Details for: RRAD

Gene ID: 6236

Symbol: RRAD

Ensembl ID: ENSG00000166592

Description: RRAD, Ras related glycolysis inhibitor and calcium channel regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.0630
    Cell Significance Index: -14.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.2766
    Cell Significance Index: -13.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 10.8749
    Cell Significance Index: 265.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.3335
    Cell Significance Index: 61.6000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 6.1030
    Cell Significance Index: 17.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5326
    Cell Significance Index: -13.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3535
    Cell Significance Index: -10.3000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.3455
    Cell Significance Index: 12.8100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.3050
    Cell Significance Index: 15.2600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.1719
    Cell Significance Index: 51.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3667
    Cell Significance Index: 145.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9846
    Cell Significance Index: 152.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1909
    Cell Significance Index: 21.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9136
    Cell Significance Index: 173.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8776
    Cell Significance Index: 39.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8683
    Cell Significance Index: 24.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8483
    Cell Significance Index: 24.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6679
    Cell Significance Index: 15.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6137
    Cell Significance Index: 60.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5094
    Cell Significance Index: 7.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4965
    Cell Significance Index: 271.1500
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.4281
    Cell Significance Index: 1.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4163
    Cell Significance Index: 10.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4134
    Cell Significance Index: 24.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4084
    Cell Significance Index: 21.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3943
    Cell Significance Index: 6.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3845
    Cell Significance Index: 347.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3730
    Cell Significance Index: 40.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3379
    Cell Significance Index: 4.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3310
    Cell Significance Index: 53.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3103
    Cell Significance Index: 23.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2963
    Cell Significance Index: 8.2800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2407
    Cell Significance Index: 3.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1793
    Cell Significance Index: 6.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1704
    Cell Significance Index: 3.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1692
    Cell Significance Index: 4.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1592
    Cell Significance Index: 3.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1583
    Cell Significance Index: 10.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1460
    Cell Significance Index: 9.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0987
    Cell Significance Index: 10.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0839
    Cell Significance Index: 157.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0834
    Cell Significance Index: 11.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0354
    Cell Significance Index: 7.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0351
    Cell Significance Index: 15.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0120
    Cell Significance Index: 0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0076
    Cell Significance Index: -5.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0079
    Cell Significance Index: -12.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0185
    Cell Significance Index: -0.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0222
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0229
    Cell Significance Index: -1.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0242
    Cell Significance Index: -13.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0253
    Cell Significance Index: -2.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0257
    Cell Significance Index: -3.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0266
    Cell Significance Index: -3.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0269
    Cell Significance Index: -9.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0287
    Cell Significance Index: -8.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0420
    Cell Significance Index: -7.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0438
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0453
    Cell Significance Index: -5.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0502
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0645
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0688
    Cell Significance Index: -14.5000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0787
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0819
    Cell Significance Index: -9.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0827
    Cell Significance Index: -3.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1146
    Cell Significance Index: -3.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1209
    Cell Significance Index: -14.2600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1222
    Cell Significance Index: -1.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1242
    Cell Significance Index: -1.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1365
    Cell Significance Index: -6.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1540
    Cell Significance Index: -12.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1637
    Cell Significance Index: -1.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1641
    Cell Significance Index: -8.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1651
    Cell Significance Index: -6.7700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1687
    Cell Significance Index: -1.3000
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: -0.1709
    Cell Significance Index: -1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1877
    Cell Significance Index: -12.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1890
    Cell Significance Index: -11.9100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2136
    Cell Significance Index: -2.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2176
    Cell Significance Index: -2.7900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2185
    Cell Significance Index: -6.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2201
    Cell Significance Index: -13.5300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2282
    Cell Significance Index: -3.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2285
    Cell Significance Index: -12.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2329
    Cell Significance Index: -6.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2445
    Cell Significance Index: -6.6600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2828
    Cell Significance Index: -2.4300
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.2845
    Cell Significance Index: -2.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2879
    Cell Significance Index: -10.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2880
    Cell Significance Index: -12.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3207
    Cell Significance Index: -11.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRAD is a Ras-related GTPase that belongs to the Ras superfamily, which is known for its involvement in signal transduction and cellular regulation. RRAD exhibits high sequence homology with other Ras-related GTPases, such as RAB and RHO, and shares similar GTPase activity and regulatory properties. The gene is predominantly expressed in various epithelial tissues, including ciliated cells, glandular epithelial cells, and cardiac myocytes, suggesting its importance in maintaining tissue homeostasis. **Pathways and Functions:** RRAD's involvement in multiple signaling pathways underscores its multifaceted role in cellular regulation. Notably, RRAD is a calcium channel regulator, influencing the activity of calcium channels and modulating intracellular calcium levels. This function is critical for various cellular processes, including muscle contraction, cell signaling, and gene expression. RRAD also interacts with calmodulin, a calcium-binding protein, to regulate its activity and downstream signaling events. In addition to calcium signaling, RRAD is involved in glycolysis regulation, modulating the activity of key enzymes and metabolic pathways. Its role in gene expression is also significant, as RRAD influences the activity of transcription factors and kinases, thereby regulating the expression of target genes. **Clinical Significance:** The dysregulation of RRAD has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. In cancer, RRAD's role in regulating glycolysis and calcium signaling may contribute to tumor growth and metastasis. In cardiovascular disease, RRAD's involvement in cardiac myocyte function and calcium signaling may influence cardiac hypertrophy and arrhythmias. Furthermore, RRAD's expression in ciliated cells and epithelial tissues suggests its potential role in respiratory and gastrointestinal diseases. Mutations in the RRAD gene have been associated with certain congenital disorders, highlighting its importance in human development and disease. In conclusion, RRAD is a complex gene with far-reaching implications in cellular regulation and disease. Further research is needed to fully elucidate the mechanisms underlying RRAD's multifaceted role and its clinical significance in various diseases.

Genular Protein ID: 1378849987

Symbol: RAD_HUMAN

Name: GTP-binding protein RAD

UniProtKB Accession Codes:

P55042 Q96F39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248782

Title: Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.

PubMed ID: 8248782

DOI: 10.1126/science.8248782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115241

Title: Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.

PubMed ID: 9115241

DOI: 10.1074/jbc.272.18.11832

PubMed ID: 18056528

Title: Rad GTPase deficiency leads to cardiac hypertrophy.

PubMed ID: 18056528

DOI: 10.1161/circulationaha.107.707257

Sequence Information:

  • Length: 308
  • Mass: 33245
  • Checksum: EF098960A371D2C4
  • Sequence:
    • MTLNGGGSGA GGSRGGGQER ERRRGSTPWG PAPPLHRRSM PVDERDLQAA LTPGALTAAA 
AGTGTQGPRL DWPEDSEDSL SSGGSDSDES VYKVLLLGAP GVGKSALARI FGGVEDGPEA 
EAAGHTYDRS IVVDGEEASL MVYDIWEQDG GRWLPGHCMA MGDAYVIVYS VTDKGSFEKA 
SELRVQLRRA RQTDDVPIIL VGNKSDLVRS REVSVDEGRA CAVVFDCKFI ETSAALHHNV 
QALFEGVVRQ IRLRRDSKEA NARRQAGTRR RESLGKKAKR FLGRIVARNS RKMAFRAKSK 
SCHDLSVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.