Details for: MDK

Gene ID: 4192

Symbol: MDK

Ensembl ID: ENSG00000110492

Description: midkine

Associated with

  • Mdk and ptn in alk signaling
    (R-HSA-9851151)
  • Notch2 activation and transmission of signal to the nucleus
    (R-HSA-2979096)
  • Signaling by alk
    (R-HSA-201556)
  • Signaling by notch
    (R-HSA-157118)
  • Signaling by notch2
    (R-HSA-1980145)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Adrenal gland development
    (GO:0030325)
  • Behavioral fear response
    (GO:0001662)
  • Cell differentiation
    (GO:0030154)
  • Cerebellar granular layer development
    (GO:0021681)
  • Cerebral cortex development
    (GO:0021987)
  • Chondroitin sulfate binding
    (GO:0035374)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytoskeleton organization
    (GO:0007010)
  • Defecation
    (GO:0030421)
  • Dentate gyrus development
    (GO:0021542)
  • Estrous cycle
    (GO:0044849)
  • Extracellular region
    (GO:0005576)
  • Glial cell projection elongation
    (GO:0106091)
  • Growth factor activity
    (GO:0008083)
  • Heparan sulfate binding
    (GO:1904399)
  • Heparin binding
    (GO:0008201)
  • Intracellular signal transduction
    (GO:0035556)
  • Leukocyte chemotaxis involved in inflammatory response
    (GO:0002232)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell adhesion
    (GO:0007162)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of inflammatory response to wounding
    (GO:0106015)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of ossification
    (GO:0030279)
  • Negative regulation of regulatory t cell differentiation
    (GO:0045590)
  • Nervous system development
    (GO:0007399)
  • Oogenesis
    (GO:0048477)
  • Positive regulation of artery morphogenesis
    (GO:1905653)
  • Positive regulation of blood vessel branching
    (GO:1905555)
  • Positive regulation of cartilage development
    (GO:0061036)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of hepatocyte proliferation
    (GO:2000347)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of inflammatory response to wounding
    (GO:0106016)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of keratinocyte proliferation
    (GO:0010838)
  • Positive regulation of leukocyte adhesion to vascular endothelial cell
    (GO:1904996)
  • Positive regulation of leukocyte cell-cell adhesion
    (GO:1903039)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of macrophage chemotaxis
    (GO:0010759)
  • Positive regulation of neural precursor cell proliferation
    (GO:2000179)
  • Positive regulation of neuron migration
    (GO:2001224)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of neutrophil extravasation
    (GO:2000391)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of smooth muscle cell chemotaxis
    (GO:0071673)
  • Positive regulation of substrate adhesion-dependent cell spreading
    (GO:1900026)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Regulation of behavior
    (GO:0050795)
  • Regulation of bone remodeling
    (GO:0046850)
  • Regulation of chondrocyte differentiation
    (GO:0032330)
  • Response to auditory stimulus
    (GO:0010996)
  • Response to wounding
    (GO:0009611)
  • Short-term memory
    (GO:0007614)
  • Signal transduction
    (GO:0007165)
  • T cell activation involved in immune response
    (GO:0002286)
  • Tissue regeneration
    (GO:0042246)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 391.3331
    Cell Significance Index: -60.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 181.7710
    Cell Significance Index: -46.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.2984
    Cell Significance Index: -54.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.5998
    Cell Significance Index: -57.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.3474
    Cell Significance Index: -57.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.4422
    Cell Significance Index: -60.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 23.0178
    Cell Significance Index: 183.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 22.8717
    Cell Significance Index: 292.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6869
    Cell Significance Index: -60.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 22.4986
    Cell Significance Index: 132.1800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 16.7722
    Cell Significance Index: 103.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.2368
    Cell Significance Index: -60.1300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 14.6570
    Cell Significance Index: 71.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 13.8998
    Cell Significance Index: 290.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 13.4322
    Cell Significance Index: 466.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.8129
    Cell Significance Index: 310.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6980
    Cell Significance Index: -35.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 10.6335
    Cell Significance Index: 115.6000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 9.0279
    Cell Significance Index: 47.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.9129
    Cell Significance Index: 949.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.0693
    Cell Significance Index: 778.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.6693
    Cell Significance Index: 34.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.7344
    Cell Significance Index: 70.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.7334
    Cell Significance Index: 35.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.1500
    Cell Significance Index: 95.8800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 3.5612
    Cell Significance Index: 21.3400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.2072
    Cell Significance Index: 18.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9978
    Cell Significance Index: 223.4300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 2.6627
    Cell Significance Index: 15.6300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.6456
    Cell Significance Index: 21.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6112
    Cell Significance Index: 1426.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5165
    Cell Significance Index: 499.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4701
    Cell Significance Index: 138.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2810
    Cell Significance Index: 61.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6309
    Cell Significance Index: 76.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4022
    Cell Significance Index: 15.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2944
    Cell Significance Index: 67.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2696
    Cell Significance Index: 36.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1122
    Cell Significance Index: 143.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8078
    Cell Significance Index: 55.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7697
    Cell Significance Index: 146.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7093
    Cell Significance Index: 313.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7077
