Details for: TFPI2

Gene ID: 7980

Symbol: TFPI2

Ensembl ID: ENSG00000105825

Description: tissue factor pathway inhibitor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 37.5048
    Cell Significance Index: -15.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.3812
    Cell Significance Index: -15.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 8.5951
    Cell Significance Index: 51.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 5.1269
    Cell Significance Index: 323.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.4259
    Cell Significance Index: 120.4700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.1386
    Cell Significance Index: 25.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.4449
    Cell Significance Index: 211.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.4184
    Cell Significance Index: 56.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.3765
    Cell Significance Index: 40.2500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.8884
    Cell Significance Index: 10.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7695
    Cell Significance Index: 60.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2716
    Cell Significance Index: 72.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2473
    Cell Significance Index: 51.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9887
    Cell Significance Index: 53.1000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.6868
    Cell Significance Index: 14.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3030
    Cell Significance Index: 59.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2048
    Cell Significance Index: 34.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0841
    Cell Significance Index: 19.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0550
    Cell Significance Index: 200.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8388
    Cell Significance Index: 97.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6478
    Cell Significance Index: 353.7800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6469
    Cell Significance Index: 5.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5535
    Cell Significance Index: 54.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5277
    Cell Significance Index: 27.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5174
    Cell Significance Index: 467.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5021
    Cell Significance Index: 945.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4305
    Cell Significance Index: 11.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3988
    Cell Significance Index: 6.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3197
    Cell Significance Index: 43.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3136
    Cell Significance Index: 51.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3055
    Cell Significance Index: 33.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3017
    Cell Significance Index: 6.4300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2436
    Cell Significance Index: 3.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2155
    Cell Significance Index: 12.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1906
    Cell Significance Index: 32.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1689
    Cell Significance Index: 19.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1664
    Cell Significance Index: 20.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1562
    Cell Significance Index: 10.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1435
    Cell Significance Index: 1.1700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1247
    Cell Significance Index: 1.1900
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1101
    Cell Significance Index: 0.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0873
    Cell Significance Index: 4.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0792
    Cell Significance Index: 50.3100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0453
    Cell Significance Index: 0.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0441
    Cell Significance Index: 3.2900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0291
    Cell Significance Index: 0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0181
    Cell Significance Index: 2.6300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0174
    Cell Significance Index: 0.1900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0069
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0085
    Cell Significance Index: -3.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0091
    Cell Significance Index: -16.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0102
    Cell Significance Index: -1.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0126
    Cell Significance Index: -5.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0128
    Cell Significance Index: -1.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0163
    Cell Significance Index: -2.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0245
    Cell Significance Index: -5.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0411
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0513
    Cell Significance Index: -14.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0534
    Cell Significance Index: -6.1000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0634
    Cell Significance Index: -0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0679
    Cell Significance Index: -13.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0763
    Cell Significance Index: -15.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0782
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0827
    Cell Significance Index: -8.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0869
    Cell Significance Index: -1.8200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0942
    Cell Significance Index: -1.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0996
    Cell Significance Index: -0.8000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1045
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1077
    Cell Significance Index: -5.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1090
    Cell Significance Index: -5.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1094
    Cell Significance Index: -4.4800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1242
    Cell Significance Index: -1.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1415
    Cell Significance Index: -10.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1417
    Cell Significance Index: -16.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1461
    Cell Significance Index: -3.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1872
    Cell Significance Index: -14.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1994
    Cell Significance Index: -15.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2243
    Cell Significance Index: -15.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2289
    Cell Significance Index: -3.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2662
    Cell Significance Index: -16.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2713
    Cell Significance Index: -12.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2727
    Cell Significance Index: -7.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2835
    Cell Significance Index: -15.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2876
    Cell Significance Index: -15.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3017
    Cell Significance Index: -4.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3270
    Cell Significance Index: -3.7200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3324
    Cell Significance Index: -2.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3351
    Cell Significance Index: -5.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFPI2 exhibits distinct characteristics that set it apart from other serine protease inhibitors. Its primary function is to inhibit the activity of thrombin, a key enzyme in the coagulation cascade, thereby preventing excessive clot formation. TFPI2 also possesses a broad substrate specificity, allowing it to inhibit other serine proteases involved in cellular processes such as proteolysis and cell signaling. Additionally, TFPI2's expression is tightly regulated by various cellular pathways, including the TGF-β and Notch signaling networks, which underscores its complex role in cellular homeostasis. **Pathways and Functions:** TFPI2's involvement in multiple cellular pathways highlights its multifaceted role in maintaining tissue homeostasis. The TFPI2's primary function in regulating blood coagulation is mediated through its inhibition of the tissue factor pathway, which is a critical step in the coagulation cascade. By preventing excessive thrombin generation, TFPI2 helps to maintain vascular homeostasis and prevent thrombotic events. Furthermore, TFPI2's inhibition of serine proteases involved in cellular processes such as proteolysis and cell signaling underscores its role in regulating cellular homeostasis and preventing tissue damage. In addition to its role in blood coagulation, TFPI2 has been implicated in various cellular processes, including: * Cellular response to fluid shear stress: TFPI2's expression is upregulated in response to fluid shear stress, indicating its role in regulating cellular response to mechanical forces. * Extracellular matrix dynamics: TFPI2's inhibition of serine proteases involved in ECM remodeling underscores its role in regulating ECM dynamics and tissue homeostasis. * Serine-type endopeptidase inhibitor activity: TFPI2's ability to inhibit serine proteases involved in cellular processes such as proteolysis and cell signaling highlights its role in regulating cellular homeostasis. **Clinical Significance:** TFPI2's role in regulating blood coagulation and cellular homeostasis makes it an essential component in the development of novel therapeutic strategies for cardiovascular diseases, such as atherosclerosis and thrombosis. Aberrant TFPI2 expression has been implicated in various disease states, including cancer, where it may contribute to tumorigenesis and metastasis. Furthermore, TFPI2's role in regulating cellular homeostasis underscores its potential as a therapeutic target in diseases characterized by tissue damage and remodeling, such as fibrosis and arthritis. In conclusion, TFPI2 is a critical regulator of blood coagulation and cellular homeostasis, with implications for the development of novel therapeutic strategies for cardiovascular diseases and cancer. Further studies are needed to fully elucidate TFPI2's role in various disease states and to explore its potential as a therapeutic target.

