Details for: PLAU

Gene ID: 5328

Symbol: PLAU

Ensembl ID: ENSG00000122861

Description: plasminogen activator, urokinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.5141
    Cell Significance Index: -18.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.7521
    Cell Significance Index: -19.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.3809
    Cell Significance Index: -14.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0734
    Cell Significance Index: -20.0200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.7350
    Cell Significance Index: 23.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.1643
    Cell Significance Index: 194.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9310
    Cell Significance Index: 79.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6560
    Cell Significance Index: 137.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0258
    Cell Significance Index: 27.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1583
    Cell Significance Index: 220.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0131
    Cell Significance Index: 29.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9107
    Cell Significance Index: 7.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.9057
    Cell Significance Index: 6.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8106
    Cell Significance Index: 80.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7808
    Cell Significance Index: 12.0800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7716
    Cell Significance Index: 6.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6504
    Cell Significance Index: 18.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5324
    Cell Significance Index: 480.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4149
    Cell Significance Index: 67.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4069
    Cell Significance Index: 44.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4030
    Cell Significance Index: 18.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3679
    Cell Significance Index: 3.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3631
    Cell Significance Index: 21.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2954
    Cell Significance Index: 38.1600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.2932
    Cell Significance Index: 2.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2798
    Cell Significance Index: 5.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1960
    Cell Significance Index: 2.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1884
    Cell Significance Index: 0.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1774
    Cell Significance Index: 21.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1235
    Cell Significance Index: 22.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1198
    Cell Significance Index: 4.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1132
    Cell Significance Index: 13.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1087
    Cell Significance Index: 48.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0990
    Cell Significance Index: 72.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0913
    Cell Significance Index: 49.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0681
    Cell Significance Index: 3.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0420
    Cell Significance Index: 0.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0321
    Cell Significance Index: 0.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0292
    Cell Significance Index: 0.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0197
    Cell Significance Index: 0.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0151
    Cell Significance Index: 10.4500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0008
    Cell Significance Index: 0.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0029
    Cell Significance Index: -0.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0060
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0084
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0101
    Cell Significance Index: -19.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0118
    Cell Significance Index: -0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0170
    Cell Significance Index: -26.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0193
    Cell Significance Index: -26.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0223
    Cell Significance Index: -16.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0258
    Cell Significance Index: -16.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0378
    Cell Significance Index: -6.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0381
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0400
    Cell Significance Index: -8.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0451
    Cell Significance Index: -3.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0458
    Cell Significance Index: -20.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0506
    Cell Significance Index: -18.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0530
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0578
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0581
    Cell Significance Index: -6.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0599
    Cell Significance Index: -11.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0601
    Cell Significance Index: -17.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0756
    Cell Significance Index: -2.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0931
    Cell Significance Index: -18.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1082
    Cell Significance Index: -2.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1101
    Cell Significance Index: -4.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1206
    Cell Significance Index: -8.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1296
    Cell Significance Index: -16.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1326
    Cell Significance Index: -19.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1592
    Cell Significance Index: -12.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1632
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1681
    Cell Significance Index: -1.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1686
    Cell Significance Index: -19.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1930
    Cell Significance Index: -4.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2114
    Cell Significance Index: -13.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2465
    Cell Significance Index: -18.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2937
    Cell Significance Index: -4.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2977
    Cell Significance Index: -20.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3096
    Cell Significance Index: -19.5100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3118
    Cell Significance Index: -2.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3368
    Cell Significance Index: -8.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3405
    Cell Significance Index: -20.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3490
    Cell Significance Index: -5.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3987
    Cell Significance Index: -10.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4008
    Cell Significance Index: -22.4900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.4261
    Cell Significance Index: -4.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4315
    Cell Significance Index: -15.8400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4375
    Cell Significance Index: -6.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4447
    Cell Significance Index: -23.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4459
    Cell Significance Index: -7.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4490
    Cell Significance Index: -19.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4512
    Cell Significance Index: -15.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4561
    Cell Significance Index: -3.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5196
    Cell Significance Index: -15.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PLAU gene encodes for the urokinase-type plasminogen activator (uPA), a serine protease that plays a central role in fibrinolysis, cell migration, and proteolysis. uPA is a zinc-dependent enzyme that catalyzes the conversion of plasminogen to plasmin, a key step in the dissolution of fibrin clots. The PLAU gene is highly expressed in various cell types, including epithelial cells, fibroblasts, and smooth muscle cells. **Pathways and Functions:** The PLAU gene is involved in several key pathways, including: 1. **Fibrinolysis:** uPA is a key regulator of fibrinolysis, the process by which fibrin clots are dissolved. uPA promotes the conversion of plasminogen to plasmin, which then breaks down fibrin clots. 2. **Cell Migration:** uPA is involved in cell migration, a process essential for tissue repair, wound healing, and cancer metastasis. 3. **Proteolysis:** uPA is a serine protease that catalyzes the degradation of various proteins, including collagen, laminin, and fibronectin. 4. **Regulation of Cell Adhesion:** uPA regulates cell adhesion mediated by integrins, a process essential for cell migration and tissue repair. **Clinical Significance:** The PLAU gene has significant clinical implications in various diseases, including: 1. **Thrombosis:** uPA is involved in the dissolution of fibrin clots, making it a potential therapeutic target for thrombosis. 2. **Cancer:** uPA is overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been associated with tumor progression and metastasis. 3. **Wound Healing:** uPA is involved in the regulation of wound healing, and its dysregulation can lead to impaired wound closure and tissue repair. 4. **Cardiovascular Disease:** uPA is involved in the regulation of smooth muscle cell migration, which is essential for vascular remodeling and cardiovascular disease. In conclusion, the PLAU gene is a critical regulator of fibrinolysis, cell migration, and proteolysis, and its dysregulation has significant clinical implications in various diseases. Further research is needed to fully understand the mechanisms of PLAU gene function and its role in human disease. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of PLAU gene function and its role in human disease. 2. The PLAU gene should be considered as a potential therapeutic target for thrombosis and cancer. 3. The PLAU gene should be studied in the context of wound healing and cardiovascular disease. 4. The PLAU gene should be evaluated in the context of other genes involved in fibrinolysis and cell migration. **References:** * [Insert references to studies on PLAU gene function and its role in human disease] **Disclaimer:** This article is for informational purposes only and should not be considered as medical advice.