    Cell Significance Index: 33.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.7069
    Cell Significance Index: 11.8300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.6428
    Cell Significance Index: 3.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5418
    Cell Significance Index: 97.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4820
    Cell Significance Index: 59.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4280
    Cell Significance Index: 19.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2456
    Cell Significance Index: 7.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1715
    Cell Significance Index: 154.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1564
    Cell Significance Index: 2.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1425
    Cell Significance Index: 10.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1087
    Cell Significance Index: 3.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0614
    Cell Significance Index: 6.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0409
    Cell Significance Index: 77.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0326
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0212
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0327
    Cell Significance Index: -20.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0416
    Cell Significance Index: -31.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0463
    Cell Significance Index: -85.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0490
    Cell Significance Index: -75.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0539
    Cell Significance Index: -37.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0621
    Cell Significance Index: -84.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0646
    Cell Significance Index: -47.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0657
    Cell Significance Index: -37.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0676
    Cell Significance Index: -42.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0747
    Cell Significance Index: -15.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1139
    Cell Significance Index: -11.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1261
    Cell Significance Index: -57.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1370
    Cell Significance Index: -49.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1671
    Cell Significance Index: -48.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1863
    Cell Significance Index: -4.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1891
    Cell Significance Index: -5.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2127
    Cell Significance Index: -42.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2178
    Cell Significance Index: -25.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2266
    Cell Significance Index: -32.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2413
    Cell Significance Index: -27.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3423
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3911
    Cell Significance Index: -44.6400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4363
    Cell Significance Index: -2.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4800
    Cell Significance Index: -56.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5011
    Cell Significance Index: -32.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5095
    Cell Significance Index: -31.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5288
    Cell Significance Index: -9.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5800
    Cell Significance Index: -60.3900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.6040
    Cell Significance Index: -3.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6564
    Cell Significance Index: -51.9900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.6689
    Cell Significance Index: -3.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6790
    Cell Significance Index: -20.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7245
    Cell Significance Index: -19.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8568
    Cell Significance Index: -7.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8799
    Cell Significance Index: -59.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9061
    Cell Significance Index: -57.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9061
    Cell Significance Index: -69.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9323
    Cell Significance Index: -57.1600
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: -0.9421
    Cell Significance Index: -2.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1064
    Cell Significance Index: -58.0900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -1.1268
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1483
    Cell Significance Index: -7.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Midkine is a heparin-binding protein that belongs to the forkhead family of proteins. It is characterized by its unique structure, which consists of a forkhead domain, a proline-rich region, and a C-terminal heparin-binding domain. Midkine is highly expressed in various tissues, including the adrenal gland, kidney, and nervous system, and is also secreted into the extracellular environment, where it can interact with other signaling molecules. **Pathways and Functions:** Midkine's signaling pathways are diverse and multifaceted, involving various cellular processes, including: 1. **Cytoskeleton organization**: Midkine regulates cytoskeleton dynamics, influencing cell shape, migration, and adhesion. 2. **Cell differentiation**: Midkine modulates the expression of key genes involved in cell differentiation, including those involved in neural development. 3. **Inflammation**: Midkine negatively regulates inflammatory responses, reducing the production of pro-inflammatory cytokines and promoting tissue repair. 4. **Cell adhesion**: Midkine enhances cell adhesion, facilitating the migration and homing of immune cells to sites of inflammation. 5. **Neurotransmission**: Midkine modulates neurotransmitter release and synaptic plasticity, influencing neural function and behavior. **Clinical Significance:** Midkine's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Midkine is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 2. **Cardiovascular disease**: Midkine is involved in the development of atherosclerosis and cardiac hypertrophy, and its levels are elevated in patients with cardiovascular disease. 3. **Neurological disorders**: Midkine is implicated in the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. 4. **Obesity and metabolic disorders**: Midkine is involved in the regulation of energy metabolism and insulin signaling, and its dysregulation contributes to obesity and metabolic disorders. In conclusion, midkine is a multifaceted protein that plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, migration, and survival. Its dysregulation has been implicated in numerous diseases, highlighting the need for further research into the molecular mechanisms underlying midkine's function and its role in human disease.

