Details for: KRT7

Gene ID: 3855

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: KRT7

Ensembl ID: ENSG00000135480

Description: keratin 7

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • extravillous trophoblast CL0008036
    CSI 50.27
    rCSI 62.19%
    PRS 93
  • epithelial cell of lower respiratory tract CL0002632
    CSI 49.87
    rCSI 38.66%
    PRS 95.99
  • duct epithelial cell CL0000068
    CSI 47.66
    rCSI 69.72%
    PRS 96.56
  • ionocyte CL0005006
    CSI 42.92
    rCSI 46%
    PRS 95.15
  • nasal mucosa goblet cell CL0002480
    CSI 42.79
    rCSI 49.63%
    PRS 94.18
  • fallopian tube secretory epithelial cell CL4030006
    CSI 39.83
    rCSI 38.34%
    PRS 93.14
  • pulmonary ionocyte CL0017000
    CSI 35.49
    rCSI 43.21%
    PRS 96.39
  • secretory cell CL0000151
    CSI 30.61
    rCSI 31.94%
    PRS 93.61
  • placental villous trophoblast CL2000060
    CSI 28.31
    rCSI 43.75%
    PRS 92.8
  • tracheal goblet cell CL1000329
    CSI 27
    rCSI 58.95%
    PRS 95.37
  • club cell CL0000158
    CSI 26.13
    rCSI 38.28%
    PRS 91.33
  • mucus secreting cell CL0000319
    CSI 25.13
    rCSI 39.91%
    PRS 97.05
  • luminal epithelial cell of mammary gland CL0002326
    CSI 24.8
    rCSI 45.05%
    PRS 96.97
  • intrahepatic cholangiocyte CL0002538
    CSI 23.21
    rCSI 55.69%
    PRS 93.97
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 21.89
    rCSI 41.38%
    PRS 97.47
  • pancreatic ductal cell CL0002079
    CSI 20.24
    rCSI 39.36%
    PRS 95.13
  • squamous epithelial cell CL0000076
    CSI 18
    rCSI 42.73%
    PRS 91.14
  • mammary gland epithelial cell CL0002327
    CSI 17.83
    rCSI 62.58%
    PRS 96.74
  • stem cell CL0000034
    CSI 17.55
    rCSI 16.92%
    PRS 91.8
  • epithelial cell CL0000066
    CSI 16.99
    rCSI 26.1%
    PRS 84
  • acinar cell CL0000622
    CSI 16.49
    rCSI 24.18%
    PRS 97.28
  • pancreatic acinar cell CL0002064
    CSI 15.75
    rCSI 20.93%
    PRS 95.98
  • multi-ciliated epithelial cell CL0005012
    CSI 15.54
    rCSI 15.51%
    PRS 89.85
  • intestine goblet cell CL0019031
    CSI 15.39
    rCSI 13.66%
    PRS 92.55
  • respiratory suprabasal cell CL4033048
    CSI 15.26
    rCSI 19.58%
    PRS 95.35
  • lung ciliated cell CL1000271
    CSI 14.73
    rCSI 17.04%
    PRS 90.25
  • syncytiotrophoblast cell CL0000525
    CSI 14.54
    rCSI 41.88%
    PRS 94.47
  • conjunctival epithelial cell CL1000432
    CSI 14.18
    rCSI 21.66%
    PRS 93.43
  • epithelial cell of lung CL0000082
    CSI 14.1
    rCSI 11.69%
    PRS 95.28
  • brush cell of tracheobronchial tree CL0002075
    CSI 13.95
    rCSI 41.4%
    PRS 97.5
  • lung neuroendocrine cell CL1000223
    CSI 13.88
    rCSI 20.54%
    PRS 94.85
  • myoepithelial cell CL0000185
    CSI 13.62
    rCSI 34.46%
    PRS 95.75
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 13.56
    rCSI 19.22%
    PRS 93.03
  • respiratory basal cell CL0002633
    CSI 13.46
    rCSI 13.94%
    PRS 95.46
  • glandular epithelial cell CL0000150
    CSI 12.81
    rCSI 33.74%
    PRS 98.13
  • epithelial cell of proximal tubule CL0002306
    CSI 12.76
    rCSI 31.17%
    PRS 89.53
  • bronchial goblet cell CL1000312
    CSI 12.59
    rCSI 50.32%
    PRS 96.29
  • basal cell CL0000646
    CSI 12.21
    rCSI 16.32%
    PRS 92.02
  • pulmonary alveolar type 2 cell CL0002063
    CSI 12.2
    rCSI 18.92%
    PRS 94.64
  • renal beta-intercalated cell CL0002201
    CSI 12.12
    rCSI 28.89%
    PRS 94.73
  • ciliated cell CL0000064
    CSI 11.93
    rCSI 19.34%
    PRS 89.15
  • fibroblast of lung CL0002553
    CSI 11.53
    rCSI 10.73%
    PRS 95.48
