexpressed in several types of cancer, including colorectal, breast, and prostate cancer. * Bone disease: SFRP1 regulates bone remodeling and is implicated in osteoporosis and bone cancer. * Neurological disease: SFRP1 regulates neuronal development and is implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * Cardiovascular disease: SFRP1 regulates angiogenesis and is implicated in cardiovascular disease. In conclusion, SFRP1 is a critical regulator of various signaling pathways involved in development, homeostasis, and disease. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in human disease.

Genular Protein ID: 2544755649

Symbol: SFRP1_HUMAN

Name: Secreted frizzled-related protein 1

UniProtKB Accession Codes:

Q8N474 O00546 O14779

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 96 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192640

Title: Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.

PubMed ID: 9192640

DOI: 10.1073/pnas.94.13.6770

PubMed ID: 9391078

Title: SARPs: a family of secreted apoptosis-related proteins.

PubMed ID: 9391078

DOI: 10.1073/pnas.94.25.13636

PubMed ID: 9724099

Title: Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors.

PubMed ID: 9724099

DOI: 10.1002/(sici)1097-0215(19980925)78:1<95::aid-ijc15>3.0.co;2-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11741940

Title: Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules.

PubMed ID: 11741940

DOI: 10.1074/jbc.m108533200

PubMed ID: 10347172

Title: Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.

PubMed ID: 10347172

DOI: 10.1074/jbc.274.23.16180

PubMed ID: 11932307

Title: Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity.

PubMed ID: 11932307

DOI: 10.1210/jcem.87.4.8375

Sequence Information:

  • Length: 314
  • Mass: 35386
  • Checksum: 29DD948706EB7143
  • Sequence:
    • MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD 
IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHAGTQ VFLCSLFAPV 
CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNATEASKP 
QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK 
KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKK 
MKNHECPTFQ SVFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.