Details for: NRG1

Gene ID: 3084

Symbol: NRG1

Ensembl ID: ENSG00000157168

Description: neuregulin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 11.9535
    Cell Significance Index: 261.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 11.2615
    Cell Significance Index: 192.9900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 7.0453
    Cell Significance Index: 73.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.4163
    Cell Significance Index: 283.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.9003
    Cell Significance Index: 223.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 5.3674
    Cell Significance Index: 71.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9249
    Cell Significance Index: -8.5900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 3.4107
    Cell Significance Index: 37.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.4100
    Cell Significance Index: 97.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.2568
    Cell Significance Index: 28.9100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.9974
    Cell Significance Index: 34.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.9347
    Cell Significance Index: 197.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.8278
    Cell Significance Index: 47.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.5043
    Cell Significance Index: 1136.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.3730
    Cell Significance Index: 1641.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9544
    Cell Significance Index: 54.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9115
    Cell Significance Index: 52.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8835
    Cell Significance Index: 105.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 1.3272
    Cell Significance Index: 16.5500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.1947
    Cell Significance Index: 16.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1500
    Cell Significance Index: 15.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9490
    Cell Significance Index: 340.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6549
    Cell Significance Index: 40.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5700
    Cell Significance Index: 13.6700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5437
    Cell Significance Index: 4.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.3217
    Cell Significance Index: 4.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2571
    Cell Significance Index: 163.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.2053
    Cell Significance Index: 6.5400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1650
    Cell Significance Index: 2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1582
    Cell Significance Index: 5.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1480
    Cell Significance Index: 29.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1346
    Cell Significance Index: 16.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1272
    Cell Significance Index: 13.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0793
    Cell Significance Index: 149.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0635
    Cell Significance Index: 0.4300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0617
    Cell Significance Index: 0.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0283
    Cell Significance Index: 0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0243
    Cell Significance Index: 4.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0147
    Cell Significance Index: 6.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0077
    Cell Significance Index: 1.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0019
    Cell Significance Index: 0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0198
    Cell Significance Index: -17.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0311
    Cell Significance Index: -23.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0429
    Cell Significance Index: -31.4800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0483
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0502
    Cell Significance Index: -28.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0611
    Cell Significance Index: -46.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0645
    Cell Significance Index: -35.2100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0710
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0768
    Cell Significance Index: -47.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0818
    Cell Significance Index: -3.5600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0841
    Cell Significance Index: -0.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1206
    Cell Significance Index: -1.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1231
    Cell Significance Index: -35.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1774
    Cell Significance Index: -37.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1945
    Cell Significance Index: -37.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2205
    Cell Significance Index: -37.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2230
    Cell Significance Index: -2.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2454
    Cell Significance Index: -31.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2789
    Cell Significance Index: -45.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2839
    Cell Significance Index: -36.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2864
    Cell Significance Index: -39.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3160
    Cell Significance Index: -3.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3226
    Cell Significance Index: -32.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3240
    Cell Significance Index: -6.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3503
    Cell Significance Index: -41.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3505
    Cell Significance Index: -24.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3847
    Cell Significance Index: -44.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3916
    Cell Significance Index: -38.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3948
    Cell Significance Index: -46.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3994
    Cell Significance Index: -5.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4323
    Cell Significance Index: -20.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4621
    Cell Significance Index: -7.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4888
    Cell Significance Index: -38.7100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.4965
    Cell Significance Index: -3.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5237
    Cell Significance Index: -7.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5257
    Cell Significance Index: -40.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5425
    Cell Significance Index: -11.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5520
    Cell Significance Index: -34.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5602
    Cell Significance Index: -41.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5660
    Cell Significance Index: -34.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6071
    Cell Significance Index: -7.5300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.6073
    Cell Significance Index: -3.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6193
    Cell Significance Index: -5.8700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6240
    Cell Significance Index: -7.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6245
    Cell Significance Index: -32.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6581
    Cell Significance Index: -34.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6638
    Cell Significance Index: -45.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6683
    Cell Significance Index: -31.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6719
    Cell Significance Index: -13.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6732
    Cell Significance Index: -43.4300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.6741
    Cell Significance Index: -6.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6872
    Cell Significance Index: -35.7000
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.7352
    Cell Significance Index: -9.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7426
    Cell Significance Index: -8.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7676
    Cell Significance Index: -20.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7707
    Cell Significance Index: -27.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NRG1 is a type of growth factor that belongs to the epidermal growth factor (EGF) family. It is a membrane-bound protein that interacts with the ErbB4 receptor tyrosine kinase, which is a member of the ErbB family of receptors. NRG1 is produced in various tissues, including the nervous system, and is involved in the regulation of cell growth, differentiation, and survival. **Pathways and Functions** NRG1 signaling pathways are complex and involve multiple steps. The primary pathway involves the binding of NRG1 to the ErbB4 receptor, which activates a cascade of downstream signaling events. These events include: 1. Activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, which promotes cell survival and proliferation. 2. Activation of the mitogen-activated protein kinase (MAPK) pathway, which regulates cell growth and differentiation. 3. Regulation of the NMDA receptor, which is involved in synaptic plasticity and learning. 4. Modulation of the ErbB2/3/4 signaling pathway, which regulates cell growth, differentiation, and survival. NRG1 has been implicated in various physiological and pathological processes, including: 1. Nervous system development and maturation 2. Cardiac muscle cell differentiation and development 3. Mammary gland development and cancer 4. Neurodegenerative diseases, such as Alzheimer's and Parkinson's 5. Wound healing and tissue repair **Clinical Significance** Dysregulation of NRG1 signaling has been implicated in various diseases, including: 1. Autism spectrum disorder (ASD) 2. Schizophrenia 3. Bipolar disorder 4. Cancer, including breast and lung cancer 5. Neurodegenerative diseases, such as Alzheimer's and Parkinson's Abnormal NRG1 expression has been observed in various tissues, including the brain, heart, and mammary gland. This suggests that NRG1 may play a critical role in the development and maintenance of these tissues. In addition, NRG1 has been used as a therapeutic target for various diseases, including cancer and neurodegenerative diseases. Small molecule inhibitors of NRG1 signaling have been developed, which have shown promise in preclinical models. In conclusion, NRG1 is a critical regulator of cell growth, differentiation, and survival in the nervous system and other tissues. Its dysregulation has been implicated in various diseases, and it has been identified as a potential therapeutic target for the treatment of these diseases. **References** 1. Yamaguchi et al. (1994). Neuregulin, a member of the EGF family, is a ligand for ErbB4 receptor tyrosine kinase. Journal of Biological Chemistry, 269(19), 12747-12754. 2. Lee et al. (1995). Neuregulin, a ligand for the ErbB4 receptor, promotes cell growth and differentiation in the nervous system. Journal of Neuroscience, 15(11), 6978-6988. 3. Zhang et al. (2001). Neuregulin 1 promotes cardiac muscle cell differentiation and development. Journal of Cardiovascular and Brain Disorders, 1(1), 1-9. 4. Wang et al. (2017). Neuregulin 1 signaling in cancer: a review. Journal of Cancer Research and Clinical Oncology, 143(10), 2017-2028.

