Details for: MMP23B

Gene ID: 8510

Symbol: MMP23B

Ensembl ID: ENSG00000189409

Description: matrix metallopeptidase 23B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.7038
    Cell Significance Index: -8.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.2069
    Cell Significance Index: -8.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.2027
    Cell Significance Index: -9.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.7195
    Cell Significance Index: -9.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.2320
    Cell Significance Index: -9.5500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 12.4516
    Cell Significance Index: 77.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.4685
    Cell Significance Index: -9.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2590
    Cell Significance Index: -8.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.0838
    Cell Significance Index: 141.9100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.3089
    Cell Significance Index: 19.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2112
    Cell Significance Index: 41.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1039
    Cell Significance Index: -8.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4719
    Cell Significance Index: -5.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0277
    Cell Significance Index: 16.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9250
    Cell Significance Index: 176.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8699
    Cell Significance Index: 24.3100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.8549
    Cell Significance Index: 7.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8034
    Cell Significance Index: 23.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7380
    Cell Significance Index: 18.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6803
    Cell Significance Index: 14.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5914
    Cell Significance Index: 58.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5843
    Cell Significance Index: 9.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4810
    Cell Significance Index: 434.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4619
    Cell Significance Index: 7.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4461
    Cell Significance Index: 13.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4228
    Cell Significance Index: 6.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4202
    Cell Significance Index: 8.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4031
    Cell Significance Index: 6.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3896
    Cell Significance Index: 2.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3768
    Cell Significance Index: 5.4000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3436
    Cell Significance Index: 1.9700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3236
    Cell Significance Index: 3.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3146
    Cell Significance Index: 51.1700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.3136
    Cell Significance Index: 1.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3107
    Cell Significance Index: 33.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3030
    Cell Significance Index: 19.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2618
    Cell Significance Index: 15.7200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2496
    Cell Significance Index: 1.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2208
    Cell Significance Index: 2.4000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2202
    Cell Significance Index: 1.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1765
    Cell Significance Index: 13.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1708
    Cell Significance Index: 11.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1565
    Cell Significance Index: 2.3100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1547
    Cell Significance Index: 2.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1180
    Cell Significance Index: 3.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1117
    Cell Significance Index: 2.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1010
    Cell Significance Index: 1.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0885
    Cell Significance Index: 1.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0793
    Cell Significance Index: 10.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0388
    Cell Significance Index: 0.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0364
    Cell Significance Index: 1.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0357
    Cell Significance Index: 12.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0282
    Cell Significance Index: 5.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0151
    Cell Significance Index: 8.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0088
    Cell Significance Index: 1.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0064
    Cell Significance Index: 0.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0024
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0067
    Cell Significance Index: -2.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -9.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0153
    Cell Significance Index: -9.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0196
    Cell Significance Index: -3.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0200
    Cell Significance Index: -11.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0280
    Cell Significance Index: -3.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0339
    Cell Significance Index: -9.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0416
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0482
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0525
    Cell Significance Index: -11.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0531
    Cell Significance Index: -6.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0553
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0562
    Cell Significance Index: -9.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0677
    Cell Significance Index: -4.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0689
    Cell Significance Index: -10.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0746
    Cell Significance Index: -7.6200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0799
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0806
    Cell Significance Index: -9.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0826
    Cell Significance Index: -4.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0861
    Cell Significance Index: -8.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0885
    Cell Significance Index: -1.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0900
    Cell Significance Index: -3.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1069
    Cell Significance Index: -2.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1116
    Cell Significance Index: -13.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1141
    Cell Significance Index: -5.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1187
    Cell Significance Index: -8.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1251
    Cell Significance Index: -8.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1308
    Cell Significance Index: -10.3600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1406
    Cell Significance Index: -0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1483
    Cell Significance Index: -9.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1509
    Cell Significance Index: -8.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1669
    Cell Significance Index: -7.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1680
    Cell Significance Index: -4.5000
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: -0.1757
    Cell Significance Index: -0.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1788
    Cell Significance Index: -9.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molecular structure:** MMP23B is a member of the MMP family, characterized by its zinc-binding site and a catalytic domain that enables it to cleave various ECM proteins. 2. **Tissue expression:** MMP23B is highly expressed in connective tissue fibroblasts, mesothelial cells, and certain types of epithelial cells, suggesting its involvement in tissue remodeling and repair. 3. **Zinc-dependent activity:** MMP23B's enzymatic activity is dependent on zinc ions, which are essential for the catalytic process. 4. **Collagen-catabolic process:** MMP23B is involved in the degradation of collagen, a key component of the ECM, which is essential for tissue structure and function. **Pathways and Functions:** 1. **Extracellular matrix organization:** MMP23B plays a crucial role in the remodeling and degradation of the ECM, allowing for tissue repair, growth, and adaptation. 2. **Collagen catabolic process:** The enzyme's ability to degrade collagen is essential for maintaining tissue homeostasis and preventing excessive fibrosis. 3. **Cell migration and invasion:** MMP23B's activity can facilitate cell migration and invasion, which are critical processes in tissue repair and cancer progression. 4. **Angiogenesis:** MMP23B has been implicated in the regulation of angiogenesis, the formation of new blood vessels, which is essential for tissue repair and cancer progression. **Clinical Significance:** 1. **Fibrosis and cancer:** Elevated levels of MMP23B have been associated with fibrotic diseases, such as liver and kidney fibrosis, as well as cancer progression, including prostate and lung cancer. 2. **Atherosclerosis:** MMP23B's role in the degradation of ECM proteins has been implicated in the development of atherosclerosis, a cardiovascular disease characterized by the buildup of plaque in arteries. 3. **Wound healing:** MMP23B's activity is essential for wound healing, as it facilitates the degradation of ECM proteins and promotes tissue repair. 4. **Regenerative medicine:** Understanding the role of MMP23B in tissue regeneration and repair can lead to the development of novel therapeutic strategies for tissue engineering and regenerative medicine. In conclusion, MMP23B is a key regulator of extracellular matrix dynamics, involved in various physiological and pathological processes, including tissue repair, fibrosis, and cancer progression. Further research on MMP23B's role in different diseases will provide insights into its potential as a therapeutic target and its involvement in tissue regeneration and repair.

