Details for: PLAT

Gene ID: 5327

Symbol: PLAT

Ensembl ID: ENSG00000104368

Description: plasminogen activator, tissue type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.3246
    Cell Significance Index: -24.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.2769
    Cell Significance Index: -24.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.7745
    Cell Significance Index: -19.8200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 25.1492
    Cell Significance Index: 93.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.1052
    Cell Significance Index: -20.1500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.7901
    Cell Significance Index: 60.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9030
    Cell Significance Index: -23.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2011
    Cell Significance Index: -24.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.8936
    Cell Significance Index: 80.4100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.5862
    Cell Significance Index: 34.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.1225
    Cell Significance Index: 307.2500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.9224
    Cell Significance Index: 28.1700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.5697
    Cell Significance Index: 22.0900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.3954
    Cell Significance Index: 30.1400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 3.1267
    Cell Significance Index: 32.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0196
    Cell Significance Index: 53.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2732
    Cell Significance Index: 78.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1697
    Cell Significance Index: 33.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0451
    Cell Significance Index: 54.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9379
    Cell Significance Index: 14.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9094
    Cell Significance Index: 21.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8678
    Cell Significance Index: 119.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7956
    Cell Significance Index: 13.1100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.7788
    Cell Significance Index: 4.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7329
    Cell Significance Index: 19.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5739
    Cell Significance Index: 7.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5539
    Cell Significance Index: 71.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4988
    Cell Significance Index: 10.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4348
    Cell Significance Index: 82.7400
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.4284
    Cell Significance Index: 2.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3070
    Cell Significance Index: 8.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3008
    Cell Significance Index: 5.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2534
    Cell Significance Index: 4.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2333
    Cell Significance Index: 28.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1921
    Cell Significance Index: 173.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1543
    Cell Significance Index: 15.2700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1396
    Cell Significance Index: 0.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1012
    Cell Significance Index: 1.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0893
    Cell Significance Index: 16.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0869
    Cell Significance Index: 14.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0685
    Cell Significance Index: 1.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0519
    Cell Significance Index: 10.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0418
    Cell Significance Index: 26.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0388
    Cell Significance Index: 0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0288
    Cell Significance Index: 39.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0229
    Cell Significance Index: 2.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0206
    Cell Significance Index: 2.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0181
    Cell Significance Index: 27.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0148
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0117
    Cell Significance Index: 4.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0036
    Cell Significance Index: 1.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0007
    Cell Significance Index: 0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0058
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0126
    Cell Significance Index: -8.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0167
    Cell Significance Index: -0.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0167
    Cell Significance Index: -3.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0181
    Cell Significance Index: -0.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0189
    Cell Significance Index: -14.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0282
    Cell Significance Index: -17.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0303
    Cell Significance Index: -22.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0397
    Cell Significance Index: -2.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0456
    Cell Significance Index: -20.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0512
    Cell Significance Index: -1.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0544
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0651
    Cell Significance Index: -13.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0725
    Cell Significance Index: -20.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0732
    Cell Significance Index: -12.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0758
    Cell Significance Index: -4.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0905
    Cell Significance Index: -4.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0938
    Cell Significance Index: -6.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0979
    Cell Significance Index: -5.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1099
    Cell Significance Index: -2.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1121
    Cell Significance Index: -16.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1169
    Cell Significance Index: -5.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1517
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1763
    Cell Significance Index: -20.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1934
    Cell Significance Index: -19.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2020
    Cell Significance Index: -6.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2106
    Cell Significance Index: -24.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2284
    Cell Significance Index: -16.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2323
    Cell Significance Index: -24.1900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2764
    Cell Significance Index: -1.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2783
    Cell Significance Index: -22.0400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2879
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3086
    Cell Significance Index: -23.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3334
    Cell Significance Index: -22.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3545
    Cell Significance Index: -21.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3622
    Cell Significance Index: -23.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3643
    Cell Significance Index: -5.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3719
    Cell Significance Index: -23.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3902
    Cell Significance Index: -8.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3917
    Cell Significance Index: -13.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4288
    Cell Significance Index: -24.0600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4294
    Cell Significance Index: -5.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4337
    Cell Significance Index: -22.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4495
    Cell Significance Index: -16.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLAT is a 329-amino acid protein that belongs to the plasminogen activator family. It is a serine protease that exhibits a high degree of specificity for plasminogen, the precursor to plasmin. The protein is produced by various cell types, including epithelial cells, endothelial cells, and fibroblasts, and is widely expressed in tissues such as the prostate, ovary, and mammary gland. PLAT is a glycoprotein that is secreted from cells and circulates in the bloodstream, where it can bind to plasminogen and initiate the fibrinolytic cascade. **Pathways and Functions:** PLAT is involved in several cellular pathways, including: 1. **Fibrinolysis:** PLAT is the primary activator of plasminogen, converting it to plasmin, which then degrades fibrin clots, preventing their propagation and promoting clot lysis. 2. **Cell Migration and Proliferation:** PLAT has been shown to regulate cell migration and proliferation by modulating the activity of various growth factors and signaling pathways. 3. **Signaling by Receptor Tyrosine Kinases:** PLAT has been implicated in the signaling pathways of receptor tyrosine kinases, including the PDGF receptor, which plays a role in cell growth and differentiation. 4. **Proteolysis:** PLAT is involved in the regulation of proteolytic activity, including the degradation of extracellular matrix proteins and the activation of other proteases. **Clinical Significance:** Dysregulation of PLAT has been implicated in several diseases, including: 1. **Thrombosis:** Overexpression of PLAT has been linked to an increased risk of thrombosis, as it can lead to excessive fibrinolysis and clot lysis. 2. **Cancer:** PLAT has been shown to promote cell migration and proliferation, making it a potential target for cancer therapy. 3. **Neurological Disorders:** PLAT has been implicated in the pathogenesis of neurological disorders, including stroke and Alzheimer's disease, where it may contribute to neuronal damage and death. 4. **Reproductive Disorders:** PLAT has been shown to play a role in reproductive disorders, including polyspermy and implantation failure. In conclusion, PLAT is a multifunctional protein that plays a critical role in regulating fibrinolysis and other cellular processes. Its dysregulation has been implicated in several diseases, highlighting the importance of PLAT in maintaining vascular and tissue homeostasis. Further research is needed to fully elucidate the mechanisms of PLAT and its role in disease pathogenesis.

