Details for: SERPINF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 233.4369
Cell Significance Index: -36.3100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 144.1000
Cell Significance Index: -36.5500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 87.1713
Cell Significance Index: -35.9100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 77.5740
Cell Significance Index: -31.5200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 75.9337
Cell Significance Index: -35.8500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 32.8989
Cell Significance Index: -31.4100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 29.4658
Cell Significance Index: -36.3300 - Cell Name: theca cell (CL0000503)
Fold Change: 14.1021
Cell Significance Index: 82.8500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.0149
Cell Significance Index: -19.7300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.0115
Cell Significance Index: -35.5600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 6.7738
Cell Significance Index: 86.7500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 6.6178
Cell Significance Index: 165.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.9367
Cell Significance Index: 677.9400 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 4.8672
Cell Significance Index: 68.2700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 4.8070
Cell Significance Index: 32.5700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.7485
Cell Significance Index: 136.1200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 4.0468
Cell Significance Index: 62.6100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.5559
Cell Significance Index: 74.4300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.9739
Cell Significance Index: 43.9000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.9457
Cell Significance Index: 40.1900 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.7348
Cell Significance Index: 21.8400 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.5463
Cell Significance Index: 326.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.4409
Cell Significance Index: 172.6300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.2349
Cell Significance Index: 54.5300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.1407
Cell Significance Index: 41.7800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1242
Cell Significance Index: 57.8200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6704
Cell Significance Index: 331.5000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2273
Cell Significance Index: 55.6300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1625
Cell Significance Index: 31.0400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9665
Cell Significance Index: 183.9400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.8482
Cell Significance Index: 12.1800 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.7142
Cell Significance Index: 4.2800 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.6281
Cell Significance Index: 3.9500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6216
Cell Significance Index: 19.9100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5971
Cell Significance Index: 264.0000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5443
Cell Significance Index: 491.4400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.4793
Cell Significance Index: 24.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4781
Cell Significance Index: 13.3600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4168
Cell Significance Index: 11.1500 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.3463
Cell Significance Index: 3.7800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2985
Cell Significance Index: 562.1300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2550
Cell Significance Index: 41.4800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2424
Cell Significance Index: 48.6300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2415
Cell Significance Index: 41.2400 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.2045
Cell Significance Index: 3.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1633
Cell Significance Index: 16.1500 - Cell Name: fibroblast of the aortic adventitia (CL0002547)
Fold Change: 0.1397
Cell Significance Index: 1.4100 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.1240
Cell Significance Index: 0.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0999
Cell Significance Index: 12.2800 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.0900
Cell Significance Index: 0.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0723
Cell Significance Index: 1.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0610
Cell Significance Index: 6.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0597
Cell Significance Index: 10.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0323
Cell Significance Index: 3.7700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0295
Cell Significance Index: 18.7600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0162
Cell Significance Index: 12.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0104
Cell Significance Index: 7.2000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.0096
Cell Significance Index: 0.0800 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.0130
Cell Significance Index: -0.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0136
Cell Significance Index: -6.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0145
Cell Significance Index: -10.7100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0187
Cell Significance Index: -34.4300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0196
Cell Significance Index: -0.6900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0226
Cell Significance Index: -34.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0273
Cell Significance Index: -17.0700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0302
Cell Significance Index: -41.0500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0354
Cell Significance Index: -19.3600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0416
Cell Significance Index: -1.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0449
Cell Significance Index: -32.8900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0488
Cell Significance Index: -1.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0504
Cell Significance Index: -28.4300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0574
Cell Significance Index: -1.5100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0594
Cell Significance Index: -21.3100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0623
Cell Significance Index: -9.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0781
Cell Significance Index: -7.9700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0843
Cell Significance Index: -5.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0849
Cell Significance Index: -17.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1050
Cell Significance Index: -6.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1058
Cell Significance Index: -30.4500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1113
Cell Significance Index: -1.8800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1662
Cell Significance Index: -3.6000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1723
Cell Significance Index: -17.9400 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.2036
Cell Significance Index: -2.1900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2082
Cell Significance Index: -15.9800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2164
Cell Significance Index: -24.7000 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.2320
Cell Significance Index: -1.1100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2365
Cell Significance Index: -30.5600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2500
Cell Significance Index: -28.6400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2538
Cell Significance Index: -29.9400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2548
Cell Significance Index: -2.1400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2628
Cell Significance Index: -12.3500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2643
Cell Significance Index: -2.1600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3002
Cell Significance Index: -18.0200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3464
Cell Significance Index: -22.3500 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3590
Cell Significance Index: -5.7000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3950
Cell Significance Index: -29.4400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4122
Cell Significance Index: -21.4700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4152
Cell Significance Index: -32.8800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4522
Cell Significance Index: -5.3900 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: -0.4873
Cell Significance Index: -4.1900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2248931682
Symbol: PEDF_HUMAN
Name: Pigment epithelium-derived factor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8434014
Title: Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.
PubMed ID: 8434014
PubMed ID: 9238088
Title: Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.
PubMed ID: 9238088
PubMed ID: 21697133
Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
PubMed ID: 21697133
DOI: 10.1167/iovs.11-7479
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12737624
Title: Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.
PubMed ID: 12737624
DOI: 10.1042/bj20030313
PubMed ID: 8473338
Title: Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.
PubMed ID: 8473338
PubMed ID: 8226833
Title: Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor.
PubMed ID: 8226833
PubMed ID: 7592790
Title: Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop.
PubMed ID: 7592790
PubMed ID: 15374885
Title: Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor.
PubMed ID: 15374885
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17032652
Title: Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.
PubMed ID: 17032652
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 21353196
Title: Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta.
PubMed ID: 21353196
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 11562499
Title: Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor.
PubMed ID: 11562499
PubMed ID: 10398730
Title: Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis.
PubMed ID: 10398730
PubMed ID: 22028381
Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.
PubMed ID: 22028381
DOI: 10.1093/jmcb/mjr024
Sequence Information:
- Length: 418
- Mass: 46312
- Checksum: 7630DD2B4026A0D3
- Sequence:
MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP VNKLAAAVSN FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT ESIIHRALYY DLISSPDIHG TYKELLDTVT APQKNLKSAS RIVFEKKLRI KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI NNWVQAQMKG KLARSTKEIP DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR VPMMSDPKAV LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP IKLTQVEHRA GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD TDTGALLFIG KILDPRGP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.