Details for: RBP1

Gene ID: 5947

Symbol: RBP1

Ensembl ID: ENSG00000114115

Description: retinol binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 283.9046
    Cell Significance Index: -44.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.3552
    Cell Significance Index: -42.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.3502
    Cell Significance Index: -41.2400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 23.5812
    Cell Significance Index: 138.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 19.0008
    Cell Significance Index: 499.6300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 12.6211
    Cell Significance Index: 71.7400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 11.9096
    Cell Significance Index: 59.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.5316
    Cell Significance Index: 266.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.1703
    Cell Significance Index: 143.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0490
    Cell Significance Index: -43.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.6842
    Cell Significance Index: 1055.2600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.3221
    Cell Significance Index: 45.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.3819
    Cell Significance Index: 221.7700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.1015
    Cell Significance Index: 52.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.3334
    Cell Significance Index: 116.1200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 4.1866
    Cell Significance Index: 22.0300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.9673
    Cell Significance Index: 19.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.5119
    Cell Significance Index: 599.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.4585
    Cell Significance Index: 1888.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.2955
    Cell Significance Index: 68.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.9827
    Cell Significance Index: 23.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5633
    Cell Significance Index: -5.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1092
    Cell Significance Index: 22.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8563
    Cell Significance Index: 138.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6451
    Cell Significance Index: 727.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5727
    Cell Significance Index: 88.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3249
    Cell Significance Index: 169.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0437
    Cell Significance Index: 62.6600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.0317
    Cell Significance Index: 4.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8715
    Cell Significance Index: 786.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8543
    Cell Significance Index: 92.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.7881
    Cell Significance Index: 4.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6217
    Cell Significance Index: 101.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5160
    Cell Significance Index: 102.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4930
    Cell Significance Index: 34.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3986
    Cell Significance Index: 75.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3867
    Cell Significance Index: 26.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3630
    Cell Significance Index: 9.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2958
    Cell Significance Index: 13.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2921
    Cell Significance Index: 28.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2574
    Cell Significance Index: 7.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1876
    Cell Significance Index: 3.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1429
    Cell Significance Index: 1.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1115
    Cell Significance Index: 14.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0985
    Cell Significance Index: 11.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0583
    Cell Significance Index: 2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0157
    Cell Significance Index: 0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0132
    Cell Significance Index: 24.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0115
    Cell Significance Index: 21.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0069
    Cell Significance Index: 10.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0277
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0303
    Cell Significance Index: -18.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0376
    Cell Significance Index: -23.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0429
    Cell Significance Index: -4.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0451
    Cell Significance Index: -25.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0461
    Cell Significance Index: -9.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0519
    Cell Significance Index: -14.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0547
    Cell Significance Index: -41.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0552
    Cell Significance Index: -40.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0641
    Cell Significance Index: -3.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0746
    Cell Significance Index: -33.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0785
    Cell Significance Index: -3.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1032
    Cell Significance Index: -12.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1167
    Cell Significance Index: -41.8600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1230
    Cell Significance Index: -0.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1266
    Cell Significance Index: -22.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1574
    Cell Significance Index: -4.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1655
    Cell Significance Index: -5.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1929
    Cell Significance Index: -38.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1998
    Cell Significance Index: -20.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2293
    Cell Significance Index: -33.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2713
    Cell Significance Index: -30.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3746
    Cell Significance Index: -44.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4113
    Cell Significance Index: -25.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4147
    Cell Significance Index: -43.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4690
    Cell Significance Index: -10.0300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.4788
    Cell Significance Index: -5.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4884
    Cell Significance Index: -7.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4894
    Cell Significance Index: -14.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5189
    Cell Significance Index: -41.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5342
    Cell Significance Index: -32.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5344
    Cell Significance Index: -15.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5361
    Cell Significance Index: -6.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5443
    Cell Significance Index: -5.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5471
    Cell Significance Index: -36.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5659
    Cell Significance Index: -43.4300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6715
    Cell Significance Index: -7.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7290
    Cell Significance Index: -11.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7559
    Cell Significance Index: -19.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8456
    Cell Significance Index: -31.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9277
    Cell Significance Index: -48.1900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.9547
    Cell Significance Index: -7.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.9827
    Cell Significance Index: -12.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0139
    Cell Significance Index: -6.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0499
    Cell Significance Index: -46.4400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -1.1248
    Cell Significance Index: -6.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RBP1 is a small, secreted protein (approximately 20 kDa) that is synthesized in the liver and secreted into the bloodstream. It is highly specific for binding retinol, with a high affinity for this ligand. RBP1 is also capable of binding other retinoids, including retinaldehyde and retinoic acid, although its affinity for these ligands is lower compared to retinol. The protein is negatively charged, which allows it to bind positively charged retinol molecules, facilitating their transport across cell membranes. **Pathways and Functions** RBP1 is involved in several key pathways, including: 1. **Retinoid Transport**: RBP1 plays a critical role in the transport of retinol from the intestine to the liver and other tissues, where it is converted into retinoic acid. 2. **Visual Phototransduction**: RBP1 is involved in the visual phototransduction pathway, where it binds retinol and facilitates its transport to the retina, where it is converted into retinaldehyde and then rhodopsin. 3. **Immune Function**: RBP1 has been shown to play a role in immune function, particularly in the regulation of immune cell function and the prevention of autoimmune diseases. 4. **Cell Growth and Differentiation**: RBP1 is involved in the regulation of cell growth and differentiation, particularly in the development and maintenance of epithelial tissues. **Clinical Significance** Dysregulation of RBP1 has been implicated in various diseases, including: 1. **Night Blindness**: RBP1 deficiency has been linked to night blindness, a condition characterized by impaired visual function in low light conditions. 2. **Autoimmune Diseases**: RBP1 has been shown to play a role in the regulation of immune cell function, and its dysregulation has been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: RBP1 has been shown to play a role in the regulation of cell growth and differentiation, and its dysregulation has been implicated in various types of cancer, including breast and lung cancer. 4. **Neurodegenerative Diseases**: RBP1 has been shown to play a role in the regulation of neuroinflammation and the prevention of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In conclusion, RBP1 is a crucial protein involved in the transport and metabolism of retinol, a form of vitamin A, in the body. Its dysregulation has been implicated in various diseases, including night blindness, autoimmune diseases, cancer, and neurodegenerative diseases. Further research is needed to fully understand the role of RBP1 in human health and disease.

