Details for: SERPINF1

Gene ID: 5176

Symbol: SERPINF1

Ensembl ID: ENSG00000132386

Description: serpin family F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.4369
    Cell Significance Index: -36.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.1000
    Cell Significance Index: -36.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.1713
    Cell Significance Index: -35.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.5740
    Cell Significance Index: -31.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.9337
    Cell Significance Index: -35.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.8989
    Cell Significance Index: -31.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.4658
    Cell Significance Index: -36.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 14.1021
    Cell Significance Index: 82.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0149
    Cell Significance Index: -19.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0115
    Cell Significance Index: -35.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.7738
    Cell Significance Index: 86.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.6178
    Cell Significance Index: 165.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.9367
    Cell Significance Index: 677.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 4.8672
    Cell Significance Index: 68.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.8070
    Cell Significance Index: 32.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.7485
    Cell Significance Index: 136.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.0468
    Cell Significance Index: 62.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.5559
    Cell Significance Index: 74.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.9739
    Cell Significance Index: 43.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9457
    Cell Significance Index: 40.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7348
    Cell Significance Index: 21.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.5463
    Cell Significance Index: 326.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4409
    Cell Significance Index: 172.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2349
    Cell Significance Index: 54.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1407
    Cell Significance Index: 41.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1242
    Cell Significance Index: 57.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6704
    Cell Significance Index: 331.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2273
    Cell Significance Index: 55.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1625
    Cell Significance Index: 31.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9665
    Cell Significance Index: 183.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8482
    Cell Significance Index: 12.1800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.7142
    Cell Significance Index: 4.2800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.6281
    Cell Significance Index: 3.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6216
    Cell Significance Index: 19.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5971
    Cell Significance Index: 264.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5443
    Cell Significance Index: 491.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4793
    Cell Significance Index: 24.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4781
    Cell Significance Index: 13.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4168
    Cell Significance Index: 11.1500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.3463
    Cell Significance Index: 3.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2985
    Cell Significance Index: 562.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2550
    Cell Significance Index: 41.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2424
    Cell Significance Index: 48.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2415
    Cell Significance Index: 41.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2045
    Cell Significance Index: 3.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1633
    Cell Significance Index: 16.1500
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.1397
    Cell Significance Index: 1.4100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1240
    Cell Significance Index: 0.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0999
    Cell Significance Index: 12.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0900
    Cell Significance Index: 0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0723
    Cell Significance Index: 1.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0610
    Cell Significance Index: 6.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0597
    Cell Significance Index: 10.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0323
    Cell Significance Index: 3.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0295
    Cell Significance Index: 18.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0162
    Cell Significance Index: 12.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0104
    Cell Significance Index: 7.2000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0096
    Cell Significance Index: 0.0800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0130
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0187
    Cell Significance Index: -34.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0196
    Cell Significance Index: -0.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0226
    Cell Significance Index: -34.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0273
    Cell Significance Index: -17.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0302
    Cell Significance Index: -41.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0354
    Cell Significance Index: -19.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0416
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0449
    Cell Significance Index: -32.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0488
    Cell Significance Index: -1.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0504
    Cell Significance Index: -28.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0574
    Cell Significance Index: -1.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0594
    Cell Significance Index: -21.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0623
    Cell Significance Index: -9.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0781
    Cell Significance Index: -7.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0843
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0849
    Cell Significance Index: -17.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1050
    Cell Significance Index: -6.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1058
    Cell Significance Index: -30.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1113
    Cell Significance Index: -1.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1662
    Cell Significance Index: -3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1723
    Cell Significance Index: -17.9400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2036
    Cell Significance Index: -2.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2082
    Cell Significance Index: -15.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2164
    Cell Significance Index: -24.7000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2320
    Cell Significance Index: -1.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2365
    Cell Significance Index: -30.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2500
    Cell Significance Index: -28.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2538
    Cell Significance Index: -29.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2548
    Cell Significance Index: -2.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2628
    Cell Significance Index: -12.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2643
    Cell Significance Index: -2.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3002
    Cell Significance Index: -18.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3464
    Cell Significance Index: -22.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3590
    Cell Significance Index: -5.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3950
    Cell Significance Index: -29.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4122
    Cell Significance Index: -21.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4152
    Cell Significance Index: -32.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4522
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.4873
    Cell Significance Index: -4.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serpin Family Member:** SERPINF1 belongs to the serpin family of protease inhibitors, which are characterized by their ability to inhibit serine proteases. 2. **Multifunctional Gene:** SERPINF1 is involved in a wide range of cellular processes, including angiogenesis, endopeptidase activity, and epithelial cell proliferation. 3. **PEDF Encoding:** The gene encodes for the protein PEDF, which is involved in retinal development, neurogenesis, and negative regulation of angiogenesis. 4. **Significantly Expressed Cells:** SERPINF1 is significantly expressed in fibroblasts of connective tissue, Sertoli cells, and other cell types involved in prostate, lung, and ovarian development. **Pathways and Functions:** 1. **Angiogenesis:** SERPINF1 negatively regulates angiogenesis by inhibiting the activity of endothelial cell migration and endothelial cell proliferation. 2. **Endopeptidase Activity:** SERPINF1 negatively regulates endopeptidase activity by inhibiting the activity of serine proteases. 3. **Epithelial Cell Proliferation:** SERPINF1 negatively regulates epithelial cell proliferation by inhibiting the activity of endopeptidases involved in cell proliferation. 4. **Neurogenesis:** PEDF, encoded by SERPINF1, positively regulates neurogenesis by promoting the development of neurons. 5. **Retinal Development:** PEDF, encoded by SERPINF1, is involved in retinal development by regulating the expression of genes involved in retinal formation. **Clinical Significance:** 1. **Cancer:** SERPINF1 has been implicated in the regulation of angiogenesis and endopeptidase activity in various cancers, including prostate, lung, and ovarian cancer. 2. **Neurological Disorders:** PEDF, encoded by SERPINF1, has been implicated in the regulation of neurogenesis and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Ocular Diseases:** PEDF, encoded by SERPINF1, has been implicated in the regulation of retinal development and ocular diseases, including age-related macular degeneration. 4. **Prostate Cancer:** SERPINF1 has been shown to be significantly expressed in prostate cancer cells and has been implicated in the regulation of angiogenesis and endopeptidase activity in prostate cancer. In conclusion, SERPINF1 is a multifunctional gene that plays a crucial role in various cellular processes, including angiogenesis, endopeptidase activity, and epithelial cell proliferation. Its expression is significantly observed in fibroblasts of connective tissue, Sertoli cells, and other cell types involved in prostate, lung, and ovarian development. The gene encodes for the protein PEDF, which is involved in retinal development, neurogenesis, and negative regulation of angiogenesis. SERPINF1 has significant clinical implications in cancer, neurological disorders, ocular diseases, and prostate cancer. Further studies are needed to fully understand the role of SERPINF1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2248931682

