Details for: HAS3

Gene ID: 3038

Symbol: HAS3

Ensembl ID: ENSG00000103044

Description: hyaluronan synthase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.55
    Marker Score: 3209
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1898
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.23
    Marker Score: 5124
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.19
    Marker Score: 404.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.12
    Marker Score: 882
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.9
    Marker Score: 4404.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9
    Marker Score: 2190
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.79
    Marker Score: 6162
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1322
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.67
    Marker Score: 556
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2712
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 376.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1378
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.57
    Marker Score: 223
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7468
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.46
    Marker Score: 1056
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.45
    Marker Score: 721
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.44
    Marker Score: 2864
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.44
    Marker Score: 3783
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.43
    Marker Score: 2283
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.43
    Marker Score: 452
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.42
    Marker Score: 2277
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.39
    Marker Score: 2908
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 758
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.35
    Marker Score: 1854
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.35
    Marker Score: 2205
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.31
    Marker Score: 244
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.31
    Marker Score: 87
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.29
    Marker Score: 380
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.29
    Marker Score: 3858
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.28
    Marker Score: 4520
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.28
    Marker Score: 154
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.27
    Marker Score: 316
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.27
    Marker Score: 2006
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.26
    Marker Score: 481
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.26
    Marker Score: 595
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.26
    Marker Score: 65
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 119
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.25
    Marker Score: 278
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.23
    Marker Score: 360
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.22
    Marker Score: 110
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 222
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.21
    Marker Score: 647
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.18
    Marker Score: 124
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 132
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 103
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.17
    Marker Score: 994
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.16
    Marker Score: 80
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.16
    Marker Score: 536
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 105
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 271
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.14
    Marker Score: 344
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.14
    Marker Score: 579
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 780
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.13
    Marker Score: 1216
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.13
    Marker Score: 362
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * HAS3 is a transmembrane protein with a single transmembrane domain. * It is a chaperone protein that helps to regulate the activity of other hyaluronan synthases. * HAS3 is a highly conserved protein, with a similar sequence in mammals and humans. * It is a key enzyme in the biosynthesis of hyaluronic acid, which is a major component of the extracellular matrix. **Pathways and functions** * HAS3 is involved in the early endosome pathway of HA biosynthesis. * It is also involved in the extravascular synthesis of HA, as well as the biosynthesis of HA in the nucleus of cells. * HAS3 is a key regulator of the expression of other genes that are involved in HA synthesis. * It is also involved in the regulation of cell migration and adhesion. **Clinical significance** * Mutations in HAS3 have been linked to a number of human diseases, including corneal dystrophy, rheumatoid arthritis, and osteoarthritis. * HAS3 inhibitors are being investigated as potential treatments for these diseases. **Additional information** * HAS3 is a highly conserved protein, with a similar sequence in mammals and humans. * It is a member of the hyaluronan synthase family of enzymes, which are responsible for the biosynthesis of hyaluronic acid. * HAS3 is a highly regulated protein, with its expression being controlled by a variety of factors, including growth factors, cytokines, and hormones.

Genular Protein ID: 4257301785

Symbol: HYAS3_HUMAN

Name: Hyaluronan synthase 3

UniProtKB Accession Codes:

O00219 A8K5T5 Q8WTZ0 Q9NYP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9083017

Title: Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase.

PubMed ID: 9083017

DOI: 10.1074/jbc.272.14.8957

PubMed ID: 23303191

Title: Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

PubMed ID: 23303191

DOI: 10.1074/jbc.m112.443879

PubMed ID: 25795779

Title: Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

PubMed ID: 25795779

DOI: 10.1074/jbc.m115.640581

PubMed ID: 26883802

Title: UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.

PubMed ID: 26883802

DOI: 10.1007/s00018-016-2158-5

PubMed ID: 30394292

Title: Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

PubMed ID: 30394292

DOI: 10.1016/j.matbio.2018.10.004

Sequence Information:

  • Length: 553
  • Mass: 62998
  • Checksum: 82F3B0C932EE9EA3
  • Sequence:
    • MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 
LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 
VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 
STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 
VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 
DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 
YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 
IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 
LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 
KKPEQYSLAF AEV

Genular Protein ID: 3686707703

Symbol: Q96RV2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96RV2

Database IDs:

ARBA 2 AlphaFoldDB 1 BRENDA 1 BioGRID-ORCS 1 CAZy 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11431361

Title: Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

PubMed ID: 11431361

Sequence Information:

  • Length: 553
  • Mass: 62894
  • Checksum: 75D8E2A3F6BD2469
  • Sequence:
    • MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 
LFAFLEHRRM QRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 
VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 
STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 
VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 
DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 
YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 
IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 
LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 
KKPEQSSLAF AEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.