Details for: MMP7

Gene ID: 4316

Symbol: MMP7

Ensembl ID: ENSG00000137673

Description: matrix metallopeptidase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.9331
    Cell Significance Index: -22.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.2670
    Cell Significance Index: -15.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.0043
    Cell Significance Index: -15.2800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 4.3684
    Cell Significance Index: 27.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.0934
    Cell Significance Index: 528.8400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.9191
    Cell Significance Index: 18.0100
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 2.3910
    Cell Significance Index: 16.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1443
    Cell Significance Index: 49.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0841
    Cell Significance Index: 1138.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6633
    Cell Significance Index: 86.6400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.4530
    Cell Significance Index: 8.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3560
    Cell Significance Index: 20.9800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1067
    Cell Significance Index: 12.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0828
    Cell Significance Index: 56.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8483
    Cell Significance Index: 39.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7933
    Cell Significance Index: 7.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7792
    Cell Significance Index: 21.2100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.5388
    Cell Significance Index: 6.6900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5231
    Cell Significance Index: 1.9700
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.5086
    Cell Significance Index: 4.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3965
    Cell Significance Index: 4.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2605
    Cell Significance Index: 3.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2331
    Cell Significance Index: 26.7000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2300
    Cell Significance Index: 0.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1964
    Cell Significance Index: 14.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0858
    Cell Significance Index: 4.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0580
    Cell Significance Index: 7.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0325
    Cell Significance Index: 24.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0281
    Cell Significance Index: 4.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0251
    Cell Significance Index: 2.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0227
    Cell Significance Index: 16.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0063
    Cell Significance Index: 1.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0109
    Cell Significance Index: -20.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0194
    Cell Significance Index: -8.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0218
    Cell Significance Index: -29.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0272
    Cell Significance Index: -17.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0282
    Cell Significance Index: -0.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0546
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0552
    Cell Significance Index: -11.6300
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0608
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0625
    Cell Significance Index: -6.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0625
    Cell Significance Index: -8.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0640
    Cell Significance Index: -29.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0814
    Cell Significance Index: -9.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1001
    Cell Significance Index: -19.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1035
    Cell Significance Index: -20.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1136
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1185
    Cell Significance Index: -17.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1232
    Cell Significance Index: -3.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1479
    Cell Significance Index: -17.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1614
    Cell Significance Index: -1.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1967
    Cell Significance Index: -20.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2203
    Cell Significance Index: -17.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2429
    Cell Significance Index: -15.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3114
    Cell Significance Index: -19.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3145
    Cell Significance Index: -21.1500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3147
    Cell Significance Index: -7.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3644
    Cell Significance Index: -6.4400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3852
    Cell Significance Index: -4.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3939
    Cell Significance Index: -14.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4596
    Cell Significance Index: -9.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4616
    Cell Significance Index: -28.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4760
    Cell Significance Index: -15.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5096
    Cell Significance Index: -17.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5118
    Cell Significance Index: -12.4000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.5849
    Cell Significance Index: -8.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5871
    Cell Significance Index: -16.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5940
    Cell Significance Index: -20.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6019
    Cell Significance Index: -19.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6376
    Cell Significance Index: -18.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6436
    Cell Significance Index: -21.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6593
    Cell Significance Index: -16.4400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6645
    Cell Significance Index: -5.0800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.6726
    Cell Significance Index: -6.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6809
    Cell Significance Index: -18.1800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.6823
    Cell Significance Index: -8.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6989
    Cell Significance Index: -24.5600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7115
    Cell Significance Index: -10.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7159
    Cell Significance Index: -18.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7184
    Cell Significance Index: -19.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7411
    Cell Significance Index: -21.1500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.7548
    Cell Significance Index: -6.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7553
    Cell Significance Index: -19.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7567
    Cell Significance Index: -20.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7888
    Cell Significance Index: -20.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8090
    Cell Significance Index: -20.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8483
    Cell Significance Index: -24.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8643
    Cell Significance Index: -15.9800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.8688
    Cell Significance Index: -18.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8714
    Cell Significance Index: -7.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8740
    Cell Significance Index: -14.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8987
    Cell Significance Index: -17.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9020
    Cell Significance Index: -19.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9099
    Cell Significance Index: -18.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9234
    Cell Significance Index: -19.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MMP7 is a serine-type endopeptidase, belonging to the MMP family, which is characterized by its ability to degrade and process various ECM components, such as collagens, elastin, and proteoglycans. MMP7 is specifically expressed in various cell types, including erythrocytes, mammary gland epithelial cells, enterocytes, kidney collecting duct principal cells, and epithelial cells of the urethra, colon, and prostate. Its expression is also regulated by estrogen receptors, suggesting a potential role in estrogen-mediated signaling. **Pathways and Functions:** MMP7 plays a crucial role in various biological processes, including: 1. **Extracellular matrix degradation**: MMP7 is involved in the breakdown of ECM components, which is essential for processes such as tissue remodeling, wound healing, and cancer metastasis. 2. **Cell migration**: MMP7 is required for the degradation of ECM components, allowing cells to migrate through the ECM, a process essential for processes such as embryonic development, tissue repair, and cancer invasion. 3. **Signal transduction**: MMP7 can activate various signaling pathways, including the ERK and PI3K/AKT pathways, which are involved in cell proliferation, differentiation, and survival. 4. **Estrogen-mediated signaling**: MMP7 is regulated by estrogen receptors, suggesting a potential role in estrogen-mediated signaling pathways, which are involved in various physiological and pathological processes, including breast cancer and osteoporosis. **Clinical Significance:** MMP7 has been implicated in various diseases, including: 1. **Cancer**: MMP7 is overexpressed in various types of cancer, including breast, lung, and prostate cancer, suggesting its potential as a prognostic marker and therapeutic target. 2. **Osteoporosis**: MMP7 is involved in bone remodeling, and its dysregulation has been linked to osteoporosis and bone fractures. 3. **Atherosclerosis**: MMP7 is involved in the degradation of ECM components, which is essential for the development of atherosclerosis. 4. **Wound healing**: MMP7 plays a crucial role in wound healing, and its dysregulation can lead to impaired wound healing and tissue repair. In conclusion, MMP7 is a critical regulator of extracellular matrix dynamics, involved in various physiological and pathological processes. Its dysregulation has been linked to various diseases, including cancer, osteoporosis, atherosclerosis, and wound healing disorders. Further research is necessary to fully understand the role of MMP7 in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 3428183338