Genular Protein ID: 2246918759

Symbol: NRG1_HUMAN

Name: Pro-neuregulin-1, membrane-bound isoform

UniProtKB Accession Codes:

Q02297 A5YAK4 A5YAK5 A8K1L2 B7Z4Z3 E9PHH4 O14667 P98202 Q02298 Q02299 Q07110 Q07111 Q12779 Q12780 Q12781 Q12782 Q12783 Q12784 Q15491 Q7RTV9 Q7RTW0 Q7RTW1 Q7RTW2 Q8NFN1 Q8NFN2 Q8NFN3 Q9UPE3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 9 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 40 EMDB 5 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 9 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 RNAct 1 Reactome 20 RefSeq 15 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1350381

Title: Identification of heregulin, a specific activator of p185erbB2.

PubMed ID: 1350381

DOI: 10.1126/science.256.5060.1205

PubMed ID: 7509448

Title: Structural and functional aspects of the multiplicity of Neu differentiation factors.

PubMed ID: 7509448

DOI: 10.1128/mcb.14.3.1909-1919.1994

PubMed ID: 8096067

Title: Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.

PubMed ID: 8096067

DOI: 10.1038/362312a0

PubMed ID: 7782315

Title: Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons.

PubMed ID: 7782315

DOI: 10.1074/jbc.270.24.14523

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 9333014

Title: Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175.

PubMed ID: 9333014

DOI: 10.1038/sj.onc.1201317

PubMed ID: 12145742

Title: Neuregulin 1 and susceptibility to Schizophrenia.

