Details for: NQO1

Gene ID: 1728

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NQO1

Ensembl ID: ENSG00000181019

Description: NAD(P)H quinone dehydrogenase 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mucous neck cell CL0000651
    CSI 31.12
    rCSI 44.86%
    PRS 94.9
  • foveolar cell of stomach CL0002179
    CSI 27.49
    rCSI 58.51%
    PRS 94.13
  • multi-ciliated epithelial cell CL0005012
    CSI 21.5
    rCSI 21.46%
    PRS 87.9
  • nasal mucosa goblet cell CL0002480
    CSI 19.66
    rCSI 22.8%
    PRS 92.96
  • ciliated cell CL0000064
    CSI 17.82
    rCSI 28.88%
    PRS 87.46
  • corneal epithelial cell CL0000575
    CSI 16.4
    rCSI 46.92%
    PRS 93.78
  • conjunctival epithelial cell CL1000432
    CSI 15.19
    rCSI 23.21%
    PRS 91.96
  • colon epithelial cell CL0011108
    CSI 14.11
    rCSI 14.78%
    PRS 90.85
  • tracheal goblet cell CL1000329
    CSI 11.17
    rCSI 24.4%
    PRS 94.32
  • myofibroblast cell CL0000186
    CSI 10.28
    rCSI 14.24%
    PRS 90.18
  • deuterosomal cell CL4033044
    CSI 10.08
    rCSI 34.06%
    PRS 87.7
  • dendritic cell CL0000451
    CSI 10.02
    rCSI 12.35%
    PRS 92.24
  • enterocyte CL0000584
    CSI 9.71
    rCSI 15.66%
    PRS 90.21
  • adipocyte CL0000136
    CSI 9.7
    rCSI 12.46%
    PRS 85.99
  • lung secretory cell CL1000272
    CSI 9.52
    rCSI 23.57%
    PRS 93.89
  • ependymal cell CL0000065
    CSI 8.46
    rCSI 17.17%
    PRS 77.52
  • paneth cell CL0000510
    CSI 8.03
    rCSI 11.85%
    PRS 96.5
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 7.56
    rCSI 17.24%
    PRS 86.72
  • goblet cell CL0000160
    CSI 7.56
    rCSI 7.14%
    PRS 90.83
  • fallopian tube secretory epithelial cell CL4030006
    CSI 6.79
    rCSI 6.54%
    PRS 91.71
  • stem cell CL0000034
    CSI 6.67
    rCSI 6.43%
    PRS 89.71
  • epithelial cell of lung CL0000082
    CSI 6.6
    rCSI 5.47%
    PRS 93.81
  • secretory cell CL0000151
    CSI 6.23
    rCSI 6.5%
    PRS 92.05
  • transit amplifying cell of colon CL0009011
    CSI 6.22
    rCSI 7.31%
    PRS 92.89
  • intestine goblet cell CL0019031
    CSI 6.1
    rCSI 5.41%
    PRS 90.8
  • epithelial cell CL0000066
    CSI 5.42
    rCSI 8.33%
    PRS 81.98
  • mammary gland epithelial cell CL0002327
    CSI 5.4
    rCSI 18.94%
    PRS 95.91
  • ciliated epithelial cell CL0000067
    CSI 5.05
    rCSI 4.44%
    PRS 85.39
  • vein endothelial cell CL0002543
    CSI 4.95
    rCSI 13.51%
    PRS 94.88
  • pulmonary capillary endothelial cell CL4028001
    CSI 4.93
    rCSI 9.4%
    PRS 96.6
  • blood vessel endothelial cell CL0000071
    CSI 4.83
    rCSI 10.02%
    PRS 91.56
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.8
    rCSI 12.41%
    PRS 91.01
  • club cell CL0000158
    CSI 4.46
    rCSI 6.54%
    PRS 89.23
  • basal cell CL0000646
    CSI 4.39
    rCSI 5.86%
    PRS 90.45
  • ionocyte CL0005006
    CSI 4.34
    rCSI 4.65%
    PRS 93.83
  • pancreatic acinar cell CL0002064
    CSI 4.3
    rCSI 5.71%
    PRS 95.09
  • duct epithelial cell CL0000068
    CSI 4.26
    rCSI 6.24%
    PRS 95.55
  • lung ciliated cell CL1000271
    CSI 4.25
    rCSI 4.91%
    PRS 88.35
  • respiratory suprabasal cell CL4033048
    CSI 4.1
    rCSI 5.26%
    PRS 94.1
  • brush cell CL0002204
    CSI 4.04
    rCSI 8.01%
    PRS 94.66
  • enteroendocrine cell CL0000164
    CSI 3.9
    rCSI 5.33%
    PRS 91.07
  • tuft cell of colon CL0009041
    CSI 3.86
    rCSI 9%
    PRS 93.87
  • intestinal tuft cell CL0019032
    CSI 3.75
    rCSI 5.72%
    PRS 93.99
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.72
    rCSI 7.03%
    PRS 96.91
  • choroid plexus epithelial cell CL0000706
    CSI 3.64
    rCSI 5.96%
    PRS 87.13
  • pancreatic ductal cell CL0002079
