Details for: BICDL2

Gene ID: 146439

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BICDL2

Ensembl ID: ENSG00000162069

Description: BICD family like cargo adaptor 2

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • conventional dendritic cell CL0000990
    CSI 46.5
    rCSI 38.82%
    PRS 98.31
  • chondrocyte CL0000138
    CSI 34.31
    rCSI 54.56%
    PRS 99.15
  • regulatory T cell CL0000815
    CSI 32.73
    rCSI 37.94%
    PRS 98.31
  • pericyte CL0000669
    CSI 31.86
    rCSI 84.84%
    PRS 95.87
  • innate lymphoid cell CL0001065
    CSI 26.33
    rCSI 54.36%
    PRS 98.77
  • mast cell CL0000097
    CSI 25.07
    rCSI 54.13%
    PRS 97.88
  • helper T cell CL0000912
    CSI 24.66
    rCSI 34.87%
    PRS 98.79
  • basal cell of epidermis CL0002187
    CSI 24.3
    rCSI 43.06%
    PRS 94.99
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 24.22
    rCSI 29.35%
    PRS 96.23
  • melanocyte of skin CL1000458
    CSI 22.59
    rCSI 30.79%
    PRS 96.09
  • secretory cell CL0000151
    CSI 20.07
    rCSI 20.94%
    PRS 99.88
  • suprabasal keratinocyte CL4033013
    CSI 19.34
    rCSI 31.57%
    PRS 96.58
  • colon epithelial cell CL0011108
    CSI 16.13
    rCSI 16.89%
    PRS 99.83
  • goblet cell CL0000160
    CSI 15.22
    rCSI 14.38%
    PRS 99.88
  • duct epithelial cell CL0000068
    CSI 14.28
    rCSI 20.9%
    PRS 99.98
  • nasal mucosa goblet cell CL0002480
    CSI 13.12
    rCSI 15.21%
    PRS 99.65
  • intestine goblet cell CL0019031
    CSI 13.1
    rCSI 11.63%
    PRS 99.8
  • endothelial cell of vascular tree CL0002139
    CSI 12.84
    rCSI 70.18%
    PRS 99.23
  • stem cell CL0000034
    CSI 12.42
    rCSI 11.97%
    PRS 99.84
  • pancreatic acinar cell CL0002064
    CSI 12.37
    rCSI 16.44%
    PRS 99.53
  • fallopian tube secretory epithelial cell CL4030006
    CSI 12.3
    rCSI 11.85%
    PRS 99.78
  • epithelial cell of lower respiratory tract CL0002632
    CSI 12.23
    rCSI 9.48%
    PRS 99.94
  • multi-ciliated epithelial cell CL0005012
    CSI 11.47
    rCSI 11.44%
    PRS 99.65
  • ciliated cell CL0000064
    CSI 10.74
    rCSI 17.41%
    PRS 99.41
  • ciliated epithelial cell CL0000067
    CSI 10.66
    rCSI 9.37%
    PRS 99.42
  • enterocyte CL0000584
    CSI 9.47
    rCSI 15.27%
    PRS 99.7
  • ionocyte CL0005006
    CSI 9.08
    rCSI 9.73%
    PRS 99.86
  • lung ciliated cell CL1000271
    CSI 8.54
    rCSI 9.87%
    PRS 99.7
  • lung secretory cell CL1000272
    CSI 8.53
    rCSI 21.1%
    PRS 99.95
  • epithelial cell of lung CL0000082
    CSI 8.51
    rCSI 7.06%
    PRS 99.95
  • colonocyte CL1000347
    CSI 8.03
    rCSI 11.51%
    PRS 99.81
  • intestinal tuft cell CL0019032
    CSI 8.02
    rCSI 12.26%
    PRS 99.67
  • brush cell of tracheobronchial tree CL0002075
    CSI 7.64
    rCSI 22.68%
    PRS 100
  • pulmonary ionocyte CL0017000
    CSI 7.61
    rCSI 9.27%
    PRS 99.83
  • club cell CL0000158
    CSI 7.56
    rCSI 11.07%
    PRS 99.94
  • transit amplifying cell CL0009010
    CSI 7.55
    rCSI 11.55%
    PRS 99.92
  • acinar cell CL0000622
    CSI 7.43
    rCSI 10.89%
    PRS 99.87
  • respiratory suprabasal cell CL4033048
    CSI 7.41
    rCSI 9.5%
    PRS 99.96
  • squamous epithelial cell CL0000076
    CSI 7.24
    rCSI 17.19%
    PRS 99.24
  • tracheal goblet cell CL1000329
    CSI 6.94
    rCSI 15.16%
    PRS 99.93
  • lung neuroendocrine cell CL1000223
    CSI 6.64
    rCSI 9.82%
    PRS 99.81
  • BEST4+ enteroycte CL4030026
    CSI 6.41
    rCSI 7.98%
    PRS 99.63
  • respiratory basal cell CL0002633
    CSI 6.19
    rCSI 6.42%
    PRS 99.94
  • deuterosomal cell CL4033044
    CSI 6.04
    rCSI 20.43%
    PRS 99.49
  • pancreatic ductal cell CL0002079
    CSI 5.93
    rCSI 11.54%
    PRS 99.75
  • conjunctival epithelial cell CL1000432
    CSI 5.58
    rCSI 8.52%
    PRS 99.76
  • mucous neck cell CL0000651
    CSI 5.56
    rCSI 8.01%
    PRS 99.78
  • enterocyte of epithelium of large intestine CL0002071
    CSI 5.43
    rCSI 28.51%
    PRS 99.89
  • intestinal epithelial cell CL0002563
    CSI 5.28
    rCSI 5.51%
    PRS 99.75
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 5.22
    rCSI 11.9%
    PRS 99.53
  • cytotoxic T cell CL0000910
    CSI 5.07
    rCSI 29.06%
    PRS 98.92
  • transit amplifying cell of colon CL0009011
    CSI 4.85
    rCSI 5.7%
    PRS 99.94
  • foveolar cell of stomach CL0002179
    CSI 4.7
    rCSI 10.01%
    PRS 99.92
  • colon goblet cell CL0009039
    CSI 4.38
    rCSI 10.41%
    PRS 99.87
  • bronchial goblet cell CL1000312
    CSI 4.07
    rCSI 16.25%
    PRS 99.96
  • enteroendocrine cell of colon CL0009042
    CSI 4.02
    rCSI 18.84%
    PRS 99.76
  • luminal cell of prostate epithelium CL0002340
    CSI 3.83
    rCSI 20.57%
    PRS 99.79
  • luminal epithelial cell of mammary gland CL0002326
    CSI 3.68
    rCSI 6.68%
    PRS 99.87
  • tracheobronchial serous cell CL0019001
    CSI 2.69
    rCSI 11.63%
    PRS 99.87
  • pancreatic stellate cell CL0002410
    CSI 2.66
    rCSI 15.49%
    PRS 99.72
  • epithelial cell of esophagus CL0002252
    CSI 1.76
    rCSI 17.35%
    PRS 99.44
  • paneth cell of colon CL0009009
    CSI 0.91
    rCSI 8.93%
    PRS 99.9
  • acinar cell of salivary gland CL0002623
    CSI 0.51
    rCSI 11.9%
    PRS 99.89

