Details for: PLA2G1B

Gene ID: 5319

Symbol: PLA2G1B

Ensembl ID: ENSG00000170890

Description: phospholipase A2 group IB

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 17.2234
    Cell Significance Index: 2940.9900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.0935
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 9.3304
    Cell Significance Index: 1065.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 3.7848
    Cell Significance Index: -0.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.7415
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3423
    Cell Significance Index: 143.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.5606
    Cell Significance Index: -1.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.2896
    Cell Significance Index: -1.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7359
    Cell Significance Index: 38.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7025
    Cell Significance Index: 18.8300
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.6777
    Cell Significance Index: 6.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6327
    Cell Significance Index: 15.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6062
    Cell Significance Index: 36.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5321
    Cell Significance Index: 52.6400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.4650
    Cell Significance Index: 2.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4375
    Cell Significance Index: 47.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3848
    Cell Significance Index: 347.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2826
    Cell Significance Index: 7.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2734
    Cell Significance Index: 44.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2197
    Cell Significance Index: 15.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2046
    Cell Significance Index: 154.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1750
    Cell Significance Index: 4.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1549
    Cell Significance Index: 0.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1075
    Cell Significance Index: 20.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0852
    Cell Significance Index: 1.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0600
    Cell Significance Index: 6.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0404
    Cell Significance Index: 8.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0388
    Cell Significance Index: 0.6400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0349
    Cell Significance Index: 0.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0241
    Cell Significance Index: 0.3500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0230
    Cell Significance Index: 0.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0204
    Cell Significance Index: 0.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0190
    Cell Significance Index: 0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0163
    Cell Significance Index: 0.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0096
    Cell Significance Index: 1.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0080
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0045
    Cell Significance Index: 3.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0023
    Cell Significance Index: 1.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0019
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0009
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0003
    Cell Significance Index: 0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0005
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0012
    Cell Significance Index: -0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0020
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0025
    Cell Significance Index: -0.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0038
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0066
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0089
    Cell Significance Index: -1.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0108
    Cell Significance Index: -0.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0116
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0117
    Cell Significance Index: -1.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0122
    Cell Significance Index: -1.2500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0128
    Cell Significance Index: -0.1800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0131
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0142
    Cell Significance Index: -0.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0148
    Cell Significance Index: -0.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0178
    Cell Significance Index: -2.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0211
    Cell Significance Index: -1.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0214
    Cell Significance Index: -0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0214
    Cell Significance Index: -1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0217
    Cell Significance Index: -0.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0224
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0227
    Cell Significance Index: -1.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0237
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0248
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0250
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0250
    Cell Significance Index: -0.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0252
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0260
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0264
    Cell Significance Index: -1.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0274
    Cell Significance Index: -0.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0279
    Cell Significance Index: -1.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0280
    Cell Significance Index: -0.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0283
    Cell Significance Index: -1.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0291
    Cell Significance Index: -1.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0309
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0322
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0323
    Cell Significance Index: -0.4900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0336
    Cell Significance Index: -0.3600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0340
    Cell Significance Index: -0.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** PLA2G1B is a calcium-dependent phospholipase A2, which catalyzes the hydrolysis of phospholipids to produce free fatty acids and lysophospholipids. 2. **Cellular Localization:** PLA2G1B is primarily expressed in epithelial cells, including those of the exocrine pancreas, type II pneumocytes, and granulocytes. 3. **Signaling Pathways:** PLA2G1B is involved in various signaling pathways, including the activation of phospholipase A2 activity, acyl chain remodeling of phospholipids, and the regulation of calcium ion transport into the cytosol. 4. **Protein Structure:** The protein structure of PLA2G1B consists of a catalytic domain and a regulatory domain, which allows for the modulation of its enzymatic activity. **Pathways and Functions:** 1. **Immune Response:** PLA2G1B plays a critical role in the innate immune response, particularly in the defense against gram-positive bacteria. It is also involved in the regulation of neutrophil chemotaxis and neutrophil-mediated immunity. 2. **Cellular Signaling:** PLA2G1B is involved in various cellular signaling pathways, including the regulation of insulin stimulus, calcium-dependent phospholipase A2 activity, and the activation of phospholipase A2 activity. 3. **Metabolism:** PLA2G1B is also involved in lipid metabolism, including the synthesis of phospholipids and the regulation of glucose import. 4. **Cellular Regulation:** PLA2G1B regulates cell proliferation, differentiation, and apoptosis, particularly in fibroblasts and podocytes. **Clinical Significance:** 1. **Inflammatory Diseases:** PLA2G1B has been implicated in various inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and autoimmune disorders. 2. **Cancer:** PLA2G1B has been found to be overexpressed in certain types of cancer, including pancreatic cancer and lung cancer. 3. **Neurological Disorders:** PLA2G1B has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Gastrointestinal Diseases:** PLA2G1B has been found to be involved in gastrointestinal diseases, including pancreatitis and inflammatory bowel disease. In conclusion, PLA2G1B is a multifunctional protein that plays a critical role in various biological processes, including immune response, cellular signaling, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 2564548055

Symbol: PA21B_HUMAN

Name: Phospholipase A2

UniProtKB Accession Codes:

P04054 B2R4H5 Q3KPI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 50 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 16 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3028739

Title: Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung.

PubMed ID: 3028739

DOI: 10.1089/dna.1.1986.5.519

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7060561

Title: Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region.

PubMed ID: 7060561

DOI: 10.1111/j.1432-1033.1982.tb05855.x

PubMed ID: 6349696

Title: The complete primary structure of phospholipase A2 from human pancreas.

PubMed ID: 6349696

DOI: 10.1016/0167-4838(83)90126-7

PubMed ID: 1420353

Title: Characterization of recombinant human and rat pancreatic phospholipases A2 secreted from Saccharomyces cerevisiae: difference in proteolytic processing.

PubMed ID: 1420353

DOI: 10.1016/0167-4781(92)90133-k

PubMed ID: 7721806

Title: The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization.

PubMed ID: 7721806

DOI: 10.1074/jbc.270.15.8963

PubMed ID: 10681567

Title: Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s.

PubMed ID: 10681567

DOI: 10.1074/jbc.275.8.5785

PubMed ID: 17603006

Title: Role of 57-72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A(2): regulation of fat and cholesterol homeostasis.

PubMed ID: 17603006

DOI: 10.1016/j.bbamem.2007.05.019

PubMed ID: 25335547

Title: sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.

PubMed ID: 25335547

DOI: 10.1038/srep06660

PubMed ID: 19297324

Title: Structural insight into the activation mechanism of human pancreatic prophospholipase A2.

PubMed ID: 19297324

DOI: 10.1074/jbc.m808029200

Sequence Information:

  • Length: 148
  • Mass: 16360
  • Checksum: C8E38B2B64AEE8CB
  • Sequence:
    • MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP FLEYNNYGCY CGLGGSGTPV 
DELDKCCQTH DNCYDQAKKL DSCKFLLDNP YTHTYSYSCS GSAITCSSKN KECEAFICNC 
DRNAAICFSK APYNKAHKNL DTKKYCQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.