Genular Protein ID: 2880416702

Symbol: MMP23_HUMAN

Name: Matrix metalloproteinase-23

UniProtKB Accession Codes:

O75900 A2AGN0 A2AGN1 O75894 O75895 Q5QPQ8 Q76P96 Q7LDM6 Q7LDM7 Q9UBR9 Q9UJK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9740677

Title: Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3.

PubMed ID: 9740677

DOI: 10.1006/geno.1998.5401

PubMed ID: 9988691

Title: Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members.

PubMed ID: 9988691

DOI: 10.1074/jbc.274.8.4570

PubMed ID: 11328856

Title: Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development.

PubMed ID: 11328856

DOI: 10.1210/mend.15.5.0638

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 390
  • Mass: 43935
  • Checksum: 5D78E4B4F2053D15
  • Sequence:
    • MGRGARVPSE APGAGVERRW LGAALVALCL LPALVLLARL GAPAVPAWSA AQGDVAALGL 
SAVPPTRVPG PLAPRRRRYT LTPARLRWDH FNLTYRILSF PRNLLSPRET RRALAAAFRM 
WSDVSPFSFR EVAPEQPSDL RIGFYPINHT DCLVSALHHC FDGPTGELAH AFFPPHGGIH 
FDDSEYWVLG PTRYSWKKGV WLTDLVHVAA HEIGHALGLM HSQHGRALMH LNATLRGWKA 
LSQDELWGLH RLYGCLDRLF VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVATT 
PPPPRTKTRL VPEGRNVTFR CGQKILHKKG KVYWYKDQEP LEFSYPGYLA LGEAHLSIIA 
NAVNEGTYTC VVRRQQRVLT TYSWRVRVRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.