Details for: DSG3

Gene ID: 1830

Symbol: DSG3

Ensembl ID: ENSG00000134757

Description: desmoglein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 11.6677
    Cell Significance Index: 34.7000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 7.7357
    Cell Significance Index: 17.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 5.7263
    Cell Significance Index: 160.0300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.5336
    Cell Significance Index: 47.5500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 4.1737
    Cell Significance Index: 5.4000
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 3.8631
    Cell Significance Index: 27.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 3.3804
    Cell Significance Index: 48.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 3.3784
    Cell Significance Index: 51.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5492
    Cell Significance Index: 34.7800
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.8552
    Cell Significance Index: 14.2700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8077
    Cell Significance Index: 14.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3547
    Cell Significance Index: 257.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9652
    Cell Significance Index: 426.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8727
    Cell Significance Index: -1.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8573
    Cell Significance Index: 51.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8361
    Cell Significance Index: 82.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6802
    Cell Significance Index: 10.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6723
    Cell Significance Index: 73.1300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.6439
    Cell Significance Index: 3.9900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5938
    Cell Significance Index: 5.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5816
    Cell Significance Index: 525.1800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.5618
    Cell Significance Index: 4.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4841
    Cell Significance Index: 7.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4679
    Cell Significance Index: 76.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4613
    Cell Significance Index: 13.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3505
    Cell Significance Index: 63.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3496
    Cell Significance Index: 24.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3460
    Cell Significance Index: 8.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2335
    Cell Significance Index: 2.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2174
    Cell Significance Index: 4.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2023
    Cell Significance Index: 14.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1504
    Cell Significance Index: 3.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0429
    Cell Significance Index: 2.2300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0283
    Cell Significance Index: 0.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0228
    Cell Significance Index: 2.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0214
    Cell Significance Index: 0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0203
    Cell Significance Index: 0.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0184
    Cell Significance Index: 1.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0088
    Cell Significance Index: 0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0048
    Cell Significance Index: 0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0016
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0030
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0041
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0046
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0051
    Cell Significance Index: -0.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0064
    Cell Significance Index: -3.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0081
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0087
    Cell Significance Index: -0.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0106
    Cell Significance Index: -0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0106
    Cell Significance Index: -2.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0137
    Cell Significance Index: -3.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0188
    Cell Significance Index: -3.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0189
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0192
    Cell Significance Index: -1.1800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0208
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0209
    Cell Significance Index: -3.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0233
    Cell Significance Index: -0.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0267
    Cell Significance Index: -2.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0307
    Cell Significance Index: -3.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0307
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0335
    Cell Significance Index: -3.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0351
    Cell Significance Index: -3.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0407
    Cell Significance Index: -3.0300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0422
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0433
    Cell Significance Index: -2.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0444
    Cell Significance Index: -1.6300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0487
    Cell Significance Index: -0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0546
    Cell Significance Index: -2.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0557
    Cell Significance Index: -2.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0561
    Cell Significance Index: -3.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0577
    Cell Significance Index: -4.4300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0599
    Cell Significance Index: -0.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0603
    Cell Significance Index: -1.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0656
    Cell Significance Index: -3.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0679
    Cell Significance Index: -1.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0691
    Cell Significance Index: -2.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0705
    Cell Significance Index: -1.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0711
    Cell Significance Index: -1.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0724
    Cell Significance Index: -3.8000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0732
    Cell Significance Index: -0.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0786
    Cell Significance Index: -4.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0799
    Cell Significance Index: -2.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0799
    Cell Significance Index: -2.1400
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0824
    Cell Significance Index: -0.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0866
    Cell Significance Index: -1.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0879
    Cell Significance Index: -1.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: DSG3 is a type II transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. 2. **Homophilic cell adhesion**: DSG3 exhibits homophilic cell adhesion properties, meaning it interacts with itself to mediate cell-cell adhesion. 3. **Calcium ion binding**: The extracellular domain of DSG3 binds to calcium ions, which is essential for its function in cell-cell adhesion. 4. **Stratified epithelial cell expression**: DSG3 is predominantly expressed in stratified epithelial cells, including those found in the skin, esophagus, and tracheobronchial tree. **Pathways and Functions:** 1. **Cell-cell adhesion**: DSG3 mediates cell-cell adhesion by interacting with other desmogleins and cadherins, thereby maintaining tissue integrity. 2. **Epithelial homeostasis**: DSG3 plays a crucial role in maintaining epithelial homeostasis by regulating cell proliferation, differentiation, and survival. 3. **Apoptotic regulation**: DSG3 has been implicated in the regulation of programmed cell death (apoptosis), particularly in response to tissue damage or stress. 4. **Cornified envelope formation**: DSG3 is involved in the formation of the cornified envelope, a critical structure in the skin that provides mechanical strength and resistance to water loss. **Clinical Significance:** 1. **Pemphigus vulgaris**: DSG3 is a target antigen in pemphigus vulgaris, an autoimmune disease characterized by blistering of the skin and mucous membranes. 2. **Autoimmune disorders**: Dysregulation of DSG3 expression has been implicated in other autoimmune disorders, including lupus erythematosus and rheumatoid arthritis. 3. **Cancer**: Aberrant expression of DSG3 has been observed in certain types of cancer, including squamous cell carcinoma and basal cell carcinoma. 4. **Skin diseases**: DSG3 has been implicated in various skin diseases, including epidermolysis bullosa acquisita and lichen planus. In conclusion, DSG3 is a complex protein that plays a vital role in maintaining epithelial homeostasis and cell-cell adhesion. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation. Further research is needed to elucidate the mechanisms underlying DSG3-mediated cell-cell adhesion and its clinical significance in human disease.

Genular Protein ID: 416195668

Symbol: DSG3_HUMAN

Name: 130 kDa pemphigus vulgaris antigen

UniProtKB Accession Codes:

P32926 A8K2V2

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 Ensembl 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1720352

Title: Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.

PubMed ID: 1720352

DOI: 10.1016/0092-8674(91)90360-b

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30528827

Title: A Homozygous Nonsense Mutation in the DSG3 Gene Causes Acantholytic Blisters in the Oral and Laryngeal Mucosa.

PubMed ID: 30528827

DOI: 10.1016/j.jid.2018.09.038

Sequence Information:

  • Length: 999
  • Mass: 107533
  • Checksum: 7553CC917E8719BA
  • Sequence:
    • MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE 
GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF VVDKNTGDIN ITAIVDREET 
PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN 
ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA 
DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK NKAEFHQSVI 
SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA 
SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT 
VYVRVPDFND NCPTAVLEKD AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS 
ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD 
GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME 
MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA 
DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD 
LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI 
VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.