    CSI 3.53
    rCSI 6.87%
    PRS 93.99
  • keratocyte CL0002363
    CSI 3.53
    rCSI 8.47%
    PRS 93.49
  • intestinal epithelial cell CL0002563
    CSI 3.48
    rCSI 3.63%
    PRS 90.86
  • squamous epithelial cell CL0000076
    CSI 3.21
    rCSI 7.62%
    PRS 89.93
  • BEST4+ enteroycte CL4030026
    CSI 3.19
    rCSI 3.96%
    PRS 92.39
  • pulmonary artery endothelial cell CL1001568
    CSI 3.13
    rCSI 4.26%
    PRS 96.14
  • pulmonary ionocyte CL0017000
    CSI 2.96
    rCSI 3.6%
    PRS 95.41
  • interstitial cell of Cajal CL0002088
    CSI 2.8
    rCSI 3.57%
    PRS 95.51
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.75
    rCSI 4.38%
    PRS 94.67
  • acinar cell CL0000622
    CSI 2.51
    rCSI 3.67%
    PRS 96.57
  • cerebral cortex endothelial cell CL1001602
    CSI 2.48
    rCSI 4.29%
    PRS 88.6
  • rod bipolar cell CL0000751
    CSI 2.45
    rCSI 4.4%
    PRS 88.73
  • respiratory hillock cell CL4030023
    CSI 2.33
    rCSI 4.16%
    PRS 95.7
  • M cell of gut CL0000682
    CSI 2.1
    rCSI 2.23%
    PRS 94.5
  • transit amplifying cell CL0009010
    CSI 2.09
    rCSI 3.2%
    PRS 95.41
  • luminal epithelial cell of mammary gland CL0002326
    CSI 2.09
    rCSI 3.79%
    PRS 96.3
  • endothelial cell of placenta CL0009092
    CSI 2.05
    rCSI 10.08%
    PRS 95.45
  • radial glial cell CL0000681
    CSI 2.04
    rCSI 2.84%
    PRS 91.36
  • respiratory basal cell CL0002633
    CSI 1.99
    rCSI 2.07%
    PRS 94.15
  • pancreatic stellate cell CL0002410
    CSI 1.98
    rCSI 11.55%
    PRS 94
  • muscle cell CL0000187
    CSI 1.96
    rCSI 4.03%
    PRS 94.8
  • mononuclear phagocyte CL0000113
    CSI 1.84
    rCSI 4.05%
    PRS 95.04
  • parietal cell CL0000162
    CSI 1.82
    rCSI 15.7%
    PRS 95.64
  • endothelial cell of vascular tree CL0002139
    CSI 1.79
    rCSI 9.77%
    PRS 89.47
  • vein endothelial cell of respiratory system CL4033008
    CSI 1.78
    rCSI 12.19%
    PRS 95.42
  • retinal pigment epithelial cell CL0002586
    CSI 1.68
    rCSI 3.33%
    PRS 89.98
  • colonocyte CL1000347
    CSI 1.61
    rCSI 2.31%
    PRS 91.04
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.5
    rCSI 4.34%
    PRS 92.18
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.46
    rCSI 4.09%
    PRS 94.85
  • intestinal crypt stem cell of colon CL0009043
    CSI 1.44
    rCSI 10.8%
    PRS 96.1
  • alveolar adventitial fibroblast CL4028006
    CSI 1.43
    rCSI 2.25%
    PRS 93.89
  • endothelial cell of arteriole CL1000412
    CSI 1.33
    rCSI 7.39%
    PRS 96.81
  • small intestine goblet cell CL1000495
    CSI 1.3
    rCSI 2.85%
    PRS 94.39
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.19
    rCSI 3.2%
    PRS 94.42
  • colon goblet cell CL0009039
    CSI 1.1
    rCSI 2.62%
    PRS 93.89
  • peptic cell CL0000155
    CSI 1.09
    rCSI 10.7%
    PRS 95.57
  • bronchial goblet cell CL1000312
    CSI 0.92
    rCSI 3.66%
    PRS 95.19
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.85
    rCSI 4.46%
    PRS 94.13
  • transit amplifying cell of small intestine CL0009012
    CSI 0.76
    rCSI 3.35%
    PRS 95.18
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.72
    rCSI 3.91%
    PRS 94.55
  • basal cell of epithelium of trachea CL1000348
    CSI 0.68
    rCSI 4.79%
    PRS 93.2
  • tracheobronchial serous cell CL0019001
    CSI 0.68
    rCSI 2.93%
    PRS 94.65
  • epithelial cell of esophagus CL0002252
    CSI 0.56
    rCSI 5.51%
    PRS 91.4
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.5
    rCSI 7.72%
    PRS 94.46
  • lung microvascular endothelial cell CL2000016
    CSI 0.41
    rCSI 7.92%
    PRS 95.91
  • respiratory goblet cell CL0002370
    CSI 0.32
    rCSI 3.44%
    PRS 95.04

