Details for: MGP

Gene ID: 4256

Symbol: MGP

Ensembl ID: ENSG00000111341

Description: matrix Gla protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 407.4699
    Cell Significance Index: -63.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 251.4751
    Cell Significance Index: -63.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.3327
    Cell Significance Index: -55.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.7583
    Cell Significance Index: -54.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.1549
    Cell Significance Index: -45.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.4901
    Cell Significance Index: -63.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.3062
    Cell Significance Index: -46.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 45.6989
    Cell Significance Index: 281.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8361
    Cell Significance Index: -62.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 15.5278
    Cell Significance Index: 1157.2700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 14.3709
    Cell Significance Index: 53.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.2407
    Cell Significance Index: 379.5600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 11.2491
    Cell Significance Index: 119.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 10.3868
    Cell Significance Index: 488.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3632
    Cell Significance Index: -31.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.6157
    Cell Significance Index: 1242.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.3494
    Cell Significance Index: 165.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 8.7590
    Cell Significance Index: 170.9500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 8.4888
    Cell Significance Index: 177.0400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 8.4431
    Cell Significance Index: 108.7300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 7.7326
    Cell Significance Index: 43.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.2524
    Cell Significance Index: 59.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.1812
    Cell Significance Index: 28.3300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.8595
    Cell Significance Index: 17.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.7155
    Cell Significance Index: 510.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.1148
    Cell Significance Index: 22.3700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.8383
    Cell Significance Index: 24.5500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.8243
    Cell Significance Index: 16.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4358
    Cell Significance Index: 20.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3545
    Cell Significance Index: 33.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0833
    Cell Significance Index: 50.5100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.9427
    Cell Significance Index: 10.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9086
    Cell Significance Index: 45.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8872
    Cell Significance Index: 12.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8783
    Cell Significance Index: 45.7500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.8508
    Cell Significance Index: 2.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5531
    Cell Significance Index: 42.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4664
    Cell Significance Index: 88.7500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.4185
    Cell Significance Index: 5.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4155
    Cell Significance Index: 18.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3510
    Cell Significance Index: 5.4300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.3495
    Cell Significance Index: 3.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3345
    Cell Significance Index: 10.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3048
    Cell Significance Index: 275.2000
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.2378
    Cell Significance Index: 1.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1199
    Cell Significance Index: 53.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1018
    Cell Significance Index: 13.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1005
    Cell Significance Index: 76.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0880
    Cell Significance Index: 10.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0533
    Cell Significance Index: 33.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0365
    Cell Significance Index: 3.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0304
    Cell Significance Index: 57.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0327
    Cell Significance Index: -1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0344
    Cell Significance Index: -63.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0351
    Cell Significance Index: -26.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0419
    Cell Significance Index: -7.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0423
    Cell Significance Index: -65.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0483
    Cell Significance Index: -7.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0491
    Cell Significance Index: -66.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0641
    Cell Significance Index: -40.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0691
    Cell Significance Index: -50.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0756
    Cell Significance Index: -42.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1180
    Cell Significance Index: -64.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1279
    Cell Significance Index: -2.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1353
    Cell Significance Index: -13.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1601
    Cell Significance Index: -57.4300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1756
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1756
    Cell Significance Index: -29.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1998
    Cell Significance Index: -57.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2237
    Cell Significance Index: -32.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2264
