Details for: C1S

Gene ID: 716

Symbol: C1S

Ensembl ID: ENSG00000182326

Description: complement C1s

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.0424
    Cell Significance Index: -32.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.8567
    Cell Significance Index: -32.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.9741
    Cell Significance Index: -31.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.5342
    Cell Significance Index: -27.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.3108
    Cell Significance Index: -32.4400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 19.7310
    Cell Significance Index: 115.9200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 15.0756
    Cell Significance Index: 86.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5501
    Cell Significance Index: -33.6200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.2621
    Cell Significance Index: 55.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9776
    Cell Significance Index: -31.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 6.0249
    Cell Significance Index: 101.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.6988
    Cell Significance Index: 163.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.5500
    Cell Significance Index: 108.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.6126
    Cell Significance Index: 633.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.1839
    Cell Significance Index: 536.3500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.0164
    Cell Significance Index: 12.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4073
    Cell Significance Index: 279.2900
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 1.4041
    Cell Significance Index: 14.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2934
    Cell Significance Index: 19.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2728
    Cell Significance Index: 16.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1232
    Cell Significance Index: 16.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8718
    Cell Significance Index: 44.0600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.7522
    Cell Significance Index: 4.7300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5409
    Cell Significance Index: 3.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4704
    Cell Significance Index: 84.8000
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.4699
    Cell Significance Index: 1.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3274
    Cell Significance Index: 15.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3036
    Cell Significance Index: 23.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2744
    Cell Significance Index: 98.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1700
    Cell Significance Index: 2.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1576
    Cell Significance Index: 18.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1261
    Cell Significance Index: 55.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0907
    Cell Significance Index: 57.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0829
    Cell Significance Index: 156.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0718
    Cell Significance Index: 14.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0384
    Cell Significance Index: 70.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0337
    Cell Significance Index: 30.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0286
    Cell Significance Index: 43.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0237
    Cell Significance Index: 14.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0225
    Cell Significance Index: 17.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0125
    Cell Significance Index: 2.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0111
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0048
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0348
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0360
    Cell Significance Index: -6.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0377
    Cell Significance Index: -21.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0402
    Cell Significance Index: -29.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0513
    Cell Significance Index: -28.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0556
    Cell Significance Index: -6.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0586
    Cell Significance Index: -3.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0689
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0721
    Cell Significance Index: -10.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0951
    Cell Significance Index: -20.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0993
    Cell Significance Index: -16.1500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1095
    Cell Significance Index: -1.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1204
    Cell Significance Index: -34.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1240
    Cell Significance Index: -12.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1579
    Cell Significance Index: -20.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1596
    Cell Significance Index: -15.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1647
    Cell Significance Index: -7.4700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1695
    Cell Significance Index: -1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1816
    Cell Significance Index: -6.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1857
    Cell Significance Index: -5.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2252
    Cell Significance Index: -15.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2268
    Cell Significance Index: -16.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2328
    Cell Significance Index: -27.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2386
    Cell Significance Index: -25.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2431
    Cell Significance Index: -14.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2443
    Cell Significance Index: -27.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2532
    Cell Significance Index: -11.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2635
    Cell Significance Index: -27.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2704
    Cell Significance Index: -31.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3031
    Cell Significance Index: -15.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3115
    Cell Significance Index: -5.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3154
    Cell Significance Index: -23.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3272
    Cell Significance Index: -12.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3750
    Cell Significance Index: -7.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3803
    Cell Significance Index: -30.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3819
    Cell Significance Index: -5.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4052
    Cell Significance Index: -10.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4092
    Cell Significance Index: -8.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4098
    Cell Significance Index: -28.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4246
    Cell Significance Index: -11.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4654
    Cell Significance Index: -13.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4702
    Cell Significance Index: -7.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4784
    Cell Significance Index: -30.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4912
    Cell Significance Index: -29.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5155
    Cell Significance Index: -33.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5198
    Cell Significance Index: -16.6500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.5231
    Cell Significance Index: -1.9700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5285
    Cell Significance Index: -5.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5287
    Cell Significance Index: -24.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5377
    Cell Significance Index: -33.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6119
    Cell Significance Index: -14.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6201
    Cell Significance Index: -32.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6247
    Cell Significance Index: -11.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6589
    Cell Significance Index: -34.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Title: Unveiling the Role of Complement C1s in the Immune System: A Comprehensive Review As an expert immunologist, I am delighted to delve into the intricacies of the complement system, a vital component of the innate immune response. In this article, we will focus on the gene encoding Complement C1s (C1S), a serine protease that plays a pivotal role in the classical pathway of complement activation. Our discussion will cover the gene's summary, key characteristics, pathways and functions, and clinical significance. Summary -------- Complement C1s is a crucial protein in the complement system, a group of proteins that work together to defend the body against pathogens. This gene encodes for the C1s subcomponent, a serine protease that catalyzes the cleavage of C4 and C2, activating the classical pathway of complement activation. The C1s protein is expressed in various tissues, including skeletal muscle, lung, and mammary gland fibroblasts, and is involved in the regulation of the complement cascade. Key Characteristics -------------------- The C1s protein is a serine protease that exhibits a unique molecular structure, consisting of two subunits connected by a disulfide bond. This structure allows for the protein to bind to C4 and C2, facilitating their cleavage and activation of the classical pathway. The C1s protein is also characterized by its ability to bind to calcium ions, which is essential for its enzymatic activity. Pathways and Functions ---------------------- The classical pathway of complement activation is initiated when C1s cleaves C4 and C2, generating C4a and C2a fragments. These fragments then bind to C1q, forming a C1q-C1r-C1s complex. This complex then binds to the Fc region of IgG antibodies, triggering a cascade of events that ultimately lead to the opsonization and clearance of pathogens. The C1s protein plays a central role in this pathway, as it is responsible for the cleavage of C4 and C2. The C1s-C4-C2 complex then activates the complement cascade, leading to the production of various complement proteins, including C3, C5, and C6. These proteins work together to form the membrane attack complex (MAC), which ultimately leads to the lysis of pathogens. Clinical Significance ------------------- Dysregulation of the complement system has been implicated in various diseases, including autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The C1s protein has been shown to play a critical role in the pathogenesis of these diseases, as it can contribute to the formation of immune complexes and the activation of the complement cascade. Furthermore, the C1s protein has been implicated in the development of cancer, as it can promote tumor growth and metastasis. The C1s protein has also been shown to be involved in the regulation of the innate immune response, and its dysregulation can lead to the development of inflammatory diseases, such as atherosclerosis and chronic obstructive pulmonary disease (COPD). Conclusion ---------- In conclusion, the Complement C1s gene plays a vital role in the immune system, particularly in the classical pathway of complement activation. The C1s protein is a serine protease that catalyzes the cleavage of C4 and C2, activating the complement cascade. The C1s protein is expressed in various tissues and is involved in the regulation of the complement cascade, making it a critical component of the innate immune response. Further research is needed to fully understand the role of C1s in disease pathogenesis and to explore potential therapeutic strategies for the treatment of diseases associated with complement dysregulation.

