Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.95
Marker Score: 2,598 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.68
Marker Score: 9,643 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.58
Marker Score: 4,927 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.42
Marker Score: 28,952 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.4
Marker Score: 2,898 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.35
Marker Score: 114,113 - Cell Name: theca cell (CL0000503)
Fold Change: 3.23
Marker Score: 2,313 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.17
Marker Score: 1,364 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.14
Marker Score: 1,309 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.91
Marker Score: 754 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.9
Marker Score: 12,495 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.88
Marker Score: 15,462 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.76
Marker Score: 1,338 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.71
Marker Score: 1,545 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.68
Marker Score: 30,203 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.59
Marker Score: 583 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.5
Marker Score: 622 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.48
Marker Score: 622 - Cell Name: keratocyte (CL0002363)
Fold Change: 2.41
Marker Score: 555 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.22
Marker Score: 29,472 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.12
Marker Score: 13,619 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.05
Marker Score: 8,855 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.97
Marker Score: 1,245 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.94
Marker Score: 624 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.92
Marker Score: 1,069 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.9
Marker Score: 3,653 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.89
Marker Score: 2,178 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.79
Marker Score: 1,180 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.79
Marker Score: 1,729 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.78
Marker Score: 2,917 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.71
Marker Score: 423 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1,151 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.55
Marker Score: 1,660 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.54
Marker Score: 343 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.48
Marker Score: 19,488 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.4
Marker Score: 2,625 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.38
Marker Score: 522 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.37
Marker Score: 936 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.34
Marker Score: 8,722 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.33
Marker Score: 1,642 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.26
Marker Score: 505 - Cell Name: fat cell (CL0000136)
Fold Change: 1.26
Marker Score: 703 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.22
Marker Score: 311 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.2
Marker Score: 352 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.18
Marker Score: 4,930 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.16
Marker Score: 2,742 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,782 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.14
Marker Score: 17,773 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.13
Marker Score: 24,142 - Cell Name: pneumocyte (CL0000322)
Fold Change: 1.1
Marker Score: 1,775 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.1
Marker Score: 1,427 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.08
Marker Score: 3,990 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.03
Marker Score: 2,098 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.02
Marker Score: 2,396 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,778 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,003 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1
Marker Score: 1,242 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1
Marker Score: 377 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404 - Cell Name: reticular cell (CL0000432)
Fold Change: 0.97
Marker Score: 355 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410 - Cell Name: contractile cell (CL0000183)
Fold Change: 0.93
Marker Score: 506 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.93
Marker Score: 995 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.92
Marker Score: 1,413 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,738 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.9
Marker Score: 291 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.89
Marker Score: 246 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.89
Marker Score: 373 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.89
Marker Score: 1,193 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5,047 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.88
Marker Score: 779 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.88
Marker Score: 945 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.87
Marker Score: 1,905 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.86
Marker Score: 4,212 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.85
Marker Score: 318 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.85
Marker Score: 2,313 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.84
Marker Score: 868 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.83
Marker Score: 244 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.82
Marker Score: 50,345 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.82
Marker Score: 7,673 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.81
Marker Score: 211 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.81
Marker Score: 18,082 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.81
Marker Score: 280 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 612 - Cell Name: tendon cell (CL0000388)
Fold Change: 0.8
Marker Score: 196 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.8
Marker Score: 4,787 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.78
Marker Score: 238 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,265 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.77
Marker Score: 708 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.76
Marker Score: 258 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390 - Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 687 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.74
Marker Score: 1,143 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.74
Marker Score: 896 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.74
Marker Score: 444
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3994444760
Symbol: C1S_HUMAN
Name: Complement C1s subcomponent
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3500856
Title: Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.
PubMed ID: 3500856
PubMed ID: 2831944
Title: Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.
PubMed ID: 2831944
DOI: 10.1021/bi00400a004
PubMed ID: 2459702
Title: Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.
PubMed ID: 2459702
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9794427
Title: Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.
PubMed ID: 9794427
PubMed ID: 2553984
Title: Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin.
PubMed ID: 2553984
PubMed ID: 3007145
Title: Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation.
PubMed ID: 3007145
PubMed ID: 6362661
Title: The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments.
PubMed ID: 6362661
DOI: 10.1042/bj2150565
PubMed ID: 2141278
Title: Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region.
PubMed ID: 2141278
DOI: 10.1021/bi00466a021
PubMed ID: 1854725
Title: Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites.
PubMed ID: 1854725
DOI: 10.1021/bi00243a014
PubMed ID: 2007122
Title: Identification of the disulfide bonds of human complement C1s.
PubMed ID: 2007122
DOI: 10.1021/bi00225a014
PubMed ID: 7779774
Title: Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling.
PubMed ID: 7779774
DOI: 10.1021/bi00022a004
PubMed ID: 11527969
Title: Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.
PubMed ID: 11527969
PubMed ID: 11390518
Title: Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases.
PubMed ID: 11390518
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27745832
Title: Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.
PubMed ID: 27745832
PubMed ID: 10775260
Title: Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.
PubMed ID: 10775260
PubMed ID: 12788922
Title: X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement.
PubMed ID: 12788922
Sequence Information:
- Length: 688
- Mass: 76684
- Checksum: 85522647A4C47205
- Sequence:
MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG TYGLYTRVKN YVDWIMKTMQ ENSTPRED
Genular Protein ID: 801953386
Symbol: F8WCZ6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 521
- Mass: 57519
- Checksum: 0ADFEDA8AAD3AB37
- Sequence:
MKNCGVNCSG DVFTALIGEI ASPNYPKPYP ENSRCEYQIR LEKGFQVVVT LRREDFDVEA ADSAGNCLDS LVFVAGDRQF GPYCGHGFPG PLNIETKSNA LDIIFQTDLT GQKKGWKLRY HGDPMPCPKE DTPNSVWEPA KAKYVFRDVV QITCLDGFEV VEGRVGATSF YSTCQSNGKW SNSKLKCQPV DCGIPESIEN GKVEDPESTL FGSVIRYTCE EPYYYMENGG GGEYHCAGNG SWVNEVLGPE LPKCVPVCGV PREPFEEKQR IIGGSDADIK NFPWQVFFDN PWAGGALINE YWVLTAAHVV EGNREPTMYV GSTSVQTSRL AKSKMLTPEH VFIHPGWKLL EVPEGRTNFD NDIALVRLKD PVKMGPTVSP ICLPGTSSDY NLMDGDLGLI SGWGRTEKRD RAVRLKAARL PVAPLRKCKE VKVEKPTADA EAYVFTPNMI CAGGEKGMDS CKGDSGGAFA VQDPNDKTKF YAAGLVSWGP QCGTYGLYTR VKNYVDWIMK TMQENSTPRE D
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.