    Cell Significance Index: -44.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2280
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2347
    Cell Significance Index: -49.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2545
    Cell Significance Index: -29.6600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2672
    Cell Significance Index: -2.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2721
    Cell Significance Index: -29.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2796
    Cell Significance Index: -56.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3870
    Cell Significance Index: -8.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4353
    Cell Significance Index: -30.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4857
    Cell Significance Index: -29.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4869
    Cell Significance Index: -57.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4971
    Cell Significance Index: -56.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5250
    Cell Significance Index: -54.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5313
    Cell Significance Index: -60.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5543
    Cell Significance Index: -38.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5876
    Cell Significance Index: -12.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6515
    Cell Significance Index: -51.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7684
    Cell Significance Index: -46.1300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.8358
    Cell Significance Index: -1.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8408
    Cell Significance Index: -52.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8528
    Cell Significance Index: -55.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9105
    Cell Significance Index: -61.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9645
    Cell Significance Index: -59.2800
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -1.0163
    Cell Significance Index: -4.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0225
    Cell Significance Index: -41.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0544
    Cell Significance Index: -28.7000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -1.1369
    Cell Significance Index: -10.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1607
    Cell Significance Index: -60.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.2304
    Cell Significance Index: -19.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGP is a 49-amino acid protein that is synthesized by fibroblasts in various tissues, including connective tissue of the prostate, mammary gland, uterine smooth muscle cells, kidney interstitial cells, and skeletal muscle satellite stem cells. It is highly expressed in tissues that undergo rapid growth and differentiation, such as during development, puberty, and pregnancy. MGP is also found in the extracellular matrix of cartilage, bone, and teeth, where it regulates the mineralization of collagen by binding to calcium ions. MGP has a unique structure, consisting of two Gla residues that are essential for its biological activity. These residues are responsible for binding to calcium ions and preventing the deposition of hydroxyapatite crystals. MGP is also a potent inhibitor of bone resorption, as it prevents the activity of osteoclasts, the cells responsible for bone degradation. **Pathways and Functions** MGP's primary function is to regulate bone mineralization by inhibiting the deposition of hydroxyapatite crystals in the extracellular matrix. This is achieved through its binding to calcium ions, which prevents the formation of calcium-phosphate complexes that are necessary for mineralization. MGP also regulates the activity of osteoclasts, the cells responsible for bone resorption, by inhibiting their activity. In addition to its role in bone mineralization, MGP also plays a role in the regulation of cartilage condensation and the formation of the extracellular matrix in various tissues. MGP is also involved in the regulation of cell differentiation and proliferation, as it is expressed in tissues that undergo rapid growth and differentiation. **Clinical Significance** Dysregulation of MGP has been implicated in various bone disorders, including osteoporosis, osteopetrosis, and Paget's disease. In osteoporosis, MGP levels are often decreased, leading to excessive calcification and bone resorption. In osteopetrosis, MGP levels are often increased, leading to impaired bone mineralization and resorption. MGP has also been implicated in the regulation of prostate cancer. Elevated levels of MGP have been found in prostate cancer tissues, where it may play a role in promoting cancer cell growth and metastasis. In conclusion, MGP is a critical regulator of bone mineralization and the extracellular matrix, and its dysregulation has significant implications for various bone disorders and diseases. Further research is needed to fully understand the role of MGP in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 4136724685

Symbol: MGP_HUMAN

Name: Matrix Gla protein

UniProtKB Accession Codes:

P08493 A0M8W5 B2R519 J3KMX7 Q2TU41 Q567P9 Q6ICN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2394711

Title: Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene.

PubMed ID: 2394711

DOI: 10.1016/s0021-9258(18)77221-9

PubMed ID: 3387234

Title: The cDNA and derived amino acid sequences for human and bovine matrix Gla protein.

PubMed ID: 3387234

DOI: 10.1093/nar/16.11.5213

PubMed ID: 2216462

Title: Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization.

PubMed ID: 2216462

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8061611

Title: Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human.

PubMed ID: 8061611

DOI: 10.1002/pro.5560030511

PubMed ID: 1939157

Title: Carboxyl-terminal proteolytic processing of matrix Gla protein.

PubMed ID: 1939157

DOI: 10.1016/s0021-9258(18)54832-8

PubMed ID: 9916809

Title: Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome.

PubMed ID: 9916809

DOI: 10.1038/5102

Sequence Information:

  • Length: 103
  • Mass: 12353
  • Checksum: 243968D715D54549
  • Sequence:
    • MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW RAKVQERIRE 
RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR GTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.