Details for: PCOLCE

Gene ID: 5118

Symbol: PCOLCE

Ensembl ID: ENSG00000106333

Description: procollagen C-endopeptidase enhancer

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.2433
    Cell Significance Index: -17.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.7436
    Cell Significance Index: -17.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.6611
    Cell Significance Index: -18.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.6459
    Cell Significance Index: -15.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.3933
    Cell Significance Index: -13.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4369
    Cell Significance Index: -17.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.8048
    Cell Significance Index: -13.1800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 11.4277
    Cell Significance Index: 70.7000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 7.4680
    Cell Significance Index: 42.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.3387
    Cell Significance Index: 93.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.5584
    Cell Significance Index: 840.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.9307
    Cell Significance Index: 124.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7565
    Cell Significance Index: -10.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2029
    Cell Significance Index: -16.5900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 3.8007
    Cell Significance Index: 22.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.7634
    Cell Significance Index: 22.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.9476
    Cell Significance Index: 84.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.7696
    Cell Significance Index: 42.8500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.0574
    Cell Significance Index: 32.6400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.0285
    Cell Significance Index: 18.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9219
    Cell Significance Index: 37.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5012
    Cell Significance Index: 16.3200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.2542
    Cell Significance Index: 6.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1644
    Cell Significance Index: 159.9100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.8984
    Cell Significance Index: 5.6500
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.7748
    Cell Significance Index: 3.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5239
    Cell Significance Index: 3.5500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.5038
    Cell Significance Index: 2.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4955
    Cell Significance Index: 94.3000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4851
    Cell Significance Index: 2.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3899
    Cell Significance Index: 8.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3823
    Cell Significance Index: 5.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3390
    Cell Significance Index: 33.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3343
    Cell Significance Index: 16.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3340
    Cell Significance Index: 66.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2893
    Cell Significance Index: 261.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2541
    Cell Significance Index: 4.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2152
    Cell Significance Index: 11.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1899
    Cell Significance Index: 22.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1663
    Cell Significance Index: 27.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1416
    Cell Significance Index: 2.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0645
    Cell Significance Index: 7.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0270
    Cell Significance Index: 4.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0146
    Cell Significance Index: 7.9500
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.0089
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0028
    Cell Significance Index: 4.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0082
    Cell Significance Index: -3.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0159
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0229
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0239
    Cell Significance Index: -0.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0250
    Cell Significance Index: -1.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0278
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0286
    Cell Significance Index: -17.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0307
    Cell Significance Index: -11.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0321
    Cell Significance Index: -3.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0353
    Cell Significance Index: -2.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0406
    Cell Significance Index: -2.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0434
    Cell Significance Index: -12.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0464
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0591
    Cell Significance Index: -7.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0690
    Cell Significance Index: -13.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0752
    Cell Significance Index: -1.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0799
    Cell Significance Index: -11.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0833
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0878
    Cell Significance Index: -18.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0908
    Cell Significance Index: -15.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0926
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1039
    Cell Significance Index: -7.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1104
    Cell Significance Index: -6.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1135
    Cell Significance Index: -5.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1208
    Cell Significance Index: -13.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1286
    Cell Significance Index: -15.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1587
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1636
    Cell Significance Index: -17.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1678
    Cell Significance Index: -13.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1744
    Cell Significance Index: -10.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1926
    Cell Significance Index: -10.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1963
    Cell Significance Index: -13.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1995
    Cell Significance Index: -12.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2061
    Cell Significance Index: -4.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2112
    Cell Significance Index: -7.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2574
    Cell Significance Index: -16.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2591
    Cell Significance Index: -12.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2616
    Cell Significance Index: -17.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2643
    Cell Significance Index: -7.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2795
    Cell Significance Index: -6.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3113
    Cell Significance Index: -8.1900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3118
    Cell Significance Index: -1.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3256
    Cell Significance Index: -10.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3272
    Cell Significance Index: -9.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PCOLCE gene is a non-coding gene that regulates the expression of collagen-related genes. It is located on chromosome 2q37.3 and is conserved across species, suggesting its evolutionary importance. The gene is primarily expressed in cells involved in collagen production, such as fibroblasts and mesenchymal stem cells. The PCOLCE gene is also involved in the regulation of collagen biosynthesis and modification, including crosslinking of collagen fibrils and proteolysis. **Pathways and Functions** The PCOLCE gene is involved in several key pathways, including: 1. **Collagen Biosynthesis and Modification**: The PCOLCE gene regulates the expression of collagen-related genes, including procollagen genes, which are essential for collagen synthesis and modification. 2. **Assembly of Collagen Fibrils**: The PCOLCE gene is involved in the assembly of collagen fibrils, which are critical components of the extracellular matrix. 3. **Crosslinking of Collagen Fibrils**: The PCOLCE gene regulates the crosslinking of collagen fibrils, which is essential for the formation of a stable extracellular matrix. 4. **Proteolysis**: The PCOLCE gene is involved in the regulation of proteolysis, which is essential for the degradation of collagen and the remodeling of the extracellular matrix. **Clinical Significance** Dysregulation of the PCOLCE gene has been implicated in various diseases, including: 1. **Osteogenesis Imperfecta**: A genetic disorder characterized by fragile bones and brittle collagen. 2. **Ehlers-Danlos Syndrome**: A group of genetic disorders characterized by hypermobile joints and fragile skin. 3. **Fibrosis**: A condition characterized by the excessive deposition of collagen in tissues, leading to organ dysfunction. 4. **Cancer**: The PCOLCE gene has been implicated in the regulation of cancer cell migration and invasion. In conclusion, the PCOLCE gene plays a critical role in regulating collagen biosynthesis and modification, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which the PCOLCE gene regulates collagen production and its implications for human disease.

Genular Protein ID: 2277068563

Symbol: PCOC1_HUMAN

Name: Procollagen C-endopeptidase enhancer 1

UniProtKB Accession Codes:

Q15113 B2R9E1 O14550

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7523404

Title: Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE).

PubMed ID: 7523404

DOI: 10.1016/s0021-9258(18)47191-8

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 9933570

Title: Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein.

PubMed ID: 9933570

DOI: 10.1006/geno.1998.5663

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10625689

Title: Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

PubMed ID: 10625689

DOI: 10.1074/jbc.275.2.1384

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 12670942

Title: NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding.

PubMed ID: 12670942

DOI: 10.1074/jbc.m302734200

Sequence Information:

  • Length: 449
  • Mass: 47972
  • Checksum: 3D88430158648796
  • Sequence:
    • MLPAATASLL GPLLTACALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS EGFPNLYPPN 
KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG SGTSGQRLGR FCGTFRPAPL 
VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA TSGTEHQFCG GRLEKAQGTL TTPNWPESDY 
PPGISCSWHI IAPPDQVIAL TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV 
PGSISSEGNE LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS 
QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP GEGLAVTVSL 
IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL MGQVEENRGP VLPPESFVVL 
HRPNQDQILT NLSKRKCPSQ PVRAAASQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.