Details for: DSC3

Gene ID: 1825

Symbol: DSC3

Ensembl ID: ENSG00000134762

Description: desmocollin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.5
    Marker Score: 845
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.35
    Marker Score: 18312.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.33
    Marker Score: 1228
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.12
    Marker Score: 2229
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.11
    Marker Score: 2393
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.11
    Marker Score: 18145
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7
    Marker Score: 1879
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.62
    Marker Score: 707
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.43
    Marker Score: 5633
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.39
    Marker Score: 1098
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.33
    Marker Score: 1112
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.18
    Marker Score: 1517
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.08
    Marker Score: 2047
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.07
    Marker Score: 448
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5188
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.04
    Marker Score: 854
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.95
    Marker Score: 230
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.93
    Marker Score: 2268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 410
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.86
    Marker Score: 1405
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.82
    Marker Score: 6134
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.79
    Marker Score: 703
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1603
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11198
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 473
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.7
    Marker Score: 1446
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 411
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.66
    Marker Score: 8844
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.66
    Marker Score: 211
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 915
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.62
    Marker Score: 551.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.62
    Marker Score: 428
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.6
    Marker Score: 241
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.58
    Marker Score: 162
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.52
    Marker Score: 4400
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.51
    Marker Score: 181
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.47
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.44
    Marker Score: 830.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 238
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.42
    Marker Score: 501
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1449
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.38
    Marker Score: 682
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.34
    Marker Score: 196
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.32
    Marker Score: 220
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.32
    Marker Score: 167
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.29
    Marker Score: 531
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.28
    Marker Score: 331
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 268
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.26
    Marker Score: 64
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.25
    Marker Score: 101
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.24
    Marker Score: 48
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.23
    Marker Score: 100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.21
    Marker Score: 213
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 423.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 492
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 108

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Other Information

**Key characteristics:** * DSC3 is a type I transmembrane protein with a predicted molecular weight of 140 kDa. * It is expressed in a variety of cell types, including stem cells, epithelial cells, and immune cells. * It is a key component of desmosomes, which are cell adhesion complexes that hold epithelial cells together. * DSC3 is a key regulator of cell-cell adhesion, as it is involved in the formation and maintenance of cell-cell junctions. * It is also involved in cell signaling, as it is a receptor for the cadherin superfamily of cell adhesion molecules. **Pathways and functions:** * DSC3 is involved in the formation and maintenance of desmosomes, which are cell adhesion complexes that hold epithelial cells together. * It is also involved in cell signaling, as it is a receptor for the cadherin superfamily of cell adhesion molecules. * It plays a role in the development of the cornified envelope, a specialized layer of cells that covers the surface of epithelial organs. * It is also involved in embryonic development, as it is expressed in embryonic stem cells and in the developing skin, hair, and nails. **Clinical significance:** * Mutations in DSC3 have been linked to a number of human diseases, including skin disorders such as psoriasis and epidermolysis bullosa simplex. * DSC3 is a potential therapeutic target for these diseases, as it is a key regulator of cell adhesion and cell signaling. **Additional notes:** * DSC3 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a ubiquitin-dependent protein, meaning that it is degraded by the proteasome when it is no longer needed. * It is a member of the desmocollin family of cell adhesion molecules, which are expressed in a variety of cell types.

Genular Protein ID: 2306803720

Symbol: DSC3_HUMAN

Name: Desmocollin-3

UniProtKB Accession Codes:

Q14574 A6NN35 Q14200 Q9HAZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929347

Title: cDNA cloning and expression of a novel human desmocollin.

PubMed ID: 7929347

DOI: 10.1016/s0021-9258(18)47193-1

PubMed ID: 7665906

Title: The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms.

PubMed ID: 7665906

DOI: 10.1111/1523-1747.ep12319935

PubMed ID: 11027496

Title: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

PubMed ID: 11027496

DOI: 10.1006/bbrc.2000.3500

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 19765682

Title: A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles.

PubMed ID: 19765682

DOI: 10.1016/j.ajhg.2009.08.015

Sequence Information:

  • Length: 896
  • Mass: 99969
  • Checksum: 6685B0A8B4C1ED85
  • Sequence:
    • MAAAGPRRSV RGAVCLHLLL TLVIFSRAGE ACKKVILNVP SKLEADKIIG RVNLEECFRS 
ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS 
KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK 
EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH 
PVFTEAIYNF EVLESSRPGT TVGVVCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS 
TGVITTVSHY LDREVVDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY 
EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSVV 
KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI 
KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP 
KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YVVICKPKMG YTDILAVDPD 
EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA 
TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG 
KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE 
MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EKLHRCNQNE 
DRMPSQDYVL TYNYEGRGSP AGSVGCCSEK QEEDGLDFLN NLEPKFITLA EACTKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.