Genular Protein ID: 3994444760

Symbol: C1S_HUMAN

Name: Complement C1s subcomponent

UniProtKB Accession Codes:

P09871 D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 2 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 4 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3500856

Title: Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.

PubMed ID: 3500856

DOI: 10.1111/j.1432-1033.1987.tb13644.x

PubMed ID: 2831944

Title: Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.

PubMed ID: 2831944

DOI: 10.1021/bi00400a004

PubMed ID: 2459702

Title: Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.

PubMed ID: 2459702

DOI: 10.1073/pnas.85.19.7307

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9794427

Title: Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.

PubMed ID: 9794427

PubMed ID: 2553984

Title: Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin.

PubMed ID: 2553984

DOI: 10.1016/0022-2836(89)90161-7

PubMed ID: 3007145

Title: Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation.

PubMed ID: 3007145

DOI: 10.1111/j.1432-1033.1986.tb09546.x

PubMed ID: 6362661

Title: The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments.

PubMed ID: 6362661

DOI: 10.1042/bj2150565

PubMed ID: 2141278

Title: Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region.

PubMed ID: 2141278

DOI: 10.1021/bi00466a021

PubMed ID: 1854725

Title: Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites.

PubMed ID: 1854725

DOI: 10.1021/bi00243a014

PubMed ID: 2007122

Title: Identification of the disulfide bonds of human complement C1s.

PubMed ID: 2007122

DOI: 10.1021/bi00225a014

PubMed ID: 7779774

Title: Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling.

PubMed ID: 7779774

DOI: 10.1021/bi00022a004

PubMed ID: 11527969

Title: Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.

PubMed ID: 11527969

DOI: 10.1074/jbc.m105934200

PubMed ID: 11390518

Title: Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases.

PubMed ID: 11390518

DOI: 10.4049/jimmunol.166.12.7612

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 18930415

Title: Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.

PubMed ID: 18930415

DOI: 10.1016/j.joca.2008.08.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27745832

Title: Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.

PubMed ID: 27745832

DOI: 10.1016/j.ajhg.2016.08.019

PubMed ID: 10775260

Title: Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.

PubMed ID: 10775260

DOI: 10.1093/emboj/19.8.1755

PubMed ID: 12788922

Title: X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement.

PubMed ID: 12788922

DOI: 10.1074/jbc.m305175200

Sequence Information:

  • Length: 688
  • Mass: 76684
  • Checksum: 85522647A4C47205
  • Sequence:
    • MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE 
LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF 
TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF 
TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF 
VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP 
NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG 
IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK 
CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN 
REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK 
MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV 
EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG 
TYGLYTRVKN YVDWIMKTMQ ENSTPRED

Genular Protein ID: 801953386

Symbol: F8WCZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8WCZ6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 521
  • Mass: 57519
  • Checksum: 0ADFEDA8AAD3AB37
  • Sequence:
    • MKNCGVNCSG DVFTALIGEI ASPNYPKPYP ENSRCEYQIR LEKGFQVVVT LRREDFDVEA 
ADSAGNCLDS LVFVAGDRQF GPYCGHGFPG PLNIETKSNA LDIIFQTDLT GQKKGWKLRY 
HGDPMPCPKE DTPNSVWEPA KAKYVFRDVV QITCLDGFEV VEGRVGATSF YSTCQSNGKW 
SNSKLKCQPV DCGIPESIEN GKVEDPESTL FGSVIRYTCE EPYYYMENGG GGEYHCAGNG 
SWVNEVLGPE LPKCVPVCGV PREPFEEKQR IIGGSDADIK NFPWQVFFDN PWAGGALINE 
YWVLTAAHVV EGNREPTMYV GSTSVQTSRL AKSKMLTPEH VFIHPGWKLL EVPEGRTNFD 
NDIALVRLKD PVKMGPTVSP ICLPGTSSDY NLMDGDLGLI SGWGRTEKRD RAVRLKAARL 
PVAPLRKCKE VKVEKPTADA EAYVFTPNMI CAGGEKGMDS CKGDSGGAFA VQDPNDKTKF 
YAAGLVSWGP QCGTYGLYTR VKNYVDWIMK TMQENSTPRE D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.