Details for: TBL2

Gene ID: 26608

Symbol: TBL2

Ensembl ID: ENSG00000106638

Description: transducin beta like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.1159
    Cell Significance Index: -20.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.3814
    Cell Significance Index: -19.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.4498
    Cell Significance Index: -21.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.2639
    Cell Significance Index: -17.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.0258
    Cell Significance Index: -17.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1863
    Cell Significance Index: -21.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5928
    Cell Significance Index: -20.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4054
    Cell Significance Index: -21.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8695
    Cell Significance Index: -11.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1991
    Cell Significance Index: 195.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5926
    Cell Significance Index: 16.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4582
    Cell Significance Index: 31.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4190
    Cell Significance Index: 8.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3740
    Cell Significance Index: 16.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3726
    Cell Significance Index: 51.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3651
    Cell Significance Index: 10.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3443
    Cell Significance Index: 34.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3168
    Cell Significance Index: 14.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2791
    Cell Significance Index: 152.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2617
    Cell Significance Index: 3.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2563
    Cell Significance Index: 50.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1910
    Cell Significance Index: 24.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1786
    Cell Significance Index: 32.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1686
    Cell Significance Index: 33.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1615
    Cell Significance Index: 10.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1588
    Cell Significance Index: 8.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1452
    Cell Significance Index: 131.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1437
    Cell Significance Index: 10.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1352
    Cell Significance Index: 1.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1117
    Cell Significance Index: 3.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1062
    Cell Significance Index: 46.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1057
    Cell Significance Index: 2.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1018
    Cell Significance Index: 19.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0782
    Cell Significance Index: 9.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0761
    Cell Significance Index: 5.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0740
    Cell Significance Index: 26.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0543
    Cell Significance Index: 1.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0528
    Cell Significance Index: 36.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0493
    Cell Significance Index: 0.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0470
    Cell Significance Index: 1.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0440
    Cell Significance Index: 1.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0387
    Cell Significance Index: 4.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0261
    Cell Significance Index: 4.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0179
    Cell Significance Index: 0.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0006
    Cell Significance Index: -0.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0019
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0114
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -23.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0146
    Cell Significance Index: -22.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0178
    Cell Significance Index: -24.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0274
    Cell Significance Index: -2.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0350
    Cell Significance Index: -19.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0382
    Cell Significance Index: -17.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0384
    Cell Significance Index: -23.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0422
    Cell Significance Index: -2.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0685
    Cell Significance Index: -8.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0741
    Cell Significance Index: -21.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0801
    Cell Significance Index: -9.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0882
    Cell Significance Index: -2.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0967
    Cell Significance Index: -14.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1107
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1116
    Cell Significance Index: -23.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1284
    Cell Significance Index: -6.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1342
    Cell Significance Index: -6.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1586
    Cell Significance Index: -12.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1703
    Cell Significance Index: -2.4200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1703
    Cell Significance Index: -2.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1760
    Cell Significance Index: -9.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1851
    Cell Significance Index: -2.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1894
    Cell Significance Index: -5.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2008
    Cell Significance Index: -20.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2070
    Cell Significance Index: -12.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2182
    Cell Significance Index: -5.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2341
    Cell Significance Index: -15.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2345
    Cell Significance Index: -18.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2358
    Cell Significance Index: -11.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2436
    Cell Significance Index: -14.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3167
    Cell Significance Index: -8.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3252
    Cell Significance Index: -9.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3290
    Cell Significance Index: -9.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3504
    Cell Significance Index: -5.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3653
    Cell Significance Index: -16.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3793
    Cell Significance Index: -6.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4344
    Cell Significance Index: -16.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4577
    Cell Significance Index: -5.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4621
    Cell Significance Index: -18.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4780
    Cell Significance Index: -9.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4977
    Cell Significance Index: -17.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5004
    Cell Significance Index: -4.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5138
    Cell Significance Index: -18.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5392
    Cell Significance Index: -9.9700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5400
    Cell Significance Index: -4.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5414
    Cell Significance Index: -8.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** TBL2 is expressed in various cell types, including extravillous trophoblasts, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. 2. **Signaling pathways:** TBL2 is involved in several signaling pathways, including the unfolded protein response, glucose starvation response, and hypoxia response. 3. **Protein binding:** TBL2 interacts with various proteins, including phosphoproteins, protein kinases, and translation initiation factors. 4. **Expression patterns:** TBL2 expression is regulated by multiple transcription factors and is dynamically altered in response to cellular stress and developmental cues. **Pathways and Functions:** 1. **Unfolded Protein Response (UPR):** TBL2 plays a crucial role in the UPR, a cellular response to endoplasmic reticulum (ER) stress. TBL2 interacts with ER chaperones and kinases to regulate ER stress signaling and mitigate cellular damage. 2. **Glucose Starvation Response:** TBL2 is involved in the glucose starvation response, a cellular response to energy deprivation. TBL2 regulates glucose metabolism and energy homeostasis by interacting with key metabolic enzymes and transcription factors. 3. **Hypoxia Response:** TBL2 is also involved in the hypoxia response, a cellular response to low oxygen levels. TBL2 regulates hypoxia-inducible factor (HIF) signaling and angiogenesis by interacting with HIF transcription factors and vascular endothelial growth factor (VEGF). 4. **Cellular Development:** TBL2 plays a critical role in cellular development, particularly in the development of extravillous trophoblasts and intestinal epithelial cells. TBL2 regulates cell proliferation, differentiation, and survival by interacting with key developmental transcription factors. **Clinical Significance:** 1. **Cancer:** TBL2 has been implicated in various cancers, including colorectal, breast, and lung cancers. TBL2 overexpression has been associated with tumor progression, metastasis, and poor prognosis. 2. **Neurological Disorders:** TBL2 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. TBL2 dysregulation has been associated with cognitive decline and neurodegeneration. 3. **Metabolic Disorders:** TBL2 has been implicated in metabolic disorders, including type 2 diabetes and obesity. TBL2 overexpression has been associated with insulin resistance, glucose intolerance, and metabolic syndrome. 4. **Pregnancy-Related Disorders:** TBL2 has been linked to pregnancy-related disorders, including preeclampsia and gestational diabetes. TBL2 dysregulation has been associated with placental dysfunction and fetal growth restriction. In conclusion, TBL2 is a multifaceted gene that plays a crucial role in various cellular processes, including stress response, development, and disease. Further research is needed to fully understand the functions and clinical significance of TBL2, but its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target.

