Details for: SCTR

Gene ID: 6344

Symbol: SCTR

Ensembl ID: ENSG00000080293

Description: secretin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.1506
    Cell Significance Index: -4.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 10.7462
    Cell Significance Index: 344.1900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.3501
    Cell Significance Index: 40.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6188
    Cell Significance Index: 111.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4406
    Cell Significance Index: 274.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4232
    Cell Significance Index: 85.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4081
    Cell Significance Index: 40.5700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4076
    Cell Significance Index: 14.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2104
    Cell Significance Index: 29.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.1822
    Cell Significance Index: 41.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1431
    Cell Significance Index: 51.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9509
    Cell Significance Index: 14.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8700
    Cell Significance Index: 94.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8170
    Cell Significance Index: 17.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7421
    Cell Significance Index: 73.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6254
    Cell Significance Index: 13.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5557
    Cell Significance Index: 13.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5175
    Cell Significance Index: 10.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4441
    Cell Significance Index: 72.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4201
    Cell Significance Index: 48.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3886
    Cell Significance Index: 5.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3794
    Cell Significance Index: 342.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2521
    Cell Significance Index: 50.0400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2469
    Cell Significance Index: 0.9300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2443
    Cell Significance Index: 2.4100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2057
    Cell Significance Index: 2.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2001
    Cell Significance Index: 3.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1467
    Cell Significance Index: 8.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1245
    Cell Significance Index: 169.2800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1097
    Cell Significance Index: 1.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1053
    Cell Significance Index: 1.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0998
    Cell Significance Index: 54.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0847
    Cell Significance Index: 2.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0802
    Cell Significance Index: 13.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0742
    Cell Significance Index: 51.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0463
    Cell Significance Index: 35.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0320
    Cell Significance Index: 49.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0282
    Cell Significance Index: 1.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0236
    Cell Significance Index: 0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0226
    Cell Significance Index: 4.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0146
    Cell Significance Index: 27.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0088
    Cell Significance Index: 0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0014
    Cell Significance Index: 0.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0007
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0032
    Cell Significance Index: -0.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0171
    Cell Significance Index: -3.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0228
    Cell Significance Index: -1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0230
    Cell Significance Index: -3.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0236
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0304
    Cell Significance Index: -3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0317
    Cell Significance Index: -3.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0329
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0366
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0399
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0521
    Cell Significance Index: -3.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0588
    Cell Significance Index: -4.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0636
    Cell Significance Index: -1.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0637
    Cell Significance Index: -2.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0648
    Cell Significance Index: -3.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0709
    Cell Significance Index: -3.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0761
    Cell Significance Index: -1.9600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0787
    Cell Significance Index: -1.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0798
    Cell Significance Index: -2.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0809
    Cell Significance Index: -3.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0828
    Cell Significance Index: -4.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0834
    Cell Significance Index: -2.7300
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0873
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0874
    Cell Significance Index: -4.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0940
    Cell Significance Index: -2.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0956
    Cell Significance Index: -3.6200
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1001
    Cell Significance Index: -0.8900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1107
    Cell Significance Index: -3.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1151
    Cell Significance Index: -2.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1173
    Cell Significance Index: -2.9300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1187
    Cell Significance Index: -1.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1189
    Cell Significance Index: -2.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1226
    Cell Significance Index: -4.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1234
    Cell Significance Index: -2.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1265
    Cell Significance Index: -3.6100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1298
    Cell Significance Index: -1.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1316
    Cell Significance Index: -3.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1324
    Cell Significance Index: -2.1800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1348
    Cell Significance Index: -2.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1351
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure:** The secretin receptor belongs to the class B/2 family of GPCRs, characterized by a seven-transmembrane domain structure. This structure enables it to interact with secretin and activate downstream signaling pathways. 2. **Secretin Binding:** The secretin receptor is specifically designed to bind secretin, a peptide hormone that regulates various physiological processes. The binding of secretin to the receptor triggers a conformational change, activating G-protein coupled signaling. 3. **Signaling Pathways:** The secretin receptor activates several signaling pathways, including adenylate cyclase-modulating G-protein coupled receptor signaling, cell surface receptor signaling, and G-protein coupled peptide hormone binding. These pathways regulate various physiological processes, including appetite regulation, glucose homeostasis, and thermogenesis. 4. **Tissue Expression:** The secretin receptor is expressed in multiple cell types, including enterocytes, pancreatic ductal cells, and renal epithelial cells. This widespread expression highlights the receptor's critical role in maintaining homeostasis across different tissues. **Pathways and Functions:** 1. **Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling:** The secretin receptor activates adenylate cyclase, a key enzyme involved in glucose homeostasis. By increasing cAMP levels, the receptor regulates glucose uptake, storage, and metabolism. 2. **Cell Surface Receptor Signaling:** The secretin receptor also activates cell surface receptor signaling pathways, which regulate various physiological processes, including appetite regulation, thermogenesis, and immune responses. 3. **G-Protein Coupled Peptide Hormone Binding:** The secretin receptor binds to secretin and activates G-protein coupled signaling, regulating various physiological processes, including glucose homeostasis, thermogenesis, and appetite regulation. 4. **Regulation of Appetite:** The secretin receptor plays a crucial role in regulating appetite by modulating the expression of appetite-regulating genes and influencing the hypothalamic-pituitary-adrenal axis. 5. **Regulation of Synaptic Plasticity:** The secretin receptor also regulates synaptic plasticity, a key mechanism underlying learning and memory. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** The secretin receptor plays a critical role in glucose homeostasis, and its dysfunction has been implicated in the development of diabetes and metabolic disorders. 2. **Thermogenesis:** The secretin receptor is involved in regulating thermogenesis, a process essential for energy expenditure and weight management. 3. **Appetite Regulation:** The secretin receptor regulates appetite, and its dysfunction has been linked to obesity and metabolic disorders. 4. **Gastrointestinal Disorders:** The secretin receptor is expressed in enterocytes, and its dysfunction has been implicated in gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). In conclusion, the secretin receptor is a complex GPCR that plays a critical role in regulating various physiological processes, including glucose homeostasis, thermogenesis, and appetite regulation. Its dysfunction has been implicated in the development of metabolic disorders, including diabetes and obesity. Further research is necessary to fully understand the immunological significance of the secretin receptor and its role in maintaining homeostasis across different tissues.