  • enteroendocrine cell CL0000164
    CSI 11.25
    rCSI 15.38%
    PRS 92.41
  • kidney epithelial cell CL0002518
    CSI 11.11
    rCSI 21.21%
    PRS 98.52
  • goblet cell CL0000160
    CSI 10.7
    rCSI 10.11%
    PRS 92.46
  • lung secretory cell CL1000272
    CSI 9.82
    rCSI 24.3%
    PRS 95.57
  • vascular associated smooth muscle cell CL0000359
    CSI 9.29
    rCSI 30.13%
    PRS 93.2
  • serous secreting cell CL0000313
    CSI 9.23
    rCSI 46.68%
    PRS 96.29
  • basal cell of epidermis CL0002187
    CSI 8.99
    rCSI 15.93%
    PRS 69.7
  • dendritic cell CL0000451
    CSI 8.66
    rCSI 10.67%
    PRS 93.56
  • respiratory hillock cell CL4030023
    CSI 8.54
    rCSI 15.23%
    PRS 96.38
  • mucous neck cell CL0000651
    CSI 8.39
    rCSI 12.1%
    PRS 96.03
  • intestinal tuft cell CL0019032
    CSI 8.22
    rCSI 12.56%
    PRS 95.17
  • enterocyte CL0000584
    CSI 7.89
    rCSI 12.72%
    PRS 91.64
  • myofibroblast cell CL0000186
    CSI 7.6
    rCSI 10.53%
    PRS 92.05
  • mononuclear phagocyte CL0000113
    CSI 7.46
    rCSI 16.42%
    PRS 96.21
  • deuterosomal cell CL4033044
    CSI 6.58
    rCSI 22.25%
    PRS 89.28
  • tracheobronchial serous cell CL0019001
    CSI 6.47
    rCSI 27.96%
    PRS 95.88
  • kidney collecting duct intercalated cell CL1001432
    CSI 6.38
    rCSI 45.54%
    PRS 91.13
  • fibroblast of breast CL4006000
    CSI 6.28
    rCSI 26.4%
    PRS 96.08
  • alternatively activated macrophage CL0000890
    CSI 6.01
    rCSI 7.55%
    PRS 97.86
  • pulmonary alveolar type 1 cell CL0002062
    CSI 5.67
    rCSI 32.69%
    PRS 92.22
  • respiratory goblet cell CL0002370
    CSI 5.55
    rCSI 60.39%
    PRS 96.09
  • foveolar cell of stomach CL0002179
    CSI 5.32
    rCSI 11.32%
    PRS 95.51
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 5.2
    rCSI 11.85%
    PRS 88.44
  • airway submucosal gland duct basal cell CL4033024
    CSI 5.15
    rCSI 32.94%
    PRS 95
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 4.85
    rCSI 5.07%
    PRS 97.86
  • lung goblet cell CL1000143
    CSI 4.78
    rCSI 53.39%
    PRS 96.38
  • basal cell of epithelium of trachea CL1000348
    CSI 4.47
    rCSI 31.58%
    PRS 94.57
  • ciliated epithelial cell CL0000067
    CSI 4.47
    rCSI 3.93%
    PRS 87.64
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.33
    rCSI 11.18%
    PRS 92.76
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.64
    rCSI 31.44%
    PRS 90.26
  • M cell of gut CL0000682
    CSI 3.55
    rCSI 3.77%
    PRS 95.37
  • pericyte CL0000669
    CSI 3.22
    rCSI 8.58%
    PRS 74.52
  • cholangiocyte CL1000488
    CSI 3.08
    rCSI 18.43%
    PRS 93.29
  • blood vessel endothelial cell CL0000071
    CSI 2.24
    rCSI 4.66%
    PRS 93.16
  • Hofbauer cell CL3000001
    CSI 2.1
    rCSI 3.97%
    PRS 97.26
  • basal cell of prostate epithelium CL0002341
    CSI 2.05
    rCSI 5.94%
    PRS 95.78
  • colon epithelial cell CL0011108
    CSI 1.86
    rCSI 1.94%
    PRS 92.5
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 1.48
    rCSI 8.44%
    PRS 94.67
  • stratified epithelial cell CL0000079
    CSI 1.37
    rCSI 8.44%
    PRS 95.5
  • neuroendocrine cell CL0000165
    CSI 1.25
    rCSI 4.83%
    PRS 95.52
  • luminal cell of prostate epithelium CL0002340
    CSI 1.04
    rCSI 5.6%
    PRS 96.7
  • epithelial cell of urethra CL1000296
    CSI 1.02
    rCSI 25.64%
    PRS 95.51
  • respiratory epithelial cell CL0002368
    CSI 0.86
    rCSI 5.34%
    PRS 98.85
  • tracheobronchial goblet cell CL0019003
    CSI 0.45
    rCSI 7.28%
    PRS 93.85
  • epithelial cell of esophagus CL0002252
    CSI 0.41
    rCSI 4.03%
    PRS 92.38