Genular Protein ID: 2240056565

Symbol: TFPI2_HUMAN

Name: Tissue factor pathway inhibitor 2

UniProtKB Accession Codes:

P48307 Q66ME8 Q8NAK6 Q9UC86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7896752

Title: cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2.

PubMed ID: 7896752

DOI: 10.1093/oxfordjournals.jbchem.a124648

PubMed ID: 8159751

Title: Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.

PubMed ID: 8159751

DOI: 10.1073/pnas.91.8.3353

PubMed ID: 11342222

Title: Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene.

PubMed ID: 11342222

DOI: 10.1016/s0167-4781(00)00298-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7872799

Title: Novel extracellular matrix-associated serine proteinase inhibitors from human skin fibroblasts.

PubMed ID: 7872799

DOI: 10.1006/abbi.1995.1168

PubMed ID: 3276312

Title: Purification and characterization of placental protein 5.

PubMed ID: 3276312

DOI: 10.1016/0006-291x(88)90546-3

PubMed ID: 15932872

Title: Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition.

PubMed ID: 15932872

DOI: 10.1074/jbc.m504105200

PubMed ID: 24333728

Title: Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

PubMed ID: 24333728

DOI: 10.1016/j.canlet.2013.12.007

Sequence Information:

  • Length: 235
  • Mass: 26934
  • Checksum: 975ABA5C53F7C65F
  • Sequence:
    • MDPARPLGLS ILLLFLTEAA LGDAAQEPTG NNAEICLLPL DYGPCRALLL RYYYDRYTQS 
CRQFLYGGCE GNANNFYTWE ACDDACWRIE KVPKVCRLQV SVDDQCEGST EKYFFNLSSM 
TCEKFFSGGC HRNRIENRFP DEATCMGFCA PKKIPSFCYS PKDEGLCSAN VTRYYFNPRY 
RTCDAFTYTG CGGNDNNFVS REDCKRACAK ALKKKKKMPK LRFASRIRKI RKKQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.