Details for: NAB2

Gene ID: 4665

Symbol: NAB2

Ensembl ID: ENSG00000166886

Description: NGFI-A binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.1784
    Cell Significance Index: -16.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.9481
    Cell Significance Index: -16.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.8683
    Cell Significance Index: -15.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4717
    Cell Significance Index: -16.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0245
    Cell Significance Index: -13.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2093
    Cell Significance Index: -16.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5716
    Cell Significance Index: -10.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.0226
    Cell Significance Index: 33.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1251
    Cell Significance Index: 15.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9736
    Cell Significance Index: 26.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9346
    Cell Significance Index: 177.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8093
    Cell Significance Index: 10.3700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7106
    Cell Significance Index: 7.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7037
    Cell Significance Index: 24.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5432
    Cell Significance Index: 53.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4951
    Cell Significance Index: 447.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4507
    Cell Significance Index: 61.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4208
    Cell Significance Index: 84.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3927
    Cell Significance Index: 27.7800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3820
    Cell Significance Index: 3.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3759
    Cell Significance Index: 9.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3518
    Cell Significance Index: 155.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3398
    Cell Significance Index: 39.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2816
    Cell Significance Index: 45.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2548
    Cell Significance Index: 7.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2310
    Cell Significance Index: 25.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2214
    Cell Significance Index: 120.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1878
    Cell Significance Index: 3.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1848
    Cell Significance Index: 22.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1652
    Cell Significance Index: 21.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1521
    Cell Significance Index: 4.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1322
    Cell Significance Index: 23.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1245
    Cell Significance Index: 6.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1238
    Cell Significance Index: 7.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1192
    Cell Significance Index: 8.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1191
    Cell Significance Index: 42.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1066
    Cell Significance Index: 1.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0865
    Cell Significance Index: 3.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0781
    Cell Significance Index: 4.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0638
    Cell Significance Index: 12.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0620
    Cell Significance Index: 1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0495
    Cell Significance Index: 1.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0451
    Cell Significance Index: 5.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0230
    Cell Significance Index: 2.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0217
    Cell Significance Index: 15.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0087
    Cell Significance Index: 0.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0166
    Cell Significance Index: -7.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0176
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0198
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0229
    Cell Significance Index: -16.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0236
    Cell Significance Index: -0.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0260
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0287
    Cell Significance Index: -17.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0289
    Cell Significance Index: -16.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0393
    Cell Significance Index: -2.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0411
    Cell Significance Index: -11.8300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0488
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0527
    Cell Significance Index: -0.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0610
    Cell Significance Index: -3.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0640
    Cell Significance Index: -2.8300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0716
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0757
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0793
    Cell Significance Index: -13.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0813
    Cell Significance Index: -2.1700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0842
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0855
    Cell Significance Index: -18.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0952
    Cell Significance Index: -10.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0972
    Cell Significance Index: -4.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1176
    Cell Significance Index: -2.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1176
    Cell Significance Index: -4.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1279
    Cell Significance Index: -8.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1499
    Cell Significance Index: -15.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1505
    Cell Significance Index: -4.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1525
    Cell Significance Index: -4.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1576
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1749
    Cell Significance Index: -13.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1809
    Cell Significance Index: -13.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1898
    Cell Significance Index: -10.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2333
    Cell Significance Index: -12.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2415
    Cell Significance Index: -5.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2543
    Cell Significance Index: -7.2900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2953
    Cell Significance Index: -2.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3229
    Cell Significance Index: -8.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3264
    Cell Significance Index: -7.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3324
    Cell Significance Index: -10.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3348
    Cell Significance Index: -10.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3357
    Cell Significance Index: -11.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3385
    Cell Significance Index: -9.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression:** NAB2 is expressed in a wide range of cell types, including pulmonary interstitial fibroblasts, enterocytes, cardiac endothelial cells, and neural cells. 2. **Developmental biology:** NAB2 is involved in developmental pathways, such as schwann cell myelination and nervous system development, highlighting its role in tissue formation and organization. 3. **Transcriptional regulation:** NAB2 regulates transcriptional processes, including negative regulation of transcription by RNA polymerase III, which underscores its potential role in modulating gene expression. 4. **Cell signaling:** NAB2 interacts with signaling pathways, including those mediated by NTRK1 and NTRK receptors, which highlights its involvement in cell signaling and response to environmental cues. **Pathways and Functions:** 1. **Egr2 and sox10-mediated initiation of schwann cell myelination:** NAB2 interacts with Egr2 and Sox10 to regulate the initiation of schwann cell myelination, a critical process in nervous system development. 2. **Endochondral ossification:** NAB2 is involved in the regulation of endochondral ossification, a process by which bone tissue is formed from cartilage. 3. **Signaling by NTRK1 (trka):** NAB2 interacts with NTRK1 to regulate signaling pathways involved in cell growth, differentiation, and survival. 4. **Regulation of DNA-templated transcription:** NAB2 regulates transcriptional processes by interacting with transcription factors and RNA polymerase III. **Clinical Significance:** 1. **Cancer association:** NAB2 has been implicated in various cancers, including schwannomas, melanomas, and gliomas, highlighting its potential role as a tumor suppressor or oncogene. 2. **Neurological disorders:** NAB2's involvement in nervous system development and myelination highlights its potential role in neurological disorders, such as multiple sclerosis and peripheral neuropathy. 3. **Immunological disorders:** NAB2's interaction with innate lymphoid cells and its role in immune regulation highlight its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, NAB2 is a complex gene that plays a critical role in various biological processes, including developmental biology, immune regulation, and cell differentiation. Its involvement in multiple signaling pathways and transcriptional processes highlights its potential role in modulating gene expression and cell behavior. Further research is needed to elucidate the clinical significance of NAB2 and its potential applications in disease diagnosis and treatment.

Genular Protein ID: 371943707

Symbol: NAB2_HUMAN

Name: NGFI-A-binding protein 2

UniProtKB Accession Codes:

Q15742 B2RAK3 O76006 Q14797

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8668170

Title: NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.

PubMed ID: 8668170

DOI: 10.1128/mcb.16.7.3545

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8649813

Title: Mader: a novel nuclear protein over expressed in human melanomas.

PubMed ID: 8649813

PubMed ID: 9126479

Title: The Nab2 and Stat6 genes share a common transcription termination region.

PubMed ID: 9126479

DOI: 10.1006/geno.1997.4609

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21836637

Title: The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.

PubMed ID: 21836637

DOI: 10.1038/embor.2011.152

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 525
  • Mass: 56594
  • Checksum: 38CF6CFEFE3756F9
  • Sequence:
    • MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET 
FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV 
PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG 
DPRIWPGRST PESDVGAGGE EEAGSPPFSP PAGGGVPEGT GAGGLAAGGT GGGPDRLEPE 
MVRMVVESVE RIFRSFPRGD AGEVTSLLKL NKKLARSVGH IFEMDDNDSQ KEEEIRKYSI 
IYGRFDSKRR EGKQLSLHEL TINEAAAQFC MRDNTLLLRR VELFSLSRQV ARESTYLSSL 
KGSRLHPEEL GGPPLKKLKQ EVGEQSHPEI QQPPPGPESY VPPYRPSLEE DSASLSGESL 
DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP 
CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.