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [KRT7](/details-gene/3855), or Keratin 7, is a protein-coding gene located on chromosome 12q13.13 that encodes a type II intermediate filament protein. As a fundamental component of the cytoskeleton, [KRT7](/details-gene/3855) provides mechanical stability and structural integrity to simple or single-layered epithelial tissues. Its expression is a hallmark of various specialized epithelial cell types, particularly those involved in secretory, transport, and barrier functions. Notably, [KRT7](/details-gene/3855) is highly expressed in trophoblasts of the placenta, epithelial cells of the respiratory and reproductive tracts, and ductal epithelia of glands. This specific expression pattern makes it a crucial biomarker in pathology, often used in immunohistochemistry to determine the origin of metastatic carcinomas. Mutations or dysregulation of [KRT7](/details-gene/3855) are associated with disorders of epithelial tissues, and its clinical relevance is noted in OMIM ([148059](https://omim.org/entry/148059)). ## Cellular Roles and Expression Landscape The expression profile of [KRT7](/details-gene/3855) underscores its role as a key structural protein in a specific subset of epithelial cells, often those lining internal organs and glands, as opposed to stratified epithelia like the skin. **Overall**, the gene shows the highest significance in cell types critical for maternal-fetal interaction and respiratory function. Its most significant expression is observed in [extravillous trophoblast](/details-cell/CL0008036) (CSI: 50.27) and [placental villous trophoblast](/details-cell/CL2000060) (CSI: 28.31), suggesting a vital role in placental development and function. Concurrently, it is a dominant marker in the respiratory system, with very high significance in [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 49.87), [ionocyte](/details-cell/CL0005006) (CSI: 42.92), [nasal mucosa goblet cell](/details-cell/CL0002480) (CSI: 42.79), [pulmonary ionocyte](/details-cell/CL0017000) (CSI: 35.49), and [club cell](/details-cell/CL0000158) (CSI: 26.13). This pattern highlights its contribution to maintaining the structural integrity and barrier function of the airways. Furthermore, [KRT7](/details-gene/3855) is a defining feature of various secretory and ductal epithelial tissues. This is evidenced by its high CSI scores in [duct epithelial cell](/details-cell/CL0000068) (CSI: 47.66), [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 39.83), [luminal epithelial cell of mammary gland](/details-cell/CL0002326) (CSI: 24.80), and [intrahepatic cholangiocyte](/details-cell/CL0002538) (CSI: 23.21). The consistent high expression across these functionally diverse yet histologically related cell types solidifies its identity as a cornerstone protein of simple and glandular epithelia, a finding established in early research on the gene's expression patterns ([Link](https://pubmed.ncbi.nlm.nih.gov/2459129/)). ## Pathways and Molecular Function The molecular functions of [KRT7](/details-gene/3855) are intrinsically linked to its role as a cytoskeletal building block. Gene Ontology annotations confirm its involvement in [Intermediate filament organization](/details-go/GO:0045109) and the formation of the [keratin filament](/details-go/GO:0045095) network within the [cytoplasm](/details-go/GO:0005737). This network is essential for providing cells with resilience against mechanical stress. The Reactome pathway annotations further elaborate on this structural role, placing [KRT7](/details-gene/3855) in the context of [Keratinization](/details-pathway/R-HSA-6805567) and the [Formation of the cornified envelope](/details-pathway/R-HSA-6809371). While classically associated with skin, these pathways also represent the broader processes of epithelial differentiation and barrier formation in which [KRT7](/details-gene/3855) participates in simple epithelia. Its contribution to [Developmental biology](/details-pathway/R-HSA-1266738) is consistent with its high expression in trophoblasts, which are crucial for embryonic implantation and placental development. Beyond its structural function, [KRT7](/details-gene/3855) is implicated in cellular signaling through [protein binding](/details-go/GO:0005515) interactions, such as its association with the G protein-coupled estrogen receptor GPER1 ([Link](https://doi.org/10.1124/mol.110.069500)) and components of the translation initiation complex ([Link](https://doi.org/10.1002/1097-4644(20010315)80:4%3C483::aid-jcb1002%3E3.0.co;2-b)), suggesting it may serve as a scaffold for organizing signaling and regulatory hubs. ## Research Directions The well-established role of [KRT7](/details-gene/3855) as a lineage marker in pathology provides a strong foundation for investigating its functional contributions to disease states, particularly in cancer and respiratory illnesses. ### Proposed Hypotheses: 1. **Role in Trophoblast Invasion:** Given its exceptionally high significance in [extravillous trophoblast](/details-cell/CL0008036), [KRT7](/details-gene/3855) may not only provide structural support but also actively regulate the invasive properties of these cells during placental implantation. Its intermediate filament network could act as a scaffold for proteins involved in cell migration and matrix remodeling. 2. **Modulation of Ion Transport in Airways:** The co-expression of [KRT7](/details-gene/3855) in specialized [ionocyte](/details-cell/CL0005006) populations suggests a potential role in organizing or stabilizing ion transport complexes, such as CFTR, at the cell membrane. Dysregulation of the [KRT7](/details-gene/3855) cytoskeleton could therefore contribute to the pathophysiology of diseases like cystic fibrosis by compromising ionocyte function. 3. **Chemoresistance in Carcinomas:** In cancers derived from [KRT7](/details-gene/3855)-positive tissues (e.g., ovarian, lung, breast adenocarcinoma), the keratin network may confer resistance to chemotherapy-induced apoptosis by sequestering signaling molecules or reinforcing cellular structure against drug-induced stress. ### Experimental Approach: To test the hypothesis that **[KRT7](/details-gene/3855) modulates ion transport in airway epithelia**, one could perform a CRISPR-Cas9-mediated knockout of [KRT7](/details-gene/3855) in primary human bronchial epithelial cells cultured at an air-liquid interface to form a polarized epithelium. The functional consequences would be assessed using Ussing chamber electrophysiology to measure chloride and sodium ion transport. Furthermore, co-immunoprecipitation followed by mass spectrometry could identify binding partners of [KRT7](/details-gene/3855) in pulmonary [ionocytes](/details-cell/CL0017000) to determine if it directly associates with ion channels or their regulators. Confocal microscopy could be used to visualize any changes in the subcellular localization of key transporters like CFTR in the absence of [KRT7](/details-gene/3855). ### Therapeutic Potential: As an intracellular structural protein, [KRT7](/details-gene/3855) is not a conventional direct drug target for inhibition or activation via small molecules or antibodies. Its primary therapeutic value lies in its role as a diagnostic and prognostic biomarker. For example, the presence or absence of [KRT7](/details-gene/3855) is routinely used to classify tumors of unknown primary origin, guiding treatment decisions. However, if the keratin cytoskeleton's role in chemoresistance is confirmed, strategies aimed at disrupting the [KRT7](/details-gene/3855) network could represent a novel chemosensitization approach. This might involve developing small molecules that interfere with keratin polymerization or its interaction with signaling proteins, thereby rendering cancer cells more vulnerable to standard therapies.