Genular Protein ID: 2141246787

Symbol: UROK_HUMAN

Name: Urokinase-type plasminogen activator

UniProtKB Accession Codes:

P00749 B4DPZ2 Q15844 Q16618 Q53XS3 Q5SWW9 Q969W6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 34 DrugCentral 1 EC 2 ELM 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 2 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3888571

Title: Molecular cloning, sequencing, and expression in Escherichia coli of human preprourokinase cDNA.

PubMed ID: 3888571

DOI: 10.1089/dna.1985.4.139

PubMed ID: 2415429

Title: Molecular cloning of cDNA coding for human preprourokinase.

PubMed ID: 2415429

DOI: 10.1016/0378-1119(85)90084-8

PubMed ID: 2987867

Title: The human urokinase-plasminogen activator gene and its promoter.

PubMed ID: 2987867

DOI: 10.1093/nar/13.8.2759

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8652631

Title: Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure.

PubMed ID: 8652631

DOI: 10.1016/0167-4838(95)00228-6

PubMed ID: 2023947

Title: Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator.

PubMed ID: 2023947

DOI: 10.1073/pnas.88.9.3992

PubMed ID: 6589620

Title: Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

PubMed ID: 6589620

DOI: 10.1073/pnas.81.15.4727

PubMed ID: 6754569

Title: The primary structure of high molecular mass urokinase from human urine. The complete amino acid sequence of the A chain.

PubMed ID: 6754569

DOI: 10.1515/bchm2.1982.363.2.1155

PubMed ID: 6749491

Title: Human low-molecular-weight urinary urokinase. Partial characterization and preliminary sequence data of the two polypeptide chains.

PubMed ID: 6749491

DOI: 10.1111/j.1432-1033.1982.tb06676.x

PubMed ID: 6754572

Title: The complete amino acid sequence of low molecular mass urokinase from human urine.

PubMed ID: 6754572

DOI: 10.1515/bchm2.1982.363.2.1043

PubMed ID: 3501295

Title: Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3.

PubMed ID: 3501295

DOI: 10.1515/bchm3.1987.368.2.1427

PubMed ID: 9151681

Title: Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility.

PubMed ID: 9151681

DOI: 10.1083/jcb.137.3.779

PubMed ID: 10340997

Title: Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility.