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [BICDL2](/details-gene/146439) (BICD family like cargo adaptor 2) is a protein-coding gene located on chromosome 16p13.3 that functions as an intracellular cargo adapter. The gene product is implicated in crucial cellular transport mechanisms, specifically '[Golgi to secretory granule transport](/details-go/GO:0055107)' and '[Vesicle transport along microtubule](/details-go/GO:0047496)'. Its expression profile indicates a significant role in a diverse array of cell types with high secretory or trafficking demands. **Overall**, it is most significant in immune cells such as [conventional dendritic cell](/details-cell/CL0000990)s and [regulatory T cell](/details-cell/CL0000815)s, as well as in structural cells like [chondrocyte](/details-cell/CL0000138)s and various epithelial and secretory cell types. This pattern suggests that [BICDL2](/details-gene/146439) is a key facilitator of protein and vesicle trafficking essential for both immune function and tissue maintenance. ## Cellular Roles and Expression Landscape The expression landscape of [BICDL2](/details-gene/146439) highlights its importance in cells characterized by high rates of protein synthesis, processing, and secretion. Its function appears conserved across multiple distinct lineages, pointing to a fundamental role in cellular logistics. - **Immune System:** [BICDL2](/details-gene/146439) shows its highest significance in [conventional dendritic cell](/details-cell/CL0000990)s (CSI: 46.50), suggesting a critical role in the complex trafficking events required for antigen processing and presentation. Its prominence in various lymphocyte populations, including [regulatory T cell](/details-cell/CL0000815)s (CSI: 32.73), [innate lymphoid cell](/details-cell/CL0001065)s (CSI: 26.33), [helper T cell](/details-cell/CL0000912)s (CSI: 24.66), and [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203)s (CSI: 24.22), is consistent with a function in cytokine secretion or the transport of effector molecules. The high significance in [mast cell](/details-cell/CL0000097)s (CSI: 25.07) further supports a role in the transport of pre-formed granular contents. - **Structural and Barrier Tissues:** The gene is highly significant in [chondrocyte](/details-cell/CL0000138)s (CSI: 34.31) and [pericyte](/details-cell/CL0000669)s (CSI: 31.86), which are responsible for secreting and organizing extracellular matrix. This suggests [BICDL2](/details-gene/146439) may be involved in the transport of matrix components like collagen. Its expression in multiple epidermal cell types, including [basal cell of epidermis](/details-cell/CL0002187) and [suprabasal keratinocyte](/details-cell/CL4033013), points to a role in maintaining the skin barrier. - **Secretory Epithelia:** A strong signal in dedicated secretory cells, such as [secretory cell](/details-cell/CL0000151)s (CSI: 20.07), [colon epithelial cell](/details-cell/CL0011108)s (CSI: 16.13), and [goblet cell](/details-cell/CL0000160)s (CSI: 15.22), directly aligns with its annotated function in vesicle transport from the Golgi apparatus. ## Pathways and Molecular Function The functional annotations for [BICDL2](/details-gene/146439) provide a clear mechanistic basis for its observed cellular expression pattern. As a component of the '[Cytoplasm](/details-go/GO:0005737)', it participates directly in intracellular trafficking pathways. Its role in '[Vesicle transport along microtubule](/details-go/GO:0047496)' suggests it acts as a linker or adapter molecule, connecting specific cargo-containing vesicles to microtubule motor proteins for directional transport. This process is fundamental to the function of nearly all its top-expressing cells, from cytokine release in T cells to mucin secretion in [goblet cell](/details-cell/CL0000160)s. The more specific process, '[Golgi to secretory granule transport](/details-go/GO:0055107)', is particularly relevant for specialized secretory cells like [mast cell](/details-cell/CL0000097)s