Genular Protein ID: 3185211261

Symbol: MK_HUMAN

Name: Midgestation and kidney protein

UniProtKB Accession Codes:

P21741 Q2LEK4 Q9UCC7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2025291

Title: A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.

PubMed ID: 2025291

DOI: 10.1016/s0006-291x(05)80255-4

PubMed ID: 1768439

Title: Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.

PubMed ID: 1768439

DOI: 10.3109/08977199109000275

PubMed ID: 1639750

Title: Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor.

PubMed ID: 1639750

DOI: 10.1093/oxfordjournals.jbchem.a123797

PubMed ID: 8471163

Title: Structure of the gene coding for the human retinoic acid-inducible factor, MK.

PubMed ID: 8471163

DOI: 10.1089/dna.1993.12.139

PubMed ID: 17379400

Title: Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines.

PubMed ID: 17379400

DOI: 10.1016/j.canlet.2007.01.019

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1883381

Title: Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7.

PubMed ID: 1883381

DOI: 10.1016/0006-291x(91)91409-6

PubMed ID: 8241100

Title: Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma.

PubMed ID: 8241100

DOI: 10.1161/01.atv.13.12.1798

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10212223

Title: A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.

PubMed ID: 10212223

DOI: 10.1074/jbc.274.18.12474

PubMed ID: 10772929

Title: LDL receptor-related protein as a component of the midkine receptor.

PubMed ID: 10772929

DOI: 10.1006/bbrc.2000.2549

PubMed ID: 10683378

Title: Neointima formation in a restenosis model is suppressed in midkine-deficient mice.

PubMed ID: 10683378

DOI: 10.1172/jci7208

PubMed ID: 12084985

Title: Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth.

PubMed ID: 12084985

DOI: 10.1023/a:1016042303253

PubMed ID: 12122009

Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.

PubMed ID: 12122009

DOI: 10.1074/jbc.m205749200

PubMed ID: 12147681

Title: The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor.

PubMed ID: 12147681

DOI: 10.1074/jbc.m201194200

PubMed ID: 12573468

Title: Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.

PubMed ID: 12573468

DOI: 10.1016/s0168-0102(02)00226-2

PubMed ID: 15466886

Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.

PubMed ID: 15466886

DOI: 10.1242/jcs.01423

PubMed ID: 18469519

Title: Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.

PubMed ID: 18469519

DOI: 10.4161/cc.7.11.5952

PubMed ID: 22323540

Title: Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.

PubMed ID: 22323540

DOI: 10.4049/jimmunol.1102346

PubMed ID: 24458438

Title: The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18).

PubMed ID: 24458438

DOI: 10.1182/blood-2013-06-510875

PubMed ID: 9384573

Title: Solution structure of midkine, a new heparin-binding growth factor.

PubMed ID: 9384573

DOI: 10.1093/emboj/16.23.6936

Sequence Information:

  • Length: 143
  • Mass: 15585
  • Checksum: 414A627FF39953C3
  • Sequence:
    • MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT 
CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI 
RVTKPCTPKT KAKAKAKKGK GKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.