PubMed ID: 10340997

DOI: 10.1093/molehr/5.6.513

PubMed ID: 10636902

Title: A urokinase receptor-associated protein with specific collagen binding properties.

PubMed ID: 10636902

DOI: 10.1074/jbc.275.3.1993

PubMed ID: 11384978

Title: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.

PubMed ID: 11384978

DOI: 10.1074/jbc.m102727200

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 14696115

Title: Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma.

PubMed ID: 14696115

DOI: 10.1002/ijc.11594

PubMed ID: 15988036

Title: Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells.

PubMed ID: 15988036

DOI: 10.1128/mcb.25.14.6279-6288.2005

PubMed ID: 20007542

Title: Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene.

PubMed ID: 20007542

DOI: 10.1182/blood-2009-07-233965

PubMed ID: 24434139

Title: TMPRSS4 induces cancer cell invasion through pro-uPA processing.

PubMed ID: 24434139

DOI: 10.1016/j.bbrc.2014.01.013

PubMed ID: 2536903

Title: Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR.

PubMed ID: 2536903

DOI: 10.1038/337579a0

PubMed ID: 1327118

Title: Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase.

PubMed ID: 1327118

DOI: 10.1021/bi00155a008

PubMed ID: 8107091

Title: Solution structure of the kringle domain from urokinase-type plasminogen activator.

PubMed ID: 8107091

DOI: 10.1006/jmbi.1994.1106

PubMed ID: 8591045

Title: The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.

PubMed ID: 8591045

DOI: 10.1016/s0969-2126(01)00203-9

PubMed ID: 10805774

Title: (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.

PubMed ID: 10805774

DOI: 10.1073/pnas.97.10.5113

PubMed ID: 16456079

Title: Structure of human urokinase plasminogen activator in complex with its receptor.

PubMed ID: 16456079

DOI: 10.1126/science.1121143

PubMed ID: 9065988

Title: Detection of polymorphisms in the human urokinase-type plasminogen activator gene.

PubMed ID: 9065988

PubMed ID: 9194591

Title: Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer.

PubMed ID: 9194591

DOI: 10.1002/elps.1150180505

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 431
  • Mass: 48523
  • Checksum: 2F7E6005A8765AC1
  • Sequence:
    • MRALLARLLL CVLVVSDSKG SNELHQVPSN CDCLNGGTCV SNKYFSNIHW CNCPKKFGGQ 
HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN 
YCRNPDNRRR PWCYVQVGLK LLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII 
GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG 
RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL 
PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY YGSEVTTKML 
CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR 
SHTKEENGLA L

Genular Protein ID: 3750573298

Symbol: Q59GZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GZ8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 207
  • Mass: 23624
  • Checksum: A16E33E1634438B4
  • Sequence:
    • HEKTLRPRFK IIGGEFTTIE NQPWFAAIYR RHRGGSVTYV CGGSLISPCW VISATHCFID 
YPQKEDYIVY LGRSRLNSNT QGEMKFEVEN LILHKDYSAD TLAHHNDIAL LKIRSKEGRC 
AQPSRTIQTI CLPSMYNDPQ FGTSCEITGF GKENSTDYLY PEQLKMTVVK LISHRECQQP 
HYYGSEVTTK MLCAADPQWK TDSCQAA

Genular Protein ID: 3875327892

Symbol: B4DNJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNJ4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 11 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 345
  • Mass: 39059
  • Checksum: 0B785D656FC58537
  • Sequence:
    • MGRPCLPWNS ATVLQQTYHA HRSDALQLGL GKHNYCRNPD NRRRPWCYVQ VGLKPLVQEC 
MVHDCADGKK PSSPPEELKF QCGQKTLRPR FKIIGGEFTT IENQPWFAAI YRRHRGGSVT 
YVCGGSLISP CWVISATHCF IDYPKKEDYI VYLGRSRLNS NTQGEMKFEV ENLILHKDYS 
ADTLAHHNDI ALLKIRSKEG RCAQPSRTIQ TICLPSMYND PQFGTSCEIT GFGKENSTDY 
LYPEQLKMTV VKLISHRECQ QPHYYGSEVT TKMLCAADPQ WKTDSCQGDS GGPFVCSLQG 
RMTLTGIVSW GRGCALKDKP GVYTRVSHFL PWIRSHTKEE NGLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.