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary NAD(P)H quinone dehydrogenase 1, encoded by the [NQO1](/details-gene/1728) gene, is a cytosolic flavoenzyme that plays a central role in cellular detoxification and protection against oxidative stress. It catalyzes the two-electron reduction of quinones, thereby preventing the formation of reactive semiquinone intermediates and subsequent oxidative damage. **Overall**, [NQO1](/details-gene/1728) shows exceptionally high significance in various epithelial and secretory cell types, including [mucous neck cell](/details-cell/CL0000651)s of the stomach, [multi-ciliated epithelial cell](/details-cell/CL0005012)s of the respiratory tract, and [corneal epithelial cell](/details-cell/CL0000575)s. This expression pattern highlights its crucial function as a frontline defense mechanism in tissues that form a barrier to the external environment. Clinically, polymorphisms and deficiency in [NQO1](/details-gene/1728) are associated with increased susceptibility to certain cancers and toxic insults ([125860](https://omim.org/entry/125860)). ## Cellular Roles and Expression Landscape The expression profile of [NQO1](/details-gene/1728) underscores its primary role as a cytoprotective enzyme in barrier tissues. **Overall**, its most significant expression is observed in a wide array of epithelial cells that are constantly exposed to xenobiotics and oxidative agents. Top cell types where [NQO1](/details-gene/1728) is a highly significant marker include: * **Gastrointestinal Tract:** [mucous neck cell](/details-cell/CL0000651) (CSI: 31.12), [foveolar cell of stomach](/details-cell/CL0002179) (CSI: 27.49), [colon epithelial cell](/details-cell/CL0011108) (CSI: 14.11), and [enterocyte](/details-cell/CL0000584) (CSI: 9.71). This suggests a critical role in detoxifying dietary compounds and protecting the gut lining from oxidative damage. * **Respiratory and Ocular Surfaces:** [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 21.50), [nasal mucosa goblet cell](/details-cell/CL0002480) (CSI: 19.66), [tracheal goblet cell](/details-cell/CL1000329) (CSI: 11.17), [corneal epithelial cell](/details-cell/CL0000575) (CSI: 16.40), and [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 15.19). High expression in these cells is consistent with a function in protecting against airborne pollutants, allergens, and pathogens. * **Other Cell Types:** Significant expression is also noted in [dendritic cell](/details-cell/CL0000451)s (CSI: 10.02), implying a role in modulating immune responses to oxidative stress, as well as in [adipocyte](/details-cell/CL0000136)s (CSI: 9.70) and [myofibroblast cell](/details-cell/CL0000186)s (CSI: 10.28), suggesting broader functions in metabolism and tissue remodeling. This widespread expression in diverse epithelial lineages points to [NQO1](/details-gene/1728) being a fundamental component of the cellular antioxidant defense system. ## Pathways and Molecular Function The functions of [NQO1](/details-gene/1728) are primarily centered on redox biology and cytoprotection. As a NAD(P)H dehydrogenase, it exhibits [Nad(p)h dehydrogenase (quinone) activity](/details-ontology/GO:0003955) and is a key player in [Cell redox homeostasis](/details-ontology/GO:0045454) and the [Response to oxidative stress](/details-ontology/GO:0006979). Research has confirmed its role as a superoxide scavenger, contributing directly to the [Removal of superoxide radicals](/details-ontology/GO:0019430) ([Link](https://doi.org/10.1124/mol.65.5.1238)). Key pathways and processes involving [NQO1](/details-gene/1728) include: * **Antioxidant Response:** [NQO1](/details-gene/1728) is a canonical target gene of the NFE2L2 (Nrf2) transcription factor, a master regulator of the antioxidant response. Its involvement is prominent in the [Keap1-nfe2l2 pathway](/details-pathway/R-HSA-9755511) and in processes related to [Nfe2l2 regulating anti-oxidant/detoxification enzymes](/details-pathway/R-HSA-9818027). * **Detoxification:** The enzyme is integral to the [Xenobiotic metabolic process](/details-ontology/GO:0006805), protecting cells from a wide range of toxins and chemical stressors, as annotated in the [Cellular response to chemical stress](/details-pathway/R-HSA-9711123) pathway. * **Regulation of Cell Death:** [NQO1](/details-gene/1728) influences cell fate by participating in the [Negative regulation of apoptotic process](/details-ontology/GO:0043066) and [Negative regulation of ferroptosis](/details-ontology/GO:0110076). Its interaction with tumor suppressors is complex; for instance, it has been shown to mediate the ubiquitin-independent proteasomal degradation of p53 and p73 ([Link](https://doi.org/10.1101/gad.319905)). * **Vitamin Metabolism:** It also contributes to the metabolic processes of fat-soluble vitamins, including [Vitamin k metabolic process](/details-ontology/GO:0042373) and [Vitamin e metabolic process](/details-ontology/GO:0042360), which is consistent with its role in reducing alpha-tocopherolquinone ([Link](https://doi.org/10.1124/mol.52.2.300)). These molecular functions are highly consistent with its expression pattern, where it acts to maintain cellular integrity in tissues under high metabolic or environmental stress. ## Research Directions The well-established role of [NQO1](/details-gene/1728) in cytoprotection and its specific expression patterns open several avenues for future investigation, particularly concerning its role in disease pathogenesis and therapy. **Proposed Hypotheses:** 1. Given its extremely high significance in gastric mucosal cells like [mucous neck cell](/details-cell/CL0000651) and [foveolar cell of stomach](/details-cell/CL0002179), we hypothesize that downregulation or functional polymorphisms of [NQO1](/details-gene/1728) are a key susceptibility factor for chronic gastritis and peptic ulcer disease, as reduced detoxification capacity would leave the gastric epithelium vulnerable to damage from *H. pylori* toxins and NSAIDs. 2. Based on its role in the [Negative regulation of apoptotic process](/details-ontology/GO:0043066) and its ability to modulate p53 stability, we hypothesize that overexpression of [NQO1](/details-gene/1728) in [colon epithelial cell](/details-cell/CL0011108)s confers a survival advantage during colorectal tumorigenesis by suppressing apoptosis and mitigating oxidative stress, thereby promoting cancer progression. **Experimental Approach:** To test the first hypothesis, a combination of *in vivo* and *in vitro* models could be employed. Specifically, one could utilize NQO1-knockout mice and subject them to a chronic *H. pylori* infection model. The extent of gastric inflammation, epithelial cell damage, oxidative stress markers (e.g., 8-hydroxy-2'-deoxyguanosine), and progression to atrophic gastritis would be compared between knockout and wild-type mice using histopathology, immunohistochemistry, and qPCR. Gastric organoids derived from these mice could further be used to dissect the cell-intrinsic role of [NQO1](/details-gene/1728) in protecting against specific bacterial toxins. **Therapeutic Potential:** [NQO1](/details-gene/1728) presents a dual-faceted therapeutic potential. In conditions driven by oxidative stress, such as neurodegenerative diseases or inflammatory bowel disease, strategies aimed at **activation** of [NQO1](/details-gene/1728) could be beneficial. Conversely, in oncology, its high expression in certain solid tumors is a vulnerability that can be exploited. This makes [NQO1](/details-gene/1728) a prime target for **bioreductive cancer therapies**, where non-toxic prodrugs (such as CB1954) are selectively activated into potent cytotoxic agents by NQO1 within the tumor microenvironment, minimizing systemic toxicity ([Link](https://doi.org/10.1021/jm991060m)).

