Details for: NQO1

Gene ID: 1728

Symbol: NQO1

Ensembl ID: ENSG00000181019

Description: NAD(P)H quinone dehydrogenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.78
    Marker Score: 24098
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.82
    Marker Score: 24512
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.76
    Marker Score: 6270
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.51
    Marker Score: 2095
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.4
    Marker Score: 8249
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.22
    Marker Score: 2451
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.07
    Marker Score: 17826
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.01
    Marker Score: 2117
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.01
    Marker Score: 9640
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.96
    Marker Score: 3730
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.69
    Marker Score: 1128
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.51
    Marker Score: 11806.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.48
    Marker Score: 5704
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168344
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.44
    Marker Score: 358
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.44
    Marker Score: 1377
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.35
    Marker Score: 432
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.34
    Marker Score: 519
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.27
    Marker Score: 367
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.27
    Marker Score: 1635
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.25
    Marker Score: 770
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.25
    Marker Score: 9331
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.24
    Marker Score: 3896
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.21
    Marker Score: 6356
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.19
    Marker Score: 810
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.17
    Marker Score: 1368
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.17
    Marker Score: 2773
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 527
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.11
    Marker Score: 695
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251742
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.04
    Marker Score: 2547
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.02
    Marker Score: 2593
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.01
    Marker Score: 347
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71759
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47984
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.98
    Marker Score: 412
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.97
    Marker Score: 207
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.97
    Marker Score: 983
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.97
    Marker Score: 2596
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15014
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.94
    Marker Score: 448
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.93
    Marker Score: 803
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5277
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.92
    Marker Score: 1353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.9
    Marker Score: 336
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.9
    Marker Score: 216
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.88
    Marker Score: 515
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 428
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 196
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.84
    Marker Score: 529
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.83
    Marker Score: 232
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.83
    Marker Score: 28713
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1675
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.82
    Marker Score: 199
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.81
    Marker Score: 734
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8
    Marker Score: 1358
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.8
    Marker Score: 1164
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.79
    Marker Score: 852
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.79
    Marker Score: 407
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.78
    Marker Score: 779
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.77
    Marker Score: 3768
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.76
    Marker Score: 1204
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.73
    Marker Score: 782
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.73
    Marker Score: 213
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.72
    Marker Score: 715
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.72
    Marker Score: 327
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.72
    Marker Score: 1305.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.71
    Marker Score: 494
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.71
    Marker Score: 752
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.71
    Marker Score: 664
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2937
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 632
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.69
    Marker Score: 929
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.69
    Marker Score: 244
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.68
    Marker Score: 196
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.67
    Marker Score: 674
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.66
    Marker Score: 658
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 588
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.65
    Marker Score: 339
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.62
    Marker Score: 1567
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.62
    Marker Score: 248
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.61
    Marker Score: 254
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.61
    Marker Score: 13049
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.61
    Marker Score: 1077
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6
    Marker Score: 3866
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.6
    Marker Score: 140

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Other Information

**Key characteristics:** - NQO1 is a protein of the NAD(P)H family of enzymes. - It is a bifunctional enzyme that can act as a NAD(P)H dehydrogenase or a NADPH dehydrogenase. - It is involved in the regulation of cellular responses to stimuli, stress, and chemical stress. **Pathways and functions:** - NQO1 is involved in various cellular processes, including cellular responses to stimuli, cellular responses to stress, and cellular response to chemical stress. - It is involved in the regulation of cell cycle progression, proliferation, differentiation, and apoptosis. - It is also involved in the regulation of inflammation, cell survival, and apoptosis. **Clinical significance:** - Mutations in NQO1 have been linked to several human diseases, including cancer, neurodegenerative diseases, and metabolic disorders. - NQO1 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional notes:** - NQO1 is a highly conserved protein with significant expression in mammalian tissues. - It is a well-characterized protein that has been extensively studied for its role in cellular responses to stimuli, stress, and chemical stress.

Genular Protein ID: 1265421833

Symbol: NQO1_HUMAN

Name: NAD(P)H dehydrogenase [quinone] 1

UniProtKB Accession Codes:

P15559 B2R5Y9 B4DNM7 B7ZAD1 Q86UK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 2 EMBL 14 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 19 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 8 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2843525

Title: Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

PubMed ID: 2843525

DOI: 10.1016/s0021-9258(18)68280-8

PubMed ID: 1657151

Title: Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.

PubMed ID: 1657151

DOI: 10.1021/bi00108a007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999809

Title: Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.

PubMed ID: 8999809

DOI: 10.1074/jbc.272.3.1437

PubMed ID: 9271353

Title: The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant.

PubMed ID: 9271353

DOI: 10.1124/mol.52.2.300

PubMed ID: 15102952

Title: NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

PubMed ID: 15102952

DOI: 10.1124/mol.65.5.1238

PubMed ID: 15687255

Title: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.

PubMed ID: 15687255

DOI: 10.1101/gad.319905

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636573

Title: Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.

PubMed ID: 21636573

DOI: 10.1074/jbc.m111.241554

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28291250

Title: Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

PubMed ID: 28291250

DOI: 10.1038/srep44532

PubMed ID: 10543876

Title: Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).

PubMed ID: 10543876

DOI: 10.1021/jm991060m

PubMed ID: 10706635

Title: Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release.

PubMed ID: 10706635

DOI: 10.1073/pnas.97.7.3177

PubMed ID: 11735396

Title: Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.

PubMed ID: 11735396

DOI: 10.1021/bi011324i

PubMed ID: 11587640

Title: Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

PubMed ID: 11587640

DOI: 10.1016/s0969-2126(01)00636-0

PubMed ID: 16700548

Title: The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

PubMed ID: 16700548

DOI: 10.1021/bi0600087

PubMed ID: 1737339

Title: NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

PubMed ID: 1737339

PubMed ID: 10447260

Title: No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population.

PubMed ID: 10447260

DOI: 10.1002/(sici)1098-1004(1999)14:1<67::aid-humu8>3.0.co;2-5

Sequence Information:

  • Length: 274
  • Mass: 30868
  • Checksum: A4010462AD00F3FE
  • Sequence:
    • MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL 
KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV 
FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC 
GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK 
KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK

Genular Protein ID: 3207259120

Symbol: B4DLR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLR8

Database IDs:

ARBA 18 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 21 ChiTaRS 1 DNASU 1 EC 2 EMBL 3 EPD 1 Ensembl 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 8 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 202
  • Mass: 22793
  • Checksum: 845809C562CA8320
  • Sequence:
    • MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL 
KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QSGILHFCGF QVLEPQLTYS 
IGHTPADARI QILEGWKKRL ENIWDETPLY FAPSSLFDLN FQAGFLMKKE VQDEEKNKKF 
GLSVGHHLGK SIPTDNQIKA RK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.