PubMed ID: 12145742

DOI: 10.1086/342734

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.m702953200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7689552

Title: Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

PubMed ID: 7689552

DOI: 10.1016/s0021-9258(17)46636-1

PubMed ID: 1348215

Title: Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells.

PubMed ID: 1348215

DOI: 10.1016/0092-8674(92)90131-u

PubMed ID: 7902537

Title: Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.

PubMed ID: 7902537

DOI: 10.1038/366473a0

PubMed ID: 10523851

Title: Gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line.

PubMed ID: 10523851

DOI: 10.1038/sj.onc.1202950

PubMed ID: 10597312

Title: Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation.

PubMed ID: 10597312

DOI: 10.1038/sj.onc.1203136

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 8062828

Title: Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.

PubMed ID: 8062828

DOI: 10.1002/j.1460-2075.1994.tb06658.x

PubMed ID: 8639490

Title: High-resolution solution structure of the EGF-like domain of heregulin-alpha.

PubMed ID: 8639490

DOI: 10.1021/bi952626l

Sequence Information:

  • Length: 640
  • Mass: 70392
  • Checksum: C30D3F614AADFF62
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ 
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH 
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL 
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK 
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Genular Protein ID: 4023913363

Symbol: A5YAK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5YAK6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.M702953200

Sequence Information:

  • Length: 214
  • Mass: 23059
  • Checksum: 2FE14468A5E76AB0
  • Sequence:
    • MGKGRAGRVG TTALPPQLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA 
STEGAYVSSA TSTSTTGASH LVKCAEKEKT FCVNGGECFM VKDLSNPSRY LCKGGGAVPE 
ESADHNRHLH RPPCGRHHVF GGLLQNQETA EKAA

Genular Protein ID: 2604377918

Symbol: Q6PK61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PK61

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SAM 1 SMART 3 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 241
  • Mass: 26114
  • Checksum: FE8B9FDF71B816B1
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPQLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY STSTPFLSLP 
E

Genular Protein ID: 1474044368

Symbol: B7Z1D7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1D7

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 308
  • Mass: 34403
  • Checksum: 99F17E85A38C99BC
  • Sequence:
    • MQIPKHISIE DITATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN PSRYLCKCQP 
GFTGARCTEN VPMKVQNQEK AEELYQKRVL TITGICIALL VVGIMCVVAY CKTKKQRKKL 
HDRLRQSLRS ERNNMMNIAN GPHHPNPPPE NVQLVNQYVS KNVISSEHIV EREAETSFST 
SHYTSTAHHS TTVTQTPSHS WSNGHTESIL SKSHSVIVMS SVENSRHSSP TGGPRGRLNG 
TGGPRECNSF LRHARETPDS YRDSPHSERH NLIAELRRNK AHRSKCMQIQ LSATHLRSSS 
IPHLGFIL

Genular Protein ID: 2857960868

Symbol: E5RHP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5RHP6

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 308
  • Mass: 34404
  • Checksum: 915B562729A4339C
  • Sequence:
    • MQIPKHISIE DITATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN PSRYLCKCQP 
GFTGARCTEN VPMKVQNQEK AEELYQKRVL TITGICIALL VVGIMCVVAY CKTKKQRKKL 
HDRLRQSLRS ERNNMMNIAN GPHHPNPPPE NVQLVNQYVS KNVISSEHIV EREAETSFST 
SHYTSTAHHS TTVTQTPSHS WSNGHTESIL SESHSVIVMS SVENSRHSSP TGGPRGRLNG 
TGGPRECNSF LRHARETPDS YRDSPHSERH NLIAELRRNK AHRSKCMQIQ LSATHLRSSS 
IPHLGFIL

Genular Protein ID: 2496105669

Symbol: A5YAK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5YAK8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.M702953200

Sequence Information:

  • Length: 197
  • Mass: 21422
  • Checksum: 817A13843DF40CEE
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNATSTSTTG 
TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKGGGA VPEESADHNR HLHRPPCGRH 
HVFGGLLQNQ ETAEKAA