Genular Protein ID: 4228128201

Symbol: TPA_HUMAN

Name: Tissue-type plasminogen activator chain A

UniProtKB Accession Codes:

P00750 A8K022 B2R8E8 Q15103 Q503B0 Q6PJA5 Q7Z7N2 Q86YK8 Q9BU99 Q9BZW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 ELM 1 EMBL 35 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 10 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6337343

Title: Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.

PubMed ID: 6337343

DOI: 10.1038/301214a0

PubMed ID: 6089198

Title: The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

PubMed ID: 6089198

DOI: 10.1073/pnas.81.17.5355

PubMed ID: 3009482

Title: The human tissue plasminogen activator gene.

PubMed ID: 3009482

DOI: 10.1016/s0021-9258(19)62711-0

PubMed ID: 3090401

Title: Cloning of cDNA coding for human tissue-type plasminogen activator and its expression in Escherichia coli.

PubMed ID: 3090401

PubMed ID: 2824147

Title: Expression of human uterine tissue-type plasminogen activator in mouse cells using BPV vectors.

PubMed ID: 2824147

DOI: 10.1089/dna.1987.6.461

PubMed ID: 3133640

Title: Nucleotide sequence of the tissue-type plasminogen activator cDNA from human fetal lung cells.

PubMed ID: 3133640

DOI: 10.1093/nar/16.12.5695

PubMed ID: 2107528

Title: Variant tissue-type plasminogen activator (PLAT) cDNA obtained from human endothelial cells.

PubMed ID: 2107528

DOI: 10.1093/nar/18.4.1086

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3161893

Title: Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.