Genular Protein ID: 3945097525

Symbol: RET1_HUMAN

Name: Retinol-binding protein 1

UniProtKB Accession Codes:

P09455 A8K2Q0 B7Z7A0 E7EWV0 F2Z2F2 Q6FGX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2992469

Title: Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein.

PubMed ID: 2992469

DOI: 10.1016/0006-291x(85)90435-8

PubMed ID: 3356192

Title: Human cellular retinol-binding protein gene organization and chromosomal location.

PubMed ID: 3356192

DOI: 10.1111/j.1432-1033.1988.tb13963.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2856408

Title: Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression.

PubMed ID: 2856408

DOI: 10.1210/mend-1-8-526

PubMed ID: 11274389

Title: Identification, retinoid binding and X-ray analysis of a human retinol-binding protein.

PubMed ID: 11274389

DOI: 10.1073/pnas.061455898

PubMed ID: 15632377

Title: Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity.

PubMed ID: 15632377

DOI: 10.1093/jnci/dji004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22665496

Title: Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6.

PubMed ID: 22665496

DOI: 10.1128/mcb.00505-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26900151

Title: Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures.

PubMed ID: 26900151

DOI: 10.1074/jbc.m116.714535

PubMed ID: 28057518

Title: Structural and molecular determinants affecting the interaction of retinol with human CRBP1.

PubMed ID: 28057518

DOI: 10.1016/j.jsb.2016.12.012

Sequence Information:

  • Length: 135
  • Mass: 15850
  • Checksum: FA47545761AFA3A2
  • Sequence:
    • MPVDFTGYWK MLVNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN 
YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM 
RVEGVVCKQV FKKVQ

Genular Protein ID: 398003152

Symbol: A0A0A0MQT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQT0

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 12 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MANE-Select 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 197
  • Mass: 22310
  • Checksum: D165093F93065BFA
  • Sequence:
    • MDPPAGFVRA GNPAVAAPQS PLSPEGAHFR AAHHPRSTGS RCPGSLQPSR PLVANWLQSL 
PEMPVDFTGY WKMLVNENFE EYLRALDVNV ALRKIANLLK PDKEIVQDGD HMIIRTLSTF 
RNYIMDFQVG KEFEEDLTGI DDRKCMTTVS WDGDKLQCVQ KGEKEGRGWT QWIEGDELHL 
EMRVEGVVCK QVFKKVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.