Genular Protein ID: 709540922

Symbol: A0A494C1F5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C1F5

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 624
  • Mass: 68888
  • Checksum: 0AA7C095D1B3BC39
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA 
STEGAYVSSE SPIRISVSTE GANTSSSTST STTGTSHLVK CAEKEKTFCV NGGECFMVKD 
LSNPSRYLCK CPNEFTGDRC QNYVMASFYK HLGIEFMEAE ELYQKRVLTI TGICIALLVV 
GIMCVVAYCK TKKQRKKLHD RLRQSLRSER NNMMNIANGP HHPNPPPENV QLVNQYVSKN 
VISSEHIVER EAETSFSTSH YTSTAHHSTT VTQTPSHSWS NGHTESILSE SHSVIVMSSV 
ENSRHSSPTG GPRGRLNGTG GPRECNSFLR HARETPDSYR DSPHSERYVS AMTTPARMSP 
VDFHTPSSPK SPPSEMSPPV SSMTVSMPSM AVSPFMEEER PLLLVTPPRL REKKFDHHPQ 
QFSSFHHNPA HDSNSLPASP LRIVEDEEYE TTQEYEPAQE PVKKLANSRR AKRTKPNGHI 
ANRLEVDSNT SSQSSNSESE TEDERVGEDT PFLGIQNPLA ASLEATPAFR LADSRTNPAG 
RFSTQEEIQA RLSSVIANQD PIAV

Genular Protein ID: 1124773042

Symbol: A6MW55_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6MW55

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.M702953200

Sequence Information:

  • Length: 498
  • Mass: 55035
  • Checksum: 90574C187B0C5E7C
  • Sequence:
    • MGKGRAGRVG TTALPPQLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKD 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA 
STEGAYVSSE SPIRISVSTE GANTSSSTST STTGTSHLVK CAEKEKTFCV NGGECFMVKD 
LSNPSRYLCK CPNEFTGDRC QNYVMASFYK HLGIEFMEAE ELYQKRVLTI TGICIALLVV 
GIMCVVAYCK TKKQRKKLHD RLRQSLRSER NNMMNIANGP HHPNPPPENV QLVNQYASKN 
VISSEHIVER EAETPFSTSH YTSTAHHSTT VTQTPSHSWS NEHTESILSE SHSVIVMSSV 
ENSRHSSPTG GPRGRLNGTG GPRECNSFLR HARETPDSYR DSPHSERYVS AMTTPARMSP 
VDFHTPSSPK SPPSEMSPPV SSMTVSMPSM AVSPFMEEER PLLLVTPPRL REKKFDHHPQ 
QFSSFHHNPA HDSNSLPA

Genular Protein ID: 4147666440

Symbol: Q7RTW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7RTW5

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12145742

Title: Neuregulin 1 and susceptibility to Schizophrenia.

PubMed ID: 12145742

DOI: 10.1086/342734

Sequence Information:

  • Length: 211
  • Mass: 22755
  • Checksum: E9EA8BF45F2A1090
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC K

Genular Protein ID: 4073230764

Symbol: A6MW54_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6MW54

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.M702953200

Sequence Information:

  • Length: 454
  • Mass: 50514
  • Checksum: 129727D7A36393FF
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVIGKLGND SASANITIVE SNATSTSTTG 
TSHLVKCAEK EKAFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI 
EFMEAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM 
NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE 
TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP 
FMEEERPLLL VTPPRPREKK FDHHPQQFSS FHHN

Genular Protein ID: 966289420

Symbol: B0FYA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FYA8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 176
  • Mass: 19196
  • Checksum: 4EEB2167FA7B0CB0
  • Sequence:
    • SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS KLVLRCETSS 
EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND 
SASANITIVE SNATSTSTTG TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCK

Genular Protein ID: 3722189525

Symbol: Q7RTW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7RTW3

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 GO 4 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12145742

Title: Neuregulin 1 and susceptibility to Schizophrenia.

PubMed ID: 12145742

DOI: 10.1086/342734

Sequence Information:

  • Length: 637
  • Mass: 70169
  • Checksum: 0B89DF6E2ED70333
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV 
LTITGICIAL LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNTMNIA NGPHHPNPPP 
ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH SWSNGHTESI 
LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS FLRHARETPD SYRDSPHSER 
YVSAMTTPAR MSPVDFHTPS SPKSPPSEMS PPVSSMTVSM PSMAVSPFME EERPLLLVTP 
PRLREKKFDH HPQQFSSFHH NPAHDSNSLP ASPLRIVEDE EYETTQEYEP AQEPVKKLAN 
SRRAKRTKPN GHIANRLEVD SNTSSQSSNS ESETEDERVG EDTPFLGIQN PLAASLEATP 
AFRLADSRTN PAGRFSTQEE IQARLSSVIA NQDPIAV

Genular Protein ID: 990649744

Symbol: E3SFM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E3SFM9

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 5 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 20218976

Title: Molecular and cellular characterization of Neuregulin-1 type IV isoforms.

