Details for: ANGPTL4

Gene ID: 51129

Symbol: ANGPTL4

Ensembl ID: ENSG00000167772

Description: angiopoietin like 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.2387
    Cell Significance Index: -23.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.9508
    Cell Significance Index: -23.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.5899
    Cell Significance Index: -19.7400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 25.5928
    Cell Significance Index: 111.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.6862
    Cell Significance Index: -19.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2708
    Cell Significance Index: -23.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8337
    Cell Significance Index: -23.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.2882
    Cell Significance Index: 55.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.1259
    Cell Significance Index: 162.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.9941
    Cell Significance Index: 25.1500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.9197
    Cell Significance Index: 36.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.7246
    Cell Significance Index: 78.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.7234
    Cell Significance Index: 39.5400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.0403
    Cell Significance Index: 28.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8186
    Cell Significance Index: 39.4000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.4605
    Cell Significance Index: 16.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3287
    Cell Significance Index: 23.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2783
    Cell Significance Index: 57.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1303
    Cell Significance Index: 32.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9512
    Cell Significance Index: 5.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9305
    Cell Significance Index: 18.1600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8749
    Cell Significance Index: 5.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7177
    Cell Significance Index: 25.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6348
    Cell Significance Index: 573.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5650
    Cell Significance Index: 26.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5312
    Cell Significance Index: 52.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5278
    Cell Significance Index: 27.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5216
    Cell Significance Index: 36.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4642
    Cell Significance Index: 34.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4137
    Cell Significance Index: 31.7500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4023
    Cell Significance Index: 4.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3238
    Cell Significance Index: 41.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3190
    Cell Significance Index: 5.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3093
    Cell Significance Index: 50.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2743
    Cell Significance Index: 52.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2696
    Cell Significance Index: 53.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2549
    Cell Significance Index: 6.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2346
    Cell Significance Index: 25.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2295
    Cell Significance Index: 41.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1971
    Cell Significance Index: 1.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1869
    Cell Significance Index: 22.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1829
    Cell Significance Index: 80.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1572
    Cell Significance Index: 10.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1410
    Cell Significance Index: 20.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1339
    Cell Significance Index: 8.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1321
    Cell Significance Index: 1.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1247
    Cell Significance Index: 3.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1012
    Cell Significance Index: 4.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0943
    Cell Significance Index: 51.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0863
    Cell Significance Index: 117.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0744
    Cell Significance Index: 2.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0650
    Cell Significance Index: 8.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0598
    Cell Significance Index: 10.2100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0520
    Cell Significance Index: 0.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0397
    Cell Significance Index: 0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0366
    Cell Significance Index: 22.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0351
    Cell Significance Index: 64.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0210
    Cell Significance Index: 2.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0180
    Cell Significance Index: 27.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0024
    Cell Significance Index: 4.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0187
    Cell Significance Index: -0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0253
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0254
    Cell Significance Index: -19.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0287
    Cell Significance Index: -18.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0435
    Cell Significance Index: -15.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0489
    Cell Significance Index: -22.1800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0638
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0772
    Cell Significance Index: -16.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0819
    Cell Significance Index: -16.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0859
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0882
    Cell Significance Index: -10.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1034
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1445
    Cell Significance Index: -16.5500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1659
    Cell Significance Index: -0.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1886
    Cell Significance Index: -11.5600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1956
    Cell Significance Index: -1.2300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2023
    Cell Significance Index: -2.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2261
    Cell Significance Index: -3.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2267
    Cell Significance Index: -23.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2272
    Cell Significance Index: -3.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2628
    Cell Significance Index: -16.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2836
    Cell Significance Index: -22.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2986
    Cell Significance Index: -3.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3287
    Cell Significance Index: -7.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3300
    Cell Significance Index: -22.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3454
    Cell Significance Index: -7.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3609
    Cell Significance Index: -9.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3659
    Cell Significance Index: -9.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3684
    Cell Significance Index: -9.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3791
    Cell Significance Index: -24.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3847
    Cell Significance Index: -21.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4406
    Cell Significance Index: -6.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4501
    Cell Significance Index: -23.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4544
    Cell Significance Index: -11.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5082
    Cell Significance Index: -8.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANGPTL4 is a protein-coding gene that encodes a protein with a short extracellular domain and a long intracellular domain. The protein is characterized by its ability to interact with various cellular components, including cell-cell junctions, lipoprotein lipase, and histone-modifying complexes. ANGPTL4 has been shown to have multiple functions, including: 1. **Negative regulation of lipoprotein lipase activity**: ANGPTL4 inhibits the activity of lipoprotein lipase, an enzyme involved in lipid metabolism. 2. **Regulation of angiogenesis**: ANGPTL4 promotes angiogenesis, the formation of new blood vessels, by interacting with angiopoietin receptors. 3. **Regulation of adipogenesis**: ANGPTL4 inhibits adipogenesis, the process of fat cell formation, by interacting with histone-modifying complexes. 4. **Regulation of cell-cell communication**: ANGPTL4 interacts with cell-cell junctions and regulates cell adhesion and migration. **Pathways and Functions** ANGPTL4 is involved in various biological pathways, including: 1. **Angiogenesis**: ANGPTL4 promotes angiogenesis by interacting with angiopoietin receptors. 2. **Adipogenesis**: ANGPTL4 inhibits adipogenesis by interacting with histone-modifying complexes. 3. **Lipid metabolism**: ANGPTL4 regulates lipid metabolism by inhibiting lipoprotein lipase activity. 4. **Cell-cell communication**: ANGPTL4 regulates cell-cell communication by interacting with cell-cell junctions. 5. **Epigenetic regulation**: ANGPTL4 interacts with histone-modifying complexes to regulate gene expression. **Clinical Significance** Dysregulation of ANGPTL4 has been implicated in various diseases, including: 1. **Metabolic disorders**: ANGPTL4 has been associated with metabolic disorders, such as type 2 diabetes and obesity. 2. **Cardiovascular diseases**: ANGPTL4 has been implicated in cardiovascular diseases, such as atherosclerosis and cardiovascular disease. 3. **Cancer**: ANGPTL4 has been associated with cancer, including breast and colon cancer. 4. **Hypoxia**: ANGPTL4 has been implicated in hypoxia, a condition characterized by low oxygen levels. In conclusion, ANGPTL4 is a multifunctional gene that plays a crucial role in various biological processes, including angiogenesis, adipogenesis, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of ANGPTL4.

