Details for: GRB7

Gene ID: 2886

Symbol: GRB7

Ensembl ID: ENSG00000141738

Description: growth factor receptor bound protein 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.71
    Marker Score: 3034
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.51
    Marker Score: 1590
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.48
    Marker Score: 1632
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.36
    Marker Score: 5260
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.34
    Marker Score: 916
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1274
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.12
    Marker Score: 2724
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.11
    Marker Score: 874
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.1
    Marker Score: 390
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.06
    Marker Score: 2498
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.04
    Marker Score: 2840
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251791
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1077
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.02
    Marker Score: 1154
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.97
    Marker Score: 859
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1421
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.95
    Marker Score: 553
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9
    Marker Score: 496
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1819
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5059
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.88
    Marker Score: 7577
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.87
    Marker Score: 523
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13320
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.85
    Marker Score: 3342
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 648.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.84
    Marker Score: 6579.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1569
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1287
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.79
    Marker Score: 528
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.78
    Marker Score: 152
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.77
    Marker Score: 3800.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 693
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 811
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 673
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.73
    Marker Score: 631
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.72
    Marker Score: 931
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.7
    Marker Score: 163
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.69
    Marker Score: 837
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.69
    Marker Score: 1575
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.67
    Marker Score: 1698
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.64
    Marker Score: 130
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.63
    Marker Score: 439
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.63
    Marker Score: 670
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 656
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.62
    Marker Score: 1651.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.61
    Marker Score: 1122
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.61
    Marker Score: 1906
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.58
    Marker Score: 307
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.57
    Marker Score: 913
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.57
    Marker Score: 718
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.57
    Marker Score: 282
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.57
    Marker Score: 266
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.56
    Marker Score: 2943
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.55
    Marker Score: 638
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.55
    Marker Score: 906
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.54
    Marker Score: 950
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 314
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.54
    Marker Score: 1913
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.54
    Marker Score: 3186.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.53
    Marker Score: 405
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.52
    Marker Score: 1236
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.52
    Marker Score: 232
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3837
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.51
    Marker Score: 428
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.51
    Marker Score: 263
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.5
    Marker Score: 713
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.5
    Marker Score: 160
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 812.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.49
    Marker Score: 1044
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.49
    Marker Score: 7899
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.49
    Marker Score: 166
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.49
    Marker Score: 183
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.48
    Marker Score: 16531.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.46
    Marker Score: 289
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.45
    Marker Score: 1024
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.45
    Marker Score: 1856.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.44
    Marker Score: 5975
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.44
    Marker Score: 176
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.43
    Marker Score: 125

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GRB7 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the EGF receptor family of cell surface receptors. * GRB7 is expressed in a variety of epithelial cell types, including luminal epithelial cells, conjunctival epithelial cells, corneal epithelial cells, and epithelial cells of the skin and urogenital tract. * GRB7 is a key regulator of epithelial cell migration and differentiation. * It is also involved in the regulation of cell cycle progression and apoptosis. **Pathways and functions:** * GRB7 is a key regulator of epithelial cell migration and differentiation. * It is involved in the formation of the mammary gland by promoting the migration of luminal epithelial cells from the ectoderm to the mesoderm. * It also plays a role in the differentiation of skin and urogenital epithelial cells. * GRB7 is also involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** * Mutations in GRB7 have been linked to a number of human diseases, including breast cancer, skin cancer, and kidney cancer. * Targeting GRB7 with antibodies has been shown to be a promising strategy for the treatment of these diseases. * GRB7 is a potential target for the development of new cancer therapies.

Genular Protein ID: 1696006265

Symbol: GRB7_HUMAN

Name: Growth factor receptor-bound protein 7

UniProtKB Accession Codes:

Q14451 B2RAV1 B3KNL0 B3KWP9 B7WP75 J3KQM4 Q53YD3 Q92568 Q96DF9 Q9Y220

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 6 RefSeq 5 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9125150

Title: Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer.

PubMed ID: 9125150

DOI: 10.1006/bbrc.1997.6218

PubMed ID: 9710451

Title: A novel variant of human Grb7 is associated with invasive esophageal carcinoma.

PubMed ID: 9710451

DOI: 10.1172/jci2921

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8988034

Title: Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma.

PubMed ID: 8988034

PubMed ID: 9516479

Title: Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

PubMed ID: 9516479

DOI: 10.1074/jbc.273.13.7717

PubMed ID: 10664463

Title: Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.

PubMed ID: 10664463

DOI: 10.1016/s0014-5793(99)01530-6

PubMed ID: 10893408

Title: Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration.

PubMed ID: 10893408

DOI: 10.1074/jbc.m001997200

PubMed ID: 10803466

Title: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.

PubMed ID: 10803466

DOI: 10.1038/sj.onc.1203469

PubMed ID: 12021278

Title: Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.

PubMed ID: 12021278

DOI: 10.1074/jbc.m203085200

PubMed ID: 12223469

Title: EphB1 associates with Grb7 and regulates cell migration.

PubMed ID: 12223469

DOI: 10.1074/jbc.m203165200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15841400

Title: Grb7-SH2 domain dimerisation is affected by a single point mutation.

PubMed ID: 15841400

DOI: 10.1007/s00249-005-0480-1

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19473962

Title: Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.

PubMed ID: 19473962

DOI: 10.1074/jbc.m109.018259

PubMed ID: 18853468

Title: The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.

PubMed ID: 18853468

DOI: 10.1002/jmr.916

PubMed ID: 20622016

Title: EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.

PubMed ID: 20622016

DOI: 10.1074/jbc.c110.114124

PubMed ID: 20665473

Title: Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.

PubMed ID: 20665473

DOI: 10.1002/jmr.1062

PubMed ID: 12975581

Title: Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.

PubMed ID: 12975581

DOI: 10.1023/a:1025498409113

PubMed ID: 17894853

Title: Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.

PubMed ID: 17894853

DOI: 10.1186/1472-6807-7-58

Sequence Information:

  • Length: 532
  • Mass: 59681
  • Checksum: A6867C20AFD46F74
  • Sequence:
    • MELDLSPPHL SSSPEDLCPA PGTPPGTPRP PDTPLPEEVK RSQPLLIPTT GRKLREEERR 
ATSLPSIPNP FPELCSPPSQ SPILGGPSSA RGLLPRDASR PHVVKVYSED GACRSVEVAA 
GATARHVCEM LVQRAHALSD ETWGLVECHP HLALERGLED HESVVEVQAA WPVGGDSRFV 
FRKNFAKYEL FKSSPHSLFP EKMVSSCLDA HTGISHEDLI QNFLNAGSFP EIQGFLQLRG 
SGRKLWKRFF CFLRRSGLYY STKGTSKDPR HLQYVADVNE SNVYVVTQGR KLYGMPTDFG 
FCVKPNKLRN GHKGLRIFCS EDEQSRTCWL AAFRLFKYGV QLYKNYQQAQ SRHLHPSCLG 
SPPLRSASDN TLVAMDFSGH AGRVIENPRE ALSVALEEAQ AWRKKTNHRL SLPMPASGTS 
LSAAIHRTQL WFHGRISREE SQRLIGQQGL VDGLFLVRES QRNPQGFVLS LCHLQKVKHY 
LILPSEEEGR LYFSMDDGQT RFTDLLQLVE FHQLNRGILP CLLRHCCTRV AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.