Genular Protein ID: 2192291723

Symbol: K2C7_HUMAN

Name: Keratin, type II cytoskeletal 7

UniProtKB Accession Codes:

P08729 Q92676 Q9BUD8 Q9Y3R7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 6 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 17 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2415537

Title: Sequence and expression of a human type II mesothelial keratin.

PubMed ID: 2415537

DOI: 10.1083/jcb.101.6.2366

PubMed ID: 2459129

Title: Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.

PubMed ID: 2459129

DOI: 10.1083/jcb.107.4.1337

PubMed ID: 10492017

Title: Sarcolectin (SCL): structure and expression of the recombinant molecule.

PubMed ID: 10492017

DOI: 10.1016/s0300-9084(99)80128-x

PubMed ID: 12359226

Title: Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse.

PubMed ID: 12359226

DOI: 10.1016/s0006-291x(02)02288-x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169732

Title: Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.

PubMed ID: 11169732

DOI: 10.1002/1097-4644(20010315)80:4<483::aid-jcb1002>3.0.co;2-b

PubMed ID: 12072504

Title: Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7.

PubMed ID: 12072504

DOI: 10.1128/jvi.76.14.7040-7048.2002

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21149639

Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

PubMed ID: 21149639

DOI: 10.1124/mol.110.069500

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 26237509

Title: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

PubMed ID: 26237509

DOI: 10.1038/nsmb.3063

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 469
  • Mass: 51386
  • Checksum: 070CBE8F66A62497
  • Sequence:
    • MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG 
AGIREVTINQ SLLAPLRLDA DPSLQRVRQE ESEQIKTLNN KFASFIDKVR FLEQQNKLLE 
TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG QLEALQVDGG RLEAELRSMQ DVVEDFKNKY 
EDEINHRTAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI 
SDTSVVLSMD NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD 
LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA 
LQRGKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVMNSTG 
GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG LLKAYSIRTA SASRRSARD