Genular Protein ID: 2641640225

Symbol: ANGL4_HUMAN

Name: Angiopoietin-related protein 4

UniProtKB Accession Codes:

Q9BY76 A8MY84 B4E089 D6W670 F5H0I2 Q53HQ6 Q53HU1 Q6UXN0 Q9HBV4 Q9NZU4 Q9Y5B3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 2 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10698685

Title: Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.

PubMed ID: 10698685

DOI: 10.1042/bj3460603

PubMed ID: 10866690

Title: Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.

PubMed ID: 10866690

DOI: 10.1128/mcb.20.14.5343-5349.2000

PubMed ID: 11953136

Title: Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis.

PubMed ID: 11953136

PubMed ID: 14583458

Title: Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.

PubMed ID: 14583458

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12015030

Title: Expression and function of hepatocellular carcinoma-related gene pp1158.

PubMed ID: 12015030

PubMed ID: 17068295

Title: Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton.

PubMed ID: 17068295

DOI: 10.1161/01.res.0000250758.63358.91

PubMed ID: 19270337

Title: Genetic variation in ANGPTL4 provides insights into protein processing and function.

PubMed ID: 19270337

DOI: 10.1074/jbc.m900553200

PubMed ID: 21398697

Title: Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.

PubMed ID: 21398697

DOI: 10.1074/jbc.m110.217638

PubMed ID: 27929370

Title: The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

PubMed ID: 27929370

DOI: 10.7554/elife.20958

PubMed ID: 29899144

Title: A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.

PubMed ID: 29899144

DOI: 10.1073/pnas.1806774115

PubMed ID: 29713054

Title: Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.

PubMed ID: 29713054

DOI: 10.1038/s41598-018-25237-7

PubMed ID: 17322881

Title: Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

PubMed ID: 17322881

DOI: 10.1038/ng1984

PubMed ID: 29899519

Title: Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

PubMed ID: 29899519

DOI: 10.1038/s41467-018-04611-z

Sequence Information:

  • Length: 406
  • Mass: 45214
  • Checksum: 219E56FEB3F602AF
  • Sequence:
    • MSGAPTAGAA LMLCAATAVL LSAQGGPVQS KSPRFASWDE MNVLAHGLLQ LGQGLREHAE 
RTRSQLSALE RRLSACGSAC QGTEGSTDLP LAPESRVDPE VLHSLQTQLK AQNSRIQQLF 
HKVAQQQRHL EKQHLRIQHL QSQFGLLDHK HLDHEVAKPA RRKRLPEMAQ PVDPAHNVSR 
LHRLPRDCQE LFQVGERQSG LFEIQPQGSP PFLVNCKMTS DGGWTVIQRR HDGSVDFNRP 
WEAYKAGFGD PHGEFWLGLE KVHSITGDRN SRLAVQLRDW DGNAELLQFS VHLGGEDTAY 
SLQLTAPVAG QLGATTVPPS GLSVPFSTWD QDHDLRRDKN CAKSLSGGWW FGTCSHSNLN 
GQYFRSIPQQ RQKLKKGIFW KTWRGRYYPL QATTMLIQPM AAEAAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.