Symbol: MMP7_HUMAN

Name: Matrilysin

UniProtKB Accession Codes:

P09237 Q9BTK9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2844164

Title: The collagenase gene family in humans consists of at least four members.

PubMed ID: 2844164

DOI: 10.1042/bj2530187

PubMed ID: 1497627

Title: Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1.

PubMed ID: 1497627

DOI: 10.1042/bj2850899

PubMed ID: 8294454

Title: Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

PubMed ID: 8294454

DOI: 10.1016/s0021-9258(17)42131-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2253219

Title: Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.

PubMed ID: 2253219

PubMed ID: 2550050

Title: Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.

PubMed ID: 2550050

DOI: 10.1021/bi00439a004

PubMed ID: 7756291

Title: Matrilysin-inhibitor complexes: common themes among metalloproteases.

PubMed ID: 7756291

DOI: 10.1021/bi00020a004

Sequence Information:

  • Length: 267
  • Mass: 29677
  • Checksum: F6BD1FC0ADA23603
  • Sequence:
    • MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK NANSLEAKLK 
EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN SPKWTSKVVT YRIVSYTRDL 
PHITVDRLVS KALNMWGKEI PLHFRKVVWG TADIMIGFAR GAHGDSYPFD GPGNTLAHAF 
APGTGLGGDA HFDEDERWTD GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD 
PQNFKLSQDD IKGIQKLYGK RSNSRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.