Details for: HAS3

Gene ID: 3038

Symbol: HAS3

Ensembl ID: ENSG00000103044

Description: hyaluronan synthase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.4302
    Cell Significance Index: -3.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.0211
    Cell Significance Index: -3.8100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 8.6415
    Cell Significance Index: 25.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.5635
    Cell Significance Index: 289.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0982
    Cell Significance Index: -3.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5202
    Cell Significance Index: 43.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3944
    Cell Significance Index: 85.4900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.3605
    Cell Significance Index: 8.4200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3468
    Cell Significance Index: 14.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5935
    Cell Significance Index: 12.6400
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.5753
    Cell Significance Index: 5.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5750
    Cell Significance Index: 15.6500
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.5073
    Cell Significance Index: 5.7800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4952
    Cell Significance Index: 4.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4312
    Cell Significance Index: 19.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4306
    Cell Significance Index: 81.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4269
    Cell Significance Index: 9.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3931
    Cell Significance Index: 70.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3725
    Cell Significance Index: 36.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3537
    Cell Significance Index: 5.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3451
    Cell Significance Index: 20.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3443
    Cell Significance Index: 42.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2949
    Cell Significance Index: 8.2400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.2862
    Cell Significance Index: 3.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2861
    Cell Significance Index: 2.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2783
    Cell Significance Index: 6.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2661
    Cell Significance Index: 9.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2412
    Cell Significance Index: 26.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2019
    Cell Significance Index: 4.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1759
    Cell Significance Index: 2.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1746
    Cell Significance Index: 28.4100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.1567
    Cell Significance Index: 1.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1488
    Cell Significance Index: 65.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1395
    Cell Significance Index: 2.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1387
    Cell Significance Index: 125.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1202
    Cell Significance Index: 2.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0996
    Cell Significance Index: 6.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0551
    Cell Significance Index: 3.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0516
    Cell Significance Index: 10.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0316
    Cell Significance Index: 0.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0308
    Cell Significance Index: 16.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0272
    Cell Significance Index: 5.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0175
    Cell Significance Index: 0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0159
    Cell Significance Index: 12.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0108
    Cell Significance Index: 0.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0096
    Cell Significance Index: 0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0078
    Cell Significance Index: 1.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0072
    Cell Significance Index: 2.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0022
    Cell Significance Index: 0.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0035
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0085
    Cell Significance Index: -3.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0109
    Cell Significance Index: -3.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0119
    Cell Significance Index: -1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0140
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0154
    Cell Significance Index: -2.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0181
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0187
    Cell Significance Index: -2.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0201
    Cell Significance Index: -0.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0256
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0276
    Cell Significance Index: -5.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0307
    Cell Significance Index: -0.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0314
    Cell Significance Index: -3.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0368
    Cell Significance Index: -3.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0393
    Cell Significance Index: -2.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0394
    Cell Significance Index: -2.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0432
    Cell Significance Index: -2.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0445
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0468
    Cell Significance Index: -3.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0468
    Cell Significance Index: -0.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0499
    Cell Significance Index: -3.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0523
    Cell Significance Index: -2.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0577
    Cell Significance Index: -3.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0662
    Cell Significance Index: -2.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0663
    Cell Significance Index: -0.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0672
    Cell Significance Index: -1.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0752
    Cell Significance Index: -2.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0781
    Cell Significance Index: -4.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0804
    Cell Significance Index: -3.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0814
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0833
    Cell Significance Index: -2.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0853
    Cell Significance Index: -1.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0863
    Cell Significance Index: -4.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0945
    Cell Significance Index: -3.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0964
    Cell Significance Index: -3.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0964
    Cell Significance Index: -3.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1001
    Cell Significance Index: -1.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1020
    Cell Significance Index: -1.5100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1040
    Cell Significance Index: -0.8600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1050
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** HAS3 is a hyaluronan synthase that catalyzes the formation of HA from UDP-glucose and N-acetylglucosamine-6-sulfate. 2. **Cellular Expression:** HAS3 is highly expressed in various cell types, including epithelial cells, stem cells, and immune cells, suggesting its involvement in tissue development, maintenance, and immune regulation. 3. **Tissue Distribution:** HAS3 is widely distributed in tissues, including the kidney, bladder, respiratory tract, skin, and colon, highlighting its role in maintaining tissue homeostasis. 4. **Regulatory Mechanisms:** HAS3 expression is regulated by various factors, including transcriptional regulators, growth factors, and cytokines, indicating its involvement in complex cellular signaling pathways. **Pathways and Functions:** 1. **Hyaluronan Biosynthesis and Export:** HAS3 is essential for the production and export of HA, which is then deposited into the ECM or released into the extracellular space. 2. **Extracellular Matrix Assembly:** HA synthesized by HAS3 plays a critical role in ECM assembly and maintenance, influencing cell migration, differentiation, and survival. 3. **Immune Regulation:** HAS3 has been implicated in modulating immune responses, including the regulation of T cell activation, proliferation, and differentiation. 4. **Cancer Metastasis:** HA produced by HAS3 has been shown to facilitate cancer cell migration, invasion, and metastasis. 5. **Inflammation and Autoimmune Diseases:** HAS3 may also contribute to the development and progression of inflammatory and autoimmune diseases by regulating HA levels and modulating immune responses. **Clinical Significance:** 1. **Cancer Therapy:** Targeting HAS3 and HA production may offer a novel therapeutic strategy for cancer treatment, particularly in reducing metastasis and improving patient outcomes. 2. **Inflammation and Autoimmune Diseases:** Modulating HAS3 expression and HA production may provide a new approach to treating inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 3. **Wound Healing and Tissue Engineering:** Understanding the role of HAS3 in HA biosynthesis and ECM assembly may lead to the development of novel wound healing strategies and tissue engineering approaches. 4. **Immunotherapy:** HAS3 may serve as a target for immunotherapies aimed at modulating immune responses and improving treatment outcomes for various diseases. In conclusion, HAS3 plays a critical role in regulating HA production, ECM assembly, and immune responses, highlighting its significance in various biological processes and diseases. Further research is needed to fully elucidate the functions and clinical implications of HAS3, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 4257301785

Symbol: HYAS3_HUMAN

Name: Hyaluronan synthase 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9083017

Title: Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase.

PubMed ID: 9083017

DOI: 10.1074/jbc.272.14.8957

PubMed ID: 23303191

Title: Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

PubMed ID: 23303191

DOI: 10.1074/jbc.m112.443879

PubMed ID: 25795779

Title: Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

PubMed ID: 25795779

DOI: 10.1074/jbc.m115.640581

PubMed ID: 26883802

Title: UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.

PubMed ID: 26883802

DOI: 10.1007/s00018-016-2158-5

PubMed ID: 30394292

Title: Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

PubMed ID: 30394292

DOI: 10.1016/j.matbio.2018.10.004

Sequence Information:

  • Length: 553
  • Mass: 62998
  • Checksum: 82F3B0C932EE9EA3
  • Sequence:
  • MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 
    LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 
    VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 
    STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 
    VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 
    DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 
    YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 
    IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 
    LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 
    KKPEQYSLAF AEV

Genular Protein ID: 3686707703

Symbol: Q96RV2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11431361

Title: Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

PubMed ID: 11431361

Sequence Information:

  • Length: 553
  • Mass: 62894
  • Checksum: 75D8E2A3F6BD2469
  • Sequence:
  • MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 
    LFAFLEHRRM QRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 
    VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 
    STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 
    VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 
    DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 
    YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 
    IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 
    LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 
    KKPEQSSLAF AEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.