Details for: MGP

Gene ID: 4256

Symbol: MGP

Ensembl ID: ENSG00000111341

Description: matrix Gla protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.33
    Marker Score: 3,690
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.21
    Marker Score: 143,304
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.17
    Marker Score: 5,431
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.15
    Marker Score: 2,953
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.04
    Marker Score: 9,204
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.99
    Marker Score: 3,804
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.88
    Marker Score: 4,148
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.81
    Marker Score: 9,962
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.59
    Marker Score: 3,092
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.58
    Marker Score: 6,724
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.51
    Marker Score: 1,510
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.5
    Marker Score: 13,514
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.46
    Marker Score: 1,439
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.42
    Marker Score: 1,099
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.14
    Marker Score: 1,793
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.09
    Marker Score: 802
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.05
    Marker Score: 1,725
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.93
    Marker Score: 1,930
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.85
    Marker Score: 2,233
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.77
    Marker Score: 4,910
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.74
    Marker Score: 11,817
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.7
    Marker Score: 5,389
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.67
    Marker Score: 4,115
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.66
    Marker Score: 945
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.59
    Marker Score: 645
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.57
    Marker Score: 645
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.57
    Marker Score: 597
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.5
    Marker Score: 4,230
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.48
    Marker Score: 703
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.47
    Marker Score: 569
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.41
    Marker Score: 4,629
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.4
    Marker Score: 1,580
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.26
    Marker Score: 663
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.24
    Marker Score: 848
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.22
    Marker Score: 2,141
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2
    Marker Score: 24,781
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.17
    Marker Score: 551
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2,162
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.11
    Marker Score: 2,894
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.1
    Marker Score: 3,058
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.09
    Marker Score: 533
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.05
    Marker Score: 5,215
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2
    Marker Score: 1,262
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.96
    Marker Score: 4,299
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.96
    Marker Score: 2,417
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.92
    Marker Score: 744
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.81
    Marker Score: 385
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.76
    Marker Score: 1,030
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.76
    Marker Score: 9,256
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.75
    Marker Score: 431
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.69
    Marker Score: 791
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.61
    Marker Score: 478
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,148
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.53
    Marker Score: 403
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.52
    Marker Score: 883
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.5
    Marker Score: 2,175
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.49
    Marker Score: 1,338
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.48
    Marker Score: 1,847
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.46
    Marker Score: 5,666
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,556
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.44
    Marker Score: 597
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.43
    Marker Score: 405
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.36
    Marker Score: 671
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.35
    Marker Score: 608
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.35
    Marker Score: 655
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3
    Marker Score: 931
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.29
    Marker Score: 1,163
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.25
    Marker Score: 301
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.24
    Marker Score: 3,372
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.24
    Marker Score: 276
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.23
    Marker Score: 493
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3,040
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.2
    Marker Score: 486
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.2
    Marker Score: 295
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2
    Marker Score: 2,924
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.2
    Marker Score: 1,692
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.19
    Marker Score: 260
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.15
    Marker Score: 416
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4,757
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.13
    Marker Score: 384
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.12
    Marker Score: 504
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.12
    Marker Score: 297
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.11
    Marker Score: 5,452
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.11
    Marker Score: 282
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.08
    Marker Score: 554
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.07
    Marker Score: 390
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1,706
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.06
    Marker Score: 737
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.06
    Marker Score: 299
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.05
    Marker Score: 333
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.04
    Marker Score: 583
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.04
    Marker Score: 524
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.01
    Marker Score: 541
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,972
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.98
    Marker Score: 405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.97
    Marker Score: 280
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGP is a 49-amino acid protein that is synthesized by fibroblasts in various tissues, including connective tissue of the prostate, mammary gland, uterine smooth muscle cells, kidney interstitial cells, and skeletal muscle satellite stem cells. It is highly expressed in tissues that undergo rapid growth and differentiation, such as during development, puberty, and pregnancy. MGP is also found in the extracellular matrix of cartilage, bone, and teeth, where it regulates the mineralization of collagen by binding to calcium ions. MGP has a unique structure, consisting of two Gla residues that are essential for its biological activity. These residues are responsible for binding to calcium ions and preventing the deposition of hydroxyapatite crystals. MGP is also a potent inhibitor of bone resorption, as it prevents the activity of osteoclasts, the cells responsible for bone degradation. **Pathways and Functions** MGP's primary function is to regulate bone mineralization by inhibiting the deposition of hydroxyapatite crystals in the extracellular matrix. This is achieved through its binding to calcium ions, which prevents the formation of calcium-phosphate complexes that are necessary for mineralization. MGP also regulates the activity of osteoclasts, the cells responsible for bone resorption, by inhibiting their activity. In addition to its role in bone mineralization, MGP also plays a role in the regulation of cartilage condensation and the formation of the extracellular matrix in various tissues. MGP is also involved in the regulation of cell differentiation and proliferation, as it is expressed in tissues that undergo rapid growth and differentiation. **Clinical Significance** Dysregulation of MGP has been implicated in various bone disorders, including osteoporosis, osteopetrosis, and Paget's disease. In osteoporosis, MGP levels are often decreased, leading to excessive calcification and bone resorption. In osteopetrosis, MGP levels are often increased, leading to impaired bone mineralization and resorption. MGP has also been implicated in the regulation of prostate cancer. Elevated levels of MGP have been found in prostate cancer tissues, where it may play a role in promoting cancer cell growth and metastasis. In conclusion, MGP is a critical regulator of bone mineralization and the extracellular matrix, and its dysregulation has significant implications for various bone disorders and diseases. Further research is needed to fully understand the role of MGP in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 4136724685

Symbol: MGP_HUMAN

Name: Matrix Gla protein

UniProtKB Accession Codes:

P08493 A0M8W5 B2R519 J3KMX7 Q2TU41 Q567P9 Q6ICN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2394711

Title: Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene.

PubMed ID: 2394711

DOI: 10.1016/s0021-9258(18)77221-9

PubMed ID: 3387234

Title: The cDNA and derived amino acid sequences for human and bovine matrix Gla protein.

PubMed ID: 3387234

DOI: 10.1093/nar/16.11.5213

PubMed ID: 2216462

Title: Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization.

PubMed ID: 2216462

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8061611

Title: Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human.

PubMed ID: 8061611

DOI: 10.1002/pro.5560030511

PubMed ID: 1939157

Title: Carboxyl-terminal proteolytic processing of matrix Gla protein.

PubMed ID: 1939157

DOI: 10.1016/s0021-9258(18)54832-8

PubMed ID: 9916809

Title: Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome.

PubMed ID: 9916809

DOI: 10.1038/5102

Sequence Information:

  • Length: 103
  • Mass: 12353
  • Checksum: 243968D715D54549
  • Sequence:
    • MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW RAKVQERIRE 
RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR GTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.