Details for: CL0000082

Cell ID: CL0000082

Cell Name: epithelial cell of lung

Marker Score Threshold: 5256
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the lung.

Synonyms: lung epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.71
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.61
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.93
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.61
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.41
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.09
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.01
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.93
    Ensembl ID: ENSG00000163399
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.93
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.92
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.75
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.7
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.7
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.7
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.61
    Ensembl ID: ENSG00000067560
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.55
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.45
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.4
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.17
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.15
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.11
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.1
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.07
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.06
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.06
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 2.06
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.03
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.02
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 2.01
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.01
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.95
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.92
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.91
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.89
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.87
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.81
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.81
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.8
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.76
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.76
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.75
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.71
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.67
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.66
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.59
    Ensembl ID: ENSG00000156110
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.59
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.57
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.57
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.53
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.46
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.43
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149925
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.42
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.37
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.33
    Ensembl ID: ENSG00000071553
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.32
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.32
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143727
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.3
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.29
    Ensembl ID: ENSG00000130203
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.28
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072210
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.26
    Ensembl ID: ENSG00000171885
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.23
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.2
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.19
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.17
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.16
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.14
    Ensembl ID: ENSG00000002330
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142599
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.12
    Ensembl ID: ENSG00000006756
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.11
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.1
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120805
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.05
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.03
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.01
    Ensembl ID: ENSG00000185883
Hovered Details

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Hovered Details

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**Key Characteristics:** 1. **Morphology:** Epithelial cells of the lung are flat, squamous cells that form a single layer on the surface of the lung, covering the airways and alveoli. 2. **Function:** These cells are involved in gas exchange, nutrient absorption, and waste removal. They also play a crucial role in regulating the immune response, producing cytokines, and responding to pathogens. 3. **Gene Expression:** Epithelial cells of the lung express a unique set of genes, including those involved in immune response, cell signaling, and protein metabolism. 4. **Cell Signaling:** These cells are responsive to various signaling pathways, including those mediated by G-protein coupled receptors, tyrosine kinases, and transcription factors. 5. **Apoptosis and Proliferation:** Epithelial cells of the lung undergo regulated apoptosis and proliferation in response to injury, inflammation, and developmental cues. 6. **Adhesion and Migration:** These cells exhibit strong adhesion to the extracellular matrix and can migrate in response to signals from the microenvironment. **Clinical Significance:** 1. **Respiratory Diseases:** Epithelial cells of the lung play a critical role in the pathogenesis of various respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and lung cancer. 2. **Infection and Inflammation:** These cells are essential for the innate and adaptive immune responses to pathogens, including viruses, bacteria, and fungi. 3. **Environmental Toxins:** Epithelial cells of the lung are exposed to environmental toxins, including cigarette smoke, air pollution, and nanoparticles, which can lead to damage and disease. 4. **Cancer:** Aberrant expression of genes involved in cell growth, division, and survival can lead to cancer in epithelial cells of the lung. 5. **Therapeutic Targeting:** Understanding the properties and behaviors of epithelial cells of the lung can inform the development of targeted therapies for various lung diseases. **Pathways/Ontology:** 1. **Adaptive Immune System:** Epithelial cells of the lung interact with T-cells, B-cells, and other immune cells to regulate the immune response. 2. **Amyloid Fiber Formation:** These cells can produce amyloid fibrils, which are associated with various diseases, including Alzheimer's disease and amyloidosis. 3. **Antigen Presentation:** Epithelial cells of the lung can present antigens to T-cells, initiating an immune response. 4. **Infection with Mycobacterium Tuberculosis:** These cells are responsive to M. tuberculosis, the causative agent of tuberculosis. 5. **SARS-CoV-2 Infection:** Epithelial cells of the lung are susceptible to SARS-CoV-2 infection, which can lead to acute respiratory distress syndrome (ARDS) and other complications. In conclusion, epithelial cells of the lung are complex, multifunctional cells that play a critical role in maintaining lung homeostasis and responding to various stimuli. Understanding their properties and behaviors is essential for elucidating the mechanisms of lung disease and developing effective therapeutic strategies.