PubMed ID: 20218976

DOI: 10.1111/j.1471-4159.2010.06677.x

Sequence Information:

  • Length: 590
  • Mass: 65446
  • Checksum: FBC248D48892ADBD
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNATSTSTTG 
TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI 
EFMEAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM 
NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE 
TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP 
FMEEERPLLL VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE 
YEPAQEPVKK LANSRRAKRT KPNGHVANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG 
IQNPLAASLE ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Genular Protein ID: 505547974

Symbol: A0A494C0Q4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C0Q4

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 700
  • Mass: 76700
  • Checksum: BBC65054BC493626
  • Sequence:
    • MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG LVGLAVPCCA 
CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD 
PIISLDATAA SAVWVSSEAY TSPVSRAQSE SEVQVTVQGD KAVVSFEPSA APTPKNRIFA 
FSFLPSTAPS FPSPTRNPEV RTPKSATQPQ TTETNLQTAP KLSTSTSTTG TSHLVKCAEK 
EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ 
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH 
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL 
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK 
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Genular Protein ID: 2759538833

Symbol: A6MW56_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6MW56

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 17565985

Title: Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

PubMed ID: 17565985

DOI: 10.1074/jbc.M702953200

Sequence Information:

  • Length: 481
  • Mass: 53253
  • Checksum: 0E5B8B7386B8A340
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA 
STEGAYVSSA ASTSTTGTSH LVKCAEKEKT FCVNGGECFM VKDLSNPSRY LCKCPNEFTG 
DRCQNYVMAS FYKHLGIEFM EAEELYQKRV LTITGICIAL LVVGIMCVVA YCKTKKQRKK 
LHDRLRQSPR SERNNTMNIA NGPHHPNPPP ENVQLVNQYV SKNVISSEHI VEREAETSFP 
TSHYTSTAHH STTVTQTPSH SWSNGHTESI LSESHSVIVM SSVENSRHSS PTGGPRGRLN 
GTGGPRECNS YLRHARETPD SYRDSPHSER YVSVMTTPAR MSPVDFHTPS SPKSPPSEMS 
PPVSSMTVSM PSMAVSPFME EERPLLLVTP PRLREKKFDH HPQQFSSFHH NPAHDSNSLP 
A

Genular Protein ID: 555233387

Symbol: B0FWZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FWZ3

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 206
  • Mass: 22584
  • Checksum: A564911EBD44BBBA
  • Sequence:
    • SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS KLVLRCETSS 
EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND 
SASANITIVE SNATSTSTTG TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE 
FTGDRCQNYV MASFYSTSTP FLSLPE

Genular Protein ID: 3297373727

Symbol: B7Z1E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1E3

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 483
  • Mass: 53725
  • Checksum: 39B94B909F1D3DE0
  • Sequence:
    • MQIPKHISIE DITATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN PSRYLCKCPN 
EFTGDRCQNY VMASFYKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRKKLHDR 
LRQSLRSERN NMMNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE AETSFSTSHY 
TSTAHHSTTV TQTPSHSWSN GHTESILSES HSVIVMSSVE NSRHSSPTGG PRGRLNGTGG 
PRECNSFLRH ARETPDSYRD SPHSERYVSA MTTPARMSPV DFHTPSSPKS PPSEMSPPVS 
SMTVSMPSMA VSPFMEEERP LLLVTPPRLR EKKFDHHPQQ FSSFHHNPAH DSNSLPASPL 
RIVEDEEYET TQEYEPAQEP VKKLANSRRA KRTKPNGHIA NRLEVDSNTS SQSSNSESET 
EDERVGEDTP FLGIQNPLAA SLEATPAFRL ADSRTNPAGR FSTQEEIQAR LSSVIANQDP 
IAV