PubMed ID: 3161893

DOI: 10.1016/s0021-9258(17)39169-x

PubMed ID: 1368681

Title: Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells.

PubMed ID: 1368681

DOI: 10.1271/bbb1961.55.1225

PubMed ID: 6682760

Title: Purification and characterization of a melanoma cell plasminogen activator.

PubMed ID: 6682760

DOI: 10.1111/j.1432-1033.1983.tb07418.x

PubMed ID: 6433976

Title: Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.

PubMed ID: 6433976

DOI: 10.1021/bi00311a020

PubMed ID: 6572897

Title: Isolation of cDNA sequences coding for a part of human tissue plasminogen activator.

PubMed ID: 6572897

DOI: 10.1073/pnas.80.2.349

PubMed ID: 2513186

Title: Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.

PubMed ID: 2513186

DOI: 10.1111/j.1432-1033.1989.tb15206.x

PubMed ID: 1900431

Title: Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.

PubMed ID: 1900431

DOI: 10.1021/bi00223a004

PubMed ID: 1645336

Title: Disulfide pairing of the recombinant kringle-2 domain of tissue plasminogen activator produced in Escherichia coli.

PubMed ID: 1645336

DOI: 10.1016/s0021-9258(18)99190-8

PubMed ID: 10340997

Title: Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility.

PubMed ID: 10340997

DOI: 10.1093/molehr/5.6.513

PubMed ID: 11384978

Title: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.

PubMed ID: 11384978

DOI: 10.1074/jbc.m102727200

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 2558718

Title: 1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator.

PubMed ID: 2558718

DOI: 10.1021/bi00450a016

PubMed ID: 1901789

Title: Kringle-2 domain of the tissue-type plasminogen activator. 1H-NMR assignments and secondary structure.

PubMed ID: 1901789

DOI: 10.1111/j.1432-1033.1991.tb15894.x

PubMed ID: 1762144

Title: Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.

PubMed ID: 1762144

DOI: 10.1016/0022-2836(91)90592-t

PubMed ID: 1310033

Title: Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.

PubMed ID: 1310033

DOI: 10.1021/bi00116a037

PubMed ID: 1602484

Title: Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.

PubMed ID: 1602484

DOI: 10.1016/0022-2836(92)90403-7

PubMed ID: 7582899

Title: The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.

PubMed ID: 7582899

DOI: 10.1016/s0969-2126(01)00217-9

PubMed ID: 8613982

Title: The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.

PubMed ID: 8613982

DOI: 10.1006/jmbi.1996.0238

PubMed ID: 9305622

Title: Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

PubMed ID: 9305622

DOI: 10.1093/emboj/16.16.4797

Sequence Information:

  • Length: 562
  • Mass: 62917
  • Checksum: B7EC9B1A5E3FDC4D
  • Sequence:
    • MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR 
NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN 
SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG 
LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ 
ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA 
QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH 
LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK 
DVPGVYTKVT NYLDWIRDNM RP

Genular Protein ID: 695188576

Symbol: B4DN26_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DN26

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 GO 3 Gene3D 4 GeneTree 1 HGNC 1 InterPro 14 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 14 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 473
  • Mass: 52992
  • Checksum: AC4FB758DDF91A1D
  • Sequence:
    • MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
IGNSDCYFGN GSAYRGTHSL TESGASCLPW NSMILIGKVY TAQNPSAQAL GLGKHNYCRN 
PDGDAKPWCH VLKNRRLTWE YCDVPSCSTC GLRQYSQPQF RIKGGLFADI ASHPWQAAIF 
AKHRRSPGER FLCGGILISS CWILSAAHCF QERFPPHHLT VILGRTYRVV PGEEEQKFEV 
EKYIVHKEFD DDTYDNDIAL LQLKSDSSRC AQESSVVRTV CLPPADLQLP DWTECELSGY 
GKHEALSPFY SERLKEAHVR LYPSSRCTSQ HLLNRTVTDN MLCAGDTRSG GPQANLHDAC 
QGDSGGPLVC LNDGRMTLVG IISWGLGCGQ KDVPGVYTKV TNYLDWIRDN MRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.