Symbol: PEDF_HUMAN

Name: Pigment epithelium-derived factor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8434014

Title: Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.

PubMed ID: 8434014

DOI: 10.1073/pnas.90.4.1526

PubMed ID: 9238088

Title: Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.

PubMed ID: 9238088

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12737624

Title: Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.

PubMed ID: 12737624

DOI: 10.1042/bj20030313

PubMed ID: 8473338

Title: Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.

PubMed ID: 8473338

DOI: 10.1016/s0021-9258(18)52964-1

PubMed ID: 8226833

Title: Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor.

PubMed ID: 8226833

DOI: 10.1016/s0021-9258(19)49439-8

PubMed ID: 7592790

Title: Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop.

PubMed ID: 7592790

DOI: 10.1074/jbc.270.43.25992

PubMed ID: 15374885

Title: Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor.

PubMed ID: 15374885

DOI: 10.1182/blood-2004-04-1569

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17032652

Title: Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.

PubMed ID: 17032652

DOI: 10.1074/jbc.m600353200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 21353196

Title: Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta.

PubMed ID: 21353196

DOI: 10.1016/j.ajhg.2011.01.015

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 11562499

Title: Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor.

PubMed ID: 11562499

DOI: 10.1073/pnas.211268598

PubMed ID: 10398730

Title: Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis.

PubMed ID: 10398730

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 418
  • Mass: 46312
  • Checksum: 7630DD2B4026A0D3
  • Sequence:
  • MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP VNKLAAAVSN 
    FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT ESIIHRALYY DLISSPDIHG 
    TYKELLDTVT APQKNLKSAS RIVFEKKLRI KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI 
    NNWVQAQMKG KLARSTKEIP DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR 
    VPMMSDPKAV LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD 
    IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP IKLTQVEHRA 
    GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD TDTGALLFIG KILDPRGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.