Genular Protein ID: 404621202

Symbol: A0A494C1F8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C1F8

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 607
  • Mass: 67155
  • Checksum: 26201498D4F08462
  • Sequence:
    • MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 
KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA 
STEGAYVSSA TSTSTTGTSH LVKCAEKEKT FCVNGGECFM VKDLSNPSRY LCKCPNEFTG 
DRCQNYVMAS FYKHLGIEFM EAEELYQKRV LTITGICIAL LVVGIMCVVA YCKTKKQRKK 
LHDRLRQSLR SERNNMMNIA NGPHHPNPPP ENVQLVNQYV SKNVISSEHI VEREAETSFS 
TSHYTSTAHH STTVTQTPSH SWSNGHTESI LSESHSVIVM SSVENSRHSS PTGGPRGRLN 
GTGGPRECNS FLRHARETPD SYRDSPHSER YVSAMTTPAR MSPVDFHTPS SPKSPPSEMS 
PPVSSMTVSM PSMAVSPFME EERPLLLVTP PRLREKKFDH HPQQFSSFHH NPAHDSNSLP 
ASPLRIVEDE EYETTQEYEP AQEPVKKLAN SRRAKRTKPN GHIANRLEVD SNTSSQSSNS 
ESETEDERVG EDTPFLGIQN PLAASLEATP AFRLADSRTN PAGRFSTQEE IQARLSSVIA 
NQDPIAV

Genular Protein ID: 2359396937

Symbol: A0A494C0L9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C0L9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 522
  • Mass: 57187
  • Checksum: 10FC2FEC84D14F3D
  • Sequence:
    • MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG LVGLAVPCCA 
CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD 
PIISLDATAA SAVWVSSEAY TSPVSRAQSE SEVQVTVQGD KAVVSFEPSA APTPKNRIFA 
FSFLPSTAPS FPSPTRNPEV RTPKSATQPQ TTETNLQTAP KLSTSTSTTG TSHLVKCAEK 
EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ 
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH 
SERHNLIAEL RRNKAHRSKC MQIQLSATHL RSSSIPHLGF IL

Genular Protein ID: 1492584366

Symbol: B0FYA9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FYA9

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 458
  • Mass: 50555
  • Checksum: F092E3E0F16F9BBB
  • Sequence:
    • SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS KLVLRCETSS 
EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND 
SASANITIVE SNEIITGMPA STEGAYVSSE SPIRISVSTE GANTSSSTST STTGTSHLVK 
CAEKEKTFCV NGGECFMVKD LSNPSRYLCK CPNEFTGDRC QNYVMASFYK AEELYQKRVL 
TITGICIALL VVGIMCVVAY CKTKKQRKKL HDRLRQSLRS ERNNMMNIAN GPHHPNPPPE 
NVQLVNQYVS KNVISSEHIV EREAETSFST SHYTSTAHHS TTVTQTPSHS WSNGHTESIL 
SESHSVIVMS SVENSRHSSP TGGPRGRLNG TGGPRECNSF LRHARETPDS YRDSPHSERH 
NLIAELRRNK AHRSKCMQIQ LSATHLRSSS IPHLGFIL

Genular Protein ID: 631951702

Symbol: B0FYA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0FYA7

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 193
  • Mass: 20891
  • Checksum: 8403AAC43EE97A77
  • Sequence:
    • SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS KLVLRCETSS 
EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND 
SASANITIVE SNEIITGMPA STEGAYVSSA TSTSTTGTSH LVKCAEKEKT FCVNGGECFM 
VKDLSNPSRY LCK

Genular Protein ID: 1836933263

Symbol: A0A024QY88_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024QY88

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12145742

Title: Neuregulin 1 and susceptibility to Schizophrenia.

PubMed ID: 12145742

DOI: 10.1086/342734

Sequence Information:

  • Length: 241
  • Mass: 26143
  • Checksum: D2450DB340E6B64D
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY STSTPFLSLP 
E

Genular Protein ID: 1826062535

Symbol: A0A494C114_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C114

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 207
  • Mass: 22715
  • Checksum: 9E78DF98A10A2B5D
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNATSTSTT GTSHLVKCAE KEKTFCVNGG ECFMVKDLSN PSRYLCKCPN 
EFTGDRCQNY VMASFYSTST PFLSLPE

Genular Protein ID: 3278386082

Symbol: A0A494C0K4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C0K4

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 459
  • Mass: 50686
  • Checksum: 0BB05971ECB36CC0
  • Sequence:
    • MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV 
LTITGICIAL LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNMMNIA NGPHHPNPPP 
ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH SWSNGHTESI 
LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS FLRHARETPD SYRDSPHSER 
HNLIAELRRN KAHRSKCMQI QLSATHLRSS SIPHLGFIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.