Genular Protein ID: 1194429114

Symbol: SCTR_HUMAN

Name: Secretin receptor

UniProtKB Accession Codes:

P47872 Q12961 Q13213 Q53T00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7864894

Title: Molecular cloning and functional expression of a human pancreatic secretin receptor.

PubMed ID: 7864894

DOI: 10.1006/bbrc.1995.1268

PubMed ID: 7612008

Title: Molecular cloning and functional characterization of a human secretin receptor.

PubMed ID: 7612008

DOI: 10.1006/bbrc.1995.1957

PubMed ID: 7700244

Title: Molecular cloning and expression of a human secretin receptor.

PubMed ID: 7700244

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 25332973

Title: The physiological roles of secretin and its receptor.

PubMed ID: 25332973

DOI: 10.3978/j.issn.2305-5839.2012.12.01

Sequence Information:

  • Length: 440
  • Mass: 50207
  • Checksum: E22CDD0EE7C0ACC1
  • Sequence:
    • MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS REQTGDLGTE 
QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN GSLFRNCTQD GWSETFPRPN 
LACGVNVNDS SNEKRHSYLL KLKVMYTVGY SSSLVMLLVA LGILCAFRRL HCTRNYIHMH 
LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL 
HTLLAISFFS ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG 
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL FGIHYIVFAF 
SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWQQWHLRE FPLHPVASFS 
NSTKASHLEQ SQGTCRTSII

Genular Protein ID: 1268224118

Symbol: Q8IV17_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IV17

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 7 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 440
  • Mass: 50221
  • Checksum: 1A9DF62C55EB89AD
  • Sequence:
    • MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS REQTGDLGTE 
QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN GSLFRNCTQD GWSETFPRPN 
LACGVNVNDS SNEKRHSYLL KLKVMYTVGY SSSLVMLLVA LGILCAFRRL HCTRNYIHMH 
LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HRAGCKLIMV LFQYCIMANY SWLLVEGLYL 
HTLLAISFFS ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG 
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL FGIHYIVFAF 
SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWQQWHLRE FPLHPVASFS 
NSTKASHLEQ SQGTCRTSII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.