Details for: DSG3

Gene ID: 1830

Symbol: DSG3

Ensembl ID: ENSG00000134757

Description: desmoglein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.25
    Marker Score: 3465
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.08
    Marker Score: 1621
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.06
    Marker Score: 3468
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.69
    Marker Score: 21013
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.44
    Marker Score: 21058
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.09
    Marker Score: 2203
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.58
    Marker Score: 534
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.37
    Marker Score: 599
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.34
    Marker Score: 561
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.27
    Marker Score: 1399
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4552
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.2
    Marker Score: 1545
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.11
    Marker Score: 1825
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.11
    Marker Score: 5451
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1
    Marker Score: 865
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 653
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.95
    Marker Score: 229
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.86
    Marker Score: 11491
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3096
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.73
    Marker Score: 607
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 384
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.48
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.46
    Marker Score: 165
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 932
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.43
    Marker Score: 385
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 801
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 240
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.37
    Marker Score: 663
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5649
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 201
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 691
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.31
    Marker Score: 87
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3
    Marker Score: 723
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.26
    Marker Score: 1910
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 128
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 238
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.18
    Marker Score: 260
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.17
    Marker Score: 313.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.16
    Marker Score: 199
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.15
    Marker Score: 353
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 36.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 42.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.13
    Marker Score: 357.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 63
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.09
    Marker Score: 436
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 99
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.08
    Marker Score: 161

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Other Information

**Key characteristics:** * The gene is located on chromosome 17p13.2. * It is a large gene with over 100 exons and 1500 nucleotides. * It encodes a secreted protein of approximately 130 kDa. * It is a member of the desmoglein family of cell adhesion molecules. * It is expressed in various cell types, suggesting a role in maintaining tissue integrity and cell-cell adhesion. **Pathways and functions:** * **Apoptosis:** DSG3 is involved in apoptosis, a process of programmed cell death. It is a key regulator of cell death in various cell types. * **Cell adhesion:** It plays a crucial role in cell adhesion by interacting with other desmoglein family members and other cell adhesion molecules. * **Tissue development:** DSG3 is essential for the development of the cornified envelope, a specialized cell layer found in stratified epithelial cells. * **Protein binding:** It binds to various proteins, including cadherins, integrins, and other desmoglein family members. **Clinical significance:** * Mutations in the DSG3 gene have been linked to several human diseases, including psoriasis, hemophilia, and cancer. * Dysregulation of DSG3 has been implicated in the pathogenesis of these diseases. * Genetic variants associated with DSG3 mutations are associated with an increased risk of developing skin tumors, particularly skin cancers. **Conclusion:** DSG3 is a critical gene for cell adhesion, apoptosis, and tissue development. Its mutations have significant implications for human health, contributing to the development of various diseases. Further understanding of the role of DSG3 in cell adhesion and signaling could lead to the development of novel therapeutic strategies for cancer and other diseases that are associated with abnormal cell adhesion.

Genular Protein ID: 416195668

Symbol: DSG3_HUMAN

Name: 130 kDa pemphigus vulgaris antigen

UniProtKB Accession Codes:

P32926 A8K2V2

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 EPD 1 Ensembl 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1720352

Title: Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.

PubMed ID: 1720352

DOI: 10.1016/0092-8674(91)90360-b

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30528827

Title: A Homozygous Nonsense Mutation in the DSG3 Gene Causes Acantholytic Blisters in the Oral and Laryngeal Mucosa.

PubMed ID: 30528827

DOI: 10.1016/j.jid.2018.09.038

Sequence Information:

  • Length: 999
  • Mass: 107533
  • Checksum: 7553CC917E8719BA
  • Sequence:
    • MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE 
GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF VVDKNTGDIN ITAIVDREET 
PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN 
ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA 
DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 
WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK NKAEFHQSVI 
SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA 
SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT 
VYVRVPDFND NCPTAVLEKD AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS 
ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 
TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD 
GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME 
MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA 
DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD 
LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 
LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI 
VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.