Details for: KRT7

Gene ID: 3855

Symbol: KRT7

Ensembl ID: ENSG00000135480

Description: keratin 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.85
    Marker Score: 5843
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.65
    Marker Score: 6665
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.41
    Marker Score: 16740
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.28
    Marker Score: 2585
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.16
    Marker Score: 1000
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.1
    Marker Score: 1529
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.03
    Marker Score: 15935.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.02
    Marker Score: 2018
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.96
    Marker Score: 6736
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.91
    Marker Score: 1359
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.78
    Marker Score: 4933
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.75
    Marker Score: 10618
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.7
    Marker Score: 960.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 2.66
    Marker Score: 1746
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.64
    Marker Score: 1797
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.51
    Marker Score: 3699.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.42
    Marker Score: 1894
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.41
    Marker Score: 695
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.35
    Marker Score: 9237
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.34
    Marker Score: 2084
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.33
    Marker Score: 80743
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.14
    Marker Score: 5223
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.13
    Marker Score: 15861
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.1
    Marker Score: 2448
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.07
    Marker Score: 27792
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.05
    Marker Score: 919
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.05
    Marker Score: 1769.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.95
    Marker Score: 394
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.92
    Marker Score: 30871
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.89
    Marker Score: 5064
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.84
    Marker Score: 12007
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.79
    Marker Score: 1856
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.74
    Marker Score: 443
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.73
    Marker Score: 1203
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.69
    Marker Score: 673
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.66
    Marker Score: 1688
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.65
    Marker Score: 2619
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.64
    Marker Score: 1726
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.54
    Marker Score: 2481
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.51
    Marker Score: 365
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.47
    Marker Score: 3695
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 833
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.43
    Marker Score: 787
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.42
    Marker Score: 733
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.42
    Marker Score: 1164
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.41
    Marker Score: 4999
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.37
    Marker Score: 1217
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.32
    Marker Score: 419
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3
    Marker Score: 2192
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.22
    Marker Score: 751
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.11
    Marker Score: 2108
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.1
    Marker Score: 6997
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.08
    Marker Score: 312
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.06
    Marker Score: 1761
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.02
    Marker Score: 8874
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1
    Marker Score: 1646
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.99
    Marker Score: 1405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.98
    Marker Score: 192
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.98
    Marker Score: 268
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5102
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.88
    Marker Score: 1857
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 661
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.85
    Marker Score: 274
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.83
    Marker Score: 7036
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.8
    Marker Score: 6922
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.8
    Marker Score: 242
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.78
    Marker Score: 553
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 838
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.75
    Marker Score: 666
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.72
    Marker Score: 1645
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.72
    Marker Score: 926
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.71
    Marker Score: 261
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2963
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2401
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.69
    Marker Score: 168296
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 254
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.64
    Marker Score: 267
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.63
    Marker Score: 326.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.63
    Marker Score: 335
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.63
    Marker Score: 175
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 412
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1138
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.6
    Marker Score: 635
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.58
    Marker Score: 383

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Other Information

**Key characteristics:** - KRT7 is a keratin protein, which are a family of structural proteins that are essential for the integrity of cell membranes and the maintenance of tissue structure. - It is a secreted protein, meaning that it is produced and released by cells and is not located within the cell itself. - It is a transmembrane protein, meaning that it has both extracellular and intracellular domains. - It is a key component of the cornified envelope, a specialized structure that protects the skin from environmental damage. - It is also involved in the intermediate filament, a cytoskeletal network that provides structural support for cells. **Pathways and functions:** - KRT7 is involved in the formation of the cornified envelope, a specialized structure that protects the skin from environmental damage. - It is also involved in the maintenance of tissue structure and integrity. - It is involved in the organization and stability of the intermediate filament, a cytoskeletal network that provides structural support for cells. **Clinical significance:** - Mutations in the KRT7 gene have been linked to several skin conditions, including ichthyosis, psoriasis, and eczema. - These mutations can lead to the formation of holes in the skin, which can be painful and disfiguring. - Understanding the role of KRT7 in skin biology has potential applications for the development of new treatments for skin diseases.

Genular Protein ID: 2192291723

Symbol: K2C7_HUMAN

Name: Keratin, type II cytoskeletal 7

UniProtKB Accession Codes:

P08729 Q92676 Q9BUD8 Q9Y3R7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 6 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 17 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2415537

Title: Sequence and expression of a human type II mesothelial keratin.

PubMed ID: 2415537

DOI: 10.1083/jcb.101.6.2366

PubMed ID: 2459129

Title: Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.

PubMed ID: 2459129

DOI: 10.1083/jcb.107.4.1337

PubMed ID: 10492017

Title: Sarcolectin (SCL): structure and expression of the recombinant molecule.

PubMed ID: 10492017

DOI: 10.1016/s0300-9084(99)80128-x

PubMed ID: 12359226

Title: Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse.

PubMed ID: 12359226

DOI: 10.1016/s0006-291x(02)02288-x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169732

Title: Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.

PubMed ID: 11169732

DOI: 10.1002/1097-4644(20010315)80:4<483::aid-jcb1002>3.0.co;2-b

PubMed ID: 12072504

Title: Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7.

PubMed ID: 12072504

DOI: 10.1128/jvi.76.14.7040-7048.2002

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21149639

Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

PubMed ID: 21149639

DOI: 10.1124/mol.110.069500

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 469
  • Mass: 51386
  • Checksum: 070CBE8F66A62497
  • Sequence:
    • MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG 
AGIREVTINQ SLLAPLRLDA DPSLQRVRQE ESEQIKTLNN KFASFIDKVR FLEQQNKLLE 
TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG QLEALQVDGG RLEAELRSMQ DVVEDFKNKY 
EDEINHRTAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI 
SDTSVVLSMD NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD 
LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA 
LQRGKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVMNSTG 
GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG LLKAYSIRTA SASRRSARD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.