Genular Protein ID: 1265421833

Symbol: NQO1_HUMAN

Name: NAD(P)H dehydrogenase [quinone] 1

UniProtKB Accession Codes:

P15559 B2R5Y9 B4DNM7 B7ZAD1 Q86UK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 2 EMBL 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 8 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2843525

Title: Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

PubMed ID: 2843525

DOI: 10.1016/s0021-9258(18)68280-8

PubMed ID: 1657151

Title: Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.

PubMed ID: 1657151

DOI: 10.1021/bi00108a007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999809

Title: Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.

PubMed ID: 8999809

DOI: 10.1074/jbc.272.3.1437

PubMed ID: 9271353

Title: The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant.

PubMed ID: 9271353

DOI: 10.1124/mol.52.2.300

PubMed ID: 15102952

Title: NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

PubMed ID: 15102952

DOI: 10.1124/mol.65.5.1238

PubMed ID: 15687255

Title: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.

PubMed ID: 15687255

DOI: 10.1101/gad.319905

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21636573

Title: Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.

PubMed ID: 21636573

DOI: 10.1074/jbc.m111.241554

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28291250

Title: Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

PubMed ID: 28291250

DOI: 10.1038/srep44532

PubMed ID: 10543876

Title: Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).

PubMed ID: 10543876

DOI: 10.1021/jm991060m

PubMed ID: 10706635

Title: Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release.

PubMed ID: 10706635

DOI: 10.1073/pnas.97.7.3177

PubMed ID: 11735396

Title: Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.

PubMed ID: 11735396

DOI: 10.1021/bi011324i

PubMed ID: 11587640

Title: Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

PubMed ID: 11587640

DOI: 10.1016/s0969-2126(01)00636-0

PubMed ID: 16700548

Title: The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

PubMed ID: 16700548

DOI: 10.1021/bi0600087

PubMed ID: 1737339

Title: NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

PubMed ID: 1737339

PubMed ID: 10447260

Title: No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population.

PubMed ID: 10447260

DOI: 10.1002/(sici)1098-1004(1999)14:1<67::aid-humu8>3.0.co;2-5

Sequence Information:

  • Length: 274
  • Mass: 30868
  • Checksum: A4010462AD00F3FE
  • Sequence:
    • MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL 
KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV 
FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC 
GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK 
KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK

Genular Protein ID: 3207259120

Symbol: B4DLR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLR8

Database IDs:

ARBA 17 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 21 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 8 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 202
  • Mass: 22793
  • Checksum: 845809C562CA8320
  • Sequence:
    • MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL 
KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QSGILHFCGF QVLEPQLTYS 
IGHTPADARI QILEGWKKRL ENIWDETPLY FAPSSLFDLN FQAGFLMKKE VQDEEKNKKF 
GLSVGHHLGK SIPTDNQIKA RK