Details for: SERPINB5

Gene ID: 5268

Symbol: SERPINB5

Ensembl ID: ENSG00000206075

Description: serpin family B member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 40.2453
    Cell Significance Index: 119.6900
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 11.1929
    Cell Significance Index: 12.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 10.6878
    Cell Significance Index: 91.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 8.9714
    Cell Significance Index: -6.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.0226
    Cell Significance Index: -5.7500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 5.9526
    Cell Significance Index: 13.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 5.1338
    Cell Significance Index: 73.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.0346
    Cell Significance Index: 209.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.9182
    Cell Significance Index: 18.0600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 2.9168
    Cell Significance Index: 20.9900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.4169
    Cell Significance Index: 18.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5326
    Cell Significance Index: 677.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2165
    Cell Significance Index: 1098.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1601
    Cell Significance Index: 32.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0691
    Cell Significance Index: 116.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8696
    Cell Significance Index: 13.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8075
    Cell Significance Index: 131.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7990
    Cell Significance Index: 98.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7905
    Cell Significance Index: -1.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7344
    Cell Significance Index: 19.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6777
    Cell Significance Index: 10.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5925
    Cell Significance Index: 40.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5271
    Cell Significance Index: 52.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4976
    Cell Significance Index: 10.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4901
    Cell Significance Index: 34.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3816
    Cell Significance Index: 68.7900
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.3406
    Cell Significance Index: 2.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3144
    Cell Significance Index: 2.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2972
    Cell Significance Index: 6.3300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.2459
    Cell Significance Index: 1.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2226
    Cell Significance Index: 42.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2006
    Cell Significance Index: 4.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1690
    Cell Significance Index: 21.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1520
    Cell Significance Index: 5.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1249
    Cell Significance Index: 5.6600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0762
    Cell Significance Index: 1.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0529
    Cell Significance Index: 1.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0406
    Cell Significance Index: 1.9100
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.0257
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0243
    Cell Significance Index: 0.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0170
    Cell Significance Index: 0.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0100
    Cell Significance Index: 0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0048
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0110
    Cell Significance Index: -6.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0128
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0129
    Cell Significance Index: -8.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0145
    Cell Significance Index: -5.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0148
    Cell Significance Index: -6.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0177
    Cell Significance Index: -3.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0190
    Cell Significance Index: -3.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0247
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0298
    Cell Significance Index: -6.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0331
    Cell Significance Index: -5.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0382
    Cell Significance Index: -5.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0473
    Cell Significance Index: -2.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0474
    Cell Significance Index: -2.2100
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0513
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0566
    Cell Significance Index: -6.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0573
    Cell Significance Index: -7.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0582
    Cell Significance Index: -4.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0605
    Cell Significance Index: -6.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0616
    Cell Significance Index: -1.5400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0729
    Cell Significance Index: -0.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0863
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0949
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0976
    Cell Significance Index: -1.0300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1004
    Cell Significance Index: -0.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1048
    Cell Significance Index: -0.9300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1050
    Cell Significance Index: -1.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1079
    Cell Significance Index: -5.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1090
    Cell Significance Index: -6.7000
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.1104
    Cell Significance Index: -0.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1106
    Cell Significance Index: -8.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1108
    Cell Significance Index: -5.7700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1199
    Cell Significance Index: -1.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1233
    Cell Significance Index: -5.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1298
    Cell Significance Index: -1.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1299
    Cell Significance Index: -0.8800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1531
    Cell Significance Index: -0.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1631
    Cell Significance Index: -9.1500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1729
    Cell Significance Index: -0.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1733
    Cell Significance Index: -6.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1745
    Cell Significance Index: -5.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1848
    Cell Significance Index: -6.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1854
    Cell Significance Index: -8.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1865
    Cell Significance Index: -4.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1866
    Cell Significance Index: -2.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1885
    Cell Significance Index: -2.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1891
    Cell Significance Index: -4.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1895
    Cell Significance Index: -6.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease inhibitor**: SERPINB5 belongs to the serpin family, characterized by its ability to inhibit serine proteases, which are involved in various cellular processes, including cell signaling, proliferation, and differentiation. 2. **Epithelial cell specificity**: SERPINB5 is primarily expressed in epithelial cells, suggesting its role in maintaining epithelial homeostasis and regulating cellular behavior. 3. **Tissue-specific expression**: SERPINB5 is significantly expressed in stem cells, basal cells, and epithelial cells of various tissues, including the epidermis, prostate, bladder, and lung. 4. **Regulation of endopeptidase activity**: SERPINB5 inhibits endopeptidases, which are involved in protein processing and signaling pathways, thereby modulating cellular behavior. **Pathways and Functions:** SERPINB5 is involved in several cellular pathways, including: 1. **Negative regulation of endopeptidase activity**: SERPINB5 inhibits endopeptidases, which are involved in protein processing and signaling pathways, thereby modulating cellular behavior. 2. **Regulation of epithelial cell proliferation**: SERPINB5 regulates epithelial cell proliferation by modulating the activity of endopeptidases involved in cell cycle progression. 3. **Morphogenesis of an epithelium**: SERPINB5 is involved in the morphogenesis of epithelial tissues, regulating cellular behavior and tissue organization. 4. **Cytoplasm and extracellular matrix organization**: SERPINB5 is involved in the organization of cytoplasm and extracellular matrix, regulating cellular behavior and tissue structure. **Clinical Significance:** The dysregulation of SERPINB5 has been implicated in various diseases, including: 1. **Cancer**: Altered expression of SERPINB5 has been observed in various types of cancer, including prostate, breast, and lung cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Inflammatory disorders**: SERPINB5 has been implicated in inflammatory disorders, such as atherosclerosis and arthritis, where its dysregulation leads to tissue damage and inflammation. 3. **Neurological disorders**: SERPINB5 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation leads to neuronal damage and dysfunction. In conclusion, SERPINB5 is a serpin family member that plays a crucial role in regulating various cellular processes, including cell proliferation, morphogenesis, and proteolysis. Its dysregulation has been implicated in various diseases, highlighting the importance of SERPINB5 in maintaining epithelial homeostasis and regulating cellular behavior. Further studies are needed to elucidate the mechanisms underlying SERPINB5 function and its role in disease pathogenesis.

Genular Protein ID: 1954691440

Symbol: SPB5_HUMAN

Name: Serpin B5

UniProtKB Accession Codes:

P36952 B2R6Y4 Q6N0B4 Q8WW89

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8290962

Title: Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.

PubMed ID: 8290962

DOI: 10.1126/science.8290962

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 7797587

Title: The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin.

PubMed ID: 7797587

DOI: 10.1074/jbc.270.26.15832

PubMed ID: 16049006

Title: Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership.

PubMed ID: 16049006

DOI: 10.1074/jbc.m503523200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15760906

Title: The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.

PubMed ID: 15760906

DOI: 10.1074/jbc.m412043200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 375
  • Mass: 42100
  • Checksum: 9F24E18505912804
  • Sequence:
    • MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF 
ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD 
FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFSESET 
KECPFRVNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES 
TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED 
TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH 
NKTRNIIFFG KFCSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.