Genular Protein ID: 1610056443

Symbol: TBL2_HUMAN

Name: Transducin beta-like protein 2

UniProtKB Accession Codes:

Q9Y4P3 Q9UQE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10575226

Title: TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.

PubMed ID: 10575226

DOI: 10.1159/000015319

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 9860302

Title: Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes.

PubMed ID: 9860302

DOI: 10.1007/s004390050874

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 447
  • Mass: 49798
  • Checksum: B260087E1A71D3F9
  • Sequence:
    • MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK 
QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK 
DFLQREHRSM RANVELDHAT LVRFSPDCRA FIVWLANGDT LRVFKMTKRE DGGYTFTATP 
EDFPKKHKAP VIDIGIANTG KFIMTASSDT TVLIWSLKGQ VLSTINTNQM NNTHAAVSPC 
GRFVASCGFT PDVKVWEVCF GKKGEFQEVV RAFELKGHSA AVHSFAFSND SRRMASVSKD 
GTWKLWDTDV EYKKKQDPYL LKTGRFEEAA GAAPCRLALS PNAQVLALAS GSSIHLYNTR 
RGEKEECFER VHGECIANLS FDITGRFLAS CGDRAVRLFH NTPGHRAMVE EMQGHLKRAS 
NESTRQRLQQ QLTQAQETLK SLGALKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.