and endocrine cells. At the molecular level, its annotated functions of '[Protein binding](/details-go/GO:0005515)' and '[Small gtpase binding](/details-go/GO:0031267)' define its role as an adapter. It likely recognizes specific protein cargo or vesicle coat proteins, and its activity is probably regulated by small GTPases (such as Rab proteins), which serve as molecular switches to control the timing and destination of vesicle transport. ## Research Directions The widespread importance of [BICDL2](/details-gene/146439) in cells with high trafficking activity opens up several avenues for future investigation, particularly in immunology and epithelial biology. **Testable Hypotheses:** 1. Given its high significance in [conventional dendritic cell](/details-cell/CL0000990)s, [BICDL2](/details-gene/146439) is hypothesized to be essential for the trafficking of MHC class II-containing vesicles to the cell surface for antigen presentation. Its disruption would likely lead to impaired activation of CD4+ [helper T cell](/details-cell/CL0000912)s. 2. In intestinal [goblet cell](/details-cell/CL0000160)s and [colon epithelial cell](/details-cell/CL0011108)s, [BICDL2](/details-gene/146439) may be a key adapter for the transport of mucin granules to the apical membrane. Loss of [BICDL2](/details-gene/146439) function could result in a defective mucus barrier, potentially contributing to inflammatory bowel diseases. 3. The high CSI in [chondrocyte](/details-cell/CL0000138)s suggests that [BICDL2](/details-gene/146439) mediates the efficient secretion of extracellular matrix proteins like type II collagen. Mutations or dysregulation of [BICDL2](/details-gene/146439) in these cells could be a contributing factor to certain forms of skeletal dysplasia. **Proposed Experiment:** To test the first hypothesis regarding its role in antigen presentation, a CRISPR-Cas9 knockout of [BICDL2](/details-gene/146439) could be performed in primary human monocyte-derived dendritic cells. Control and knockout DCs would be pulsed with a known peptide antigen and then co-cultured with antigen-specific CD4+ T cells. The functional consequences would be assessed by measuring T cell proliferation (e.g., via CFSE dilution by flow cytometry) and effector cytokine production (e.g., IFN-γ and IL-2 by ELISA). A direct assessment of vesicle trafficking could be made by quantifying the surface expression of MHC class II molecules on the DCs via flow cytometry following stimulation. **Therapeutic Potential:** [BICDL2](/details-gene/146439) is likely unsuitable as a direct therapeutic target for systemic inhibition. Its function is fundamental to cellular transport, and its significant expression in a broad range of critical cell types suggests that systemic targeting would result in severe, widespread toxicity. However, understanding its specific role in the pathology of diseases driven by defective secretion or trafficking (e.g., certain immunodeficiencies, cystic fibrosis-like conditions, or chondrodysplasias) could reveal its utility as a disease biomarker or a target for gene therapies aimed at restoring function in specific cell populations.

Genular Protein ID: 876257705

Symbol: BICL2_HUMAN

Name: BICD family-like cargo adapter 2

UniProtKB Accession Codes:

A1A5D9 Q658L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 508
  • Mass: 56834
  • Checksum: A3E6222CF0B2473E
  • Sequence:
    • MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL ALQLQQKEKD 
LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN HELRRGLAAR GAEWEARAVE 
LEGDVEALRA QLGEQRSEQQ DSGRERARAL SELSEQNLRL SQQLAQASQT EQELQRELDA 
LRGQCQAQAL AGAELRTRLE SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE 
LLLLRRERRE HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA 
HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL SPAEILEEKE 
VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL HSALSDRDEA VNKALELSLQ 
LNRVSLERDS LSRELLRAIR QKVALTQELE AWQDDMQVVI GQQLRSQRQK ELSASASSST 
PRRAAPRFSL RLGPGPAGGF LSNLFRRT